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Volumn 1, Issue 6, 2012, Pages 665-675

Structural and Biological Features of FOXP3 Dimerization Relevant to Regulatory T Cell Function

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; INTERLEUKIN 2; LYSINE; TRANSCRIPTION FACTOR FOXP3;

EID: 84863212714     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2012.04.012     Document Type: Article
Times cited : (80)

References (44)
  • 3
    • 0037008698 scopus 로고    scopus 로고
    • Disabling receptor ensembles with rationally designed interface peptidomimetics
    • Berezov A., Chen J., Liu Q., Zhang H.T., Greene M.I., Murali R. Disabling receptor ensembles with rationally designed interface peptidomimetics. J. Biol. Chem. 2002, 277:28330-28339.
    • (2002) J. Biol. Chem. , vol.277 , pp. 28330-28339
    • Berezov, A.1    Chen, J.2    Liu, Q.3    Zhang, H.T.4    Greene, M.I.5    Murali, R.6
  • 4
    • 17044393922 scopus 로고    scopus 로고
    • Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells
    • Bettelli E., Dastrange M., Oukka M. Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc. Natl. Acad. Sci. USA 2005, 102:5138-5143.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5138-5143
    • Bettelli, E.1    Dastrange, M.2    Oukka, M.3
  • 7
    • 33745463549 scopus 로고    scopus 로고
    • The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells
    • Chae W.J., Henegariu O., Lee S.K., Bothwell A.L. The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc. Natl. Acad. Sci. USA 2006, 103:9631-9636.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 9631-9636
    • Chae, W.J.1    Henegariu, O.2    Lee, S.K.3    Bothwell, A.L.4
  • 9
    • 33846016948 scopus 로고    scopus 로고
    • Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation
    • Chen C., Rowell E.A., Thomas R.M., Hancock W.W., Wells A.D. Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation. J. Biol. Chem. 2006, 281:36828-36834.
    • (2006) J. Biol. Chem. , vol.281 , pp. 36828-36834
    • Chen, C.1    Rowell, E.A.2    Thomas, R.M.3    Hancock, W.W.4    Wells, A.D.5
  • 10
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 2003, 4:330-336.
    • (2003) Nat. Immunol. , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 11
    • 0038434099 scopus 로고    scopus 로고
    • Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis
    • Gambineri E., Torgerson T.R., Ochs H.D. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr. Opin. Rheumatol. 2003, 15:430-435.
    • (2003) Curr. Opin. Rheumatol. , vol.15 , pp. 430-435
    • Gambineri, E.1    Torgerson, T.R.2    Ochs, H.D.3
  • 12
    • 57249097253 scopus 로고    scopus 로고
    • Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between forkhead box protein 3 expression and disease severity
    • 1105-1112, e1
    • Gambineri E., Perroni L., Passerini L., Bianchi L., Doglioni C., Meschi F., Bonfanti R., Sznajer Y., Tommasini A., Lawitschka A., et al. Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between forkhead box protein 3 expression and disease severity. J. Allergy Clin. Immunol. 2008, 122. 1105-1112, e1.
    • (2008) J. Allergy Clin. Immunol. , vol.122
    • Gambineri, E.1    Perroni, L.2    Passerini, L.3    Bianchi, L.4    Doglioni, C.5    Meschi, F.6    Bonfanti, R.7    Sznajer, Y.8    Tommasini, A.9    Lawitschka, A.10
  • 13
    • 0026178213 scopus 로고
    • X-linked lymphoreticular disease in the scurfy (sf) mutant mouse
    • Godfrey V.L., Wilkinson J.E., Russell L.B. X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am. J. Pathol. 1991, 138:1379-1387.
    • (1991) Am. J. Pathol. , vol.138 , pp. 1379-1387
    • Godfrey, V.L.1    Wilkinson, J.E.2    Russell, L.B.3
  • 14
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 15
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri R., Cox T., Yasayko S.A., Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 2003, 4:337-342.
    • (2003) Nat. Immunol. , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 16
    • 77953973423 scopus 로고    scopus 로고
    • Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3
    • Koh K.P., Sundrud M.S., Rao A. Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3. PLoS ONE 2009, 4:e8109.
    • (2009) PLoS ONE , vol.4
    • Koh, K.P.1    Sundrud, M.S.2    Rao, A.3
  • 17
    • 84863229506 scopus 로고    scopus 로고
    • Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells
    • Kwon H.S., Lim H.W., Wu J., Schnölzer M., Verdin E., Ott M. Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J. Immunol. 2012, 188:2712-2721.
    • (2012) J. Immunol. , vol.188 , pp. 2712-2721
    • Kwon, H.S.1    Lim, H.W.2    Wu, J.3    Schnölzer, M.4    Verdin, E.5    Ott, M.6
  • 20
    • 34547821980 scopus 로고    scopus 로고
    • FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease
    • Li B., Samanta A., Song X., Iacono K.T., Brennan P., Chatila T.A., Roncador G., Banham A.H., Riley J.L., Wang Q., et al. FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease. Int. Immunol. 2007, 19:825-835.
