-
1
-
-
0035909925
-
Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-γ-independent pathway
-
Afanasyeva, M., Wang, Y., Kaya, Z., Stafford, E.A., Dohmen, K.M., Sadighi Akha, A.A. and Rose, N.R. (2001) Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-γ-independent pathway. Circulation, 104, 3145-3151.
-
(2001)
Circulation
, vol.104
, pp. 3145-3151
-
-
Afanasyeva, M.1
Wang, Y.2
Kaya, Z.3
Stafford, E.A.4
Dohmen, K.M.5
Sadighi Akha, A.A.6
Rose, N.R.7
-
2
-
-
0029116336
-
Interleukin 12 induces tyrosine phosphorylation and activation of Stat4 in human lymphocytes
-
Bacon, C.M., Petricoin, E.F., III, Ortaldo, J.R., Rees, R.C., Lamer, A.C., Johnston, J.A. and O'Shea, J.J. (1995) Interleukin 12 induces tyrosine phosphorylation and activation of Stat4 in human lymphocytes. Proc. Natl Acad. Sci. USA, 92, 7307-7311.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 7307-7311
-
-
Bacon, C.M.1
Petricoin E.F. III2
Ortaldo, J.R.3
Rees, R.C.4
Lamer, A.C.5
Johnston, J.A.6
O'Shea, J.J.7
-
3
-
-
0029799912
-
Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon α and γ
-
Bromberg, J.F., Horvath, C.M., Wen, Z., Schreiber, R.D. and Darnell, J.E.J. (1996) Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon α and γ. Proc. Natl Acad. Sci. USA, 93, 7673-7678.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 7673-7678
-
-
Bromberg, J.F.1
Horvath, C.M.2
Wen, Z.3
Schreiber, R.D.4
Darnell, J.E.J.5
-
4
-
-
18444415725
-
Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M
-
Broxmeyer, H.E. et al. (2002) Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M. Immunity, 16, 815-825.
-
(2002)
Immunity
, vol.16
, pp. 815-825
-
-
Broxmeyer, H.E.1
-
5
-
-
0034283962
-
Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii
-
Cai, G., Radzanowski, T., Villegas, E.N., Kastelein, R. and Hunter, C.A. (2000) Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii. J. Immunol., 165, 2619-2627.
-
(2000)
J. Immunol.
, vol.165
, pp. 2619-2627
-
-
Cai, G.1
Radzanowski, T.2
Villegas, E.N.3
Kastelein, R.4
Hunter, C.A.5
-
6
-
-
0029666298
-
STAT3β, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription
-
Caldenhoven, E., van Dijk, T.B., Solari, R., Armstrong, J., Raaijmakers, J.A., Lammers, J.W., Koenderman, L. and de Groot, R.P. (1996) STAT3β, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription. J. Biol. Chem., 271, 13221-13227.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 13221-13227
-
-
Caldenhoven, E.1
Van Dijk, T.B.2
Solari, R.3
Armstrong, J.4
Raaijmakers, J.A.5
Lammers, J.W.6
Koenderman, L.7
De Groot, R.P.8
-
7
-
-
0034789247
-
Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis
-
Chitnis, T., Najafian, N., Benou, C., Salama, A.D., Grusby, M.J., Sayegh, M.H. and Khoury, S.J. (2001) Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J. Clin. Invest., 108, 739-747.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 739-747
-
-
Chitnis, T.1
Najafian, N.2
Benou, C.3
Salama, A.D.4
Grusby, M.J.5
Sayegh, M.H.6
Khoury, S.J.7
-
8
-
-
0030469719
-
Activation of Stat4 by IL-12 and IFN-α: Evidence for the involvement of ligand induced tyrosine and serine phosphorylation
-
Cho, S.S., Bacon, C.M., Sudarshan, C., Rees, R.C., Finbloom, D., Pine, R. and O'Shea, J.J. (1996) Activation of Stat4 by IL-12 and IFN-α: evidence for the involvement of ligand induced tyrosine and serine phosphorylation. J. Immunol., 157, 4781-4789.
