-
1
-
-
16444377660
-
Dependence of self-tolerance on TRAF6-directed development of thymic stroma
-
Akiyama T., Maeda S., Yamane S., Ogino K., Kasai M., Kajiura F., Matsumoto M., and Inoue J. Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308 (2005) 248-251
-
(2005)
Science
, vol.308
, pp. 248-251
-
-
Akiyama, T.1
Maeda, S.2
Yamane, S.3
Ogino, K.4
Kasai, M.5
Kajiura, F.6
Matsumoto, M.7
Inoue, J.8
-
2
-
-
33646007658
-
Interleukin-2-dependent mechanisms of tolerance and immunity in vivo
-
Antony P.A., Paulos C.M., Ahmadzadeh M., Akpinarli A., Palmer D.C., Sato N., Kaiser A., Hinrichs C.S., Klebanoff C.A., Tagaya Y., and Restifo N.P. Interleukin-2-dependent mechanisms of tolerance and immunity in vivo. J. Immunol. 176 (2006) 5255-5266
-
(2006)
J. Immunol.
, vol.176
, pp. 5255-5266
-
-
Antony, P.A.1
Paulos, C.M.2
Ahmadzadeh, M.3
Akpinarli, A.4
Palmer, D.C.5
Sato, N.6
Kaiser, A.7
Hinrichs, C.S.8
Klebanoff, C.A.9
Tagaya, Y.10
Restifo, N.P.11
-
3
-
-
2542420993
-
In vivo instruction of suppressor commitment in naive T cells
-
Apostolou I., and von Boehmer H. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199 (2004) 1401-1408
-
(2004)
J. Exp. Med.
, vol.199
, pp. 1401-1408
-
-
Apostolou, I.1
von Boehmer, H.2
-
4
-
-
34248598295
-
+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
-
+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat. Immunol. 8 (2007) 351-358
-
(2007)
Nat. Immunol.
, vol.8
, pp. 351-358
-
-
Aschenbrenner, K.1
D'Cruz, L.M.2
Vollmann, E.H.3
Hinterberger, M.4
Emmerich, J.5
Swee, L.K.6
Rolink, A.7
Klein, L.8
-
6
-
-
16844369607
-
Natural regulatory T cells in infectious disease
-
Belkaid Y., and Rouse B.T. Natural regulatory T cells in infectious disease. Nat. Immunol. 6 (2005) 353-360
-
(2005)
Nat. Immunol.
, vol.6
, pp. 353-360
-
-
Belkaid, Y.1
Rouse, B.T.2
-
8
-
-
34547769253
-
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
-
Benson M.J., Pino-Lagos K., Rosemblatt M., and Noelle R.J. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J. Exp. Med. 204 (2007) 1765-1774
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1765-1774
-
-
Benson, M.J.1
Pino-Lagos, K.2
Rosemblatt, M.3
Noelle, R.J.4
-
9
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., Weiner H.L., and Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006) 235-238
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
Korn, T.4
Strom, T.B.5
Oukka, M.6
Weiner, H.L.7
Kuchroo, V.K.8
-
11
-
-
0035162560
-
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
-
Brunkow M.E., Jeffery E.W., Hjerrild K.A., Paeper B., Clark L.B., Yasayko S.A., Wilkinson J.E., Galas D., Ziegler S.F., and Ramsdell F. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27 (2001) 68-73
-
(2001)
Nat. Genet.
, vol.27
, pp. 68-73
-
-
Brunkow, M.E.1
Jeffery, E.W.2
Hjerrild, K.A.3
Paeper, B.4
Clark, L.B.5
Yasayko, S.A.6
Wilkinson, J.E.7
Galas, D.8
Ziegler, S.F.9
Ramsdell, F.10
-
12
-
-
33845935950
-
IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells
-
Burchill M.A., Yang J., Vogtenhuber C., Blazar B.R., and Farrar M.A. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J. Immunol. 178 (2007) 280-290
-
(2007)
J. Immunol.
, vol.178
, pp. 280-290
-
-
Burchill, M.A.1
Yang, J.2
Vogtenhuber, C.3
Blazar, B.R.4
Farrar, M.A.5
-
13
-
-
0017111730
-
Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses
-
Cantor H., Shen F.W., and Boyse E.A. Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses. J. Exp. Med. 143 (1976) 1391-1400
-
(1976)
J. Exp. Med.
, vol.143
, pp. 1391-1400
-
-
Cantor, H.1
Shen, F.W.2
Boyse, E.A.3
-
14
-
-
33846805925
-
CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes
-
Caudy A.A., Reddy S.T., Chatila T., Atkinson J.P., and Verbsky J.W. CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. J. Allergy Clin. Immunol. 119 (2007) 482-487
-
(2007)
