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Volumn 381, Issue , 2014, Pages 83-124

Transcriptional control of regulatory T cells

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD45RB ANTIGEN; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A; CORE BINDING FACTOR BETA; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; NUCLEAR RECEPTOR NR4A3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 10; PROTEIN KINASE B; PROTEIN P50; PROTEIN P52; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SMAD PROTEIN; SPHINGOSINE 1 PHOSPHATE RECEPTOR; STROMAL INTERACTION MOLECULE 1; STROMAL INTERACTION MOLECULE 2; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELB; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TRANSCRIPTION FACTOR;

EID: 84921729777     PISSN: 0070217X     EISSN: 21969965     Source Type: Book Series    
DOI: 10.1007/82_2014_373     Document Type: Article
Times cited : (17)

References (194)
  • 3
    • 33747891558 scopus 로고    scopus 로고
    • Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance
    • Ambrosino E, Spadaro M, Iezzi M, Curcio C, Forni G, Musiani P, Wei WZ, Cavallo F (2006) Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance. Cancer Res 66(15):7734–7740. doi:10.1158/0008-5472. CAN-06-1432
    • (2006) Cancer Res , vol.66 , Issue.15 , pp. 7734-7740
    • Ambrosino, E.1    Spadaro, M.2    Iezzi, M.3    Curcio, C.4    Forni, G.5    Musiani, P.6    Wei, W.Z.7    Cavallo, F.8
  • 4
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou I, Sarukhan A, Klein L, von Boehmer H (2002) Origin of regulatory T cells with known specificity for antigen. Nat Immunol 3(8):756–763
    • (2002) Nat Immunol , vol.3 , Issue.8 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    Von Boehmer, H.4
  • 5
    • 0029788211 scopus 로고    scopus 로고
    • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    • Asano M, Toda M, Sakaguchi N, Sakaguchi S (1996) Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 184(2):387–396
    • (1996) J Exp Med , vol.184 , Issue.2 , pp. 387-396
    • Asano, M.1    Toda, M.2    Sakaguchi, N.3    Sakaguchi, S.4
  • 6
    • 27444435581 scopus 로고    scopus 로고
    • Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma
    • Attia P, Maker AV, Haworth LR, Rogers-Freezer L, Rosenberg SA (2005) Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma. J Immunother 28(6):582–592
    • (2005) J Immunother , vol.28 , Issue.6 , pp. 582-592
    • Attia, P.1    Maker, A.V.2    Haworth, L.R.3    Rogers-Freezer, L.4    Rosenberg, S.A.5
  • 9
    • 28644447974 scopus 로고    scopus 로고
    • Regulatory T cells in ovarian cancer: Biology and therapeutic potential
    • Barnett B, Kryczek I, Cheng P, Zou W, Curiel TJ (2005) Regulatory T cells in ovarian cancer: biology and therapeutic potential. Am J Reprod Immunol 54(6):369–377
    • (2005) Am J Reprod Immunol , vol.54 , Issue.6 , pp. 369-377
    • Barnett, B.1    Kryczek, I.2    Cheng, P.3    Zou, W.4    Curiel, T.J.5
  • 12
    • 17044393922 scopus 로고    scopus 로고
    • Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells
    • Bettelli E, Dastrange M, Oukka M (2005) Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci USA 102(14):5138–5143
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.14 , pp. 5138-5143
    • Bettelli, E.1    Dastrange, M.2    Oukka, M.3
  • 13
    • 34250342883 scopus 로고    scopus 로고
    • The impact of regulatory T cells on carcinogen-induced sarcogenesis
    • Betts G, Twohig J, Van den Broek M, Sierro S, Godkin A, Gallimore A (2007) The impact of regulatory T cells on carcinogen-induced sarcogenesis. Br J Cancer 96(12):1849–1854. doi:10.1038/sj.bjc.6603824
    • (2007) Br J Cancer , vol.96 , Issue.12 , pp. 1849-1854
    • Betts, G.1    Twohig, J.2    Van Den Broek, M.3    Sierro, S.4    Godkin, A.5    Gallimore, A.6
  • 14
    • 19944434216 scopus 로고    scopus 로고
    • NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells
    • Bopp T, Palmetshofer A, Serfling E, Heib V, Schmitt S, Richter C, Klein M, Schild H, Schmitt E, Stassen M (2005) NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells. J Exp Med 201(2):181–187. doi:10.1084/jem.20041538
    • (2005) J Exp Med , vol.201 , Issue.2 , pp. 181-187
    • Bopp, T.1    Palmetshofer, A.2    Serfling, E.3    Heib, V.4    Schmitt, S.5    Richter, C.6    Klein, M.7    Schild, H.8    Schmitt, E.9    Stassen, M.10
  • 15
    • 83855163995 scopus 로고    scopus 로고
    • Uncovering the role of 5-hydroxymethylcytosine in the epigenome
    • Branco MR, Ficz G, Reik W (2012) Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet 13(1):7–13. doi:10.1038/nrg3080
    • (2012) Nat Rev Genet , vol.13 , Issue.1 , pp. 7-13
    • Branco, M.R.1    Ficz, G.2    Reik, W.3
  • 19
    • 33845935950 scopus 로고    scopus 로고
    • IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells
    • Burchill MA, Yang J, Vogtenhuber C, Blazar BR, Farrar MA (2007) IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol 178(1):280–290
    • (2007) J Immunol , vol.178 , Issue.1 , pp. 280-290
    • Burchill, M.A.1    Yang, J.2    Vogtenhuber, C.3    Blazar, B.R.4    Farrar, M.A.5
  • 21
    • 84868087600 scopus 로고    scopus 로고
    • Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/ NF-kappaB
