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Volumn 14, Issue 3, 2013, Pages 230-237

Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR RECEPTOR NR4A3; NUCLEAR RECEPTOR NUR77; TRANSCRIPTION FACTOR FOXP3;

EID: 85027932757     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2520     Document Type: Article
Times cited : (245)

References (50)
  • 2
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot, J.D., Gavin, M.A. & Rudensky, A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4, 330-336 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 3
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori, S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061 (2003).
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 4
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri, R., Cox, T., Yasayko, S.A. & Ramsdell, F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4, 337-342 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 5
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett, C.L. et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27, 20-21 (2001).
    • (2001) Nat. Genet. , vol.27 , pp. 20-21
    • Bennett, C.L.1
  • 6
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
    • Sakaguchi, S. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22, 531-562 (2004).
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 7
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmmunity
    • Shevach, E.M. Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 18, 423-449 (2000).
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 423-449
    • Shevach, E.M.1
  • 8
    • 71749094333 scopus 로고    scopus 로고
    • Development of Foxp3+ regulatory t cells is driven by the c-Rel enhanceosome
    • Ruan, Q. et al. Development of Foxp3+ regulatory t cells is driven by the c-Rel enhanceosome. Immunity 31, 932-940 (2009).
    • (2009) Immunity , vol.31 , pp. 932-940
    • Ruan, Q.1
  • 9
    • 71749088574 scopus 로고    scopus 로고
    • Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor
    • Long, M., Park, S.G., Strickland, I., Hayden, M.S. & Ghosh, S. Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity 31, 921-931 (2009).
    • (2009) Immunity , vol.31 , pp. 921-931
    • Long, M.1    Park, S.G.2    Strickland, I.3    Hayden, M.S.4    Ghosh, S.5
  • 10
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Zheng, Y. et al. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463, 808-812 (2010).
    • (2010) Nature , vol.463 , pp. 808-812
    • Zheng, Y.1
  • 11
    • 38349095578 scopus 로고    scopus 로고
    • Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
    • Tone, Y. et al. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat. Immunol. 9, 194-202 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 194-202
    • Tone, Y.1
  • 12
    • 33747801470 scopus 로고    scopus 로고
    • IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo
    • Zorn, E. et al. IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 108, 1571-1579 (2006).
    • (2006) Blood , vol.108 , pp. 1571-1579
    • Zorn, E.1
  • 13
    • 70349741295 scopus 로고    scopus 로고
    • Indispensable role of the Runx1-Cbfβ transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells
    • Kitoh, A. et al. Indispensable role of the Runx1-Cbfβ transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells. Immunity 31, 609-620 (2009).
    • (2009) Immunity , vol.31 , pp. 609-620
    • Kitoh, A.1
  • 14
    • 70350451993 scopus 로고    scopus 로고
    • Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells
    • Rudra, D. et al. Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat. Immunol. 10, 1170-1177 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 1170-1177
    • Rudra, D.1
  • 15
    • 70449706325 scopus 로고    scopus 로고
    • Runx proteins regulate Foxp3 expression
    • Bruno, L. et al. Runx proteins regulate Foxp3 expression. J. Exp. Med. 206, 2329-2337 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 2329-2337
    • Bruno, L.1
  • 16
    • 77953811224 scopus 로고    scopus 로고
    • Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
    • Ouyang, W. et al. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat. Immunol. 11, 618-627 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 618-627
    • Ouyang, W.1
  • 17
    • 77957724587 scopus 로고    scopus 로고
    • The Ets-1 transcription factor controls the development and function of natural regulatory T cells
    • Mouly, E. et al. The Ets-1 transcription factor controls the development and function of natural regulatory T cells. J. Exp. Med. 207, 2113-2125 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 2113-2125
    • Mouly, E.1
  • 18
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3
    • Chen, W. et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1
  • 19
    • 0038526314 scopus 로고    scopus 로고
    • Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors
    • Wang, Z. et al. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature 423, 555-560 (2003).