-
(1996)
J. Immunol.
, vol.157
, pp. 4781-4789
-
-
Cho, S.S.1
Bacon, C.M.2
Sudarshan, C.3
Rees, R.C.4
Finbloom, D.5
Pine, R.6
O'Shea, J.J.7
-
9
-
-
0033525511
-
Interleukin-12 induces expression of interferon regulatory factor-1 via signal transducer and activator of transcription-4 in human T helper type I cells
-
Coccia, E.M., Passini, N., Battistini, A., Pini, C., Sinigaglia, F. and Rogge, L. (1999) Interleukin-12 induces expression of interferon regulatory factor-1 via signal transducer and activator of transcription-4 in human T helper type I cells. J. Biol. Chem., 274, 6698-6703.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 6698-6703
-
-
Coccia, E.M.1
Passini, N.2
Battistini, A.3
Pini, C.4
Sinigaglia, F.5
Rogge, L.6
-
10
-
-
0030840464
-
STATs and gene regulation
-
Darnell, J.E.J. (1997) STATs and gene regulation. Science, 277, 1630-1636.
-
(1997)
Science
, vol.277
, pp. 1630-1636
-
-
Darnell, J.E.J.1
-
11
-
-
0033564574
-
IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells
-
Galon, J., Sudarshan, C., Ito, S., Finbloom, D. and O'Shea, J.J. (1999) IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. J. Immunol., 162, 7256-7262.
-
(1999)
J. Immunol.
, vol.162
, pp. 7256-7262
-
-
Galon, J.1
Sudarshan, C.2
Ito, S.3
Finbloom, D.4
O'Shea, J.J.5
-
12
-
-
0029053852
-
Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins
-
Hoey, T., Sun, Y.L., Williamson, K. and Xu, X. (1995) Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity, 2, 461-472.
-
(1995)
Immunity
, vol.2
, pp. 461-472
-
-
Hoey, T.1
Sun, Y.L.2
Williamson, K.3
Xu, X.4
-
13
-
-
0345422708
-
Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence
-
Holz, A., Bot, A., Coon, B., Wolfe, T., Grusby, M.J. and von Herrath, M.G. (1999) Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence. J. Immunol., 163, 5374-5382.
-
(1999)
J. Immunol.
, vol.163
, pp. 5374-5382
-
-
Holz, A.1
Bot, A.2
Coon, B.3
Wolfe, T.4
Grusby, M.J.5
Von Herrath, M.G.6
-
14
-
-
0035072249
-
Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer
-
Hughes, T.R. et al. (2001) Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. Nat. Biotechnol., 19, 342-347.
-
(2001)
Nat. Biotechnol.
, vol.19
, pp. 342-347
-
-
Hughes, T.R.1
-
15
-
-
0035893018
-
A mandatory role for STAT4 in IL-12 induction of mouse T cell CCR5
-
Iwasaki, M., Mukai, T., Nakajima, C., Yang, Y.F., Gao, P., Yamaguchi, N., Tomura, M., Fujiwara, H. and Hamaoka, T. (2001) A mandatory role for STAT4 in IL-12 induction of mouse T cell CCR5. J. Immunol., 167, 6877-6883.
-
(2001)
J. Immunol.
, vol.167
, pp. 6877-6883
-
-
Iwasaki, M.1
Mukai, T.2
Nakajima, C.3
Yang, Y.F.4
Gao, P.5
Yamaguchi, N.6
Tomura, M.7
Fujiwara, H.8
Hamaoka, T.9
-
16
-
-
0028943484
-
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcripton (Stat)3 and Stat4
-
Jacobson, N.G., Szabo, S.J., Weber-Nordt, R.M., Zhong, Z., Schreiber, R.D., Darnell, J.E., Jr and Murphy, K.M. (1995) Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcripton (Stat)3 and Stat4. J. Exp. Med., 181, 1755-1762.