    • Camperio C, Caristi S, Fanelli G, Soligo M, Del Porto P, Piccolella E (2012) Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/ NF-kappaB. PLoS ONE 7(10):e48303. doi:10.1371/journal.pone.0048303
    • (2012) Plos ONE , vol.7 , Issue.10 , pp. e48303
    • Camperio, C.1    Caristi, S.2    Fanelli, G.3    Soligo, M.4    Del Porto, P.5    Piccolella, E.6
  • 23
    • 0036387193 scopus 로고    scopus 로고
    • Forkhead transcription factors: Key players in development and metabolism
    • Carlsson P, Mahlapuu M (2002) Forkhead transcription factors: key players in development and metabolism. Dev Biol 250(1):1–23
    • (2002) Dev Biol , vol.250 , Issue.1 , pp. 1-23
    • Carlsson, P.1    Mahlapuu, M.2
  • 25
    • 33745463549 scopus 로고    scopus 로고
    • The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells
    • Chae WJ, Henegariu O, Lee SK, Bothwell AL (2006) The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc Natl Acad Sci USA 103(25):9631–9636. doi:10.1073/pnas.0600225103
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.25 , pp. 9631-9636
    • Chae, W.J.1    Henegariu, O.2    Lee, S.K.3    Bothwell, A.L.4
  • 26
    • 70049113279 scopus 로고    scopus 로고
    • CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner
    • Chaudhry A, Rudra D, Treuting P, Samstein RM, Liang Y, Kas A, Rudensky AY (2009) CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 326(5955):986–991. doi:10.1126/science.1172702
    • (2009) Science , vol.326 , Issue.5955 , pp. 986-991
    • Chaudhry, A.1    Rudra, D.2    Treuting, P.3    Samstein, R.M.4    Liang, Y.5    Kas, A.6    Rudensky, A.Y.7
  • 28
    • 80052827580 scopus 로고    scopus 로고
    • Selective recruitment of regulatory T cell through CCR6-CCL20 in hepatocellular carcinoma fosters tumor progression and predicts poor prognosis
    • Chen KJ, Lin SZ, Zhou L, Xie HY, Zhou WH, Taki-Eldin A, Zheng SS (2011a) Selective recruitment of regulatory T cell through CCR6-CCL20 in hepatocellular carcinoma fosters tumor progression and predicts poor prognosis. PLoS ONE 6(9):e24671. doi:10.1371/journal. pone.0024671
    • (2011) Plos ONE , vol.6 , Issue.9
    • Chen, K.J.1    Lin, S.Z.2    Zhou, L.3    Xie, H.Y.4    Zhou, W.H.5    Taki-Eldin, A.6    Zheng, S.S.7
  • 29
    • 79958021546 scopus 로고    scopus 로고
    • IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo
    • Chen Q, Kim YC, Laurence A, Punkosdy GA, Shevach EM (2011b) IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo. J Immunol 186(11): 6329–6337. doi:10.4049/jimmunol.1100061
    • (2011) J Immunol , vol.186 , Issue.11 , pp. 6329-6337
    • Chen, Q.1    Kim, Y.C.2    Laurence, A.3    Punkosdy, G.A.4    Shevach, E.M.5
  • 30
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM (2003) Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198(12):1875–1886
    • (2003) J Exp Med , vol.198 , Issue.12 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6    Mcgrady, G.7    Wahl, S.M.8
  • 32
    • 51049089025 scopus 로고    scopus 로고
    • The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease
    • Chong MM, Rasmussen JP, Rudensky AY, Littman DR (2008) The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med 205(9):2005–2017. doi:10.1084/jem.20081219
    • (2008) J Exp Med , vol.205 , Issue.9 , pp. 2005-2017
    • Chong, M.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3    Littman, D.R.4
  • 34
    • 84862986986 scopus 로고    scopus 로고
    • PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells
    • Cipolletta D, Feuerer M, Li A, Kamei N, Lee J, Shoelson SE, Benoist C, Mathis D (2012) PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature 486(7404):549–553. doi:10.1038/nature11132
    • (2012) Nature , vol.486 , Issue.7404 , pp. 549-553
    • Cipolletta, D.1    Feuerer, M.2    Li, A.3    Kamei, N.4    Lee, J.5    Shoelson, S.E.6    Benoist, C.7    Mathis, D.8
  • 35
    • 0033388099 scopus 로고    scopus 로고
    • An early developmental transcription factor complex that is more stable on nucleosome core particles than on free DNA
    • Cirillo LA, Zaret KS (1999) An early developmental transcription factor complex that is more stable on nucleosome core particles than on free DNA. Mol Cell 4(6):961–969
    • (1999) Mol Cell , vol.4 , Issue.6 , pp. 961-969
    • Cirillo, L.A.1    Zaret, K.S.2
  • 36
    • 0027270989 scopus 로고
    • Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5
    • Clark KL, Halay ED, Lai E, Burley SK (1993) Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Nature 364(6436):412–420. doi:10.1038/364412a0
    • (1993) Nature , vol.364 , Issue.6436 , pp. 412-420
    • Clark, K.L.1    Halay, E.D.2    Lai, E.3    Burley, S.K.4
  • 39
    • 33847397525 scopus 로고    scopus 로고
    • Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells
    • Crellin NK, Garcia RV, Levings MK (2007) Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells. Blood 109(5):2014–2022. doi:10.1182/blood-2006-07-035279
    • (2007) Blood , vol.109 , Issue.5 , pp. 2014-2022
    • Crellin, N.K.1    Garcia, R.V.2    Levings, M.K.3
  • 40
    • 65549123867 scopus 로고    scopus 로고
    • Natural and adaptive Foxp3+ regulatory T cells: More of the same or a division of labor?
