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Volumn 19, Issue 4, 2007, Pages 345-354

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

EID: 34047174849     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxm014     Document Type: Article
Times cited : (734)

References (39)
  • 1
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot, J. D., Gavin, M. A. and Rudensky, A. Y. 2003. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4:330.
    • (2003) Nat. Immunol. , vol.4 , pp. 330
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 2
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori, S., Nomura, T. and Sakaguchi, S. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057.
    • (2003) Science , vol.299 , pp. 1057
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 3
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri, R., Cox, T., Yasayko, S. A. and Ramsdell, F. 2003. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4:337.
    • (2003) Nat. Immunol. , vol.4 , pp. 337
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 5
    • 13144261691 scopus 로고    scopus 로고
    • FOXP3 acts as a rheostat of the immune response
    • Ochs, H. D., Ziegler, S. F. and Torgerson, T. R. 2005. FOXP3 acts as a rheostat of the immune response. Immunol. Rev. 203:156.
    • (2005) Immunol. Rev. , vol.203 , pp. 156
    • Ochs, H.D.1    Ziegler, S.F.2    Torgerson, T.R.3
  • 6
    • 33745211931 scopus 로고    scopus 로고
    • Defective regulatory and effector T cell functions in patients with FOXP3 mutations
    • Bacchetta, R., Passerini, L., Gambineri, E. et al. 2006. Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J. Clin. Invest. 116:1713.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1713
    • Bacchetta, R.1    Passerini, L.2    Gambineri, E.3
  • 7
    • 27644449311 scopus 로고    scopus 로고
    • The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs
    • Allan, S. E., Passerini, L., Bacchetta, R. et al. 2005. The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs. J. Clin. Invest. 115:3276.
    • (2005) J. Clin. Invest. , vol.115 , pp. 3276
    • Allan, S.E.1    Passerini, L.2    Bacchetta, R.3
  • 8
    • 19344374571 scopus 로고    scopus 로고
    • HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells
    • Oswald-Richter, K., Grill, S. M., Shariat, N. et al. 2004. HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells. PLoS Biol. 2:E198.
    • (2004) PLoS Biol. , vol.2
    • Oswald-Richter, K.1    Grill, S.M.2    Shariat, N.3
  • 9
    • 8344275995 scopus 로고    scopus 로고
    • Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
    • Yagi, H., Nomura, T., Nakamura, K. et al. 2004. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int. Immunol. 16:1643.
    • (2004) Int. Immunol. , vol.16 , pp. 1643
    • Yagi, H.1    Nomura, T.2    Nakamura, K.3
  • 10
    • 15244354491 scopus 로고    scopus 로고
    • De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+ cells
    • Walker, M. R., Carson, B. D., Nepom, G. T., Ziegler, S. F. and Buckner, J. H. 2005. De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+ cells. Proc. Natl Acad. Sci. USA 102:4103.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 4103
    • Walker, M.R.1    Carson, B.D.2    Nepom, G.T.3    Ziegler, S.F.4    Buckner, J.H.5
  • 11
    • 0346969978 scopus 로고    scopus 로고
    • Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells
    • Walker, M. R., Kasprowicz, D. J., Gersuk, V. H. et al. 2003. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J. Clin. Invest. 112:1437.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1437
    • Walker, M.R.1    Kasprowicz, D.J.2    Gersuk, V.H.3
  • 12
    • 33646240855 scopus 로고    scopus 로고
    • Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development
    • Gavin, M. A., Torgerson, T. R., Houston, E. et al. 2006. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc. Natl Acad. Sci. USA 103:6659.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 6659
    • Gavin, M.A.1    Torgerson, T.R.2    Houston, E.3
  • 13
    • 33644844341 scopus 로고    scopus 로고
    • Molecular mechanisms underlying FOXP3 induction in human T cells
    • Mantel, P. Y., Ouaked, N., Ruckert, B. et al. 2006. Molecular mechanisms underlying FOXP3 induction in human T cells. J. Immunol. 176:3593.
    • (2006) J. Immunol. , vol.176 , pp. 3593
    • Mantel, P.Y.1    Ouaked, N.2    Ruckert, B.3
  • 14
    • 20844432429 scopus 로고    scopus 로고
    • Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level
    • Roncador, G., Brown, P. J., Maestre, L. et al. 2005. Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur. J. Immunol. 35:1681.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 1681
    • Roncador, G.1    Brown, P.J.2    Maestre, L.3
  • 15
    • 0035806323 scopus 로고    scopus 로고
    • Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    • Levings, M. K., Sangregorio, R. and Roncarolo, M. G. 2001. Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 193:1295.