J. Allergy Clin. Immunol.
, vol.119
, pp. 482-487
-
-
Caudy, A.A.1
Reddy, S.T.2
Chatila, T.3
Atkinson, J.P.4
Verbsky, J.W.5
-
16
-
-
33846016948
-
Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation
-
Chen C., Rowell E.A., Thomas R.M., Hancock W.W., and Wells A.D. Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation. J. Biol. Chem. 281 (2006) 36828-36834
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 36828-36834
-
-
Chen, C.1
Rowell, E.A.2
Thomas, R.M.3
Hancock, W.W.4
Wells, A.D.5
-
17
-
-
0028037782
-
Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalitis
-
Chen Y., Kuchroo V.K., Inobe J., Hafler D.A., and Weiner H.L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalitis. Science 265 (1994) 1237-1240
-
(1994)
Science
, vol.265
, pp. 1237-1240
-
-
Chen, Y.1
Kuchroo, V.K.2
Inobe, J.3
Hafler, D.A.4
Weiner, H.L.5
-
18
-
-
0348223787
-
+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
-
+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198 (2003) 1875-1886
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
Lei, K.J.4
Li, L.5
Marinos, N.6
McGrady, G.7
Wahl, S.M.8
-
19
-
-
33750499991
-
A role for Dicer in immune regulation
-
Cobb B.S., Hertweck A., Smith J., O'Connor E., Graf D., Cook T., Smale S.T., Sakaguchi S., Livesey F.J., Fisher A.G., and Merkenschlager M.A. A role for Dicer in immune regulation. J. Exp. Med. 203 (2006) 2519-2527
-
(2006)
J. Exp. Med.
, vol.203
, pp. 2519-2527
-
-
Cobb, B.S.1
Hertweck, A.2
Smith, J.3
O'Connor, E.4
Graf, D.5
Cook, T.6
Smale, S.T.7
Sakaguchi, S.8
Livesey, F.J.9
Fisher, A.G.10
Merkenschlager, M.A.11
-
20
-
-
36549030784
-
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
-
Collison L.W., Workman C.J., Kuo T.T., Boyd K., Wang Y., Vignali K.M., Cross R., Sehy D., Blumberg R.S., and Vignali D.A. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450 (2007) 566-569
-
(2007)
Nature
, vol.450
, pp. 566-569
-
-
Collison, L.W.1
Workman, C.J.2
Kuo, T.T.3
Boyd, K.4
Wang, Y.5
Vignali, K.M.6
Cross, R.7
Sehy, D.8
Blumberg, R.S.9
Vignali, D.A.10
-
22
-
-
2442522323
-
Autoreactive T cells in healthy individuals
-
Danke N.A., Koelle D.M., Yee C., Beheray S., and Kwok W.W. Autoreactive T cells in healthy individuals. J. Immunol. 172 (2004) 5967-5972
-
(2004)
J. Immunol.
, vol.172
, pp. 5967-5972
-
-
Danke, N.A.1
Koelle, D.M.2
Yee, C.3
Beheray, S.4
Kwok, W.W.5
-
23
-
-
10844252294
-
+ regulatory cell activation and function by dendritic cells
-
+ regulatory cell activation and function by dendritic cells. Int. Immunol. 16 (2004) 1769-1780
-
(2004)
Int. Immunol.
, vol.16
, pp. 1769-1780
-
-
Fehérvári, Z.1
Sakaguchi, S.2
-
25
-
-
33846980131
-
Epigenetic control of the foxp3 locus in regulatory T cells
-
10.1371/journal.pbio.0050038
-
Floess S., Freyer J., Siewert C., Baron U., Olek S., Polansky J., Schlawe K., Chang H.D., Bopp T., Schmitt E., et al. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol. 5 (2007) e38 10.1371/journal.pbio.0050038
-
(2007)
PLoS Biol.
, vol.5
-
-
Floess, S.1
Freyer, J.2
Siewert, C.3
Baron, U.4
Olek, S.5
Polansky, J.6
Schlawe, K.7
Chang, H.D.8
Bopp, T.9
Schmitt, E.10
-
26
-
-
0037385330
-
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
-
Fontenot J.D., Gavin M.A., and Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4 (2003) 330-336
-
(2003)
Nat. Immunol.