-
(1995)
J. Exp. Med.
, vol.181
, pp. 1755-1762
-
-
Jacobson, N.G.1
Szabo, S.J.2
Weber-Nordt, R.M.3
Zhong, Z.4
Schreiber, R.D.5
Darnell J.E., Jr.6
Murphy, K.M.7
-
17
-
-
0029937270
-
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
-
Kaplan, M.H., Sun, Y.-L., Hoey, T. and Grusby, M.J. (1996) Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature, 382, 174-177.
-
(1996)
Nature
, vol.382
, pp. 174-177
-
-
Kaplan, M.H.1
Sun, Y.-L.2
Hoey, T.3
Grusby, M.J.4
-
18
-
-
0030584778
-
Herpesvirus saimiri immortalized γδ T cell line activated by IL-12
-
Klein, J.L., Fickenscher, H., Holliday, J.E., Biesinger, B. and Fleckenstein, B. (1996) Herpesvirus saimiri immortalized γδ T cell line activated by IL-12. J. Immunol., 156, 2754-2760.
-
(1996)
J. Immunol.
, vol.156
, pp. 2754-2760
-
-
Klein, J.L.1
Fickenscher, H.2
Holliday, J.E.3
Biesinger, B.4
Fleckenstein, B.5
-
19
-
-
0034671942
-
Stat4 regulates multiple components of IFN-γ-inducing signaling pathways
-
Lawless, V.A., Zhang, S., Ozes, O.N., Bruns, H.A., Oldham, I., Hoey, T., Grusby, M.J. and Kaplan, M.H. (2000) Stat4 regulates multiple components of IFN-γ-inducing signaling pathways. J. Immunol., 165, 6803-6808.
-
(2000)
J. Immunol.
, vol.165
, pp. 6803-6808
-
-
Lawless, V.A.1
Zhang, S.2
Ozes, O.N.3
Bruns, H.A.4
Oldham, I.5
Hoey, T.6
Grusby, M.J.7
Kaplan, M.H.8
-
20
-
-
0031919849
-
Jaks and STATs: Biological implications
-
Leonard, W.J. and O'Shea, J.J. (1998) Jaks and STATs: biological implications. Annu. Rev. Immunol., 16, 293-322.
-
(1998)
Annu. Rev. Immunol.
, vol.16
, pp. 293-322
-
-
Leonard, W.J.1
O'Shea, J.J.2
-
21
-
-
0035911232
-
Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis
-
Matsukawa, A., Kaplan, M.H., Hogaboam, C.M., Lukacs, N.W. and Kunkel, S.L. (2001) Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis. J. Exp. Med., 193, 679-688.
-
(2001)
J. Exp. Med.
, vol.193
, pp. 679-688
-
-
Matsukawa, A.1
Kaplan, M.H.2
Hogaboam, C.M.3
Lukacs, N.W.4
Kunkel, S.L.5
-
22
-
-
0029790559
-
Requirements for interleukin-4-induced gene expression and functional characterization of Stat6
-
Mikita, T., Campbell, D., Wu, P., Williamson, K. and Schindler, U. (1996) Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol. Cell. Biol., 16, 5811-5820.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 5811-5820
-
-
Mikita, T.1
Campbell, D.2
Wu, P.3
Williamson, K.4
Schindler, U.5
-
23
-
-
0037125988
-
STAT4 serine phosphorylation is critical for IL-12-induced IFN-γ production but not for cell proliferation
-
Morinobu, A., Gadina, M., Strober, W., Visconti, R., Fornace, A., Montagna, C., Feldman, G.M., Nishikomori, R. and O'Shea, J.J. (2002) STAT4 serine phosphorylation is critical for IL-12-induced IFN-γ production but not for cell proliferation. Proc. Natl Acad. Sci. USA, 99, 12281-12286.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 12281-12286
-
-
Morinobu, A.1
Gadina, M.2
Strober, W.3
Visconti, R.4
Fornace, A.5
Montagna, C.6
Feldman, G.M.7
Nishikomori, R.8
O'Shea, J.J.9
-
24
-
-
0020050314
-
A catalogue of splice junction sequences
-
Mount, S.M. (1982) A catalogue of splice junction sequences. Nucleic Acids Res., 10, 459-472.
-
(1982)
Nucleic Acids Res.
