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Volumn 11, Issue 6, 1999, Pages 677-688

Ectopic expression of activated Stat6 induces the expression of Th2- specific cytokines and transcription factors in developing Th1 cells

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; CYTOKINE; ESTROGEN RECEPTOR; GAMMA INTERFERON; HYBRID PROTEIN; INTERLEUKIN 4 ANTIBODY; RECOMBINANT INTERLEUKIN 12; RECOMBINANT INTERLEUKIN 2; RECOMBINANT INTERLEUKIN 4; STAT6 PROTEIN; TRANSCRIPTION FACTOR GATA 3;

EID: 0033427612     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80142-9     Document Type: Article
Times cited : (248)

References (58)
  • 1
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas, A.K., Murphy, K.M., and Sher, A. (1996). Functional diversity of helper T lymphocytes. Nature 383, 787-793.
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 2
    • 0032412441 scopus 로고    scopus 로고
    • Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
    • Agarwal, S., and Rao, A. (1998a). Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9, 765-775.
    • (1998) Immunity , vol.9 , pp. 765-775
    • Agarwal, S.1    Rao, A.2
  • 3
    • 0345019804 scopus 로고    scopus 로고
    • Long-range transcriptional regulation of cytokine gene expression
    • Agarwal, S., and Rao, A. (1998b). Long-range transcriptional regulation of cytokine gene expression. Curr. Opin. Immunol. 10, 345-352.
    • (1998) Curr. Opin. Immunol. , vol.10 , pp. 345-352
    • Agarwal, S.1    Rao, A.2
  • 5
    • 0023622458 scopus 로고
    • Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies
    • Cherwinski, H.M., Schumacher, J.H., Brown, K.D., and Mosmann, T.R. (1987). Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J. Exp. Med. 166, 1229-1244.
    • (1987) J. Exp. Med. , vol.166 , pp. 1229-1244
    • Cherwinski, H.M.1    Schumacher, J.H.2    Brown, K.D.3    Mosmann, T.R.4
  • 7
    • 0032906187 scopus 로고    scopus 로고
    • GATA-3 significantly downregulates IFN-γ production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels
    • Ferber, I.A., Lee, H.J., Zonin, F., Heath, V., Mui, A., Arai, N., and O'Garra, A. (1999). GATA-3 significantly downregulates IFN-γ production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels. Clin. Immunol. 97, 134-144.
    • (1999) Clin. Immunol. , vol.97 , pp. 134-144
    • Ferber, I.A.1    Lee, H.J.2    Zonin, F.3    Heath, V.4    Mui, A.5    Arai, N.6    O'Garra, A.7
  • 9
    • 0030604714 scopus 로고    scopus 로고
    • The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4
    • Ho, I.-C., Hodge, M.R., Rooney, J.W., and Glimcher, L.H. (1996). The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 85, 973-983.
    • (1996) Cell , vol.85 , pp. 973-983
    • Ho, I.-C.1    Hodge, M.R.2    Rooney, J.W.3    Glimcher, L.H.4
  • 10
    • 0032538985 scopus 로고    scopus 로고
    • C-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms
    • Ho, I.C., Lo, D., and Glimcher, L.H. (1998). C-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms. J. Exp. Med. 188, 1859-1166.
    • (1998) J. Exp. Med. , vol.188 , pp. 1859-11166
    • Ho, I.C.1    Lo, D.2    Glimcher, L.H.3
  • 13
    • 0031572577 scopus 로고    scopus 로고
    • IL-4 and IL-13 production in differentiated T helper type 2 cells is not IL-4 dependent
    • Huang, H., Hu, L.J., Chen, H., Ben, S.S., and Paul, W.E. (1997). IL-4 and IL-13 production in differentiated T helper type 2 cells is not IL-4 dependent. J. Immunol. 159, 3731-3738.
    • (1997) J. Immunol. , vol.159 , pp. 3731-3738
    • Huang, H.1    Hu, L.J.2    Chen, H.3    Ben, S.S.4    Paul, W.E.5
  • 14
    • 0032550342 scopus 로고    scopus 로고
    • Impaired interleukin 4 signaling in T helper type 1 cells
    • Huang, H., and Paul, W.E. (1998). Impaired interleukin 4 signaling in T helper type 1 cells. J. Exp. Med. 187, 1305-1313.