, vol.4
, pp. 330-336
-
-
Fontenot, J.D.1
Gavin, M.A.2
Rudensky, A.Y.3
-
28
-
-
0027509812
-
+ T cell subset that inhibits this autoimmune potential
-
+ T cell subset that inhibits this autoimmune potential. J. Exp. Med. 177 (1993) 627-636
-
(1993)
J. Exp. Med.
, vol.177
, pp. 627-636
-
-
Fowell, D.1
Mason, D.2
-
29
-
-
33646240855
-
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development
-
Gavin M.A., Torgerson T.R., Houston E., DeRoos P., Ho W.Y., Stray-Pedersen A., Ocheltree E.L., Greenberg P.D., Ochs H.D., and Rudensky A.Y. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc. Natl. Acad. Sci. USA 103 (2006) 6659-6664
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 6659-6664
-
-
Gavin, M.A.1
Torgerson, T.R.2
Houston, E.3
DeRoos, P.4
Ho, W.Y.5
Stray-Pedersen, A.6
Ocheltree, E.L.7
Greenberg, P.D.8
Ochs, H.D.9
Rudensky, A.Y.10
-
30
-
-
33847153417
-
Foxp3-dependent programme of regulatory T-cell differentiation
-
Gavin M.A., Rasmussen J.P., Fontenot J.D., Vasta V., Manganiello V.C., Beavo J.A., and Rudensky A.Y. Foxp3-dependent programme of regulatory T-cell differentiation. Nature 445 (2007) 771-775
-
(2007)
Nature
, vol.445
, pp. 771-775
-
-
Gavin, M.A.1
Rasmussen, J.P.2
Fontenot, J.D.3
Vasta, V.4
Manganiello, V.C.5
Beavo, J.A.6
Rudensky, A.Y.7
-
32
-
-
33847370194
-
Regulatory T cells dynamically control the primary immune response to foreign antigen
-
Haribhai D., Lin W., Relland L.M., Truong N., Williams C.B., and Chatila T.A. Regulatory T cells dynamically control the primary immune response to foreign antigen. J. Immunol. 178 (2007) 2961-2972
-
(2007)
J. Immunol.
, vol.178
, pp. 2961-2972
-
-
Haribhai, D.1
Lin, W.2
Relland, L.M.3
Truong, N.4
Williams, C.B.5
Chatila, T.A.6
-
33
-
-
36048978911
-
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
-
Hill J.A., Feuerer M., Tash K., Haxhinasto S., Perez J., Melamed R., Mathis D., and Benoist C. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 27 (2007) 786-800
-
(2007)
Immunity
, vol.27
, pp. 786-800
-
-
Hill, J.A.1
Feuerer, M.2
Tash, K.3
Haxhinasto, S.4
Perez, J.5
Melamed, R.6
Mathis, D.7
Benoist, C.8
-
34
-
-
36549019912
-
Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
-
Hirota K., Yoshitomi H., Hashimoto M., Maeda S., Teradaira S., Sugimoto N., Yamaguchi T., Nomura T., Ito H., Nakamura T., et al. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J. Exp. Med. 204 (2007) 2803-2812
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2803-2812
-
-
Hirota, K.1
Yoshitomi, H.2
Hashimoto, M.3
Maeda, S.4
Teradaira, S.5
Sugimoto, N.6
Yamaguchi, T.7
Nomura, T.8
Ito, H.9
Nakamura, T.10
-
35
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S., Nomura T., and Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299 (2003) 1057-1061
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
36
-
-
33645102841
-
An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
-
Hsieh C.S., Zheng Y., Liang Y., Fontenot J.D., and Rudensky A.Y. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 7 (2006) 401-410
-
(2006)
Nat. Immunol.
, vol.7
, pp. 401-410
-
-
Hsieh, C.S.1
Zheng, Y.2
Liang, Y.3
Fontenot, J.D.4
Rudensky, A.Y.5
-
37
-
-
27744528888
-
Homing to suppress: address codes for Treg migration
-
Huehn J., and Hamann A. Homing to suppress: address codes for Treg migration. Trends Immunol. 26 (2005) 632-636
-
(2005)
Trends Immunol.
, vol.26
, pp. 632-636
-
-
Huehn, J.1
Hamann, A.2
-
38
-
-
0033136302
-
Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
-
Itoh M., Takahashi T., Sakaguchi N., Kuniyasu Y., Shimizu J., Otsuka F., and Sakaguchi S. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162 (1999) 5317-5326
-
(1999)
J. Immunol.
, vol.162
, pp. 5317-5326
-
-
Itoh, M.1
Takahashi, T.2
Sakaguchi, N.3
Kuniyasu, Y.4
Shimizu, J.5
Otsuka, F.6
Sakaguchi, S.7
-
39
-
-
0035320679
-
+ regulatory T cells induced by an agonist self-peptide
-
+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2 (2001) 301-306
-
(2001)
Nat. Immunol.