    • (2003) Nature , vol.423 , pp. 555-560
    • Wang, Z.1
  • 20
    • 0030977267 scopus 로고    scopus 로고
    • Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis
    • Cheng, L.E., Chan, F.K., Cado, D. & Winoto, A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 16, 1865-1875 (1997).
    • (1997) EMBO J. , vol.16 , pp. 1865-1875
    • Cheng, L.E.1    Chan, F.K.2    Cado, D.3    Winoto, A.4
  • 21
    • 79953769170 scopus 로고    scopus 로고
    • The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells
    • Sekiya, T. et al. The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells. Nat. Commun. 2, 269 (2011).
    • (2011) Nat. Commun. , vol.2 , pp. 269
    • Sekiya, T.1
  • 22
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran, A.E. et al. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 208, 1279-1289 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1279-1289
    • Moran, A.E.1
  • 23
    • 36048978911 scopus 로고    scopus 로고
    • Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
    • Hill, J.A. et al. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 27, 786-800 (2007).
    • (2007) Immunity , vol.27 , pp. 786-800
    • Hill, J.A.1
  • 24
    • 58149214356 scopus 로고    scopus 로고
    • Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
    • Wei, G. et al. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 30, 155-167 (2009).
    • (2009) Immunity , vol.30 , pp. 155-167
    • Wei, G.1
  • 25
    • 33947600584 scopus 로고    scopus 로고
    • Regulatory T cell development in the absence of functional Foxp3
    • Lin, W. et al. Regulatory T cell development in the absence of functional Foxp3. Nat. Immunol. 8, 359-368 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 359-368
    • Lin, W.1
  • 26
    • 34548724573 scopus 로고    scopus 로고
    • Transcriptional analysis of clonal deletion in vivo
    • Baldwin, T.A. & Hogquist, K.A. Transcriptional analysis of clonal deletion in vivo. J. Immunol. 179, 837-844 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 837-844
    • Baldwin, T.A.1    Hogquist, K.A.2
  • 27
    • 84857989935 scopus 로고    scopus 로고
    • Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion
    • Fassett, M.S., Jiang, W., D'Alise, A.M., Mathis, D. & Benoist, C. Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion. Proc. Natl. Acad. Sci. USA 109, 3891-3896 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 3891-3896
    • Fassett, M.S.1    Jiang, W.2    D'alise, A.M.3    Mathis, D.4    Benoist, C.5
  • 28
    • 0029914914 scopus 로고    scopus 로고
    • Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
    • Zhou, T. et al. Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells. J. Exp. Med. 183, 1879-1892 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 1879-1892
    • Zhou, T.1
  • 29
    • 0028807837 scopus 로고
    • A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection
    • Calnan, B.J., Szychowski, S., Chan, F.K., Cado, D. & Winoto, A. A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity 3, 273-282 (1995).
    • (1995) Immunity , vol.3 , pp. 273-282
    • Calnan, B.J.1    Szychowski, S.2    Chan, F.K.3    Cado, D.4    Winoto, A.5
  • 30
    • 0025317650 scopus 로고
    • The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome
    • Lyon, M.F., Peters, J., Glenister, P.H., Ball, S. & Wright, E. The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome. Proc. Natl. Acad. Sci. USA 87, 2433-2437 (1990).
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 2433-2437
    • Lyon, M.F.1    Peters, J.2    Glenister, P.H.3    Ball, S.4    Wright, E.5
  • 31
    • 0026178213 scopus 로고
    • X-linked lymphoreticular disease in the scurfy (sf) mutant mouse
    • Godfrey, V.L., Wilkinson, J.E. & Russell, L.B. X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am. J. Pathol. 138, 1379-1387 (1991).
    • (1991) Am. J. Pathol. , vol.138 , pp. 1379-1387
    • Godfrey, V.L.1    Wilkinson, J.E.2    Russell, L.B.3
  • 32
    • 70049098536 scopus 로고    scopus 로고
    • Regulatory T cells reinforce intestinal homeostasis
    • Barnes, M.J. & Powrie, F. Regulatory T cells reinforce intestinal homeostasis. Immunity 31, 401-411 (2009).