    • Curotto de Lafaille MA, Lafaille JJ (2009) Natural and adaptive Foxp3+ regulatory T cells: more of the same or a division of labor? Immunity 30(5):626–635. doi:10.1016/j.immuni.2009.05. 02
    • (2009) Immunity , vol.30 , Issue.5 , pp. 626-635
    • De Curotto Lafaille, M.A.1    Lafaille, J.J.2
  • 41
    • 27544446622 scopus 로고    scopus 로고
    • Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling
    • D’Cruz LM, Klein L (2005) Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol 6(11):1152–1159
    • (2005) Nat Immunol , vol.6 , Issue.11 , pp. 1152-1159
    • D’Cruz, L.M.1    Klein, L.2
  • 45
    • 77749245821 scopus 로고    scopus 로고
    • C-Rel but not NF-kappaB1 is important for T regulatory cell development
    • Deenick EK, Elford AR, Pellegrini M, Hall H, Mak TW, Ohashi PS (2010) c-Rel but not NF-kappaB1 is important for T regulatory cell development. Eur J Immunol 40(3):677–681. doi:10.1002/eji.201040298
    • (2010) Eur J Immunol , vol.40 , Issue.3 , pp. 677-681
    • Deenick, E.K.1    Elford, A.R.2    Pellegrini, M.3    Hall, H.4    Mak, T.W.5    Ohashi, P.S.6
  • 47
    • 79952985551 scopus 로고    scopus 로고
    • The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
    • Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, Xiao B, Worley PF, Powell JD (2011) The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol 12(4):295–303. doi:10.1038/ni.2005
    • (2011) Nat Immunol , vol.12 , Issue.4 , pp. 295-303
    • Delgoffe, G.M.1    Pollizzi, K.N.2    Waickman, A.T.3    Heikamp, E.4    Meyers, D.J.5    Horton, M.R.6    Xiao, B.7    Worley, P.F.8    Powell, J.D.9
  • 49
    • 2142645808 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
    • Fantini MC, Becker C, Monteleone G, Pallone F, Galle PR, Neurath MF (2004) Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 172(9):5149–5153
    • (2004) J Immunol , vol.172 , Issue.9 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3    Pallone, F.4    Galle, P.R.5    Neurath, M.F.6
  • 52
    • 67649170980 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells: differentiation, specification, subphenotypes
    • Feuerer M, Hill JA, Mathis D, Benoist C (2009b) Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol 10(7):689–695. doi:10.1038/ni.1760
    • (2009) Nat Immunol , vol.10 , Issue.7 , pp. 689-695
    • Feuerer, M.1    Hill, J.A.2    Mathis, D.3    Benoist, C.4
  • 54
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4(4):330–336
    • (2003) Nat Immunol , vol.4 , Issue.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 58
    • 54349086262 scopus 로고    scopus 로고
    • Differential requirement of PKC-theta in the development and function of natural regulatory T cells
    • Gupta S, Manicassamy S, Vasu C, Kumar A, Shang W, Sun Z (2008) Differential requirement of PKC-theta in the development and function of natural regulatory T cells. Mol Immunol 46(2):213-224. doi:10.1016/j.molimm.2008.08.275
    • (2008) Mol Immunol , vol.46 , Issue.2 , pp. 213-224
    • Gupta, S.1    Manicassamy, S.2    Vasu, C.3    Kumar, A.4    Shang, W.5    Sun, Z.6
  • 59
    • 70849108700 scopus 로고    scopus 로고
    • Three distinct domains contribute to nuclear transport of murine Foxp3
    • Hancock WW, Ozkaynak E (2009) Three distinct domains contribute to nuclear transport of murine Foxp3. PLoS ONE 4(11):e7890. doi:10.1371/journal.pone.0007890
    • (2009) Plos ONE , vol.4 , Issue.11 , pp. e7890
    • Hancock, W.W.1    Ozkaynak, E.2
  • 60
    • 77954395996 scopus 로고    scopus 로고
    • Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells
    • Harada Y, Elly C, Ying G, Paik JH, DePinho RA, Liu YC (2010) Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. J Exp Med 207(7):1381–1391. doi:10.1084/jem.20100004
    • (2010) J Exp Med , vol.207 , Issue.7 , pp. 1381-1391
    • Harada, Y.1    Elly, C.2    Ying, G.3    Paik, J.H.4    Depinho, R.A.5    Liu, Y.C.6
  • 62
    • 41149113441 scopus 로고    scopus 로고
    • The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
    • Haxhinasto S, Mathis D, Benoist C (2008) The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med 205:565–574
    • (2008) J Exp Med , vol.205 , pp. 565-574
    • Haxhinasto, S.1    Mathis, D.2    Benoist, C.3
  • 64
    • 36048978911 scopus 로고    scopus 로고
    • Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
    • Hill JA, Feuerer M, Tash K, Haxhinasto S, Perez J, Melamed R, Mathis D, Benoist C (2007) Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 27(5):786–800. doi:10.1016/j.immuni.2007.09.010
    • (2007) Immunity , vol.27 , Issue.5 , pp. 786-800
    • Hill, J.A.1    Feuerer, M.2    Tash, K.3    Haxhinasto, S.4    Perez, J.5    Melamed, R.6    Mathis, D.7    Benoist, C.8
  • 65
    • 82155170171 scopus 로고    scopus 로고
    • B7/CD28 in central tolerance: costimulation promotes maturation of regulatory T cell precursors and prevents their clonal deletion
    • Hinterberger M, Wirnsberger G, Klein L (2011) B7/CD28 in central tolerance: costimulation promotes maturation of regulatory T cell precursors and prevents their clonal deletion. Front Immunol 2:30. doi:10.3389/fimmu.2011.00030
    • (2011) Front Immunol , vol.2 , pp. 30
    • Hinterberger, M.1    Wirnsberger, G.2    Klein, L.3
  • 66
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299(5609):1057–1061
    • (2003) Science , vol.299 , Issue.5609 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 67
    • 84862814979 scopus 로고    scopus 로고
    • Selection of regulatory T cells in the thymus
    • Hsieh CS, Lee HM, Lio CW (2012) Selection of regulatory T cells in the thymus. Nat Rev Immunol 12(3):157–167. doi:10.1038/nri3155
    • (2012) Nat Rev Immunol , vol.12 , Issue.3 , pp. 157-167
    • Hsieh, C.S.1    Lee, H.M.2    Lio, C.W.3
  • 68
    • 4143066714 scopus 로고    scopus 로고
    • Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors
    • Hsieh CS, Liang Y, Tyznik AJ, Self SG, Liggitt D, Rudensky AY (2004) Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 21(2):267–277
    • (2004) Immunity , vol.21 , Issue.2 , pp. 267-277
    • Hsieh, C.S.1    Liang, Y.2    Tyznik, A.J.3    Self, S.G.4    Liggitt, D.5    Rudensky, A.Y.6
  • 70
    • 58849118836 scopus 로고    scopus 로고
    • Epigenetic control of FOXP3 expression: The key to a stable regulatory T-cell lineage?
