The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

Journal of Immunology

Volumn 168, Issue 10, 2002, Pages 5024-5031

  Stahl, Marie ^a   Dijkers, Pascale F ^a   Kops, Geert J P L ^a   Lens, Susanne M A ^a   Coffer, Paul J ^a   Burgering, Boudewijn M T ^a   Medema, René H ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; INTERLEUKIN 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P27; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR FOXO4; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENE INACTIVATION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

EID: 0037094096     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.10.5024     Document Type: Article

References (34)

1. The role of the CD28 receptor during T cell responses to antigen
2. Interleukin-2: Inception, impact, and implications
3. The IL-2 receptor complex: Its structure, function, and target genes
4. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
5. Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway
6. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
7. Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase
8. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
9. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
10. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal
11. Regulation of cell death protease caspase-9 by phosphorylation
12. Direct control of the Forkhead transcription factor AFX by protein kinase B
13. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
14. Unified nomenclature for the winged helix/forkhead transcription factors
15. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
16. The Forkhead transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
17. Forkhead transcription factors: New insights into protein kinase B (c-akt) signaling
18. Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX
19. Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B
20. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-I and germline signaling
21. kip1
22. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
23. Kip1
24. kip1 expression in human peripheral T lymphocytes
25. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
26. 1 cyclin-Cdk protein kinase activity, is related to p21
27. Cip/Kip cyclin-dependent kinase inhibitors: Brakes of the cell cycle engine during development
28. Bim: A novel member of the Bcl-2 family that promotes apoptosis
29. Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors
30. Bcl-2 family proteins
31. BCl-2 family: Regulators of cell death
32. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
33. Mature T lymphocyte apoptosis: Immune regulation in a dynamic and unpredictable antigenic environment
34. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity