Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses

Journal of Experimental Medicine

Volumn 201, Issue 4, 2005, Pages 615-626

  Grenningloh, Roland ^a   Bok, Yun Kang ^a   Ho, I Cheng ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; ONCOPROTEIN; PROTEIN; PROTEIN E26 TRANSFORMATION SPECIFIC 1; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNE RESPONSE; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTO ONCOGENE; REGULATORY MECHANISM; TH1 CELL;

ANIMALS; CELL PROLIFERATION; COLITIS; CYTOKINES; FEMALE; INFLAMMATION; MICE; MICE, KNOCKOUT; MICE, SCID; PROTO-ONCOGENE PROTEIN C-ETS-1; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; T-BOX DOMAIN PROTEINS; TH1 CELLS; TRANSCRIPTION FACTORS;

EID: 14244251950     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20041330     Document Type: Article

References (51)

1. Del Prete, G. 1998. The concept of type-1 and type-2 helper T cells and their cytokines in humans. Int. Rev. Immunol. 16:427-455.
2. Mosmann, T.R., and R.L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145-173.
3. Glimcher, L.H., and K.M. Murphy. 2000. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 14:1693-1711.
4. Asseman, C., S. Fowler, and F. Powrie. 2000. Control of experimental inflammatory bowel disease by regulatory T cells. Am. J. Respir. Crit. Care Med. 162:S185-S189.
5. de Waal Malefyt, R., H. Yssel, and J.E. de Vries. 1993. Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation. J. Immunol. 150:4754-4765.
6. Zheng, W., and R.A. Flavell. 1997. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell. 89:587-596.
7. Szabo, S.J., S.T. Kim, G.L. Costa, X. Zhang, C.G. Fathman, and L.H. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 100:655-669.
8. Pai, S.Y., M.L. Truitt, and I.C. Ho. 2004. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc. Natl. Acad. Sci. USA. 101:1993-1998.
9. Kurata, H., H.J. Lee, A. O'Garra, and N. Arai. 1999. Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. Immunity. 11:677-688.
10. Ouyang, W., S.H. Ranganath, K. Weindel, D. Bhattacharya, T.L. Murphy, W.C. Sha, and K.M. Murphy. 1998. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity. 9:745-755.
11. Afkarian, M., J.R. Sedy, J. Yang, N.G. Jacobson, N. Cereb, S.Y. Yang, T.L. Murphy, and K.M. Murphy. 2002. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat. Immunol. 3:549-557.
12. Lighvani, A.A., D.M. Frucht, D. Jankovic, H. Yamane, J. Aliberti, B.D. Hissong, B.V. Nguyen, M. Gadina, A. Sher, W.E. Paul, and J.J. O'Shea. 2001. T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA. 98:15137-15142.
13. Mullen, A.C., F.A. High, A.S. Hutchins, H.W. Lee, A.V. Villarino, D.M. Livingston, A.L. Kung, N. Cereb, T.P. Yao, S.Y. Yang, and S.L. Reiner. 2001. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science. 292:1907-1910.
14. Szabo, S.J., B.M. Sullivan, S.L. Peng, and L.H. Glimcher. 2003. Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 21:713-758.
15. Szabo, S.J., A.S. Dighe, U. Gubler, and K.M. Murphy. 1997. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817-824.
16. Oikawa, T., and T. Yamada. 2003. Molecular biology of the Ets family of transcription factors. Gene. 303:11-34.
17. Sharrocks, A.D. 2001. The ETS-domain transcription factor family. Nat. Rev. Mol. Cell Biol. 2:827-837.
18. Barton, K., N. Muthusamy, C. Fischer, C.N. Ting, T.L. Walunas, L.L. Lanier, and J.M. Leiden. 1998. The Ets-1. transcription factor is required for the development of natural killer cells in mice. Immunity. 9:555-563.
19. Bories, J.C., D.M. Willerford, D. Grevin, L. Davidson, A. Camus, P. Martin, D. Stehelin, and F.W. Alt. 1995. Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature. 377:635-638.
20. Muthusamy, N., K. Barton, and J.M. Leiden. 1995. Defective activation and survival of T cells lacking the Ets-1 transcription factor. Nature. 377:639-642.
21. Blumenthal, S.G., G. Aichele, T. Wirth, A.P. Czernilofsky, A. Nordheim, and J. Dittmer. 1999. Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-1 Tax1. J. Biol. Chem. 274:2910-12916.
22. Romano-Spica, V., P. Georgiou, H. Suzuki, T.S. Papas, and N.K. Bhat. 1995. Role of ETS1 in IL-2 gene expression. J. Immunol. 154:2724-2732.
23. Thomas, R.S., M.J. Tymms, L.H. McKinlay, M.F. Shannon, A. Seth, and I. Kola. 1997. ETS1, NFkappaB and AP1 synergistically transactivate the human GM-CSF promoter. Oncogene. 14:2845-2855.
24. Murphy, K.M., A.B. Heimberger, and D.Y. Loh. 1990. Induction byantigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science. 250:1720-1723.
25. Kishikawa, H., J. Sun, A. Choi, S.C. Miaw, and I.C. Ho. 2001. The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3. J. Immunol. 167:4414-4420.