    • (1998) J. Exp. Med. , vol.187 , pp. 1305-1313
    • Huang, H.1    Paul, W.E.2
  • 15
    • 0032133157 scopus 로고    scopus 로고
    • A conditionally active form of Stat6 can mimic certain effects of IL-4
    • Kamogawa, Y., Lee, H.J., Johnston, J.A., McMahon, M., O'Garra, A., and Arai, N. (1998). A conditionally active form of Stat6 can mimic certain effects of IL-4. J. Immunol. 161, 1074-1077.
    • (1998) J. Immunol. , vol.161 , pp. 1074-1077
    • Kamogawa, Y.1    Lee, H.J.2    Johnston, J.A.3    McMahon, M.4    O'Garra, A.5    Arai, N.6
  • 16
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells
    • Kaplan, M., Schindler, U., Smiley, S.T., and Grusby, M.J. (1996). Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 4, 313-319.
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 18
    • 0020602877 scopus 로고
    • Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells
    • Kaye, J., Porcelli, S., Tite, J., Jones, B., and Janeway, C.A. (1983). Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells. J. Exp. Med. 158, 836-856.
    • (1983) J. Exp. Med. , vol.158 , pp. 836-856
    • Kaye, J.1    Porcelli, S.2    Tite, J.3    Jones, B.4    Janeway, C.A.5
  • 19
    • 0028219966 scopus 로고
    • An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth
    • Keegan, A.D., Nelms, K., White, M., Wang, L.M., Pierce, J.H., and Paul, W.E. (1994). An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth. Cell 76, 811-820.
    • (1994) Cell , vol.76 , pp. 811-820
    • Keegan, A.D.1    Nelms, K.2    White, M.3    Wang, L.M.4    Pierce, J.H.5    Paul, W.E.6
  • 20
    • 0029795585 scopus 로고    scopus 로고
    • Interleukin-4-induced Stat6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene
    • Kotanides, H., and Reich, N.C. (1996). Interleukin-4-induced Stat6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene. J. Biol. Chem. 271, 25555-25561.
    • (1996) J. Biol. Chem. , vol.271 , pp. 25555-25561
    • Kotanides, H.1    Reich, N.C.2
  • 21
    • 0030927197 scopus 로고    scopus 로고
    • T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and Stat6
    • Kubo, M., Ransom, J., Webb, D., Hashimoto, Y., Tada, T., and Nakayama, T. (1997). T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and Stat6. EMBO J. 16, 4007-4020.
    • (1997) EMBO J. , vol.16 , pp. 4007-4020
    • Kubo, M.1    Ransom, J.2    Webb, D.3    Hashimoto, Y.4    Tada, T.5    Nakayama, T.6
  • 22
    • 0026328818 scopus 로고
    • Generation and analysis of interleukin-4 deficient mice
    • Kuhn, R., Rajewsly, K., and Muller, W. (1991). Generation and analysis of interleukin-4 deficient mice. Science 254, 707-710.
    • (1991) Science , vol.254 , pp. 707-710
    • Kuhn, R.1    Rajewsly, K.2    Muller, W.3
  • 24
    • 0032031412 scopus 로고    scopus 로고
    • Characterization of cis-regulatory elements and nuclear factors conferring Th2-specific expression of the IL-5 gene: A role for a GATA-binding protein
    • Lee, HJ., O'Garra, A., Arai, K., and Arai, N. (1998). Characterization of cis-regulatory elements and nuclear factors conferring Th2-specific expression of the IL-5 gene: A role for a GATA-binding protein. J. Immunol. 160, 2343-2352.
    • (1998) J. Immunol. , vol.160 , pp. 2343-2352
    • Lee, H.J.1    O'Garra, A.2    Arai, K.3    Arai, N.4
  • 25
    • 0029002136 scopus 로고
    • A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
    • Littlewood, T.D., Hancock, D.C., Danielian, P.S., Parker, M.G., and Evan, G.I. (1995). A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acid Res. 23, 1686-1690.
    • (1995) Nucleic Acid Res. , vol.23 , pp. 1686-1690
    • Littlewood, T.D.1    Hancock, D.C.2    Danielian, P.S.3    Parker, M.G.4    Evan, G.I.5
  • 26
    • 0031204428 scopus 로고    scopus 로고
    • Identification of a Stat6 domain required for IL-4-induced activation of transcription
    • Lu, B., Reichel, M., Fisher, D.A., Smith, J.F., and Rothman, P. (1997). Identification of a Stat6 domain required for IL-4-induced activation of transcription. J. Immunol. 159, 1255-1264.
