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Volumn 22, Issue 16, 2003, Pages 4237-4248

Distinct requirements for the naturally occurring splice forms Stat4α and Stat4β in IL-12 responses

Author keywords

IL 12; Stat4; T helper cells; Transcription

Indexed keywords

AMINO ACID; COMPLEMENTARY DNA; GAMMA INTERFERON; INTERLEUKIN 12; ISOPROTEIN; STAT4 ALPHA PROTEIN; STAT4 BETA PROTEIN; STAT4 PROTEIN; UNCLASSIFIED DRUG;

EID: 0042466572     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg393     Document Type: Article
Times cited : (80)

References (63)
  • 1
    • 0035909925 scopus 로고    scopus 로고
    • Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-γ-independent pathway
    • Afanasyeva, M., Wang, Y., Kaya, Z., Stafford, E.A., Dohmen, K.M., Sadighi Akha, A.A. and Rose, N.R. (2001) Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-γ-independent pathway. Circulation, 104, 3145-3151.
    • (2001) Circulation , vol.104 , pp. 3145-3151
    • Afanasyeva, M.1    Wang, Y.2    Kaya, Z.3    Stafford, E.A.4    Dohmen, K.M.5    Sadighi Akha, A.A.6    Rose, N.R.7
  • 3
    • 0029799912 scopus 로고    scopus 로고
    • Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon α and γ
    • Bromberg, J.F., Horvath, C.M., Wen, Z., Schreiber, R.D. and Darnell, J.E.J. (1996) Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon α and γ. Proc. Natl Acad. Sci. USA, 93, 7673-7678.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7673-7678
    • Bromberg, J.F.1    Horvath, C.M.2    Wen, Z.3    Schreiber, R.D.4    Darnell, J.E.J.5
  • 4
    • 18444415725 scopus 로고    scopus 로고
    • Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M
    • Broxmeyer, H.E. et al. (2002) Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M. Immunity, 16, 815-825.
    • (2002) Immunity , vol.16 , pp. 815-825
    • Broxmeyer, H.E.1
  • 5
    • 0034283962 scopus 로고    scopus 로고
    • Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii
    • Cai, G., Radzanowski, T., Villegas, E.N., Kastelein, R. and Hunter, C.A. (2000) Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii. J. Immunol., 165, 2619-2627.
    • (2000) J. Immunol. , vol.165 , pp. 2619-2627
    • Cai, G.1    Radzanowski, T.2    Villegas, E.N.3    Kastelein, R.4    Hunter, C.A.5
  • 7
    • 0034789247 scopus 로고    scopus 로고
    • Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis
    • Chitnis, T., Najafian, N., Benou, C., Salama, A.D., Grusby, M.J., Sayegh, M.H. and Khoury, S.J. (2001) Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J. Clin. Invest., 108, 739-747.
    • (2001) J. Clin. Invest. , vol.108 , pp. 739-747
    • Chitnis, T.1    Najafian, N.2    Benou, C.3    Salama, A.D.4    Grusby, M.J.5    Sayegh, M.H.6    Khoury, S.J.7
  • 8
    • 0030469719 scopus 로고    scopus 로고
    • Activation of Stat4 by IL-12 and IFN-α: Evidence for the involvement of ligand induced tyrosine and serine phosphorylation
    • Cho, S.S., Bacon, C.M., Sudarshan, C., Rees, R.C., Finbloom, D., Pine, R. and O'Shea, J.J. (1996) Activation of Stat4 by IL-12 and IFN-α: evidence for the involvement of ligand induced tyrosine and serine phosphorylation. J. Immunol., 157, 4781-4789.
    • (1996) J. Immunol. , vol.157 , pp. 4781-4789
    • Cho, S.S.1    Bacon, C.M.2    Sudarshan, C.3    Rees, R.C.4    Finbloom, D.5    Pine, R.6    O'Shea, J.J.7
  • 9
    • 0033525511 scopus 로고    scopus 로고
    • Interleukin-12 induces expression of interferon regulatory factor-1 via signal transducer and activator of transcription-4 in human T helper type I cells
    • Coccia, E.M., Passini, N., Battistini, A., Pini, C., Sinigaglia, F. and Rogge, L. (1999) Interleukin-12 induces expression of interferon regulatory factor-1 via signal transducer and activator of transcription-4 in human T helper type I cells. J. Biol. Chem., 274, 6698-6703.