    • Huehn J, Polansky JK, Hamann A (2009) Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? Nat Rev Immunol 9(2):83–89. doi:10.1038/nri2474
    • (2009) Nat Rev Immunol , vol.9 , Issue.2 , pp. 83-89
    • Huehn, J.1    Polansky, J.K.2    Hamann, A.3
  • 72
  • 73
    • 3242736641 scopus 로고    scopus 로고
    • Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice
    • Jones E, Dahm-Vicker M, Simon AK, Green A, Powrie F, Cerundolo V, Gallimore A (2002) Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. Cancer Immun 2:1
    • (2002) Cancer Immun , vol.2 , pp. 1
    • Jones, E.1    Dahm-Vicker, M.2    Simon, A.K.3    Green, A.4    Powrie, F.5    Cerundolo, V.6    Gallimore, A.7
  • 74
    • 15044366139 scopus 로고    scopus 로고
    • Forkhead transcription factors in immunology
    • Jonsson H, Peng SL (2005) Forkhead transcription factors in immunology. Cell Mol Life Sci 62(4):397–409. doi:10.1007/s00018-004-4365-8
    • (2005) Cell Mol Life Sci , vol.62 , Issue.4 , pp. 397-409
    • Jonsson, H.1    Peng, S.L.2
  • 76
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: Mechanisms of differentiation and function
    • Josefowicz SZ, Lu LF, Rudensky AY (2012a) Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 30:531–564. doi:10.1146/annurev.immunol.25.022106. 141623
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 78
    • 65549100376 scopus 로고    scopus 로고
    • Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1
    • Josefowicz SZ, Wilson CB, Rudensky AY (2009) Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1. J Immunol 182(11):6648–6652. doi:10.4049/jimmunol.0803320
    • (2009) J Immunol , vol.182 , Issue.11 , pp. 6648-6652
    • Josefowicz, S.Z.1    Wilson, C.B.2    Rudensky, A.Y.3
  • 79
    • 83455225616 scopus 로고    scopus 로고
    • FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1
    • Katoh H, Qin ZS, Liu R, Wang L, Li W, Li X, Wu L, Du Z, Lyons R, Liu CG, Liu X, Dou Y, Zheng P, Liu Y (2011) FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1. Mol Cell 44(5):770–784. doi:10.1016/j.molcel.2011.10.012
    • (2011) Mol Cell , vol.44 , Issue.5 , pp. 770-784
    • Katoh, H.1    Qin, Z.S.2    Liu, R.3    Wang, L.4    Li, W.5    Li, X.6    Wu, L.7    Du, Z.8    Lyons, R.9    Liu, C.G.10    Liu, X.11    Dou, Y.12    Zheng, P.13    Liu, Y.14
  • 81
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri R, Cox T, Yasayko SA, Ramsdell F (2003) An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 4(4):337–342
    • (2003) Nat Immunol , vol.4 , Issue.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 82
    • 34447265236 scopus 로고    scopus 로고
    • CREB/ATF-dependent T cell receptor-induced Foxp3 gene expression: A role for DNA methylation
    • Kim HP, Leonard WJ (2007) CREB/ATF-dependent T cell receptor-induced Foxp3 gene expression: a role for DNA methylation. J Exp Med 204(7):1543–1551
    • (2007) J Exp Med , vol.204 , Issue.7 , pp. 1543-1551
    • Kim, H.P.1    Leonard, W.J.2
  • 85
    • 27944455288 scopus 로고    scopus 로고
    • Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen
    • Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK (2005) Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med 202(10):1375–1386. doi:10.1084/jem.20050855
    • (2005) J Exp Med , vol.202 , Issue.10 , pp. 1375-1386
    • Knoechel, B.1    Lohr, J.2    Kahn, E.3    Bluestone, J.A.4    Abbas, A.K.5
  • 86
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ (2009) The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 10(6):595–602. doi:10.1038/ni.1731
    • (2009) Nat Immunol , vol.10 , Issue.6 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5    Campbell, D.J.6
  • 87
    • 77953973423 scopus 로고    scopus 로고
    • Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3
    • Koh KP, Sundrud MS, Rao A (2009) Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3. PLoS ONE 4(12):e8109. doi:10.1371/ journal.pone.0008109
    • (2009) Plos ONE , vol.4 , Issue.12
    • Koh, K.P.1    Sundrud, M.S.2    Rao, A.3
  • 91
    • 0346995283 scopus 로고    scopus 로고
    • Complete regression of experimental solid tumors by combination LEC/chTNT-3 immunotherapy and CD25+ T-cell depletion
    • Li J, Hu P, Khawli LA, Epstein AL (2003) Complete regression of experimental solid tumors by combination LEC/chTNT-3 immunotherapy and CD25+ T-cell depletion. Cancer Res 63(23):8384–8392
    • (2003) Cancer Res , vol.63 , Issue.23 , pp. 8384-8392
    • Li, J.1    Hu, P.2    Khawli, L.A.3    Epstein, A.L.4
  • 94
    • 37849009964 scopus 로고    scopus 로고
    • A two-step process for thymic regulatory T cell development
    • Lio CW, Hsieh CS (2008) A two-step process for thymic regulatory T cell development. Immunity 28(1):100–111. doi:10.1016/j.immuni.2007.11.021
    • (2008) Immunity , vol.28 , Issue.1 , pp. 100-111
    • Lio, C.W.1    Hsieh, C.S.2
  • 95
    • 51049110261 scopus 로고    scopus 로고
    • Dicer-dependent microRNA pathway safeguards regulatory T cell function
    • Liston A, Lu LF, O’Carroll D, Tarakhovsky A, Rudensky AY (2008) Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med 205(9):1993–2004. doi:10.1084/jem.20081062
    • (2008) J Exp Med , vol.205 , Issue.9 , pp. 1993-2004
    • Liston, A.1    Lu, L.F.2    O’Carroll, D.3    Tarakhovsky, A.4    Rudensky, A.Y.5
  • 96
    • 77958173509 scopus 로고    scopus 로고
    • The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression
    • Liu B, Tahk S, Yee KM, Fan G, Shuai K (2010) The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression. Science 330(6003):521–525. doi:10.1126/ science.1193787
    • (2010) Science , Issue.6003 , pp. 521-525
    • Liu, B.1    Tahk, S.2    Yee, K.M.3    Fan, G.4    Shuai, K.5
  • 97
    • 67649185215 scopus 로고    scopus 로고
    • The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR
    • Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H (2009) The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat Immunol 10(7):769–777. doi:10.1038/ni.1743
    • (2009) Nat Immunol , vol.10 , Issue.7 , pp. 769-777