, vol.2
, pp. 301-306
-
-
Jordan, M.S.1
Boesteanu, A.2
Reed, A.J.3
Petrone, A.L.4
Holenbeck, A.E.5
Lerman, M.A.6
Naji, A.7
Caton, A.J.8
-
40
-
-
10744226628
-
NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner
-
Kajiura F., Sun S., Nomura T., Izumi K., Ueno T., Bando Y., Kuroda N., Han H., Li Y., Matsushima A., et al. NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. J. Immunol. 172 (2004) 2067-2075
-
(2004)
J. Immunol.
, vol.172
, pp. 2067-2075
-
-
Kajiura, F.1
Sun, S.2
Nomura, T.3
Izumi, K.4
Ueno, T.5
Bando, Y.6
Kuroda, N.7
Han, H.8
Li, Y.9
Matsushima, A.10
-
42
-
-
0036568942
-
+ regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression
-
+ regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J. Immunol. 168 (2002) 4399-4405
-
(2002)
J. Immunol.
, vol.168
, pp. 4399-4405
-
-
Kawahata, K.1
Misaki, Y.2
Yamauchi, M.3
Tsunekawa, S.4
Setoguchi, K.5
Miyazaki, J.6
Yamamoto, K.7
-
43
-
-
0037385314
-
An essential role for Scurfin in CD4+CD25+ T regulatory cells
-
Khattri R., Cox T., Yasayko S.A., and Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4 (2003) 337-342
-
(2003)
Nat. Immunol.
, vol.4
, pp. 337-342
-
-
Khattri, R.1
Cox, T.2
Yasayko, S.A.3
Ramsdell, F.4
-
44
-
-
33846485153
-
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
-
Kim J.M., Rasmussen J.P., and Rudensky A.Y. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8 (2007) 191-197
-
(2007)
Nat. Immunol.
, vol.8
, pp. 191-197
-
-
Kim, J.M.1
Rasmussen, J.P.2
Rudensky, A.Y.3
-
45
-
-
0041806547
-
In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro
-
Klein L., Khazaie K., and von Boehmer H. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc. Natl. Acad. Sci. USA 100 (2003) 8886-8891
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8886-8891
-
-
Klein, L.1
Khazaie, K.2
von Boehmer, H.3
-
47
-
-
29244435493
-
Inducing and expanding regulatory T cell populations by foreign antigen
-
Kretschmer K., Apostolou I., Hawiger D., Khazaie K., Nussenzweig M.C., and von Boehmer H. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 6 (2005) 1219-1227
-
(2005)
Nat. Immunol.
, vol.6
, pp. 1219-1227
-
-
Kretschmer, K.1
Apostolou, I.2
Hawiger, D.3
Khazaie, K.4
Nussenzweig, M.C.5
von Boehmer, H.6
-
48
-
-
33846423147
-
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease
-
Lahl K., Loddenkemper C., Drouin C., Freyer J., Arnason J., Eberl G., Hamann A., Wagner H., Huehn J., and Sparwasser T. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J. Exp. Med. 204 (2007) 57-63
-
(2007)
J. Exp. Med.
, vol.204
, pp. 57-63
-
-
Lahl, K.1
Loddenkemper, C.2
Drouin, C.3
Freyer, J.4
Arnason, J.5
Eberl, G.6
Hamann, A.7
Wagner, H.8
Huehn, J.9
Sparwasser, T.10
-
49
-
-
33947162110
-
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
-
Laurence A., Tato C.M., Davidson T.S., Kanno Y., Chen Z., Yao Z., Blank R.B., Meylan F., Siegel R., Hennighausen L., et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26 (2007) 371-381
-
(2007)
Immunity
, vol.26
, pp. 371-381
-
-
Laurence, A.1
Tato, C.M.2
Davidson, T.S.3
Kanno, Y.4
Chen, Z.5
Yao, Z.6
Blank, R.B.7
Meylan, F.8
Siegel, R.9
Hennighausen, L.10
-
51
-
-
37149018400
-
FOXP3 actively represses transcription by recruiting the HAT/HDAC complex
-
Li B., and Greene M.I. FOXP3 actively represses transcription by recruiting the HAT/HDAC complex. Cell Cycle 6 (2007) 1432-1436
-
(2007)
Cell Cycle
, vol.6
, pp. 1432-1436
-
-
Li, B.1
Greene, M.I.2
-
52
-
-
33947600584
-
Regulatory T cell development in the absence of functional Foxp3
-
Lin W., Haribhai D., Relland L.M., Truong N., Carlson M.R., Williams C.B., and Chatila T.A. Regulatory T cell development in the absence of functional Foxp3. Nat. Immunol. 8 (2007) 359-368
-
(2007)
Nat. Immunol.