    • (1999) J. Biol. Chem. , vol.274 , pp. 6698-6703
    • Coccia, E.M.1    Passini, N.2    Battistini, A.3    Pini, C.4    Sinigaglia, F.5    Rogge, L.6
  • 10
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell, J.E.J. (1997) STATs and gene regulation. Science, 277, 1630-1636.
    • (1997) Science , vol.277 , pp. 1630-1636
    • Darnell, J.E.J.1
  • 11
    • 0033564574 scopus 로고    scopus 로고
    • IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells
    • Galon, J., Sudarshan, C., Ito, S., Finbloom, D. and O'Shea, J.J. (1999) IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. J. Immunol., 162, 7256-7262.
    • (1999) J. Immunol. , vol.162 , pp. 7256-7262
    • Galon, J.1    Sudarshan, C.2    Ito, S.3    Finbloom, D.4    O'Shea, J.J.5
  • 12
    • 0029053852 scopus 로고
    • Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins
    • Hoey, T., Sun, Y.L., Williamson, K. and Xu, X. (1995) Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity, 2, 461-472.
    • (1995) Immunity , vol.2 , pp. 461-472
    • Hoey, T.1    Sun, Y.L.2    Williamson, K.3    Xu, X.4
  • 13
    • 0345422708 scopus 로고    scopus 로고
    • Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence
    • Holz, A., Bot, A., Coon, B., Wolfe, T., Grusby, M.J. and von Herrath, M.G. (1999) Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence. J. Immunol., 163, 5374-5382.
    • (1999) J. Immunol. , vol.163 , pp. 5374-5382
    • Holz, A.1    Bot, A.2    Coon, B.3    Wolfe, T.4    Grusby, M.J.5    Von Herrath, M.G.6
  • 14
    • 0035072249 scopus 로고    scopus 로고
    • Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer
    • Hughes, T.R. et al. (2001) Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. Nat. Biotechnol., 19, 342-347.
    • (2001) Nat. Biotechnol. , vol.19 , pp. 342-347
    • Hughes, T.R.1
  • 16
    • 0028943484 scopus 로고
    • Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcripton (Stat)3 and Stat4
    • Jacobson, N.G., Szabo, S.J., Weber-Nordt, R.M., Zhong, Z., Schreiber, R.D., Darnell, J.E., Jr and Murphy, K.M. (1995) Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcripton (Stat)3 and Stat4. J. Exp. Med., 181, 1755-1762.
    • (1995) J. Exp. Med. , vol.181 , pp. 1755-1762
    • Jacobson, N.G.1    Szabo, S.J.2    Weber-Nordt, R.M.3    Zhong, Z.4    Schreiber, R.D.5    Darnell J.E., Jr.6    Murphy, K.M.7
  • 17
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan, M.H., Sun, Y.-L., Hoey, T. and Grusby, M.J. (1996) Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature, 382, 174-177.
    • (1996) Nature , vol.382 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.-L.2    Hoey, T.3    Grusby, M.J.4
  • 20
    • 0031919849 scopus 로고    scopus 로고
    • Jaks and STATs: Biological implications
    • Leonard, W.J. and O'Shea, J.J. (1998) Jaks and STATs: biological implications. Annu. Rev. Immunol., 16, 293-322.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 293-322
    • Leonard, W.J.1    O'Shea, J.J.2
  • 21
    • 0035911232 scopus 로고    scopus 로고
    • Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis
    • Matsukawa, A., Kaplan, M.H., Hogaboam, C.M., Lukacs, N.W. and Kunkel, S.L. (2001) Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis. J. Exp. Med., 193, 679-688.
    • (2001) J. Exp. Med. , vol.193 , pp. 679-688
    • Matsukawa, A.1    Kaplan, M.H.2    Hogaboam, C.M.3    Lukacs, N.W.4    Kunkel, S.L.5
  • 22
    • 0029790559 scopus 로고    scopus 로고
    • Requirements for interleukin-4-induced gene expression and functional characterization of Stat6
    • Mikita, T., Campbell, D., Wu, P., Williamson, K. and Schindler, U. (1996) Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol. Cell. Biol., 16, 5811-5820.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5811-5820
    • Mikita, T.1    Campbell, D.2    Wu, P.3    Williamson, K.4    Schindler, U.5
  • 24
    • 0020050314 scopus 로고
    • A catalogue of splice junction sequences
    • Mount, S.M. (1982) A catalogue of splice junction sequences. Nucleic Acids Res., 10, 459-472.