    • Liu, G.1    Burns, S.2    Huang, G.3    Boyd, K.4    Proia, R.L.5    Flavell, R.A.6    Chi, H.7
  • 98
    • 44049087148 scopus 로고    scopus 로고
    • A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells
    • Liu Y, Zhang P, Li J, Kulkarni AB, Perruche S, Chen W (2008) A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat Immunol 9(6):632–640. doi:10.1038/ni.1607
    • (2008) Nat Immunol , vol.9 , Issue.6 , pp. 632-640
    • Liu, Y.1    Zhang, P.2    Li, J.3    Kulkarni, A.B.4    Perruche, S.5    Chen, W.6
  • 99
    • 71749088574 scopus 로고    scopus 로고
    • Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor
    • Long M, Park SG, Strickland I, Hayden MS, Ghosh S (2009a) Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity 31(6):921–931. doi:10.1016/j.immuni.2009.09.022
    • (2009) Immunity , vol.31 , Issue.6 , pp. 921-931
    • Long, M.1    Park, S.G.2    Strickland, I.3    Hayden, M.S.4    Ghosh, S.5
  • 100
    • 71749088574 scopus 로고    scopus 로고
    • Nuclear factor-kB modulates regulatory T cell development by directly regulating expression of the Foxp3 transcription factor
    • Long M, Park SG, Strickland I, Hayden MS, Ghosh S (2009b) Nuclear factor-kB modulates regulatory T cell development by directly regulating expression of the Foxp3 transcription factor. Immunity 31:921–931. doi:10.1016/j.immuni.2009.09.022
    • (2009) Immunity , vol.31 , pp. 921-931
    • Long, M.1    Park, S.G.2    Strickland, I.3    Hayden, M.S.4    Ghosh, S.5
  • 102
    • 80054869808 scopus 로고    scopus 로고
    • Foxp3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity
    • Mackey-Cushman SL, Gao J, Holmes DA, Nunoya JI, Wang R, Unutmaz D, Su L (2011) Foxp3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity. Genes Immun 12(7):559–567. doi:10.1038/gene.2011.31
    • (2011) Genes Immun , vol.12 , Issue.7 , pp. 559-567
    • Mackey-Cushman, S.L.1    Gao, J.2    Holmes, D.A.3    Nunoya, J.I.4    Wang, R.5    Unutmaz, D.6    Su, L.7
  • 106
    • 17144400393 scopus 로고    scopus 로고
    • TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
    • Marie JC, Letterio JJ, Gavin M, Rudensky AY (2005) TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J Exp Med 201(7):1061–1067
    • (2005) J Exp Med , vol.201 , Issue.7 , pp. 1061-1067
    • Marie, J.C.1    Letterio, J.J.2    Gavin, M.3    Rudensky, A.Y.4
  • 109
    • 77954417145 scopus 로고    scopus 로고
    • PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors
    • Merkenschlager M, von Boehmer H (2010) PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors. J Exp Med 207(7):1347–1350. doi:10.1084/jem.20101156
    • (2010) J Exp Med , vol.207 , Issue.7 , pp. 1347-1350
    • Merkenschlager, M.1    Von Boehmer, H.2
  • 110
    • 84857416489 scopus 로고    scopus 로고
    • Plasticity of Foxp3+ T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells
    • Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, Hori S (2012) Plasticity of Foxp3+ T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity 36(2):262–275. doi:10.1016/j.immuni. 2011.12.012
    • (2012) Immunity , vol.36 , Issue.2 , pp. 262-275
    • Miyao, T.1    Floess, S.2    Setoguchi, R.3    Luche, H.4    Fehling, H.J.5    Waldmann, H.6    Huehn, J.7    Hori, S.8
  • 112
    • 65549146581 scopus 로고    scopus 로고
    • CARMA1 controls an early checkpoint in the thymic development of Foxp3+ regulatory T cells
    • Molinero LL, Yang J, Gajewski T, Abraham C, Farrar MA, Alegre ML (2009) CARMA1 controls an early checkpoint in the thymic development of Foxp3+ regulatory T cells. J Immunol 182(11):6736–6743. doi:10.4049/jimmunol.0900498
    • (2009) J Immunol , vol.182 , Issue.11 , pp. 6736-6743
    • Molinero, L.L.1    Yang, J.2    Gajewski, T.3    Abraham, C.4    Farrar, M.A.5    Alegre, M.L.6
  • 114
    • 48249098821 scopus 로고    scopus 로고
    • Epigenetic inheritance of DNA methylation limits activation-induced expression of FOXP3 in conventional human CD25- CD4+ T cells
    • Nagar M, Vernitsky H, Cohen Y, Dominissini D, Berkun Y, Rechavi G, Amariglio N, Goldstein I (2008) Epigenetic inheritance of DNA methylation limits activation-induced expression of FOXP3 in conventional human CD25- CD4+ T cells. Int Immunol 20(8):1041–1055
    • (2008) Int Immunol , vol.20 , Issue.8 , pp. 1041-1055
    • Nagar, M.1    Vernitsky, H.2    Cohen, Y.3    Dominissini, D.4    Berkun, Y.5    Rechavi, G.6    Amariglio, N.7    Goldstein, I.8
  • 115
    • 84878197960 scopus 로고    scopus 로고
    • Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry
    • Oh-Hora M, Komatsu N, Pishyareh M, Feske S, Hori S, Taniguchi M, Rao A, Takayanagi H (2013) Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry. Immunity 38(5):881–895. doi:10.1016/j.immuni.2013.02.008
    • (2013) Immunity , vol.38 , Issue.5 , pp. 881-895
    • Oh-Hora, M.1    Komatsu, N.2    Pishyareh, M.3    Feske, S.4    Hori, S.5    Taniguchi, M.6    Rao, A.7    Takayanagi, H.8
  • 117
    • 0038549067 scopus 로고    scopus 로고
    • PI3 K in lymphocyte development, differentiation and activation
    • Okkenhaug K, Vanhaesebroeck B (2003) PI3 K in lymphocyte development, differentiation and activation. Nat Rev Immunol 3(4):317–330. doi:10.1038/nri1056
    • (2003) Nat Rev Immunol , vol.3 , Issue.4 , pp. 317-330
    • Okkenhaug, K.1    Vanhaesebroeck, B.2
  • 118
    • 0033168037 scopus 로고    scopus 로고
    • Tumor rejection by in vivo administration of anti-CD25 (Interleukin-2 receptor alpha) monoclonal antibody
    • Onizuka S, Tawara I, Shimizu J, Sakaguchi S, Fujita T, Nakayama E (1999) Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res 59(13):3128–3133
    • (1999) Cancer Res , vol.59 , Issue.13 , pp. 3128-3133
    • Onizuka, S.1    Tawara, I.2    Shimizu, J.3    Sakaguchi, S.4    Fujita, T.5    Nakayama, E.6
  • 120
    • 16844378685 scopus 로고    scopus 로고
    • Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma
    • Ormandy LA, Hillemann T, Wedemeyer H, Manns MP, Greten TF, Korangy F (2005) Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res 65(6):2457–2464