, vol.10
, pp. 459-472
-
-
Mount, S.M.1
-
25
-
-
0033835830
-
Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation
-
Murphy, T.L., Geissal, E.D., Farrar, J.D. and Murphy, K.M. (2000) Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation. Mol. Cell. Biol., 20, 7121-7131.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 7121-7131
-
-
Murphy, T.L.1
Geissal, E.D.2
Farrar, J.D.3
Murphy, K.M.4
-
26
-
-
0031023756
-
Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases
-
Musti, A.M., Treier, M. and Bohmann, D. (1997) Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases. Science, 275, 400-402.
-
(1997)
Science
, vol.275
, pp. 400-402
-
-
Musti, A.M.1
Treier, M.2
Bohmann, D.3
-
27
-
-
0037144547
-
Critical role for STAT4 activation by type 1 interferons in the interferon-γ response to viral infection
-
Nguyen, K.B., Watford, W.T., Salomon, R., Hofmann, S.R., Pien, G.C., Morinobu, A., Gadina, M., O'Shea, J.J. and Biron, C.A. (2002) Critical role for STAT4 activation by type 1 interferons in the interferon-γ response to viral infection. Science, 297, 2063-2066.
-
(2002)
Science
, vol.297
, pp. 2063-2066
-
-
Nguyen, K.B.1
Watford, W.T.2
Salomon, R.3
Hofmann, S.R.4
Pien, G.C.5
Morinobu, A.6
Gadina, M.7
O'Shea, J.J.8
Biron, C.A.9
-
28
-
-
0037040991
-
SH2-B family members differentially regulate JAK family tyrosine kinases
-
O'Brien, K.B., O'Shea, J.J. and Carter-Su, C. (2002) SH2-B family members differentially regulate JAK family tyrosine kinases. J. Biol. Chem., 277, 8673-8681.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 8673-8681
-
-
O'Brien, K.B.1
O'Shea, J.J.2
Carter-Su, C.3
-
29
-
-
0030765924
-
Jaks, STATs, cytokine signal transduction and immunoregulation: Are we there yet?
-
O'Shea, J.J. (1997) Jaks, STATs, cytokine signal transduction and immunoregulation: are we there yet? Immunity, 7, 1-11.
-
(1997)
Immunity
, vol.7
, pp. 1-11
-
-
O'Shea, J.J.1
-
30
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann, B. et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity, 13, 715-725.
-
(2000)
Immunity
, vol.13
, pp. 715-725
-
-
Oppmann, B.1
-
31
-
-
0033616607
-
The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway
-
Ouyang, W., Jacobson, N.G., Bhattacharya, D., Gorham, J.D., Fenoglio, D., Sha, W.C., Murphy, T.L. and Murphy, K.M. (1999) The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway. Proc. Natl Acad. Sci. USA, 96, 3888-3893.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3888-3893
-
-
Ouyang, W.1
Jacobson, N.G.2
Bhattacharya, D.3
Gorham, J.D.4
Fenoglio, D.5
Sha, W.C.6
Murphy, T.L.7
Murphy, K.M.8
-
32
-
-
0034644775
-
Dimer stability as a determinant of differential DNA binding activity of Stat3 isoforms
-
Park, O.K., Schaefer, L.K., Wang, W. and Schaefer, T.S. (2000) Dimer stability as a determinant of differential DNA binding activity of Stat3 isoforms. J. Biol. Chem., 275, 32244-32249.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 32244-32249
-
-
Park, O.K.1
Schaefer, L.K.2
Wang, W.3
Schaefer, T.S.4
-
33
-
-
0029655971
-
Function of Stat2 protein in transcriptional activation by α interferon
-
Qureshi, S.A., Leung, S., Kerr, I.M., Stark, G.R. and Darnell, J.E., Jr (1996) Function of Stat2 protein in transcriptional activation by α interferon. Mol. Cell. Biol., 16, 288-293.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 288-293
-
-
Qureshi, S.A.1
Leung, S.2
Kerr, I.M.3
Stark, G.R.4
Darnell J.E., Jr.5
-
34
-
-
0033594812
-
Identification of SH2-bβ as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2
-
Rui, L. and Carter-Su, C. (1999) Identification of SH2-bβ as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2. Proc. Natl Acad. Sci. USA, 96, 7172-7177.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 7172-7177