    • (1982) Nucleic Acids Res. , vol.10 , pp. 459-472
    • Mount, S.M.1
  • 25
    • 0033835830 scopus 로고    scopus 로고
    • Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation
    • Murphy, T.L., Geissal, E.D., Farrar, J.D. and Murphy, K.M. (2000) Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation. Mol. Cell. Biol., 20, 7121-7131.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 7121-7131
    • Murphy, T.L.1    Geissal, E.D.2    Farrar, J.D.3    Murphy, K.M.4
  • 26
    • 0031023756 scopus 로고    scopus 로고
    • Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases
    • Musti, A.M., Treier, M. and Bohmann, D. (1997) Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases. Science, 275, 400-402.
    • (1997) Science , vol.275 , pp. 400-402
    • Musti, A.M.1    Treier, M.2    Bohmann, D.3
  • 28
    • 0037040991 scopus 로고    scopus 로고
    • SH2-B family members differentially regulate JAK family tyrosine kinases
    • O'Brien, K.B., O'Shea, J.J. and Carter-Su, C. (2002) SH2-B family members differentially regulate JAK family tyrosine kinases. J. Biol. Chem., 277, 8673-8681.
    • (2002) J. Biol. Chem. , vol.277 , pp. 8673-8681
    • O'Brien, K.B.1    O'Shea, J.J.2    Carter-Su, C.3
  • 29
    • 0030765924 scopus 로고    scopus 로고
    • Jaks, STATs, cytokine signal transduction and immunoregulation: Are we there yet?
    • O'Shea, J.J. (1997) Jaks, STATs, cytokine signal transduction and immunoregulation: are we there yet? Immunity, 7, 1-11.
    • (1997) Immunity , vol.7 , pp. 1-11
    • O'Shea, J.J.1
  • 30
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann, B. et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity, 13, 715-725.
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1
  • 32
    • 0034644775 scopus 로고    scopus 로고
    • Dimer stability as a determinant of differential DNA binding activity of Stat3 isoforms
    • Park, O.K., Schaefer, L.K., Wang, W. and Schaefer, T.S. (2000) Dimer stability as a determinant of differential DNA binding activity of Stat3 isoforms. J. Biol. Chem., 275, 32244-32249.
    • (2000) J. Biol. Chem. , vol.275 , pp. 32244-32249
    • Park, O.K.1    Schaefer, L.K.2    Wang, W.3    Schaefer, T.S.4
  • 33
  • 34
    • 0033594812 scopus 로고    scopus 로고
    • Identification of SH2-bβ as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2
    • Rui, L. and Carter-Su, C. (1999) Identification of SH2-bβ as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2. Proc. Natl Acad. Sci. USA, 96, 7172-7177.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7172-7177
    • Rui, L.1    Carter-Su, C.2
  • 35
    • 0029075875 scopus 로고
    • Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3
    • Schaefer, T.S., Sanders, L.K. and Nathans, D. (1995) Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3. Proc. Natl Acad. Sci. USA, 92, 9097-9101.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9097-9101
    • Schaefer, T.S.1    Sanders, L.K.2    Nathans, D.3
  • 37
    • 0026725868 scopus 로고
    • Proteins of transcription factor ISGF-3: One gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon α
    • Schindler, C., Fu, X.Y., Improta, T., Aebersold, R. and Darnell, J.E., Jr (1992) Proteins of transcription factor ISGF-3: one gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon α. Proc. Natl Acad. Sci. USA, 89, 7836-7839.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7836-7839
    • Schindler, C.1    Fu, X.Y.2    Improta, T.3    Aebersold, R.4    Darnell J.E., Jr.5
  • 39
    • 0027493650 scopus 로고
    • A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ
    • Shuai, K., Stark, G.R., Kerr, I.M. and Darnell, J.E., Jr (1993) A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ. Science, 261, 1744-1746.
    • (1993) Science , vol.261 , pp. 1744-1746
    • Shuai, K.1    Stark, G.R.2    Kerr, I.M.3    Darnell J.E., Jr.4
  • 40
    • 0029742102 scopus 로고    scopus 로고
    • Enhancement of antiproliferative activity of γ interferon by the specific inhibition of tyrosine dephosphorylation of Stat1
    • Shuai, K., Liao, J. and Song, M.M. (1996) Enhancement of antiproliferative activity of γ interferon by the specific inhibition of tyrosine dephosphorylation of Stat1. Mol. Cell. Biol., 16, 4932-4941.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4932-4941
    • Shuai, K.1    Liao, J.2    Song, M.M.3
  • 41
    • 0032550312 scopus 로고    scopus 로고
    • T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells
    • Simpson, S.J., Shah, S., Comiskey, M., de Jong, Y.P., Wang, B., Mizoguchi, E., Bhan, A.K. and Terhorst, C. (1998) T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells. J. Exp. Med., 187, 1225-1234.