    • (2005) Cancer Res , vol.65 , Issue.6 , pp. 2457-2464
    • Ormandy, L.A.1    Hillemann, T.2    Wedemeyer, H.3    Manns, M.P.4    Greten, T.F.5    Korangy, F.6
  • 121
    • 77953267301 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development
    • Ouyang W, Beckett O, Ma Q, Li MO (2010a) Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development. Immunity 32(5):642–653. doi:10.1016/j.immuni.2010.04.012
    • (2010) Immunity , vol.32 , Issue.5 , pp. 642-653
    • Ouyang, W.1    Beckett, O.2    Ma, Q.3    Li, M.O.4
  • 122
    • 77953811224 scopus 로고    scopus 로고
    • Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
    • Ouyang W, Beckett O, Ma Q, Paik JH, DePinho RA, Li MO (2010b) Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat Immunol 11(7):618–627. doi:10. 1038/ni.1884
    • (2010) Nat Immunol , vol.11 , Issue.7 , pp. 618-627
    • Ouyang, W.1    Beckett, O.2    Ma, Q.3    Paik, J.H.4    Depinho, R.A.5    Li, M.O.6
  • 124
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM (2012) The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 12(4):252–264. doi:10.1038/nrc3239
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1
  • 126
    • 78149408519 scopus 로고    scopus 로고
    • Methylation matters: Binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
    • Polansky JK, Schreiber L, Thelemann C, Ludwig L, Krüger M, Baumgrass R, Cording S, Floess S, Hamann A, Huehn J (2010) Methylation matters: Binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells. J Mol Med 88(10):1029–1040. doi:10.1007/s00109-010-0642-1
    • (2010) J Mol Med , vol.88 , Issue.10 , pp. 1029-1040
    • Polansky, J.K.1    Schreiber, L.2    Thelemann, C.3    Ludwig, L.4    Krüger, M.5    Baumgrass, R.6    Cording, S.7    Floess, S.8    Hamann, A.9    Huehn, J.10
  • 127
    • 0027517545 scopus 로고
    • Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
    • Powrie F, Leach MW, Mauze S, Caddle LB, Coffman RL (1993) Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol 5(11):1461–1471
    • (1993) Int Immunol , vol.5 , Issue.11 , pp. 1461-1471
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Caddle, L.B.4    Coffman, R.L.5
  • 128
    • 51049108540 scopus 로고    scopus 로고
    • Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma
    • Quezada SA, Peggs KS, Simpson TR, Shen Y, Littman DR, Allison JP (2008) Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma. J Exp Med 205(9):2125–2138. doi:10.1084/jem. 20080099
    • (2008) J Exp Med , vol.205 , Issue.9 , pp. 2125-2138
    • Quezada, S.A.1    Peggs, K.S.2    Simpson, T.R.3    Shen, Y.4    Littman, D.R.5    Allison, J.P.6
  • 129
    • 0346195644 scopus 로고    scopus 로고
    • C-Rel is required for chromatin remodeling across the IL-2 gene promoter
    • Rao S, Gerondakis S, Woltring D, Shannon MF (2003) c-Rel is required for chromatin remodeling across the IL-2 gene promoter. J Immunol 170(7):3724–3731
    • (2003) J Immunol , vol.170 , Issue.7 , pp. 3724-3731
    • Rao, S.1    Gerondakis, S.2    Woltring, D.3    Shannon, M.F.4
  • 130
    • 71749094333 scopus 로고    scopus 로고
    • Development of Foxp3+ regulatory T cells is driven by the c-Rel enhanceosome
    • Ruan Q, Kameswaran V, Tone Y, Li L, Liou HC, Green MI, Tone M, Chen YH (2009) Development of Foxp3+ regulatory T cells is driven by the c-Rel enhanceosome. Immunity 31:932–940. doi:10.1016/j.immuni.2009.10.006
    • (2009) Immunity , vol.31 , pp. 932-940
    • Ruan, Q.1    Kameswaran, V.2    Tone, Y.3    Li, L.4    Liou, H.C.5    Green, M.I.6    Tone, M.7    Chen, Y.H.8
  • 133
    • 70350451993 scopus 로고    scopus 로고
    • Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells
    • Rudra D, Egawa T, Chong MM, Treuting P, Littman DR, Rudensky AY (2009) Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol 10(11):1170–1177. doi:10.1038/ni.1795
    • (2009) Nat Immunol , vol.10 , Issue.11 , pp. 1170-1177
    • Rudra, D.1    Egawa, T.2    Chong, M.M.3    Treuting, P.4    Littman, D.R.5    Rudensky, A.Y.6
  • 135
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155(3):1151–1164
    • (1995) J Immunol , vol.155 , Issue.3 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 136
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S, Yamaguchi T, Nomura T, Ono M (2008) Regulatory T cells and immune tolerance. Cell 133(5):775–787. doi:10.1016/j.cell.2008.05.009
    • (2008) Cell , vol.133 , Issue.5 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 138
    • 84863619688 scopus 로고    scopus 로고
    • Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict
    • Samstein RM, Josefowicz SZ, Arvey A, Treuting PM, Rudensky AY (2012b) Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell 150(1):29–38. doi:10.1016/j.cell.2012.05.031
    • (2012) Cell , vol.150 , Issue.1 , pp. 29-38
    • Samstein, R.M.1    Josefowicz, S.Z.2    Arvey, A.3    Treuting, P.M.4    Rudensky, A.Y.5
  • 139
    • 33748999526 scopus 로고    scopus 로고
    • TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells
    • Sato S, Sanjo H, Tsujimura T, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Takeuchi O, Akira S (2006) TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int Immunol 18(10):1405–1411. doi:10.1093/intimm/dxl082
    • (2006) Int Immunol , vol.18 , Issue.10 , pp. 1405-1411
    • Sato, S.1    Sanjo, H.2    Tsujimura, T.3    Ninomiya-Tsuji, J.4    Yamamoto, M.5    Kawai, T.6    Takeuchi, O.7    Akira, S.8
  • 141
    • 84866403123 scopus 로고    scopus 로고
    • Smad3 binding to the Foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut
    • Schlenner SM, Weigmann B, Ruan Q, Chen Y, von Boehmer H (2012) Smad3 binding to the Foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut. J Exp Med 209(9):1529–1535. doi:10.1084/jem.20112646
    • (2012) J Exp Med , vol.209 , Issue.9 , pp. 1529-1535
    • Schlenner, S.M.1    Weigmann, B.2    Ruan, Q.3    Chen, Y.4    Von Boehmer, H.5
  • 144
    • 84895540450 scopus 로고    scopus 로고
    • The treg-specific demethylated region stabilizes Foxp3 expression independently of NF-kB signaling