-
-
Rui, L.1
Carter-Su, C.2
-
35
-
-
0029075875
-
Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3
-
Schaefer, T.S., Sanders, L.K. and Nathans, D. (1995) Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3. Proc. Natl Acad. Sci. USA, 92, 9097-9101.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9097-9101
-
-
Schaefer, T.S.1
Sanders, L.K.2
Nathans, D.3
-
36
-
-
0030611426
-
Functional differences between Stat3α and Stat3β
-
Schaefer, T.S., Sanders, L.K., Park, O.K. and Nathans, D. (1997) Functional differences between Stat3α and Stat3β. Mol. Cell. Biol., 17, 5307-5316.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 5307-5316
-
-
Schaefer, T.S.1
Sanders, L.K.2
Park, O.K.3
Nathans, D.4
-
37
-
-
0026725868
-
Proteins of transcription factor ISGF-3: One gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon α
-
Schindler, C., Fu, X.Y., Improta, T., Aebersold, R. and Darnell, J.E., Jr (1992) Proteins of transcription factor ISGF-3: one gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon α. Proc. Natl Acad. Sci. USA, 89, 7836-7839.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 7836-7839
-
-
Schindler, C.1
Fu, X.Y.2
Improta, T.3
Aebersold, R.4
Darnell J.E., Jr.5
-
39
-
-
0027493650
-
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ
-
Shuai, K., Stark, G.R., Kerr, I.M. and Darnell, J.E., Jr (1993) A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ. Science, 261, 1744-1746.
-
(1993)
Science
, vol.261
, pp. 1744-1746
-
-
Shuai, K.1
Stark, G.R.2
Kerr, I.M.3
Darnell J.E., Jr.4
-
40
-
-
0029742102
-
Enhancement of antiproliferative activity of γ interferon by the specific inhibition of tyrosine dephosphorylation of Stat1
-
Shuai, K., Liao, J. and Song, M.M. (1996) Enhancement of antiproliferative activity of γ interferon by the specific inhibition of tyrosine dephosphorylation of Stat1. Mol. Cell. Biol., 16, 4932-4941.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4932-4941
-
-
Shuai, K.1
Liao, J.2
Song, M.M.3
-
41
-
-
0032550312
-
T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells
-
Simpson, S.J., Shah, S., Comiskey, M., de Jong, Y.P., Wang, B., Mizoguchi, E., Bhan, A.K. and Terhorst, C. (1998) T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells. J. Exp. Med., 187, 1225-1234.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1225-1234
-
-
Simpson, S.J.1
Shah, S.2
Comiskey, M.3
De Jong, Y.P.4
Wang, B.5
Mizoguchi, E.6
Bhan, A.K.7
Terhorst, C.8
-
42
-
-
0032785433
-
STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis
-
Stamm, L.M., Satoskar, A.A., Ghosh, S.K., David, J.R. and Satoskar, A.R. (1999) STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis. Eur. J. Immunol., 29, 2524-2529.
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 2524-2529
-
-
Stamm, L.M.1
Satoskar, A.A.2
Ghosh, S.K.3
David, J.R.4
Satoskar, A.R.5
-
43
-
-
0034254417
-
Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi
-
Tarleton, R.L., Grusby, M.J. and Zhang, L. (2000) Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. J. Immunol., 165, 1520-1525.
-
(2000)
J. Immunol.
, vol.165
, pp. 1520-1525
-
-
Tarleton, R.L.1
Grusby, M.J.2
Zhang, L.3
-
44
-
-
0034880117
-
Role of interleukin-12 and stat-4 in the regulation of airway inflammation and hyperreactivity in respiratory syncytial virus infection
-
Tekkanat, K.K., Maassab, H., Berlin, A.A., Lincoln, P.M., Evanoff, H.L., Kaplan, M.H. and Lukacs, N.W. (2001) Role of interleukin-12 and stat-4 in the regulation of airway inflammation and hyperreactivity in respiratory syncytial virus infection. Am. J. Pathol., 159, 631-638.
