Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation

Science

Volumn 325, Issue 5943, 2009, Pages 1006-1010

  Johnston, Robert J ^a,b   Poholek, Amanda C ^c   DiToro, Daniel ^a   Yusuf, Isharat ^a   Eto, Danelle ^a   Barnett, Burton ^a   Dent, Alexander L ^d   Craft, Joe ^c   Crotty, Shane ^a,b  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; PROTEIN BCL 6;

ANTAGONISM; ANTIBODY; BIOLOGICAL DEVELOPMENT; GENE EXPRESSION; IMMUNITY; INHIBITION; MOLECULAR ANALYSIS; RODENT;

ANIMAL CELL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; GERMINAL CENTER; HELPER CELL; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; ANTIBODY FORMATION; ARENAVIRIDAE INFECTIONS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINEAGE; CYTOKINES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GERMINAL CENTER; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RNA, MESSENGER; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; TRANSCRIPTION FACTORS;

MUS;

EID: 69249109601     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1175870     Document Type: Article

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40. We thank R. Kageyama, L. Crickard, K. Hansen, C. Kim, and K. Van Gunst for technical assistance; S. Kaech for helpful discussions; A. Haberman and S. Kerfoot for technical help; and the NIH Tetramer Core for providing MHC class II tetramer reagents. Supported by LIAI institutional funds, a Pew Scholar Award, a Cancer Research Institute Award, and National Institute of Allergy and Infectious Diseases grants R01 072543 and NIAID R01 063107 (S.C.); Rheuminations Inc., the Arthritis Foundation, the Connecticut Chapter of the Lupus Foundation of America, and NIH grants AR40072, AR44076, and P30 AR053495 (J.C.); and fellowships from the UCSD/LIAI Immunology NIH Training Grant (I.Y. and R.J.J.). R.J.J. is a member of the UCSD Biomedical Sciences (BMS) graduate program. Microarray data have been deposited at the NCBI Gene Expression Omnibus (GSE16697). Author contributions are as follows: LCMV TFH identification and microarrays, I.Y. and S.C.; Bcl6-RV and Blimp1-RV experiments, R.J.J., D.D., B.B.; TFH migration, D.E.; Blimp-1 conditional knockout experiments, D.D.; Bcl6-/-mice, A.L.D.; Bcl6-/-experiments, A.C.P.; writing, S.C. (with intellectual and editorial contributions from the other authors); project conception and experimental design, S.C. and J.C.