, vol.8
, pp. 359-368
-
-
Lin, W.1
Haribhai, D.2
Relland, L.M.3
Truong, N.4
Carlson, M.R.5
Williams, C.B.6
Chatila, T.A.7
-
53
-
-
4544241811
-
Tolerance, not immunity, crucially depends on IL-2
-
Malek T.R., and Bayer A.L. Tolerance, not immunity, crucially depends on IL-2. Nat. Rev. Immunol. 4 (2004) 665-674
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 665-674
-
-
Malek, T.R.1
Bayer, A.L.2
-
54
-
-
33847242598
-
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
-
Marson A., Kretschmer K., Frampton G.M., Jacobsen E.S., Polansky J.K., MacIsaac K.D., Levine S.S., Fraenkel E., von Boehmer H., and Young R.A. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 445 (2007) 931-935
-
(2007)
Nature
, vol.445
, pp. 931-935
-
-
Marson, A.1
Kretschmer, K.2
Frampton, G.M.3
Jacobsen, E.S.4
Polansky, J.K.5
MacIsaac, K.D.6
Levine, S.S.7
Fraenkel, E.8
von Boehmer, H.9
Young, R.A.10
-
58
-
-
33847415066
-
Natural regulatory T cells: mechanisms of suppression
-
Miyara M., and Sakaguchi S. Natural regulatory T cells: mechanisms of suppression. Trends Mol. Med. 13 (2007) 108-116
-
(2007)
Trends Mol. Med.
, vol.13
, pp. 108-116
-
-
Miyara, M.1
Sakaguchi, S.2
-
59
-
-
34447503805
-
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
-
Mucida D., Park Y., Kim G., Turovskaya O., Scott I., Kronenberg M., and Cheroutre H. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317 (2007) 256-260
-
(2007)
Science
, vol.317
, pp. 256-260
-
-
Mucida, D.1
Park, Y.2
Kim, G.3
Turovskaya, O.4
Scott, I.5
Kronenberg, M.6
Cheroutre, H.7
-
61
-
-
13144261691
-
FOXP3 acts as a rheostat of the immune response
-
Ochs H.D., Ziegler S.F., and Torgerson T.R. FOXP3 acts as a rheostat of the immune response. Immunol. Rev. 203 (2005) 156-164
-
(2005)
Immunol. Rev.
, vol.203
, pp. 156-164
-
-
Ochs, H.D.1
Ziegler, S.F.2
Torgerson, T.R.3
-
62
-
-
34247215187
-
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
-
Ono M., Yaguchi H., Ohkura N., Kitabayashi I., Nagamura Y., Nomura T., Miyachi Y., Tsukada T., and Sakaguchi S. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature 446 (2007) 685-689
-
(2007)
Nature
, vol.446
, pp. 685-689
-
-
Ono, M.1
Yaguchi, H.2
Ohkura, N.3
Kitabayashi, I.4
Nagamura, Y.5
Nomura, T.6
Miyachi, Y.7
Tsukada, T.8
Sakaguchi, S.9
-
66
-
-
0032212631
-
Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development
-
Ranger A.M., Oukka M., Rengarajan J., and Glimcher L.H. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Immunity 9 (1998) 627-635
-
(1998)
Immunity
, vol.9
, pp. 627-635
-
-
Ranger, A.M.1
Oukka, M.2
Rengarajan, J.3
Glimcher, L.H.4
-
67
-
-
0030973579
-
Transcription factors of the NFAT family: regulation and function
-
Rao A., Luo C., and Hogan P.G. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15 (1997) 707-747
-
(1997)
Annu. Rev. Immunol.
, vol.15
, pp. 707-747
-
-
Rao, A.1
Luo, C.2
Hogan, P.G.3
-
68
-
-
0034679567
-
+ regulatory cells that control intestinal inflammation
-
+ regulatory cells that control intestinal inflammation. J. Exp. Med. 192 (2000) 295-302
-
(2000)
J. Exp. Med.
, vol.192
, pp. 295-302
-
-
Read, S.1
Malmstrom, V.2
Powrie, F.3
-
69
-
-
0033730056
-
Animal models of autoimmunity and their relevance to human diseases
-
Sakaguchi S. Animal models of autoimmunity and their relevance to human diseases. Curr. Opin. Immunol. 12 (2000) 684-690
-
(2000)
Curr. Opin. Immunol.
, vol.12
, pp. 684-690
-
-
Sakaguchi, S.1
-
70
-
-
16844365788
-
+ regulatory T cells in immunological tolerance to self and non-self
-
+ regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6 (2005) 345-352
-
(2005)
Nat. Immunol.