-
(2001)
Am. J. Pathol.
, vol.159
, pp. 631-638
-
-
Tekkanat, K.K.1
Maassab, H.2
Berlin, A.A.3
Lincoln, P.M.4
Evanoff, H.L.5
Kaplan, M.H.6
Lukacs, N.W.7
-
45
-
-
15844396183
-
Requirement for Stat4 in interleukin-12 mediated responses of natural killer and T cells
-
Thierfelder, W.E. et al. (1996) Requirement for Stat4 in interleukin-12 mediated responses of natural killer and T cells. Nature, 382, 171-174.
-
(1996)
Nature
, vol.382
, pp. 171-174
-
-
Thierfelder, W.E.1
-
46
-
-
0028970060
-
Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
-
Trinchieri, G. (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol., 13, 251-276.
-
(1995)
Annu. Rev. Immunol.
, vol.13
, pp. 251-276
-
-
Trinchieri, G.1
-
47
-
-
0034661699
-
Cutting edge: Chandra, a novel four-transmembrane domain protein differentially expressed in helper type 1 lymphocytes
-
Venkataraman, C., Schaefer, G. and Schindler, U. (2000) Cutting edge: Chandra, a novel four-transmembrane domain protein differentially expressed in helper type 1 lymphocytes. J. Immunol., 165, 632-636.
-
(2000)
J. Immunol.
, vol.165
, pp. 632-636
-
-
Venkataraman, C.1
Schaefer, G.2
Schindler, U.3
-
48
-
-
0029903770
-
2-terminal domains stabilizes binding of two dimers to tandem DNA sites
-
2-terminal domains stabilizes binding of two dimers to tandem DNA sites. EMBO J., 15, 5616-5626.
-
(1996)
EMBO J.
, vol.15
, pp. 5616-5626
-
-
Vinkemeier, U.1
Cohen, S.L.2
Moarefi, I.3
Chait, B.T.4
Kuriyan, J.5
Darnell J.E., Jr.6
-
49
-
-
0032512661
-
Structure of the amino-terminal protein interaction domain of STAT-4
-
Vinkemeier, U., Moarefi, I., Darnell, J.E., Jr. and Kuriyan, J. (1998) Structure of the amino-terminal protein interaction domain of STAT-4. Science, 279, 1048-1052.
-
(1998)
Science
, vol.279
, pp. 1048-1052
-
-
Vinkemeier, U.1
Moarefi, I.2
Darnell J.E., Jr.3
Kuriyan, J.4
-
50
-
-
0034284088
-
Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity
-
Visconti, R., Gadina, M., Chiariello, M., Chen, E.H., Stancato, L.F., Gutkind, J.S. and O'Shea, J.J. (2000) Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. Blood, 96, 1844-1852.
-
(2000)
Blood
, vol.96
, pp. 1844-1852
-
-
Visconti, R.1
Gadina, M.2
Chiariello, M.3
Chen, E.H.4
Stancato, L.F.5
Gutkind, J.S.6
O'Shea, J.J.7
-
51
-
-
0029826282
-
Naturally occurring dominant negative variants of Stat5
-
Wang, D., Stravopodis, D., Teglund, S., Kitazawa, J. and Ihle, J.N. (1996) Naturally occurring dominant negative variants of Stat5. Mol. Cell. Biol., 16, 6141-6148.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 6141-6148
-
-
Wang, D.1
Stravopodis, D.2
Teglund, S.3
Kitazawa, J.4
Ihle, J.N.5
-
52
-
-
0034142208
-
A small amphipathic α-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5
-
Wang, D., Moriggl, R., Stravopodis, D., Carpino, N., Marine, J.C., Teglund, S., Feng, J. and Ihle, J.N. (2000) A small amphipathic α-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5. EMBO J., 19, 392-399.
-
(2000)
EMBO J.