    • (1997) J. Immunol. , vol.159 , pp. 1255-1264
    • Lu, B.1    Reichel, M.2    Fisher, D.A.3    Smith, J.F.4    Rothman, P.5
  • 27
    • 0029790559 scopus 로고    scopus 로고
    • Requirements for interleukin-4-induced gene expression and functional characterization of Stat6
    • Mikita, T., Campbell, D., Wu, P., Williamson, K., and Schindler, U. (1996). Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol. Cell. Biol. 16, 5811-5820.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5811-5820
    • Mikita, T.1    Campbell, D.2    Wu, P.3    Williamson, K.4    Schindler, U.5
  • 29
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann, T., and Coffman, R. (1989). TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145-173.
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 145-173
    • Mosmann, T.1    Coffman, R.2
  • 30
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann, T.R., Cherwinski, H., Bond, M.W., Giedlin, M.A., and Coffman, R.L. (1986). Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357.
    • (1986) J. Immunol. , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 34
    • 0031569126 scopus 로고    scopus 로고
    • Roles of IL-4 and IFN-γ in stabilizing the T helper cell type 1 and 2 phenotype
    • Nakamura, T., Lee, R.K., Nam, S.Y., Podack, E.R., Bottomly, K., and Flavell, R.A. (1997). Roles of IL-4 and IFN-γ in stabilizing the T helper cell type 1 and 2 phenotype. J. Immunol. 158, 2648-2653.
    • (1997) J. Immunol. , vol.158 , pp. 2648-2653
    • Nakamura, T.1    Lee, R.K.2    Nam, S.Y.3    Podack, E.R.4    Bottomly, K.5    Flavell, R.A.6
  • 36
    • 0032033419 scopus 로고    scopus 로고
    • Cytokines induce the development of functionally heterogenous T helper cell substes
    • O'Garra, A. (1998). Cytokines induce the development of functionally heterogenous T helper cell substes. Immunity 8, 275-283.
    • (1998) Immunity , vol.8 , pp. 275-283
    • O'Garra, A.1
  • 39
    • 0028877441 scopus 로고
    • Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells
    • Pritchard, C.A., Samuels, M.L., Bosch, E., and McMahon, M. (1995). Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells. Mol. Cell. Biol. 15, 6430-6442.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6430-6442
    • Pritchard, C.A.1    Samuels, M.L.2    Bosch, E.3    McMahon, M.4
  • 40
    • 0029057858 scopus 로고
    • Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis
    • Quelle, F.W., Shimoda, K., Thierfelder, W., Fischer, C., Kim, A., Ruben, S.M., Cleveland, J.L., Pierce, J.H., Keegan, A.D., Nelms, K., et al. (1995). Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol. Cell. Biol. 15, 3336-3343.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3336-3343
    • Quelle, F.W.1    Shimoda, K.2    Thierfelder, W.3    Fischer, C.4    Kim, A.5    Ruben, S.M.6    Cleveland, J.L.7    Pierce, J.H.8    Keegan, A.D.9    Nelms, K.10
  • 44
    • 0028288179 scopus 로고
    • Lymphokine production by human T cells in disease states
    • Romagnani, S. (1994). Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 12, 227-257.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 227-257
    • Romagnani, S.1
  • 45
    • 0029885698 scopus 로고    scopus 로고
    • Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor
    • Ryan, J.J., McReynolds, L.J., Keegan, A., Wang, L.H., Garfein, E., Rothman, P., Nelms, K., and Paul, W.E. (1996). Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor. Immunity 4, 123-132.
    • (1996) Immunity , vol.4 , pp. 123-132
    • Ryan, J.J.1    McReynolds, L.J.2    Keegan, A.3    Wang, L.H.4    Garfein, E.5    Rothman, P.6    Nelms, K.7    Paul, W.E.8
  • 47
    • 0028853170 scopus 로고
    • NF-E2 and GATA binding motifs are required for the formation of DNase I hypersensitive site 4 of the human β-globin locus control region
    • Stamatoyannopoulos, J.A., Goodwin, A., Joyce, T., and Lowrey, C.H. (1995). NF-E2 and GATA binding motifs are required for the formation of DNase I hypersensitive site 4 of the human β-globin locus control region. EMBO J. 14, 106-116.