, vol.6
, pp. 345-352
-
-
Sakaguchi, S.1
-
71
-
-
0020451946
-
Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis
-
Sakaguchi S., Takahashi T., and Nishizuka Y. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J. Exp. Med. 156 (1982) 1577-1586
-
(1982)
J. Exp. Med.
, vol.156
, pp. 1577-1586
-
-
Sakaguchi, S.1
Takahashi, T.2
Nishizuka, Y.3
-
72
-
-
0021997185
-
Organ-specific autoimmune diseases induced in mice by elimination of T-cell subset. I. Evidence for the active participation of T cells in natural self-tolerance: deficit of a T-cell subset as a possible cause of autoimmune disease
-
Sakaguchi S., Fukuma K., Kuribayashi K., and Masuda T. Organ-specific autoimmune diseases induced in mice by elimination of T-cell subset. I. Evidence for the active participation of T cells in natural self-tolerance: deficit of a T-cell subset as a possible cause of autoimmune disease. J. Exp. Med. 161 (1985) 72-87
-
(1985)
J. Exp. Med.
, vol.161
, pp. 72-87
-
-
Sakaguchi, S.1
Fukuma, K.2
Kuribayashi, K.3
Masuda, T.4
-
73
-
-
0029150110
-
Immunologic tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
-
Sakaguchi S., Sakaguchi N., Asano M., Itoh M., and Toda M. Immunologic tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155 (1995) 1151-1164
-
(1995)
J. Immunol.
, vol.155
, pp. 1151-1164
-
-
Sakaguchi, S.1
Sakaguchi, N.2
Asano, M.3
Itoh, M.4
Toda, M.5
-
77
-
-
0037152162
-
Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node
-
Scheinecker C., McHugh R., Shevach E.M., and Germain R.N. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J. Exp. Med. 196 (2002) 1079-1090
-
(2002)
J. Exp. Med.
, vol.196
, pp. 1079-1090
-
-
Scheinecker, C.1
McHugh, R.2
Shevach, E.M.3
Germain, R.N.4
-
79
-
-
15444374646
-
+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
-
+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 201 (2005) 723-735
-
(2005)
J. Exp. Med.
, vol.201
, pp. 723-735
-
-
Setoguchi, R.1
Hori, S.2
Takahashi, T.3
Sakaguchi, S.4
-
80
-
-
33747143361
-
From vanilla to 28 flavors: multiple varieties of T regulatory cells
-
Shevach E.M. From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity 25 (2006) 195-201
-
(2006)
Immunity
, vol.25
, pp. 195-201
-
-
Shevach, E.M.1
-
82
-
-
0033571105
-
+ T cells: a common basis between tumor immunity and autoimmunity
-
+ T cells: a common basis between tumor immunity and autoimmunity. J. Immunol. 163 (1999) 5211-5218
-
(1999)
J. Immunol.
, vol.163
, pp. 5211-5218
-
-
Shimizu, J.1
Yamazaki, S.2
Sakaguchi, S.3
-
84
-
-
0035180067
-
Control of intestinal inflammation by regulatory T cells
-
Singh B., Read S., Asseman C., Malmstrom V., Mottet C., Stephens L.A., Stepankova R., Tlaskalova H., and Powrie F. Control of intestinal inflammation by regulatory T cells. Immunol. Rev. 182 (2001) 190-200
-
(2001)
Immunol. Rev.
, vol.182
, pp. 190-200
-
-
Singh, B.1
Read, S.2
Asseman, C.3
Malmstrom, V.4
Mottet, C.5
Stephens, L.A.6
Stepankova, R.7
Tlaskalova, H.8
Powrie, F.9
-
85
-
-
28444444122
-
+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivity
-
+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivity. Proc. Natl. Acad. Sci. USA 102 (2005) 17418-17423
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 17418-17423
-
-
Stephens, L.A.1
Gray, D.2
Anderton, S.M.3
-
87
-
-
34547757390
-
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
-
Sun C.M., Hall J.A., Blank R.B., Bouladoux N., Oukka M., Mora J.R., and Belkaid Y. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204 (2007) 1775-1785
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1775-1785
-
-
Sun, C.M.1
Hall, J.A.2
Blank, R.B.3
Bouladoux, N.4
Oukka, M.5
Mora, J.R.6
Belkaid, Y.7
-
88
-
-
33745851174
-
Toll-like receptors on regulatory T cells: expanding immune regulation
-
Sutmuller R.P., Morgan M.E., Netea M.G., Grauer O., and Adema G.J. Toll-like receptors on regulatory T cells: expanding immune regulation. Trends Immunol. 27 (2006) 387-393
-
(2006)
Trends Immunol.
