Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

Nature Immunology

Volumn 9, Issue 2, 2008, Pages 194-202

  Tone, Yukiko ^a   Furuuchi, Keiji ^a   Kojima, Yoshitsugu ^a   Tykocinski, Mark L ^a   Greene, Mark I ^a   Tone, Masahide ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; SMAD3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR NFAT;

ACETYLATION; ANIMAL CELL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL FUNCTION; CELL SURVIVAL; CONTROLLED STUDY; ENHANCER REGION; GENE ACTIVITY; GENE INDUCTION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MONONUCLEAR CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; ENHANCER ELEMENTS (GENETICS); FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; MICE; MOLECULAR SEQUENCE DATA; NFATC TRANSCRIPTION FACTORS; SMAD3 PROTEIN; T-LYMPHOCYTES, REGULATORY;

EID: 38349095578     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1549     Document Type: Article

References (31)

1. Shevach, E.M. Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 18, 423-449 (2000).
2. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22, 531-562 (2004).
3. + regulatory T cells. Nat. Immunol. 4, 330-336 (2003).
4. Brunkow, M.E. et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27, 68-73 (2001).
5. Bennett, C.L. et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27, 20-21 (2001).
6. Gavin, M.A. et al. Foxp3-dependent programme of regulatory T-cell differentiation. Nature 445, 771-775 (2007).
7. Hori, S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061 (2003).
8. + T regulatory cells. Nat. Immunol. 4, 337-342 (2003).
9. Wan, Y.Y. & Flavell, R.A. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 445, 766-770 (2007).
10. Wu, Y. et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126, 375-387 (2006).
11. Bettelli, E., Dastrange, M. & Oukka, M. Foxp3 interacts with nuclear factor of activated T cells and NF-kB to repress cytokine gene expression and effector functions of T helper cells. Proc. Natl. Acad. Sci. USA 102, 5138-5143 (2005).
12. Ono, M. et al. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature 446, 685-689 (2007).
13. Li, B. et al. FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc. Natl. Acad. Sci. USA 104, 4571-4576 (2007).
14. Mantel, P.Y. et al. Molecular mechanisms underlying FOXP3 induction in human T cells. J. Immunol. 176, 3593-3602 (2006).
15. Kim, H.P. & Leonard, W.J. CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: A role for DNA methylation. J. Exp. Med. 204, 1543-1551 (2007).
16. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
17. - T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 172, 5149-5153 (2004).
18. Tone, Y. et al. OX40 gene expression is upregulated by chromatin remodeling in its promoter region containing Sp1/Sp3, YY1 and NF-kB binding sites. J. Immunol. 179, 1760-1767 (2007).
19. Tone, M., Powell, M.J., Tone, Y., Thompson, S.A. & Waldmann, H. IL-10 gene expression is controlled by the transcription factors Sp1 and Sp3. J. Immunol. 165, 286-291 (2000).
20. Jain, J., McCaffrey, P.G., Valge-Archer, V.E. & Rao, A. Nuclear factor of activated T cells contains Fos and Jun, Nature 356, 901-804 (1992).
21. Li, M.O., Sanjabi, S. & Flavell, R.A. Transforming growth factor-β controls development, homeostasis, and tolerance of Tcells by regulatory T cell-dependent and independent mechanisms. Immunity 25, 455-471 (2006).
22. Massague, J., Seoane, J. & Wotton, D. Smad transcription factors. Genes Dev. 19, 2783-2810 (2005).
23. Zhu, Y., Richardson, J.A., Parada, L.F. & Graff, J.M. Smad3 mutant mice develop metastatic colorectal cancer Cell 94, 703-714 (1998).
24. Jinnin, M., Ihn, H. & Tamaki, K. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-β1-incluced extracellular matrix expression. Mol. Pharmacol. 69, 597-607 (2006).
25. Licona-Limon, P. & Soldevila, G. The role of TGF-β superfamily during T cell development: New insights. Immunol. Lett. 109, 1-12 (2007).
26. Zou, W. Regulatory Tcells, tumour immunity and immunotherapy. Nat. Rev. Immunol. 6, 295-307 (2006).
27. Peters, N. & Sacks, D. Immune privilege in sites of chronic infection: Leishmania and regulatory T cells. Immunol. Rev. 213, 159-179 (2006).
28. 1 regulatory T cells in the periphery of T-cell receptor transgenic mice tolerized to transplants. J. Immunol. 172, 6003-6010 (2004).
29. + regulatory T cells. J. Immunol. 178, 280-290 (2007).
30. + T regulatory cells. J. Immunol. 178, 4022-4026 (2007).
31. Frohman, M.A., Dush, M.K. & Martin, G.R. Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. USA 85, 8998-9002 (1988).