    • Schreiber L, Pietzsch B, Floess S, Farah C, Jänsch L, Schmitz I, Huehn J (2014) The treg-specific demethylated region stabilizes Foxp3 expression independently of NF-kB signaling. PLoS ONE 9(2):e88318. doi:10.1371/journal.pone.0088318
    • (2014) Plos ONE , vol.9 , Issue.2 , pp. e88318
    • Schreiber, L.1    Pietzsch, B.2    Floess, S.3    Farah, C.4    Jänsch, L.5    Schmitz, I.6    Huehn, J.7
  • 149
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmmunity
    • Shevach EM (2000) Regulatory T cells in autoimmmunity. Annu Rev Immunol 18:423–449
    • (2000) Annu Rev Immunol , vol.18 , pp. 423-449
    • Shevach, E.M.1
  • 150
    • 79960369458 scopus 로고    scopus 로고
    • HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    • Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, Chi H (2011) HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med 208(7):1367–1376. doi:10.1084/jem.20110278
    • (2011) J Exp Med , vol.208 , Issue.7 , pp. 1367-1376
    • Shi, L.Z.1    Wang, R.2    Huang, G.3    Vogel, P.4    Neale, G.5    Green, D.R.6    Chi, H.7
  • 151
    • 0033571105 scopus 로고    scopus 로고
    • Induction of tumor immunity by removing CD25+CD4+ T cells: A common basis between tumor immunity and autoimmunity
    • Shimizu J, Yamazaki S, Sakaguchi S (1999) Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J Immunol 163(10):5211–5218
    • (1999) J Immunol , vol.163 , Issue.10 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 153
    • 0037094096 scopus 로고    scopus 로고
    • The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2
    • Stahl M, Dijkers PF, Kops GJ, Lens SM, Coffer PJ, Burgering BM, Medema RH (2002) The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol 168(10):5024–5031
    • (2002) J Immunol , vol.168 , Issue.10 , pp. 5024-5031
    • Stahl, M.1    Dijkers, P.F.2    Kops, G.J.3    Lens, S.M.4    Coffer, P.J.5    Burgering, B.M.6    Medema, R.H.7
  • 154
    • 84872681454 scopus 로고    scopus 로고
    • Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3+ regulatory T cells
    • Strainic MG, Shevach EM, An F, Lin F, Medof ME (2013) Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3+ regulatory T cells. Nat Immunol 14(2):162–171. doi:10.1038/ni.2499
    • (2013) Nat Immunol , vol.14 , Issue.2 , pp. 162-171
    • Strainic, M.G.1    Shevach, E.M.2    An, F.3    Lin, F.4    Medof, M.E.5
  • 155
    • 33748460087 scopus 로고    scopus 로고
    • Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis
    • Sugimoto N, Oida T, Hirota K, Nakamura K, Nomura T, Uchiyama T, Sakaguchi S (2006) Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int Immunol 18(8):1197–1209. doi:10.1093/ intimm/dxl060
    • (2006) Int Immunol , vol.18 , Issue.8 , pp. 1197-1209
    • Sugimoto, N.1    Oida, T.2    Hirota, K.3    Nakamura, K.4    Nomura, T.5    Uchiyama, T.6    Sakaguchi, S.7
  • 157
    • 34247885976 scopus 로고    scopus 로고
    • Regulatory T-cell gene expression: ChIP’ing away at Foxp3
    • Sundrud MS, Rao A (2007) Regulatory T-cell gene expression: ChIP’ing away at Foxp3. Immunol Cell Biol 85(3):177–178. doi:10.1038/sj.icb.7100051
    • (2007) Immunol Cell Biol , vol.85 , Issue.3 , pp. 177-178
    • Sundrud, M.S.1    Rao, A.2
  • 158
    • 13944260538 scopus 로고    scopus 로고
    • CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    • Tai X, Cowan M, Feigenbaum L, Singer A (2005) CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat Immunol 6(2):152–162
    • (2005) Nat Immunol , vol.6 , Issue.2 , pp. 152-162
    • Tai, X.1    Cowan, M.2    Feigenbaum, L.3    Singer, A.4
  • 160
    • 80051914562 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis
    • Tian L, Altin JA, Makaroff LE, Franckaert D, Cook MC, Goodnow CC, Dooley J, Liston A (2011) Foxp3+ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis. Blood 118(7):1845–1853. doi:10.1182/blood-2011-04-346056
    • (2011) Blood , vol.118 , Issue.7 , pp. 1845-1853
    • Tian, L.1    Altin, J.A.2    Makaroff, L.E.3    Franckaert, D.4    Cook, M.C.5    Goodnow, C.C.6    Dooley, J.7    Liston, A.8
  • 162
    • 79551697900 scopus 로고    scopus 로고
    • To be or not to be a Treg cell: Lineage decisions controlled by epigenetic mechanisms
    • Toker A, Huehn J (2011) To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms. Sci Signal 4 (158):pe4. doi:10.1126/scisignal.2001783
    • (2011) Sci Signal , vol.4 , Issue.158 , pp. 4
    • Toker, A.1    Huehn, J.2
  • 164
    • 35448930435 scopus 로고    scopus 로고
    • Induction of FOXP3 expression in naive human CD4+FOXP3- T cells by T cell receptor stimulation is TGF-beta-dependent but does not confer a regulatory phenotype
    • Tran DQ, Ramsey H, Shevach EM (2007) Induction of FOXP3 expression in naive human CD4+FOXP3- T cells by T cell receptor stimulation is TGF-beta-dependent but does not confer a regulatory phenotype. Blood 110(8):2983–2990
    • (2007) Blood , vol.110 , Issue.8 , pp. 2983-2990
    • Tran, D.Q.1    Ramsey, H.2    Shevach, E.M.3
  • 165
    • 84877710866 scopus 로고    scopus 로고
    • Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection
    • Tubo NJ, Pagan AJ, Taylor JJ, Nelson RW, Linehan JL, Ertelt JM, Huseby ES, Way SS, Jenkins MK (2013) Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection. Cell 153(4):785–796. doi:10.1016/j.cell.2013.04.007
    • (2013) Cell , vol.153 , Issue.4 , pp. 785-796
    • Tubo, N.J.1    Pagan, A.J.2    Taylor, J.J.3    Nelson, R.W.4    Linehan, J.L.5    Ertelt, J.M.6    Huseby, E.S.7    Way, S.S.8    Jenkins, M.K.9
  • 166
    • 34848849785 scopus 로고    scopus 로고
    • Forkhead transcription factors II
    • Tuteja G, Kaestner KH (2007) Forkhead transcription factors II. Cell 131(1):192. doi:10.1016/j. cell.2007.09.016
    • (2007) Cell , vol.131 , Issue.1 , pp. 192
    • Tuteja, G.1    Kaestner, K.H.2
  • 170
    • 51549104932 scopus 로고    scopus 로고
    • IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development
    • Vang KB, Yang J, Mahmud SA, Burchill MA, Vegoe AL, Farrar MA (2008) IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development. J Immunol 181(5):3285–3290
