Molecular mechanisms underlying FOXP3 induction in human T cells

Journal of Immunology

Volumn 176, Issue 6, 2006, Pages 3593-3602

  Mantel, Pierre Yves ^a   Ouaked, Nadia ^a   Rückert, Beate ^a   Karagiannidis, Christian ^a   Welz, Roland ^a   Blaser, Kurt ^a   Schmidt Weber, Carsten B ^a  

^a SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; MESSENGER RNA; RAPAMYCIN; STEROID; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC2; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CAAT BOX; CHROMATIN; CONTROLLED STUDY; DNA STRUCTURE; HELA CELL; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; LEUKEMIA CELL LINE; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; REGULATORY T LYMPHOCYTE; REPORTER GENE; SIGNAL TRANSDUCTION; TATA BOX; TRANSLATION INITIATION;

EID: 33644844341     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.6.3593     Document Type: Article

References (56)

1. Miller, J. F., and W. R. Heath. 1993. Self-ignorance in the peripheral T-cell pool. Immunol. Rev. 133: 131-150.
2. 2 in vitro. J. Allergy Clin. Immunol. 93: 758-767.
3. Sakaguchi, S., K. Fukuma, K. Kuribayashi, and T. Masuda. 1985. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J. Exp. Med. 161: 72-87.
4. + suppressor T cells. J. Exp. Med. 193: F41-F46.
5. Akdis, M., J. Verhagen, A. Taylor, F. Karamloo, C. Karagiannidis, R. Crameri, S. Thunberg, G. Deniz, R. Valenta, H. Fiebig, et al. 2004. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J. Exp. Med. 199: 1567-1575.
6. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296.
7. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10: 1969-1980.
8. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164: 183-190.
9. + T cells by regulatory T cells during persistent retroviral infection. Immunity 20: 293-303.
10. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164.
11. Bennett, C. L., M. E. Brunkow, F. Ramsdell, K. C. O'Briant, Q. Zhu, R. L. Fuleihan, A. O. Shigeoka, H. D. Ochs, and P. F. Chance. 2001. A rare polyadenylation signal mutation of the FOXP3 gene (AAUAAA→AAUGAA) leads to the IPEX syndrome. Immunogenetics 53: 435-439.
12. Schubert, L. A., E. Jeffery, Y. Zhang, F. Ramsdell, and S. F. Ziegler. 2001. Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J. Biol Chem. 276: 37672-37679.
13. Bettelli, E., M. Dastrange, and M. Oukka. 2005. Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells. Proc. Natl. Acad. Sci. USA 102: 5138-5143.
14. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
15. + regulatory T cells. Nat. Immunol. 4: 330-336.
16. Levy-Lahad, E., and R. S. Wildin. 2001. Neonatal diabetes mellitus, enteropathy, thrombocytopenia, and endocrinopathy: further evidence for an X-linked lethal syndrome. J. Pediatr. 138: 577-580.
17. Godfrey, V. L., J. E. Wilkinson, and L. B. Russell. 1991. X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am. J. Pathol. 138: 1379-1387.
18. Khattri, R., D. Kasprowicz, T. Cox, M. Mortrud, M. W. Appleby, M. E. Brunkow, S. F. Ziegler, and F. Ramsdell. 2001. The amount of scurfin protein determines peripheral T cell number and responsiveness. J. Immunol. 167: 6312-6320.
19. + T regulatory cells. Nat. Immunol. 4: 337-342.
20. + T cells. J. Clin. Invest. 112: 1437-1443.
21. Karagiannidis, C., M. Akdis, P. Holopainen, N. J. Woolley, G. Hense, B. Ruckert, P. Y. Mantel, G. Menz, C. A. Akdis, K. Blaser, and C. B. Schmidt-Weber. 2004. Glucocorticoids up-regulate FOXP3 expression and regulatory T cells in asthma. J. Allergy Clin. Immunol. 114: 1425-1433.
22. + regulatory T cell compartment. J. Immunol. 173: 2227-2230.
23. + regulatory cells, restores self-tolerance, and facilitates regeneration of β cell function in overtly diabetic nonobese diabetic mice. Transplantation 79: 1091-1096.
24. + precursors. Am. J. Transplant. 4: 1614-1627.
25. Mayor, C., M. Brudno, J. R. Schwartz, A. Poliakov, E. M. Rubin, K. A. Frazer, L. S. Pachter, and I. Dubchak. 2000. VISTA: visualizing global DNA sequence alignments of arbitrary length. Bioinformatics 16: 1046-1047.
26. Wohlfahrt, J. G., C. Karagiannidis, S. Kunzmann, M. M. Epstein, W. Kempf, K. Blaser, and C. B. Schmidt-Weber. 2004. Ephrin-AI suppresses Th2 cell activation and provides a regulatory link to lung epithelial cells. J. Immunol. 172: 843-850.
27. Hamalainen, H. K., J. C. Tubman, S. Vikman, T. Kyrola, E. Ylikoski, J. A. Warrington, and R. Lahesmaa. 2001. Identification and validation of endogenous dogenous reference genes for expression profiling of T helper cell differentiation by quantitative real-time RT-PCR. Anal. Biochem. 299: 63-70.
