-
1
-
-
84859388345
-
Selection of self-reactive T cells in the thymus
-
Stritesky, G.L., Jameson, S.C. & Hogquist, K.A. Selection of self-reactive T cells in the thymus. Annu. Rev. Immunol. 30, 95-114 (2012).
-
(2012)
Annu. Rev. Immunol.
, vol.30
, pp. 95-114
-
-
Stritesky, G.L.1
Jameson, S.C.2
Hogquist, K.A.3
-
2
-
-
0037385330
-
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
-
Fontenot, J.D., Gavin, M.A. & Rudensky, A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4, 330-336 (2003).
-
(2003)
Nat. Immunol.
, vol.4
, pp. 330-336
-
-
Fontenot, J.D.1
Gavin, M.A.2
Rudensky, A.Y.3
-
3
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori, S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061 (2003).
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
4
-
-
0037385314
-
An essential role for Scurfin in CD4+CD25+ T regulatory cells
-
Khattri, R., Cox, T., Yasayko, S.A. & Ramsdell, F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4, 337-342 (2003).
-
(2003)
Nat. Immunol.
, vol.4
, pp. 337-342
-
-
Khattri, R.1
Cox, T.2
Yasayko, S.A.3
Ramsdell, F.4
-
5
-
-
0035167967
-
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
-
Bennett, C.L. et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27, 20-21 (2001).
-
(2001)
Nat. Genet.
, vol.27
, pp. 20-21
-
-
Bennett, C.L.1
-
6
-
-
2442484053
-
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
-
Sakaguchi, S. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22, 531-562 (2004).
-
(2004)
Annu. Rev. Immunol.
, vol.22
, pp. 531-562
-
-
Sakaguchi, S.1
-
7
-
-
0034084162
-
Regulatory T cells in autoimmmunity
-
Shevach, E.M. Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 18, 423-449 (2000).
-
(2000)
Annu. Rev. Immunol.
, vol.18
, pp. 423-449
-
-
Shevach, E.M.1
-
8
-
-
71749094333
-
Development of Foxp3+ regulatory t cells is driven by the c-Rel enhanceosome
-
Ruan, Q. et al. Development of Foxp3+ regulatory t cells is driven by the c-Rel enhanceosome. Immunity 31, 932-940 (2009).
-
(2009)
Immunity
, vol.31
, pp. 932-940
-
-
Ruan, Q.1
-
9
-
-
71749088574
-
Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor
-
Long, M., Park, S.G., Strickland, I., Hayden, M.S. & Ghosh, S. Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity 31, 921-931 (2009).
-
(2009)
Immunity
, vol.31
, pp. 921-931
-
-
Long, M.1
Park, S.G.2
Strickland, I.3
Hayden, M.S.4
Ghosh, S.5
-
10
-
-
76749133610
-
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
-
Zheng, Y. et al. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463, 808-812 (2010).
-
(2010)
Nature
, vol.463
, pp. 808-812
-
-
Zheng, Y.1
-
11
-
-
38349095578
-
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
-
Tone, Y. et al. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat. Immunol. 9, 194-202 (2008).
-
(2008)
Nat. Immunol.
, vol.9
, pp. 194-202
-
-
Tone, Y.1
-
12
-
-
33747801470
-
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo
-
Zorn, E. et al. IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 108, 1571-1579 (2006).
-
(2006)
Blood
, vol.108
, pp. 1571-1579
-
-
Zorn, E.1
-
13
-
-
70349741295
-
Indispensable role of the Runx1-Cbfβ transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells
-
Kitoh, A. et al. Indispensable role of the Runx1-Cbfβ transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells. Immunity 31, 609-620 (2009).
-
(2009)
Immunity
, vol.31
, pp. 609-620
-
-
Kitoh, A.1
-
14
-
-
70350451993
-
Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells
-
Rudra, D. et al. Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat. Immunol. 10, 1170-1177 (2009).
-
(2009)
Nat. Immunol.
, vol.10
, pp. 1170-1177
-
-
Rudra, D.1
-
15
-
-
70449706325
-
Runx proteins regulate Foxp3 expression
-
Bruno, L. et al. Runx proteins regulate Foxp3 expression. J. Exp. Med. 206, 2329-2337 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 2329-2337
-
-
Bruno, L.1
-
16
-
-
77953811224
-
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
-
Ouyang, W. et al. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat. Immunol. 11, 618-627 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 618-627
-
-
Ouyang, W.1
-
17
-
-
77957724587
-
The Ets-1 transcription factor controls the development and function of natural regulatory T cells
-
Mouly, E. et al. The Ets-1 transcription factor controls the development and function of natural regulatory T cells. J. Exp. Med. 207, 2113-2125 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2113-2125
-
-
Mouly, E.1
-
18
-
-
0348223787
-
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3
-
Chen, W. et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
-
19
-
-
0038526314
-
Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors
-
Wang, Z. et al. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature 423, 555-560 (2003).