    • (2008) J Immunol , vol.181 , Issue.5 , pp. 3285-3290
    • Vang, K.B.1    Yang, J.2    Mahmud, S.A.3    Burchill, M.A.4    Vegoe, A.L.5    Farrar, M.A.6
  • 171
    • 77952767221 scopus 로고    scopus 로고
    • Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development
    • Vang KB, Yang J, Pagan AJ, Li LX, Wang J, Green JM, Beg AA, Farrar MA (2010) Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development. J Immunol 184(8):4074–4077. doi:10.4049/jimmunol.0903933
    • (2010) J Immunol , vol.184 , Issue.8 , pp. 4074-4077
    • Vang, K.B.1    Yang, J.2    Pagan, A.J.3    Li, L.X.4    Wang, J.5    Green, J.M.6    Beg, A.A.7    Farrar, M.A.8
  • 172
    • 39449083806 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
    • Venuprasad K, Huang H, Harada Y, Elly C, Subramaniam M, Spelsberg T, Su J, Liu YC (2008) The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1. Nat Immunol 9(3):245–253. doi:10.1038/ni1564
    • (2008) Nat Immunol , vol.9 , Issue.3 , pp. 245-253
    • Venuprasad, K.1    Huang, H.2    Harada, Y.3    Elly, C.4    Subramaniam, M.5    Spelsberg, T.6    Su, J.7    Liu, Y.C.8
  • 173
    • 3142737258 scopus 로고    scopus 로고
    • Foxp3 expressing CD4+CD25high regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells
    • Viguier M, Lemaitre F, Verola O, Cho MS, Gorochov G, Dubertret L, Bachelez H, Kourilsky P, Ferradini L (2004) Foxp3 expressing CD4+CD25high regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells. J Immunol 173(2):1444–1453
    • (2004) J Immunol , vol.173 , Issue.2 , pp. 1444-1453
    • Viguier, M.1    Lemaitre, F.2    Verola, O.3    Cho, M.S.4    Gorochov, G.5    Dubertret, L.6    Bachelez, H.7    Kourilsky, P.8    Ferradini, L.9
  • 175
    • 33746111852 scopus 로고    scopus 로고
    • The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
    • Wan YY, Chi H, Xie M, Schneider MD, Flavell RA (2006) The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol 7(8):851–858. doi:10.1038/ni1355
    • (2006) Nat Immunol , vol.7 , Issue.8 , pp. 851-858
    • Wan, Y.Y.1    Chi, H.2    Xie, M.3    Schneider, M.D.4    Flavell, R.A.5
  • 176
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
    • Wan YY, Flavell RA (2007) Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 445(7129):766–770
    • (2007) Nature , vol.445 , Issue.7129 , pp. 766-770
    • Wan, Y.Y.1    Flavell, R.A.2
  • 177
    • 80053130719 scopus 로고    scopus 로고
    • An essential role of the transcription factor GATA-3 for the function of regulatory T cells
    • Wang Y, Su MA, Wan YY (2011) An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity 35(3):337–348. doi:10.1016/j.immuni.2011.08.012
    • (2011) Immunity , vol.35 , Issue.3 , pp. 337-348
    • Wang, Y.1    Su, M.A.2    Wan, Y.Y.3
  • 180
    • 34247271308 scopus 로고    scopus 로고
    • Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
    • Williams LM, Rudensky AY (2007) Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol 8(3):277–284. doi:10.1038/ni1437
    • (2007) Nat Immunol , vol.8 , Issue.3 , pp. 277-284
    • Williams, L.M.1    Rudensky, A.Y.2
  • 183
    • 84867266681 scopus 로고    scopus 로고
    • Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner
    • Xiong Y, Khanna S, Grzenda AL, Sarmento OF, Svingen PA, Lomberk GA, Urrutia RA, Faubion WA Jr (2012) Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner. J Biol Chem 287(41):34372–34385. doi:10.1074/jbc.M111.325332
    • (2012) J Biol Chem , vol.287 , Issue.41 , pp. 34372-34385
    • Xiong, Y.1    Khanna, S.2    Grzenda, A.L.3    Sarmento, O.F.4    Svingen, P.A.5    Lomberk, G.A.6    Urrutia, R.A.7    Faubion, W.A.8
  • 184
    • 77957025756 scopus 로고    scopus 로고
    • Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I
    • Xu L, Kitani A, Stuelten C, McGrady G, Fuss I, Strober W (2010) Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I. Immunity 33(3):313–325. doi:10.1016/j.immuni.2010.09.001
    • (2010) Immunity , vol.33 , Issue.3 , pp. 313-325
    • Xu, L.1    Kitani, A.2    Stuelten, C.3    Mcgrady, G.4    Fuss, I.5    Strober, W.6
  • 188
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY (2010) Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463(7282):808–812. doi:10.1038/nature08750
    • (2010) Nature , vol.463 , Issue.7282 , pp. 808-812
    • Zheng, Y.1    Josefowicz, S.2    Chaudhry, A.3    Peng, X.P.4    Forbush, K.5    Rudensky, A.Y.6
  • 189
    • 33847220736 scopus 로고    scopus 로고
    • Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    • Zheng Y, Josefowicz SZ, Kas A, Chu TT, Gavin MA, Rudensky AY (2007) Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 445(7130):936–940
    • (2007) Nature , vol.445 , Issue.7130 , pp. 936-940
    • Zheng, Y.1    Josefowicz, S.Z.2    Kas, A.3    Chu, T.T.4    Gavin, M.A.5    Rudensky, A.Y.6
  • 192
    • 51049120236 scopus 로고    scopus 로고
    • Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity
    • Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA (2008b) Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med 205(9):1983–1991. doi:10.1084/jem.20080707
    • (2008) J Exp Med , vol.205 , Issue.9 , pp. 1983-1991
    • Zhou, X.1    Jeker, L.T.2    Fife, B.T.3    Zhu, S.4    Erson, M.S.5    Mcmanus, M.T.6    Bluestone, J.A.7
  • 193
    • 61849172455 scopus 로고    scopus 로고
    • FOXP3 and its partners: Structural and biochemical insights into the regulation of FOXP3 activity. 42(1–3):19–28
    • Zhou Z, Song X, Li B, Greene MI (2008c) FOXP3 and its partners: structural and biochemical insights into the regulation of FOXP3 activity. Immunol Res 42(1–3):19–28. doi:10.1007/ s12026-008-8029-x
    • (2008) Immunol Res
    • Zhou, Z.1    Song, X.2    Li, B.3    Greene, M.I.4
  • 194
    • 33646168597 scopus 로고    scopus 로고
    • FOXP3: Of mice and men
    • Ziegler SF (2006) FOXP3: of mice and men. Annu Rev Immunol 24:209–226
    • (2006) Annu Rev Immunol , vol.24 , pp. 209-226
    • Ziegler, S.F.1


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