28. Kunzmann, S., J. O. Wohlfahrt, S. Itoh, H. Asao, M. Komada, C. A. Akdis, K. Blaser, and C. B. Schmidt-Weber. 2003. SARA and Hgs attenuate susceptibility to TGF-β1-mediated T cell suppression. FASEB J. 17: 194-202.
29. Schmidt-Weber, C. B., A. Rao, and A. H. Lichtman. 2000. Integration of TCR and IL-4 signals through STAT6 and the regulation of IL-4 gene expression. Mol. Immunol. 37: 767-774,
30. Hagen, G., J. Dennig, A. Preiss, M. Beato, and G. Suske. 1995. Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3. J. Biol. Chem. 270: 24989-24994.
31. Nan, X., H. H. Ng, C. A. Johnson, C. D. Laherty, B. M. Turner, R. N. Eisenman, and A. Bird. 1998. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393: 386-389.
32. Benoist, C., and P. Chambon. 1981. In vivo sequence requirements of the SV40 early promotor region. Nature 290: 304-310.
33. Suske, G. 1999. The Sp-family of transcription factors. Gene 238: 291-300.
34. Lin, J. X., and W. J. Leonard. 1997. The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor β-chain promoter through noncanonical Egr and Sp1 binding sites. Mol. Cell. Biol. 17: 3714-3722.
35. Messi, M., I. Giacchetto, K. Nagata, A. Lanzavecchia, G. Natoli, and F. Sallusto. 2003. Memory and flexibility of cytokine gene expression as separable properties of human Th1 and Th2 lymphocytes. Nat. Immunol. 4: 78-86.
36. Agarwal, S., and A. Rao. 1998. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9: 765-775.
37. Fontenot, J. D., J. P. Rasmussen, L. M. Williams, J. L. Dooley, A. G. Farr, and A. Y. Rudensky. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22: 329-341.
38. Ramsdell, F. 2003. Foxp3 and natural regulatory T cells: key to a cell lineage? Immunity 19: 165-168.
39. Majello, B., P. De Luca, and L. Lania. 1997. Sp3 is a bifunctional transcription regulator with modular independent activation and repression domains. J. Biol. Chem. 272: 4021-4026.
40. Chen, T. C., S. P. Cobbold, P. J. Fairchild, and H. Waldmann. 2004. Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen. J. Immunol. 172: 5900-5907.
41. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198: 1875-1886.
42. Rao, P. E., A. L. Petrone, and P. D. Ponath. 2005. Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-β. J. Immunol. 174: 1446-1455.
43. + regulatory T cell compartment. J. Immunol 173: 2227-2230.
44. Bluestone, J. A. 1995. New perspectives of CD28-B7-mediated T cell costimulation. Immunity 2: 555-559.
45. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383: 787-793.
46. O'Garra, A. 1998. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8: 275-283.
47. Jain, J., Z. Miner, and A. Rao. 1993. Analysis of the preexisting and nuclear forms of nuclear factor of activated T cells. J. Immunol. 151: 837-848.
48. Rooney, J. W., T. Hoey, and L. H. Glimcher. 1995. Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. Immunity 2: 473-483.
49. Dolganov, G., S. Bort, M. Lovett, J. Burr, L. Schubert, D. Short, M. McGum, C. Gibson, and D. B. Lewis. 1996. Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31. Blood 87: 3316-3326.
50. Perkins, D., Z. Wang, C. Donovan, H. He, D. Mark, G. Guan, Y. Wang, T. Walunas, J. Bluestone, J. Listman, and P. W. Finn. 1996. Regulation of CTLA-4 expression during T cell activation. J. Immunol. 156: 4154-4159.
51. Dunn, C. J., A. J. Wagstaff, C. M. Perry, G. L. Plosker, and K. L. Goa. 2001. Cyclosporin: an updated review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (neoral)1 in organ transplantation. Drugs 61: 1957-2016.
52. Baan, C. C., B. J. van der Mast, M. Klepper, W. M. Mol, A. M. Peeters, S. S. Korevaar, A. H. Balk, and W. Weimar. 2005. Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells. Transplantation 80: 110-117.
53. + regulatory T cells. Blood 105: 4743-4748.
54. Asai, K., S. Hachimura, M. Kimura, T. Toraya, M. Yamashita, T. Nakayama, and S. Kaminogawa. 2002. T cell hyporesponsiveness induced by oral administration of ovalbumin is associated with impaired NFAT nuclear translocation and p27kip1 degradation. J. Immunol. 169: 4723-4731.
55. Heissmeyer, V., F. Macian, S. H. Im, R. Varma, S. Feske, K. Venuprasad, H. Gu, Y. C. Liu, M. L. Dustin, and A. Rao. 2004. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5: 255-265.
56. + suppressor T cells in vivo. Nat. Immunol. 3: 33-41.