    • (2001) J. Exp. Med. , vol.193 , pp. 1295
    • Levings, M.K.1    Sangregorio, R.2    Roncarolo, M.G.3
  • 16
    • 29144534608 scopus 로고    scopus 로고
    • Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells
    • Crellin, N. K., Garcia, R. V., Hadisfar, O., Allan, S. E., Steiner, T. S. and Levings, M. K. 2005. Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells. J. Immunol. 175:8051.
    • (2005) J. Immunol. , vol.175 , pp. 8051
    • Crellin, N.K.1    Garcia, R.V.2    Hadisfar, O.3    Allan, S.E.4    Steiner, T.S.5    Levings, M.K.6
  • 17
    • 0035813231 scopus 로고    scopus 로고
    • Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
    • Schubert, L. A., Jeffery, E., Zhang, Y., Ramsdell, F. and Ziegler, S. F. 2001. Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J. Biol. Chem. 276:37672.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37672
    • Schubert, L.A.1    Jeffery, E.2    Zhang, Y.3    Ramsdell, F.4    Ziegler, S.F.5
  • 19
    • 0035503984 scopus 로고    scopus 로고
    • Spectral compensation for flow cytometry: Visualization artifacts, limitations, and caveats
    • Roederer, M. 2001. Spectral compensation for flow cytometry: visualization artifacts, limitations, and caveats. Cytometry 45:194.
    • (2001) Cytometry , vol.45 , pp. 194
    • Roederer, M.1
  • 20
    • 34047137083 scopus 로고    scopus 로고
    • Transient regulatory T-cells: A state attained by all activated human T-cells
    • Pillai, V., Ortega, S. B., Wang, C. K. and Karandikar, N. J. 2006. Transient regulatory T-cells: A state attained by all activated human T-cells. Clin. Immunol.
    • (2006) Clin. Immunol.
    • Pillai, V.1    Ortega, S.B.2    Wang, C.K.3    Karandikar, N.J.4
  • 22
    • 13944260538 scopus 로고    scopus 로고
    • CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    • Tai, X., Cowan, M., Feigenbaum, L. and Singer, A. 2005. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 6:152.
    • (2005) Nat. Immunol. , vol.6 , pp. 152
    • Tai, X.1    Cowan, M.2    Feigenbaum, L.3    Singer, A.4
  • 23
    • 2442592788 scopus 로고    scopus 로고
    • Toll-like receptor ligands directly promote activated CD4+ T cell survival
    • Gelman, A. E., Zhang, J., Choi, Y. and Turka, L. A. 2004. Toll-like receptor ligands directly promote activated CD4+ T cell survival. J. Immunol. 172:6065.
    • (2004) J. Immunol. , vol.172 , pp. 6065
    • Gelman, A.E.1    Zhang, J.2    Choi, Y.3    Turka, L.A.4
  • 24
    • 33746228122 scopus 로고    scopus 로고
    • FOXP3 controls regulatory T cell function through cooperation with NFAT
    • Wu, Y., Borde, M., Heissmeyer, V. et al. 2006. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126:375.
    • (2006) Cell , vol.126 , pp. 375
    • Wu, Y.1    Borde, M.2    Heissmeyer, V.3
  • 25
    • 33846016948 scopus 로고    scopus 로고
    • Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation
    • Chen, C., Rowell, E. A., Thomas, R. M., Hancock, W. W. and Wells, A. D. 2006. Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation. J. Biol. Chem. 281:36828.
    • (2006) J. Biol. Chem. , vol.281 , pp. 36828
    • Chen, C.1    Rowell, E.A.2    Thomas, R.M.3    Hancock, W.W.4    Wells, A.D.5
  • 26
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
    • Liu, W., Putnam, A. L., Xu-Yu, Z. et al. 2006. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 203:1701.
    • (2006) J. Exp. Med. , vol.203 , pp. 1701
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3
  • 27
    • 33745813929 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    • Seddiki, N., Santner-Nanan, B., Martinson, J. et al. 2006. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J. Exp. Med. 203:1693.
    • (2006) J. Exp. Med. , vol.203 , pp. 1693
    • Seddiki, N.1    Santner-Nanan, B.2    Martinson, J.3
  • 28
    • 0036886390 scopus 로고    scopus 로고
    • The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells
    • Levings, M. K., Bacchetta, R., Schulz, U. and Roncarolo, M. G. 2002. The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. Int. Arch. Allergy Immunol. 129:263.