26. Boyd, K.E., J. Wells, J. Gutman, S.M. Bartley, and P.J. Farnham. 1998. c-Myc target gene specificity is determined by a post-DNAbinding mechanism. Proc. Natl. Acad. Sci. USA. 95:13887-13892.
27. Bhat, N.K., K.L. Komschlies, S. Fujiwara, R.J. Fisher, B.J. Mathieson, T.A. Gregorio, H.A. Young, J.W. Kasik, K. Ozato, and T.S. Papas. 1989. Expression of ets genes in mouse thymocyte subsets and T cells. J. Immunol. 142:672-678.
28. Bhat, N.K., C.B. Thompson, T. Lindsten, C.H. June, S. Fujiwara, S. Koizumi, R.J. Fisher, and T.S. Papas. 1990. Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1. Proc. Natl. Acad. Sci. USA. 87:3723-3727.
29. Wakkach, A., N. Fournier, V. Brun, J.P. Breittmayer, F. Cottrez, and H. Groux. 2003. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity. 18:605-617.
30. Moore, K.W., R. de Waal Malefyt, R.L. Coffman, and A. O'Garra. 2001. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19:683-765.
31. Powrie, F., M.W. Leach, S. Mauze, S. Menon, L.B. Caddle, and R.L. Coffman. 1994. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity. 1:553-562.
32. Grogan, J.L., M. Mohrs, B. Harmon, D.A. Lacy, J.W. Sedat, and R.M. Locksley. 2001. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity. 14:205-215.
33. Soutto, M., F. Zhang, B. Enerson, Y. Tong, M. Boothby, and T.M. Aune. 2002. A minimal IFN-gamma promoter confers Th1 selective expression. J. Immunol. 169:4205-4212.
34. Cho, J.Y., V. Grigura, T.L. Murphy, and K. Murphy. 2003. Identification of cooperative monomeric Brachyury sites conferring T-bet responsiveness to the proximal IFN-gamma promoter. Int. Immunol. 15:1149-1160.
35. Rutherford, M.N., A. Kumar, S.J. Haque, J. Ghysdael, and B.R. Williams. 1997. Specific binding of the ETS-domain protein to the interferon-stimulated response element. J. Interferon Cytokine Res. 17:1-10.
36. Hilliard, B.A., N. Mason, L. Xu, J. Sun, S.E. Lamhamedi-Cherradi, H.C. Liou, C. Hunter, and Y.H. Chen. 2002. Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. J. Clin. Invest. 110:843-850.
37. Mason, N.J., H.C. Liou, and C.A. Hunter. 2004. T cell-intrinsic expression of c-Rel regulates Th1 cell responses essential for resistance to Toxoplasma gondii. J. Immunol. 172:3704-3711.
38. Lohoff M., G.S. Duncan, D. Ferrick, H.W. Mittrucker, S. Bischof, S. Prechtl, M. Rollinghoff, E. Schmitt, A. Pahl, and T.W. Mak. 2000. Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells. J. Exp. Med. 192:325-336.
39. Mullen, A.C., A.S. Hutchins, F.A. High, H.W. Lee, K.J. Sykes, L.A. Chodosh, and S.L. Reiner. 2002. HIx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction. Nat. Immunol. 3:652-658.
40. Zheng, W.P., Q. Zhao, X. Zhao, B. Li, M. Hubank, D.G. Schatz, and R.A. Flavell. 2004. Up-regulation of Hlx in immature Th cells induces IFN-gamma expression. J. Immunol. 172:114-122.
41. Zhu, J., J. Cote-Sierra, L. Guo, and W.E. Paul. 2003. Stat5 activation plays a critical role in Th2 differentiation. Immunity. 19:739-748.
42. Bassuk, A.G., R.T. Anandappa, and J.M. Leiden. 1997. Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells. J. Virol. 71:3563-3573.
43. Rameil, P., P. Lecine, J. Ghysdael, F. Gouilleux, B. Kahn-Perles, and J. Imbert. 2000. IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells. Oncogene. 19:2086-2097.
44. Townsend, M.J., A.S. Weinmann, J.L. Matsuda, R. Salomon, P.J. Farnham, C.A. Biron, L. Gapin, and L.H. Glimcher. 2004. T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity. 20:477-494.
45. Walunas, T.L., B. Wang, C.R. Wang, and J.M. Leiden. 2000. Cutting edge: the Ets1 transcription factor is required for the development of NK T cells in mice. J. Immunol. 164:2857-2860.
46. Hagenbaugh, A., S. Sharma, S.M. Dubinett, S.H. Wei, R. Aranda, H. Cheroutre, D.J. Fowell, S. Binder, B. Tsao, R.M. Locksley, et al. 1997. Altered immune responses in interleukin 10 transgenic mice. J. Exp. Med. 185:2101-2110.
47. Asseman, C., S. Mauze, M.W. Leach, R.L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:995-1004.
48. + regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295-302.
49. Groux, H., A. O'Garra, M. Bigler, M. Rouleau, S. Antonenko, J.E. de Vries, and M.G. Roncarolo. 1997. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 389:737-742.
50. Powell, M.J., S.A. Thompson, Y. Tone, H. Waldmann, and M. Tone. 2000. Posttranscriptional regulation of IL-10 gene expression through sequences in the 3′-untranslated region. J. Immunol. 165:292-296.
51. Tone, M., M.J. Powell, Y. Tone, S.A. Thompson, and H. Waldmann. 2000. IL-10 gene expression is controlled by the transcription factors Sp1 and Sp3. J. Immunol. 165:286-291.