-
(2003)
Nature
, vol.423
, pp. 555-560
-
-
Wang, Z.1
-
20
-
-
0030977267
-
Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis
-
Cheng, L.E., Chan, F.K., Cado, D. & Winoto, A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 16, 1865-1875 (1997).
-
(1997)
EMBO J.
, vol.16
, pp. 1865-1875
-
-
Cheng, L.E.1
Chan, F.K.2
Cado, D.3
Winoto, A.4
-
21
-
-
79953769170
-
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells
-
Sekiya, T. et al. The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells. Nat. Commun. 2, 269 (2011).
-
(2011)
Nat. Commun.
, vol.2
, pp. 269
-
-
Sekiya, T.1
-
22
-
-
79958251745
-
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
-
Moran, A.E. et al. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 208, 1279-1289 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1279-1289
-
-
Moran, A.E.1
-
23
-
-
36048978911
-
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
-
Hill, J.A. et al. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 27, 786-800 (2007).
-
(2007)
Immunity
, vol.27
, pp. 786-800
-
-
Hill, J.A.1
-
24
-
-
58149214356
-
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
-
Wei, G. et al. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 30, 155-167 (2009).
-
(2009)
Immunity
, vol.30
, pp. 155-167
-
-
Wei, G.1
-
25
-
-
33947600584
-
Regulatory T cell development in the absence of functional Foxp3
-
Lin, W. et al. Regulatory T cell development in the absence of functional Foxp3. Nat. Immunol. 8, 359-368 (2007).
-
(2007)
Nat. Immunol.
, vol.8
, pp. 359-368
-
-
Lin, W.1
-
26
-
-
34548724573
-
Transcriptional analysis of clonal deletion in vivo
-
Baldwin, T.A. & Hogquist, K.A. Transcriptional analysis of clonal deletion in vivo. J. Immunol. 179, 837-844 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 837-844
-
-
Baldwin, T.A.1
Hogquist, K.A.2
-
27
-
-
84857989935
-
Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion
-
Fassett, M.S., Jiang, W., D'Alise, A.M., Mathis, D. & Benoist, C. Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion. Proc. Natl. Acad. Sci. USA 109, 3891-3896 (2012).
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 3891-3896
-
-
Fassett, M.S.1
Jiang, W.2
D'alise, A.M.3
Mathis, D.4
Benoist, C.5
-
28
-
-
0029914914
-
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
-
Zhou, T. et al. Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells. J. Exp. Med. 183, 1879-1892 (1996).
-
(1996)
J. Exp. Med.
, vol.183
, pp. 1879-1892
-
-
Zhou, T.1
-
29
-
-
0028807837
-
A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection
-
Calnan, B.J., Szychowski, S., Chan, F.K., Cado, D. & Winoto, A. A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity 3, 273-282 (1995).
-
(1995)
Immunity
, vol.3
, pp. 273-282
-
-
Calnan, B.J.1
Szychowski, S.2
Chan, F.K.3
Cado, D.4
Winoto, A.5
-
30
-
-
0025317650
-
The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome
-
Lyon, M.F., Peters, J., Glenister, P.H., Ball, S. & Wright, E. The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome. Proc. Natl. Acad. Sci. USA 87, 2433-2437 (1990).
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 2433-2437
-
-
Lyon, M.F.1
Peters, J.2
Glenister, P.H.3
Ball, S.4
Wright, E.5
-
31
-
-
0026178213
-
X-linked lymphoreticular disease in the scurfy (sf) mutant mouse
-
Godfrey, V.L., Wilkinson, J.E. & Russell, L.B. X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am. J. Pathol. 138, 1379-1387 (1991).
-
(1991)
Am. J. Pathol.
, vol.138
, pp. 1379-1387
-
-
Godfrey, V.L.1
Wilkinson, J.E.2
Russell, L.B.3
-
32
-
-
70049098536
-
Regulatory T cells reinforce intestinal homeostasis
-
Barnes, M.J. & Powrie, F. Regulatory T cells reinforce intestinal homeostasis. Immunity 31, 401-411 (2009).
-
(2009)
Immunity
, vol.31
, pp. 401-411
-
-
Barnes, M.J.1
Powrie, F.2
-
33
-
-
0031058466
-
Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo
-
Brocker, T., Riedinger, M. & Karjalainen, K. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J. Exp. Med. 185, 541-550 (1997).
-
(1997)
J. Exp. Med.
, vol.185
, pp. 541-550
-
-
Brocker, T.1
Riedinger, M.2
Karjalainen, K.3
-
34
-
-
0030775139
-
Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules
-
Kirberg, J., Berns, A. & von Boehmer, H. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. J. Exp. Med. 186, 1269-1275 (1997).
-
(1997)
J. Exp. Med.
, vol.186
, pp. 1269-1275
-
-
Kirberg, J.1
Berns, A.2
Von Boehmer, H.3
-
35
-
-
34250019385
-
Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia
-
Mullican, S.E. et al. Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia. Nat. Med. 13, 730-735 (2007).