    • (1998) J. Exp. Med. , vol.187 , pp. 1225-1234
    • Simpson, S.J.1    Shah, S.2    Comiskey, M.3    De Jong, Y.P.4    Wang, B.5    Mizoguchi, E.6    Bhan, A.K.7    Terhorst, C.8
  • 42
    • 0032785433 scopus 로고    scopus 로고
    • STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis
    • Stamm, L.M., Satoskar, A.A., Ghosh, S.K., David, J.R. and Satoskar, A.R. (1999) STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis. Eur. J. Immunol., 29, 2524-2529.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 2524-2529
    • Stamm, L.M.1    Satoskar, A.A.2    Ghosh, S.K.3    David, J.R.4    Satoskar, A.R.5
  • 43
    • 0034254417 scopus 로고    scopus 로고
    • Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi
    • Tarleton, R.L., Grusby, M.J. and Zhang, L. (2000) Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. J. Immunol., 165, 1520-1525.
    • (2000) J. Immunol. , vol.165 , pp. 1520-1525
    • Tarleton, R.L.1    Grusby, M.J.2    Zhang, L.3
  • 44
    • 0034880117 scopus 로고    scopus 로고
    • Role of interleukin-12 and stat-4 in the regulation of airway inflammation and hyperreactivity in respiratory syncytial virus infection
    • Tekkanat, K.K., Maassab, H., Berlin, A.A., Lincoln, P.M., Evanoff, H.L., Kaplan, M.H. and Lukacs, N.W. (2001) Role of interleukin-12 and stat-4 in the regulation of airway inflammation and hyperreactivity in respiratory syncytial virus infection. Am. J. Pathol., 159, 631-638.
    • (2001) Am. J. Pathol. , vol.159 , pp. 631-638
    • Tekkanat, K.K.1    Maassab, H.2    Berlin, A.A.3    Lincoln, P.M.4    Evanoff, H.L.5    Kaplan, M.H.6    Lukacs, N.W.7
  • 45
    • 15844396183 scopus 로고    scopus 로고
    • Requirement for Stat4 in interleukin-12 mediated responses of natural killer and T cells
    • Thierfelder, W.E. et al. (1996) Requirement for Stat4 in interleukin-12 mediated responses of natural killer and T cells. Nature, 382, 171-174.
    • (1996) Nature , vol.382 , pp. 171-174
    • Thierfelder, W.E.1
  • 46
    • 0028970060 scopus 로고
    • Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri, G. (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol., 13, 251-276.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 47
    • 0034661699 scopus 로고    scopus 로고
    • Cutting edge: Chandra, a novel four-transmembrane domain protein differentially expressed in helper type 1 lymphocytes
    • Venkataraman, C., Schaefer, G. and Schindler, U. (2000) Cutting edge: Chandra, a novel four-transmembrane domain protein differentially expressed in helper type 1 lymphocytes. J. Immunol., 165, 632-636.
    • (2000) J. Immunol. , vol.165 , pp. 632-636
    • Venkataraman, C.1    Schaefer, G.2    Schindler, U.3
  • 49
    • 0032512661 scopus 로고    scopus 로고
    • Structure of the amino-terminal protein interaction domain of STAT-4
    • Vinkemeier, U., Moarefi, I., Darnell, J.E., Jr. and Kuriyan, J. (1998) Structure of the amino-terminal protein interaction domain of STAT-4. Science, 279, 1048-1052.
    • (1998) Science , vol.279 , pp. 1048-1052
    • Vinkemeier, U.1    Moarefi, I.2    Darnell J.E., Jr.3    Kuriyan, J.4
  • 50
    • 0034284088 scopus 로고    scopus 로고
    • Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity
    • Visconti, R., Gadina, M., Chiariello, M., Chen, E.H., Stancato, L.F., Gutkind, J.S. and O'Shea, J.J. (2000) Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. Blood, 96, 1844-1852.