    • (2007) Int. Immunol. , vol.19 , pp. 825-835
    • Li, B.1    Samanta, A.2    Song, X.3    Iacono, K.T.4    Brennan, P.5    Chatila, T.A.6    Roncador, G.7    Banham, A.H.8    Riley, J.L.9    Wang, Q.10
  • 21
    • 34748837333 scopus 로고    scopus 로고
    • Biochemistry and therapeutic implications of mechanisms involved in FOXP3 activity in immune suppression
    • Li B., Saouaf S.J., Samanta A., Shen Y., Hancock W.W., Greene M.I. Biochemistry and therapeutic implications of mechanisms involved in FOXP3 activity in immune suppression. Curr. Opin. Immunol. 2007, 19:583-588.
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 583-588
    • Li, B.1    Saouaf, S.J.2    Samanta, A.3    Shen, Y.4    Hancock, W.W.5    Greene, M.I.6
  • 24
    • 80054869808 scopus 로고    scopus 로고
    • FoxP3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity
    • Mackey-Cushman S.L., Gao J., Holmes D.A., Nunoya J.I., Wang R., Unutmaz D., Su L. FoxP3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity. Genes Immun. 2011, 12:559-567.
    • (2011) Genes Immun. , vol.12 , pp. 559-567
    • Mackey-Cushman, S.L.1    Gao, J.2    Holmes, D.A.3    Nunoya, J.I.4    Wang, R.5    Unutmaz, D.6    Su, L.7
  • 26
    • 0027423758 scopus 로고
    • Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers
    • Pavletich N.P., Pabo C.O. Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. Science 1993, 261:1701-1707.
    • (1993) Science , vol.261 , pp. 1701-1707
    • Pavletich, N.P.1    Pabo, C.O.2
  • 28
    • 59549088662 scopus 로고    scopus 로고
    • ProtorP: a protein-protein interaction analysis server
    • Reynolds C., Damerell D., Jones S. ProtorP: a protein-protein interaction analysis server. Bioinformatics 2009, 25:413-414.
    • (2009) Bioinformatics , vol.25 , pp. 413-414
    • Reynolds, C.1    Damerell, D.2    Jones, S.3
  • 29
    • 33645075732 scopus 로고    scopus 로고
    • In vivo sites and cellular mechanisms of T reg cell-mediated suppression
    • Rudensky A.Y., Campbell D.J. In vivo sites and cellular mechanisms of T reg cell-mediated suppression. J. Exp. Med. 2006, 203:489-492.
    • (2006) J. Exp. Med. , vol.203 , pp. 489-492
    • Rudensky, A.Y.1    Campbell, D.J.2
  • 30
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995, 155:1151-1164.
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 33
    • 16844378209 scopus 로고    scopus 로고
    • Natural regulatory T cells and self-tolerance
    • Schwartz R.H. Natural regulatory T cells and self-tolerance. Nat. Immunol. 2005, 6:327-330.
    • (2005) Nat. Immunol. , vol.6 , pp. 327-330
    • Schwartz, R.H.1
  • 34
    • 0036445512 scopus 로고    scopus 로고
    • Analysis of α-helical coiled coils with the program TWISTER reveals a structural mechanism for stutter compensation
    • Strelkov S.V., Burkhard P. Analysis of α-helical coiled coils with the program TWISTER reveals a structural mechanism for stutter compensation. J. Struct. Biol. 2002, 137:54-64.
    • (2002) J. Struct. Biol. , vol.137 , pp. 54-64
    • Strelkov, S.V.1    Burkhard, P.2
  • 38
    • 0042591396 scopus 로고    scopus 로고
    • Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors
    • Wang B., Lin D., Li C., Tucker P. Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors. J. Biol. Chem. 2003, 278:24259-24268.
    • (2003) J. Biol. Chem. , vol.278 , pp. 24259-24268
    • Wang, B.1    Lin, D.2    Li, C.3    Tucker, P.4
  • 40
    • 0036346861 scopus 로고    scopus 로고
    • Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome
    • Wildin R.S., Smyk-Pearson S., Filipovich A.H. Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J. Med. Genet. 2002, 39:537-545.
    • (2002) J. Med. Genet. , vol.39 , pp. 537-545
    • Wildin, R.S.1    Smyk-Pearson, S.2    Filipovich, A.H.3
  • 42
    • 78049240315 scopus 로고    scopus 로고
    • Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function
    • Xiao Y., Li B., Zhou Z., Hancock W.W., Zhang H., Greene M.I. Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function. Curr. Opin. Immunol. 2010, 22:583-591.
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 583-591
    • Xiao, Y.1    Li, B.2    Zhou, Z.3    Hancock, W.W.4    Zhang, H.5    Greene, M.I.6
  • 43
    • 33646168597 scopus 로고    scopus 로고
    • FOXP3: of mice and men
    • Ziegler S.F. FOXP3: of mice and men. Annu. Rev. Immunol. 2006, 24:209-226.
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 209-226
    • Ziegler, S.F.1
  • 44
    • 34250863911 scopus 로고    scopus 로고
    • FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene
    • Zuo T., Wang L., Morrison C., Chang X., Zhang H., Li W., Liu Y., Wang Y., Liu X., Chan M.W., et al. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell 2007, 129:1275-1286.
    • (2007) Cell , vol.129 , pp. 1275-1286
    • Zuo, T.1    Wang, L.2    Morrison, C.3    Chang, X.4    Zhang, H.5    Li, W.6    Liu, Y.7    Wang, Y.8    Liu, X.9    Chan, M.W.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.