-
(2007)
Nat. Med.
, vol.13
, pp. 730-735
-
-
Mullican, S.E.1
-
36
-
-
37849009964
-
A two-step process for thymic regulatory T cell development
-
Lio, C.W. & Hsieh, C.S. A two-step process for thymic regulatory T cell development. Immunity 28, 100-111 (2008).
-
(2008)
Immunity
, vol.28
, pp. 100-111
-
-
Lio, C.W.1
Hsieh, C.S.2
-
37
-
-
58149376454
-
Dendritic cells in the thymus contribute to T-regulatory cell induction
-
Proietto, A.I. et al. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc. Natl. Acad. Sci. USA 105, 19869-19874 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 19869-19874
-
-
Proietto, A.I.1
-
38
-
-
78649880379
-
The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells
-
Sirin, O., Lukov, G.L., Mao, R., Conneely, O.M. & Goodell, M.A. The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells. Nat. Cell Biol. 12, 1213-1219 (2010).
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 1213-1219
-
-
Sirin, O.1
Lukov, G.L.2
Mao, R.3
Conneely, O.M.4
Goodell, M.A.5
-
39
-
-
0035980060
-
Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis
-
Masuyama, N. et al. Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis. J. Biol. Chem. 276, 32799-32805 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 32799-32805
-
-
Masuyama, N.1
-
40
-
-
0030069074
-
Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes
-
Kanangat, S. et al. Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes. Eur. J. Immunol. 26, 161-165 (1996).
-
(1996)
Eur. J. Immunol.
, vol.26
, pp. 161-165
-
-
Kanangat, S.1
-
41
-
-
77954166341
-
Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice
-
Lahl, K. et al. Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice. J. Immunol. 183, 5662-5672 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 5662-5672
-
-
Lahl, K.1
-
42
-
-
77950261975
-
How are TH2-type immune responses initiated and amplified? Nat
-
Paul, W.E. & Zhu, J. How are TH2-type immune responses initiated and amplified? Nat. Rev. Immunol. 10, 225-235 (2010).
-
(2010)
Rev. Immunol.
, vol.10
, pp. 225-235
-
-
Paul, W.E.1
Zhu, J.2
-
43
-
-
0032723235
-
Nur77 transcription activity correlates with its apoptotic function in vivo
-
Kuang, A.A., Cado, D. & Winoto, A. Nur77 transcription activity correlates with its apoptotic function in vivo. Eur. J. Immunol. 29, 3722-3728 (1999).
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 3722-3728
-
-
Kuang, A.A.1
Cado, D.2
Winoto, A.3
-
44
-
-
31344480633
-
LAT-mediated signaling in CD4+CD25+ regulatory T cell development
-
Koonpaew, S., Shen, S., Flowers, L. & Zhang, W. LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J. Exp. Med. 203, 119-129 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 119-129
-
-
Koonpaew, S.1
Shen, S.2
Flowers, L.3
Zhang, W.4
-
45
-
-
33746111852
-
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
-
Wan, Y.Y., Chi, H., Xie, M., Schneider, M.D. & Flavell, R.A. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat. Immunol. 7, 851-858 (2006).
-
(2006)
Nat. Immunol.
, vol.7
, pp. 851-858
-
-
Wan, Y.Y.1
Chi, H.2
Xie, M.3
Schneider, M.D.4
Flavell, R.A.5
-
46
-
-
60549113390
-
Differential requirement for CARMA1 in agonist-selected T-cell development
-
Medoff, B.D. et al. Differential requirement for CARMA1 in agonist-selected T-cell development. Eur. J. Immunol. 39, 78-84 (2009).
-
(2009)
Eur. J. Immunol.
, vol.39
, pp. 78-84
-
-
Medoff, B.D.1
-
47
-
-
1842480966
-
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation
-
Schmidt-Supprian, M. et al. Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation. Proc. Natl. Acad. Sci. USA 101, 4566-4571 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 4566-4571
-
-
Schmidt-Supprian, M.1
-
48
-
-
0141678951
-
Mature T cells depend on signaling through the IKK complex
-
Schmidt-Supprian, M. et al. Mature T cells depend on signaling through the IKK complex. Immunity 19, 377-389 (2003).
-
(2003)
Immunity
, vol.19
, pp. 377-389
-
-
Schmidt-Supprian, M.1
-
49
-
-
54349086262
-
Differential requirement of PKC-θ in the development and function of natural regulatory T cells
-
Gupta, S. et al. Differential requirement of PKC-θ in the development and function of natural regulatory T cells. Mol. Immunol. 46, 213-224 (2008).
-
(2008)
Mol. Immunol.
, vol.46
, pp. 213-224
-
-
Gupta, S.1
-
50
-
-
72449191782
-
Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons
-
Kadkhodaei, B. et al. Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons. J. Neurosci. 29, 15923-15932 (2009).
-
(2009)
J. Neurosci
, vol.29
, pp. 15923-15932
-
-
Kadkhodaei, B.1
|