    • (2000) Blood , vol.96 , pp. 1844-1852
    • Visconti, R.1    Gadina, M.2    Chiariello, M.3    Chen, E.H.4    Stancato, L.F.5    Gutkind, J.S.6    O'Shea, J.J.7
  • 52
    • 0034142208 scopus 로고    scopus 로고
    • A small amphipathic α-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5
    • Wang, D., Moriggl, R., Stravopodis, D., Carpino, N., Marine, J.C., Teglund, S., Feng, J. and Ihle, J.N. (2000) A small amphipathic α-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5. EMBO J., 19, 392-399.
    • (2000) EMBO J. , vol.19 , pp. 392-399
    • Wang, D.1    Moriggl, R.2    Stravopodis, D.3    Carpino, N.4    Marine, J.C.5    Teglund, S.6    Feng, J.7    Ihle, J.N.8
  • 53
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen, Z., Zhong, Z. and Darnell, J.E., Jr (1995) Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell, 82, 241-250.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell J.E., Jr.3
  • 54
    • 0035879351 scopus 로고    scopus 로고
    • Cutting edge: Differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells
    • White, S.J., Underhill, G.H., Kaplan, M.H. and Kansas, G.S. (2001) Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells. J. Immunol., 167, 628-631.
    • (2001) J. Immunol. , vol.167 , pp. 628-631
    • White, S.J.1    Underhill, G.H.2    Kaplan, M.H.3    Kansas, G.S.4
  • 55
    • 0024199329 scopus 로고
    • Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements
    • Williams, T., Admon, A., Luscher, B. and Tjian, R. (1988) Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes Dev., 2, 1557-1569.
    • (1988) Genes Dev. , vol.2 , pp. 1557-1569
    • Williams, T.1    Admon, A.2    Luscher, B.3    Tjian, R.4
  • 56
    • 0029739627 scopus 로고    scopus 로고
    • Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain
    • Xu, X., Sun, Y.-L. and Hoey, T. (1996) Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science, 273, 794-797.
    • (1996) Science , vol.273 , pp. 794-797
    • Xu, X.1    Sun, Y.-L.2    Hoey, T.3
  • 57
    • 0028931589 scopus 로고
    • The genomic structure of the STAT genes: Multiple exons in coincident sites in Stat1 and Stat2
    • Yan, R., Qureshi, S., Zhong, Z., Wen, Z. and Darnell, J.E., Jr (1995) The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. Nucleic Acids Res., 23, 459-463.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 459-463
    • Yan, R.1    Qureshi, S.2    Zhong, Z.3    Wen, Z.4    Darnell J.E., Jr.5
  • 58
    • 0036008472 scopus 로고    scopus 로고
    • Specific ablation of Stat3β distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock
    • Yoo, J.Y., Huso, D.L., Nathans, D. and Desiderio, S. (2002) Specific ablation of Stat3β distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock. Cell, 108, 331-344.
    • (2002) Cell , vol.108 , pp. 331-344
    • Yoo, J.Y.1    Huso, D.L.2    Nathans, D.3    Desiderio, S.4
  • 59
    • 0034254177 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-γ expression
    • Zhang, S. and Kaplan, M.H. (2000) The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-γ expression. J. Immunol., 165, 1374-1380.
    • (2000) J. Immunol. , vol.165 , pp. 1374-1380
    • Zhang, S.1    Kaplan, M.H.2
  • 61
    • 0034234605 scopus 로고    scopus 로고
    • Differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not Stat4
    • Zhang, S., Lukacs, N.W., Lawless, V.A., Kunkel, S.L. and Kaplan, M.H. (2000b) Differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not Stat4. J. Immunol., 165, 10-14.
    • (2000) J. Immunol. , vol.165 , pp. 10-14
    • Zhang, S.1    Lukacs, N.W.2    Lawless, V.A.3    Kunkel, S.L.4    Kaplan, M.H.5
  • 62
    • 0032845125 scopus 로고    scopus 로고
    • Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation
    • Zhang, X., Wrzeszczynska, M.H., Horvath, C.M. and Darnell, J.E., Jr (1999) Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation. Mol. Cell. Biol., 19, 7138-7146.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 7138-7146
    • Zhang, X.1    Wrzeszczynska, M.H.2    Horvath, C.M.3    Darnell J.E., Jr.4
  • 63
    • 0029037960 scopus 로고
    • Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice
    • Zhumabekov, T., Corbella, P., Tolaini, M. and Kioussis, D. (1995) Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J. Immunol. Methods, 185, 133-140.
    • (1995) J. Immunol. Methods , vol.185 , pp. 133-140
    • Zhumabekov, T.1    Corbella, P.2    Tolaini, M.3    Kioussis, D.4


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