Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 28, 2008, Pages 9721-9726

  Kimura, Akihiro ^a   Naka, Tetsuji ^b   Nohara, Keiko ^c   Fujii Kuriyama, Yoshiaki ^d   Kishimoto, Tadamitsu ^a  

^a OSAKA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^c NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^d UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Dioxin receptor; IL 17; IL 6; Regulatory T cells; ROR

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; INTERLEUKIN 17; INTERLEUKIN 6; STAT1 PROTEIN; STAT5 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL LOSS; CELL MATURATION; FEMALE; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION REGULATION; INTERLEUKIN-17; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; RECEPTORS, ARYL HYDROCARBON; STAT1 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; T-LYMPHOCYTES, HELPER-INDUCER; TRANSFORMING GROWTH FACTOR BETA;

EID: 47749107262     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0804231105     Document Type: Article

References (28)

1. Langrish CL, et al. (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201:233-240.
2. Bettelli E, et al. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235-238.
3. Murphy CA, et al. (2003) Divergent pro- and anti-inflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 198:1951-1957.
4. Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F (2007) Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8:942-949.
5. Harrington LE, et al. (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6:1123-1132.
6. Stumhofer JS, et al. (2006) Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 7:937-945.
7. Laurence A, et al. (2007) Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26:371-381.
8. Ivanov II, et al. (2006) The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126:1121-1133.
9. Yang XO, et al. (2008) T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ. Immunity 28:29-39.
10. Quintana FJ, et al. (2008) Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 453:65-71.
11. Veldhoen M, et al. (2008) The aryl hydrocarbon receptor links T(H)17-cell-mediated autoimmunity to environmental toxins. Nature 453:106-109.
12. Ema M, et al. (1992) cDNA cloning and structure of mouse putative Ah receptor. Biochem Biophys Res Commun 184:246-253.
13. Burbach KM, Poland A, Bradfield CA (1992) Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc Natl Acad Sci USA 89:8185-8189.
14. Perdew GH (1988) Association of the Ah receptor with the 90-kDa heat shock protein. J Biol Chem 263:13802-13805.
15. Bell DR, Poland A (2000) A Binding of aryl hydrocarbon receptor (AhR) to AhR-interacting protein. The role of hsp90. J Biol Chem 275:36407-36414.
16. Kazlauskas A, Poellinger L, Pongratz I (1999) Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (Aryl hydrocarbon) receptor. J Biol Chem 274:13519-13524.
17. Fujii-Kuriyama Y, Ema M, Miura J, Sogawa K (1994) Ah receptor: A novel ligand-activated transcription factor. Exp Clin Immunogenet 1:65-74.
18. Ohtake F, et al. (2003) Modulation of estrogen receptor signaling by association with the activated dioxin receptor. Nature 423:545-550.
19. Dragan YP, Schrenk D (2000) Animal studies addressing the carcinogenicity of TCDD (or related compounds) with an emphasis on tumour promotion. Food Addit Contam 17:289-302.
20. Puga A, Tomlinson CR, Xia Y (2005) Ah receptor signals cross-talk with multiple developmental pathways. Biochem Pharmacol 69:199-207.
21. Ohtake F, et al. (2007) Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature 446:562-566.
22. Funatake CJ, et al. (2005) Cutting edge: Activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4+ CD25+ cells with characteristics of regulatory T cells. J Immunol 175:4184-4188.
23. Negishi T, et al. (2005) Effects of aryl hydrocarbon receptor signaling on the modulation of TH1/TH2 balance. J Immunol 175:7348-7356.
24. Korn T, et al. (2007) IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448:484-487.
25. Mathur AN, et al. (2007) Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol 178:4901-4907.
26. Kimura A, Naka T, Kishimoto T (2007) IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells. Proc Natl Acad Sci USA 104:12099-12104.
27. Wang LH, et al. (2004) Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells. Immunity 20:205-218.
28. + regulatory T cells. Proc Natl Acad Sci USA 104:18169-18174.