    • (2002) Int. Arch. Allergy Immunol. , vol.129 , pp. 263
    • Levings, M.K.1    Bacchetta, R.2    Schulz, U.3    Roncarolo, M.G.4
  • 29
    • 33747143361 scopus 로고    scopus 로고
    • From vanilla to 28 flavors: Multiple varieties of T regulatory cells
    • Shevach, E. M. 2006. From vanilla to 28 flavors: Multiple varieties of T regulatory cells. Immunity 25:195.
    • (2006) Immunity , vol.25 , pp. 195
    • Shevach, E.M.1
  • 30
    • 0037099733 scopus 로고    scopus 로고
    • Human CD4(+)CD25(+) regulatory, contactdependent T cells induce interleukin 10-producing, contactindependent type 1-like regulatory T cells [corrected]
    • Dieckmann, D., Bruett, C. H., Ploettner, H., Lutz, M. B. and Schuler, G. 2002. Human CD4(+)CD25(+) regulatory, contactdependent T cells induce interleukin 10-producing, contactindependent type 1-like regulatory T cells [corrected]. J. Exp. Med. 196:247.
    • (2002) J. Exp. Med. , vol.196 , pp. 247
    • Dieckmann, D.1    Bruett, C.H.2    Ploettner, H.3    Lutz, M.B.4    Schuler, G.5
  • 31
    • 0037099719 scopus 로고    scopus 로고
    • Infectious tolerance: Human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells
    • Jonuleit, H., Schmitt, E., Kakirman, H., Stassen, M., Knop, J. and Enk, A. H. 2002. Infectious tolerance: Human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J. Exp. Med. 196:255.
    • (2002) J. Exp. Med. , vol.196 , pp. 255
    • Jonuleit, H.1    Schmitt, E.2    Kakirman, H.3    Stassen, M.4    Knop, J.5    Enk, A.H.6
  • 32
    • 33746342752 scopus 로고    scopus 로고
    • FOXP3 ensembles in T-cell regulation
    • Li, B., Samanta, A., Song, X. et al. 2006. FOXP3 ensembles in T-cell regulation. Immunol. Rev. 212:99.
    • (2006) Immunol. Rev. , vol.212 , pp. 99
    • Li, B.1    Samanta, A.2    Song, X.3
  • 33
    • 0036006813 scopus 로고    scopus 로고
    • Alternate signalling pathways from the interleukin-2 receptor
    • Ellery, J. M. and Nicholls, P. J. 2002. Alternate signalling pathways from the interleukin-2 receptor. Cytokine Growth Factor Rev. 13:27.
    • (2002) Cytokine Growth Factor Rev. , vol.13 , pp. 27
    • Ellery, J.M.1    Nicholls, P.J.2
  • 34
    • 17644389199 scopus 로고    scopus 로고
    • TNF/TNFR family members in costimulation of T cell responses
    • Watts, T. H. 2005. TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 23:23.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 23
    • Watts, T.H.1
  • 35
    • 33746336533 scopus 로고    scopus 로고
    • The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology
    • Sansom, D. M. and Walker, L. S. 2006. The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology. Immunol. Rev. 212:131.
    • (2006) Immunol. Rev. , vol.212 , pp. 131
    • Sansom, D.M.1    Walker, L.S.2
  • 36
    • 33644835247 scopus 로고    scopus 로고
    • TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells
    • Zheng, S. G., Wang, J. H., Stohl, W., Kim, K. S., Gray, J. D. and Horwitz, D. A. 2006. TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells. J. Immunol. 176:3321.
    • (2006) J. Immunol. , vol.176 , pp. 3321
    • Zheng, S.G.1    Wang, J.H.2    Stohl, W.3    Kim, K.S.4    Gray, J.D.5    Horwitz, D.A.6
  • 37
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen, W., Jin, W., Hardegen, N. et al. 2003. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198:1875.
    • (2003) J. Exp. Med. , vol.198 , pp. 1875
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 39
    • 0030069074 scopus 로고    scopus 로고
    • Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes
    • Kanangat, S., Blair, P., Reddy, R. et al. 1996. Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes. Eur. J. Immunol. 26:161.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 161
    • Kanangat, S.1    Blair, P.2    Reddy, R.3


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