, vol.27
, pp. 387-393
-
-
Sutmuller, R.P.1
Morgan, M.E.2
Netea, M.G.3
Grauer, O.4
Adema, G.J.5
-
89
-
-
0036721772
-
The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7
-
Szanya V., Ermann J., Taylor C., Holness C., and Fathman C.G. The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J. Immunol. 169 (2002) 2461-2465
-
(2002)
J. Immunol.
, vol.169
, pp. 2461-2465
-
-
Szanya, V.1
Ermann, J.2
Taylor, C.3
Holness, C.4
Fathman, C.G.5
-
90
-
-
33645067654
-
+ T cells and dendritic cells in vivo
-
+ T cells and dendritic cells in vivo. J. Exp. Med. 203 (2006) 505-511
-
(2006)
J. Exp. Med.
, vol.203
, pp. 505-511
-
-
Tadokoro, C.E.1
Shakhar, G.2
Shen, S.3
Ding, Y.4
Lino, A.C.5
Maraver, A.6
Lafaille, J.J.7
Dustin, M.L.8
-
91
-
-
39449126502
-
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
-
Tang Q., and Bluestone J.A. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat. Immunol. 9 (2008) 239-244
-
(2008)
Nat. Immunol.
, vol.9
, pp. 239-244
-
-
Tang, Q.1
Bluestone, J.A.2
-
92
-
-
0031647622
-
+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state
-
+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10 (1998) 1969-1980
-
(1998)
Int. Immunol.
, vol.10
, pp. 1969-1980
-
-
Takahashi, T.1
Kuniyasu, Y.2
Toda, M.3
Sakaguchi, N.4
Itoh, M.5
Iwata, M.6
Shimizu, J.7
Sakaguchi, S.8
-
93
-
-
0034679560
-
+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
-
+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192 (2000) 303-310
-
(2000)
J. Exp. Med.
, vol.192
, pp. 303-310
-
-
Takahashi, T.1
Tagami, T.2
Yamazaki, S.3
Uede, T.4
Shimizu, J.5
Sakaguchi, N.6
Mak, T.W.7
Sakaguchi, S.8
-
94
-
-
29244482759
-
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice
-
Tang Q., Adams J.Y., Tooley A.J., Bi M., Fife B.T., Serra P., Santamaria P., Locksley R.M., Krummel M.F., and Bluestone J.A. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat. Immunol. 7 (2006) 83-92
-
(2006)
Nat. Immunol.
, vol.7
, pp. 83-92
-
-
Tang, Q.1
Adams, J.Y.2
Tooley, A.J.3
Bi, M.4
Fife, B.T.5
Serra, P.6
Santamaria, P.7
Locksley, R.M.8
Krummel, M.F.9
Bluestone, J.A.10
-
95
-
-
18744398397
-
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
-
Taniuchi I., Osato M., Egawa T., Sunshine M.J., Bae S.C., Komori T., Ito Y., and Littman D.R. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111 (2002) 621-633
-
(2002)
Cell
, vol.111
, pp. 621-633
-
-
Taniuchi, I.1
Osato, M.2
Egawa, T.3
Sunshine, M.J.4
Bae, S.C.5
Komori, T.6
Ito, Y.7
Littman, D.R.8
-
96
-
-
0031821875
-
+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
-
+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188 (1998) 287-296
-
(1998)
J. Exp. Med.
, vol.188
, pp. 287-296
-
-
Thornton, A.M.1
Shevach, E.M.2
-
97
-
-
33750375612
-
+ T cells during cure of colitis
-
+ T cells during cure of colitis. J. Immunol. 177 (2006) 5852-5860
-
(2006)
J. Immunol.
, vol.177
, pp. 5852-5860
-
-
Uhlig, H.H.1
Coombes, J.2
Mottet, C.3
Izcue, A.4
Thompson, C.5
Fanger, A.6
Tannapfel, A.7
Fontenot, J.D.8
Ramsdell, F.9
Powrie, F.10
-
98
-
-
9244244736
-
Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
-
van Santen H.M., Benoist C., and Mathis D. Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 200 (2004) 1221-1230
-
(2004)
J. Exp. Med.
, vol.200
, pp. 1221-1230
-
-
van Santen, H.M.1
Benoist, C.2
Mathis, D.3
-
99
-
-
32244442562
-
TGF-β in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGF-β in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
-
100
-
-
2442450433
-
IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells
-
Vieira P.L., Christensen J.R., Minaee S., O'Neill E.J., Barrat F.J., Boonstra A., Barthlott T., Stockinger B., Wraith D.C., and O'Garra A. IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells. J. Immunol. 172 (2004) 5986-5993
-
(2004)
J. Immunol.
, vol.172
, pp. 5986-5993
-
-
Vieira, P.L.1
Christensen, J.R.2
Minaee, S.3
O'Neill, E.J.4
Barrat, F.J.5
Boonstra, A.6
Barthlott, T.7
Stockinger, B.8
Wraith, D.C.9
O'Garra, A.10
-
101
-
-
16844362608
-
Mechanisms of suppression by suppressor T cells
-
von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat. Immunol. 6 (2005) 338-344
-
(2005)
Nat. Immunol.