, vol.19
, pp. 392-399
-
-
Wang, D.1
Moriggl, R.2
Stravopodis, D.3
Carpino, N.4
Marine, J.C.5
Teglund, S.6
Feng, J.7
Ihle, J.N.8
-
53
-
-
0029117304
-
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
-
Wen, Z., Zhong, Z. and Darnell, J.E., Jr (1995) Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell, 82, 241-250.
-
(1995)
Cell
, vol.82
, pp. 241-250
-
-
Wen, Z.1
Zhong, Z.2
Darnell J.E., Jr.3
-
54
-
-
0035879351
-
Cutting edge: Differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells
-
White, S.J., Underhill, G.H., Kaplan, M.H. and Kansas, G.S. (2001) Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells. J. Immunol., 167, 628-631.
-
(2001)
J. Immunol.
, vol.167
, pp. 628-631
-
-
White, S.J.1
Underhill, G.H.2
Kaplan, M.H.3
Kansas, G.S.4
-
55
-
-
0024199329
-
Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements
-
Williams, T., Admon, A., Luscher, B. and Tjian, R. (1988) Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes Dev., 2, 1557-1569.
-
(1988)
Genes Dev.
, vol.2
, pp. 1557-1569
-
-
Williams, T.1
Admon, A.2
Luscher, B.3
Tjian, R.4
-
56
-
-
0029739627
-
Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain
-
Xu, X., Sun, Y.-L. and Hoey, T. (1996) Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science, 273, 794-797.
-
(1996)
Science
, vol.273
, pp. 794-797
-
-
Xu, X.1
Sun, Y.-L.2
Hoey, T.3
-
57
-
-
0028931589
-
The genomic structure of the STAT genes: Multiple exons in coincident sites in Stat1 and Stat2
-
Yan, R., Qureshi, S., Zhong, Z., Wen, Z. and Darnell, J.E., Jr (1995) The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. Nucleic Acids Res., 23, 459-463.
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 459-463
-
-
Yan, R.1
Qureshi, S.2
Zhong, Z.3
Wen, Z.4
Darnell J.E., Jr.5
-
58
-
-
0036008472
-
Specific ablation of Stat3β distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock
-
Yoo, J.Y., Huso, D.L., Nathans, D. and Desiderio, S. (2002) Specific ablation of Stat3β distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock. Cell, 108, 331-344.
-
(2002)
Cell
, vol.108
, pp. 331-344
-
-
Yoo, J.Y.1
Huso, D.L.2
Nathans, D.3
Desiderio, S.4
-
59
-
-
0034254177
-
The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-γ expression
-
Zhang, S. and Kaplan, M.H. (2000) The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-γ expression. J. Immunol., 165, 1374-1380.
-
(2000)
J. Immunol.
, vol.165
, pp. 1374-1380
-
-
Zhang, S.1
Kaplan, M.H.2
-
61
-
-
0034234605
-
Differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not Stat4
-
Zhang, S., Lukacs, N.W., Lawless, V.A., Kunkel, S.L. and Kaplan, M.H. (2000b) Differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not Stat4. J. Immunol., 165, 10-14.
-
(2000)
J. Immunol.
, vol.165
, pp. 10-14
-
-
Zhang, S.1
Lukacs, N.W.2
Lawless, V.A.3
Kunkel, S.L.4
Kaplan, M.H.5
-
62
-
-
0032845125
-
Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation
-
Zhang, X., Wrzeszczynska, M.H., Horvath, C.M. and Darnell, J.E., Jr (1999) Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation. Mol. Cell. Biol., 19, 7138-7146.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 7138-7146
-
-
Zhang, X.1
Wrzeszczynska, M.H.2
Horvath, C.M.3
Darnell J.E., Jr.4
-
63
-
-
0029037960
-
Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice
-
Zhumabekov, T., Corbella, P., Tolaini, M. and Kioussis, D. (1995) Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J. Immunol. Methods, 185, 133-140.
-
(1995)
J. Immunol. Methods
, vol.185
, pp. 133-140
-
-
Zhumabekov, T.1
Corbella, P.2
Tolaini, M.3
Kioussis, D.4
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