    • (1995) EMBO J. , vol.14 , pp. 106-116
    • Stamatoyannopoulos, J.A.1    Goodwin, A.2    Joyce, T.3    Lowrey, C.H.4
  • 48
    • 0025222698 scopus 로고
    • IL-4 directs the development of Th2-like helper effectors
    • Swain, S.L., Weinberg, A.D., English, M., and Huston, G. (1990). IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145, 3796-3806.
    • (1990) J. Immunol. , vol.145 , pp. 3796-3806
    • Swain, S.L.1    Weinberg, A.D.2    English, M.3    Huston, G.4
  • 49
    • 0029071483 scopus 로고
    • Developmental commitment in the Th2 lineage by extinction of IL-12 signaling
    • Szabo, S.J., Jacobson, N.G., Dighe, A.S., Gubler, U., and Murphy, K. M. (1995). Developmental commitment in the Th2 lineage by extinction of IL-12 signaling. Immunity 2, 665-675.
    • (1995) Immunity , vol.2 , pp. 665-675
    • Szabo, S.J.1    Jacobson, N.G.2    Dighe, A.S.3    Gubler, U.4    Murphy, K.M.5
  • 50
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    • Szabo, S.J., Dighe, A.S., Gubler, U., and Murphy, K.M. (1997). Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185, 817-824.
    • (1997) J. Exp. Med. , vol.185 , pp. 817-824
    • Szabo, S.J.1    Dighe, A.S.2    Gubler, U.3    Murphy, K.M.4
  • 52
    • 0031593671 scopus 로고    scopus 로고
    • Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region
    • Takemoto, N., Koyano-Nakagawa, N., Yokota, T., Arai, N., Miyatake, S., and Arai, K.I. (1998). Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region. Int. Immunol. 10, 1981-1985.
    • (1998) Int. Immunol. , vol.10 , pp. 1981-1985
    • Takemoto, N.1    Koyano-Nakagawa, N.2    Yokota, T.3    Arai, N.4    Miyatake, S.5    Arai, K.I.6
  • 53
    • 0029974563 scopus 로고    scopus 로고
    • IL-4 function can be transferred to the IL-2 receptor by tyrosine containing sequences found in the IL-4 receptor a chain
    • Wang, H.Y., Paul, W.E., and Keegan, A.D. (1996). IL-4 function can be transferred to the IL-2 receptor by tyrosine containing sequences found in the IL-4 receptor a chain. Immunity 4, 113-121.
    • (1996) Immunity , vol.4 , pp. 113-121
    • Wang, H.Y.1    Paul, W.E.2    Keegan, A.D.3
  • 55
    • 0032528425 scopus 로고    scopus 로고
    • Regulation of apoptosis by tyrosine-containing domains of IL-4Rα: Y497 and Y713, but not the Stat6-docking tyrosines, signal protection from apoptosis
    • Zamorano, J., and Keegan, A.D. (1998). Regulation of apoptosis by tyrosine-containing domains of IL-4Rα: Y497 and Y713, but not the Stat6-docking tyrosines, signal protection from apoptosis. J. Immunol. 161, 859-867.
    • (1998) J. Immunol. , vol.161 , pp. 859-867
    • Zamorano, J.1    Keegan, A.D.2
  • 56
    • 0030764961 scopus 로고    scopus 로고
    • Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene
    • Zhang, D.H., Conn, L., Ray, P., Bottomly, K., and Ray, A. (1997). Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J. Biol. Chem. 272, 21597-21603.
    • (1997) J. Biol. Chem. , vol.272 , pp. 21597-21603
    • Zhang, D.H.1    Conn, L.2    Ray, P.3    Bottomly, K.4    Ray, A.5
  • 57
    • 0032531605 scopus 로고    scopus 로고
    • Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3
    • Zhang, D.H., Yang, L., and Ray, A. (1998). Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3. J. Immunol. 161, 3817-3821.
    • (1998) J. Immunol. , vol.161 , pp. 3817-3821
    • Zhang, D.H.1    Yang, L.2    Ray, A.3
  • 58
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng, W., and Flavell, R.A. (1997). The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596.
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2


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