, vol.6
, pp. 338-344
-
-
von Boehmer, H.1
-
102
-
-
33746342782
-
Infectious tolerance and the long-term acceptance of transplanted tissue
-
Waldmann H., Adams E., Fairchild P., and Cobbold S. Infectious tolerance and the long-term acceptance of transplanted tissue. Immunol. Rev. 212 (2006) 301-313
-
(2006)
Immunol. Rev.
, vol.212
, pp. 301-313
-
-
Waldmann, H.1
Adams, E.2
Fairchild, P.3
Cobbold, S.4
-
103
-
-
33847125247
-
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
-
Wan Y.Y., and Flavell R.A. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 445 (2007) 766-770
-
(2007)
Nature
, vol.445
, pp. 766-770
-
-
Wan, Y.Y.1
Flavell, R.A.2
-
104
-
-
33847647528
-
Regulatory T cells and cancer
-
Wang H.Y., and Wang R.F. Regulatory T cells and cancer. Curr. Opin. Immunol. 19 (2007) 217-223
-
(2007)
Curr. Opin. Immunol.
, vol.19
, pp. 217-223
-
-
Wang, H.Y.1
Wang, R.F.2
-
106
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
Wellcome Trust Case Control Consortium
-
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447 (2007) 661-678
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
107
-
-
33746228122
-
FOXP3 controls regulatory T cell function through cooperation with NFAT
-
Wu Y., Borde M., Heissmeyer V., Feuerer M., Lapan A.D., Stroud J.C., Bates D.L., Guo L., Han A., Ziegler S.F., et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126 (2006) 375-387
-
(2006)
Cell
, vol.126
, pp. 375-387
-
-
Wu, Y.1
Borde, M.2
Heissmeyer, V.3
Feuerer, M.4
Lapan, A.D.5
Stroud, J.C.6
Bates, D.L.7
Guo, L.8
Han, A.9
Ziegler, S.F.10
-
108
-
-
8344275995
-
+ regulatory T cells
-
+ regulatory T cells. Int. Immunol. 16 (2004) 1643-1656
-
(2004)
Int. Immunol.
, vol.16
, pp. 1643-1656
-
-
Yagi, H.1
Nomura, T.2
Nakamura, K.3
Yamazaki, S.4
Kitawaki, T.5
Hori, S.6
Maeda, M.7
Onodera, M.8
Uchiyama, T.9
Fujii, S.10
Sakaguchi, S.11
-
109
-
-
34447643405
-
Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor
-
Yamaguchi T., Hirota K., Nagahama K., Ohkawa K., Takahashi T., Nomura T., and Sakaguchi S. Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity 27 (2007) 145-159
-
(2007)
Immunity
, vol.27
, pp. 145-159
-
-
Yamaguchi, T.1
Hirota, K.2
Nagahama, K.3
Ohkawa, K.4
Takahashi, T.5
Nomura, T.6
Sakaguchi, S.7
-
110
-
-
33847246293
-
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
-
Yamanouchi J., Rainbow D., Serra P., Howlett S., Hunter K., Garner V.E., Gonzalez-Munoz A., Clark J., Veijola R., Cubbon R., et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat. Genet. 39 (2007) 329-337
-
(2007)
Nat. Genet.
, vol.39
, pp. 329-337
-
-
Yamanouchi, J.1
Rainbow, D.2
Serra, P.3
Howlett, S.4
Hunter, K.5
Garner, V.E.6
Gonzalez-Munoz, A.7
Clark, J.8
Veijola, R.9
Cubbon, R.10
-
112
-
-
34247564147
-
Nonredundant roles for Stat5a/b in directly regulating Foxp3
-
Yao Z., Kanno Y., Kerenyi M., Stephens G., Durant L., Watford W.T., Laurence A., Robinson G.W., Shevach E.M., Moriggl R., et al. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 109 (2007) 4368-4375
-
(2007)
Blood
, vol.109
, pp. 4368-4375
-
-
Yao, Z.1
Kanno, Y.2
Kerenyi, M.3
Stephens, G.4
Durant, L.5
Watford, W.T.6
Laurence, A.7
Robinson, G.W.8
Shevach, E.M.9
Moriggl, R.10
-
114
-
-
33847220736
-
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
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Zheng Y., Josefowicz S.Z., Kas A., Chu T.T., Gavin M.A., and Rudensky A.Y. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 445 (2007) 936-940
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(2007)
Nature
, vol.445
, pp. 936-940
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Zheng, Y.1
Josefowicz, S.Z.2
Kas, A.3
Chu, T.T.4
Gavin, M.A.5
Rudensky, A.Y.6
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