Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

Immunity

Volumn 29, Issue 1, 2008, Pages 44-56

  Yang, Xuexian O ^a   Nurieva, Roza ^a   Martinez, Gustavo J ^a   Kang, Hong Soon ^b   Chung, Yeonseok ^a   Pappu, Bhanu P ^a   Shah, Bhavin ^a   Chang, Seon Hee ^a   Schluns, Kimberly S ^a   Watowich, Stephanie S ^a   Feng, Xin Hua ^c   Jetten, Anton M ^b   Dong, Chen ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

CELLIMMUNO; MOLIMMUNO

Indexed keywords

CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 17F; INTERLEUKIN 6; RED FLUORESCENT PROTEIN; SMAD4 PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR ROR ALPHA; TRANSCRIPTION FACTOR ROR GAMMA T; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; DOWN REGULATION; ENZYME REGULATION; GENE INSERTION; GENE SEQUENCE; IMMUNE RESPONSE; MOUSE; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FLOW CYTOMETRY; IMMUNOPRECIPITATION; INFLAMMATION; INTERLEUKIN-17; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY; TRANSDUCTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA1;

EID: 46749138596     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2008.05.007     Document Type: Article

References (28)

1. Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., Weiner H.L., and Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006) 235-238
2. Chae W.J., Henegariu O., Lee S.K., and Bothwell A.L. The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc. Natl. Acad. Sci. USA 103 (2006) 9631-9636
3. Chu G.C., Dunn N.R., Anderson D.C., Oxburgh L., and Robertson E.J. Differential requirements for Smad4 in TGF{beta}-dependent patterning of the early mouse embryo. Development 131 (2004) 3501-3512
4. Cobaleda C., Jochum W., and Busslinger M. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 449 (2007) 473-477
5. Dong C. TH17 cells in development: An updated view of their molecular identity and genetic programming. Nat. Rev. Immunol. 8 (2008) 337-348
6. Dong C., and Flavell R.A. Cell fate decision: T-helper 1 and 2 subsets in immune responses. Arthritis Res. 2 (2000) 179-188
7. Feng X.H., and Derynck R. Specificity and versatility in tgf-beta signaling through Smads. Annu. Rev. Cell Dev. Biol. 21 (2005) 659-693
8. Fontenot J.D., Rasmussen J.P., Williams L.M., Dooley J.L., Farr A.G., and Rudensky A.Y. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22 (2005) 329-341
9. Hsieh C.S., Liang Y., Tyznik A.J., Self S.G., Liggitt D., and Rudensky A.Y. Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 21 (2004) 267-277
10. Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., and Littman D.R. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126 (2006) 1121-1133
11. Korn T., Reddy J., Gao W., Bettelli E., Awasthi A., Petersen T.R., Backstrom B.T., Sobel R.A., Wucherpfennig K.W., Strom T.B., et al. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat. Med. 13 (2007) 423-431
12. Kurebayashi S., Ueda E., Sakaue M., Patel D.D., Medvedev A., Zhang F., and Jetten A.M. Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. Proc. Natl. Acad. Sci. USA 97 (2000) 10132-10137
13. Kurebayashi S., Nakajima T., Kim S.-C., Chang C.-Y., McDonnell D.P., Renaud J.-P., and Jetten A.M. Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor ROR. Biochem. Biophys. Res. Commun. 315 (2004) 919-927
14. Laurence A., Tato C.M., Davidson T.S., Kanno Y., Chen Z., Yao Z., Blank R.B., Meylan F., Siegel R., Hennighausen L., et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26 (2007) 371-381
15. Lee P.P., Fitzpatrick D.R., Beard C., Jessup H.K., Lehar S., Makar K.W., Perez-Melgosa M., Sweetser M.T., Schlissel M.S., Nguyen S., et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15 (2001) 763-774
16. Lee S.-M., Gao B., and Fang D. FoxP3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1. Blood 111 (2008) 3599-3606
17. Li B., Samanta A., Song X., Iacono K.T., Bembas K., Tao R., Basu S., Riley J.L., Hancock W.W., Shen Y., et al. FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc. Natl. Acad. Sci. USA 104 (2007) 4571-4576
18. Marie J.C., Letterio J.J., Gavin M., and Rudensky A.Y. TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J. Exp. Med. 201 (2005) 1061-1067
19. Mucida D., Park Y., Kim G., Turovskaya O., Scott I., Kronenberg M., and Cheroutre H. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317 (2007) 256-260
20. Nurieva R., Yang X.O., Martinez G., Zhang Y., Panopoulos A.D., Ma L., Schluns K., Tian Q., Watowich S.S., Jetten A.M., and Dong C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448 (2007) 480-483
21. Selvaraj R.K., and Geiger T.L. A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta. J. Immunol. 179 (2007) 11 p following 1390
22. Shull M.M., Ormsby I., Kier A.B., Pawlowski S., Diebold R.J., Yin M., Allen R., Sidman C., Proetzel G., Calvin D., et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359 (1992) 693-699
23. Williams L.M., and Rudensky A.Y. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat. Immunol. 8 (2007) 277-284
24. Wing K., Fehervari Z., and Sakaguchi S. Emerging possibilities in the development and function of regulatory T cells. Int. Immunol. 18 (2006) 991-1000
25. Xu L., Kitani A., Fuss I., and Strober W. Cutting edge: Regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J. Immunol. 178 (2007) 6725-6729
26. Yang X.O., Panopoulos A.D., Nurieva R., Chang S.H., Wang D., Watowich S.S., and Dong C. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 282 (2007) 9358-9363
27. Yang X.O., Chang S.H., Park H., Nurieva R., Shah B., Acero L., Wang Y.-H., Schluns K.S., Broaddus R.R., Zhu Z., and Dong C. Regulation of inflammatory responses by IL-17F. J. Exp. Med. 205 (2008) 1063-1075
28. Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., Ma L., Shah B., Panopoulos A.D., Schluns K.S., et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR[alpha] and ROR. Immunity 28 (2008) 29-39