    • (2009) Immunity , vol.31 , pp. 401-411
    • Barnes, M.J.1    Powrie, F.2
  • 33
    • 0031058466 scopus 로고    scopus 로고
    • Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo
    • Brocker, T., Riedinger, M. & Karjalainen, K. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J. Exp. Med. 185, 541-550 (1997).
    • (1997) J. Exp. Med. , vol.185 , pp. 541-550
    • Brocker, T.1    Riedinger, M.2    Karjalainen, K.3
  • 34
    • 0030775139 scopus 로고    scopus 로고
    • Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules
    • Kirberg, J., Berns, A. & von Boehmer, H. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. J. Exp. Med. 186, 1269-1275 (1997).
    • (1997) J. Exp. Med. , vol.186 , pp. 1269-1275
    • Kirberg, J.1    Berns, A.2    Von Boehmer, H.3
  • 35
    • 34250019385 scopus 로고    scopus 로고
    • Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia
    • Mullican, S.E. et al. Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia. Nat. Med. 13, 730-735 (2007).
    • (2007) Nat. Med. , vol.13 , pp. 730-735
    • Mullican, S.E.1
  • 36
    • 37849009964 scopus 로고    scopus 로고
    • A two-step process for thymic regulatory T cell development
    • Lio, C.W. & Hsieh, C.S. A two-step process for thymic regulatory T cell development. Immunity 28, 100-111 (2008).
    • (2008) Immunity , vol.28 , pp. 100-111
    • Lio, C.W.1    Hsieh, C.S.2
  • 37
    • 58149376454 scopus 로고    scopus 로고
    • Dendritic cells in the thymus contribute to T-regulatory cell induction
    • Proietto, A.I. et al. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc. Natl. Acad. Sci. USA 105, 19869-19874 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 19869-19874
    • Proietto, A.I.1
  • 38
    • 78649880379 scopus 로고    scopus 로고
    • The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells
    • Sirin, O., Lukov, G.L., Mao, R., Conneely, O.M. & Goodell, M.A. The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells. Nat. Cell Biol. 12, 1213-1219 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , pp. 1213-1219
    • Sirin, O.1    Lukov, G.L.2    Mao, R.3    Conneely, O.M.4    Goodell, M.A.5
  • 39
    • 0035980060 scopus 로고    scopus 로고
    • Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis
    • Masuyama, N. et al. Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis. J. Biol. Chem. 276, 32799-32805 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 32799-32805
    • Masuyama, N.1
  • 40
    • 0030069074 scopus 로고    scopus 로고
    • Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes
    • Kanangat, S. et al. Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes. Eur. J. Immunol. 26, 161-165 (1996).
    • (1996) Eur. J. Immunol. , vol.26 , pp. 161-165
    • Kanangat, S.1
  • 41
    • 77954166341 scopus 로고    scopus 로고
    • Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice
    • Lahl, K. et al. Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice. J. Immunol. 183, 5662-5672 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 5662-5672
    • Lahl, K.1
  • 42
    • 77950261975 scopus 로고    scopus 로고
    • How are TH2-type immune responses initiated and amplified? Nat
    • Paul, W.E. & Zhu, J. How are TH2-type immune responses initiated and amplified? Nat. Rev. Immunol. 10, 225-235 (2010).
    • (2010) Rev. Immunol. , vol.10 , pp. 225-235
    • Paul, W.E.1    Zhu, J.2
  • 43
    • 0032723235 scopus 로고    scopus 로고
    • Nur77 transcription activity correlates with its apoptotic function in vivo
    • Kuang, A.A., Cado, D. & Winoto, A. Nur77 transcription activity correlates with its apoptotic function in vivo. Eur. J. Immunol. 29, 3722-3728 (1999).
    • (1999) Eur. J. Immunol. , vol.29 , pp. 3722-3728
    • Kuang, A.A.1    Cado, D.2    Winoto, A.3
  • 44
    • 31344480633 scopus 로고    scopus 로고
    • LAT-mediated signaling in CD4+CD25+ regulatory T cell development
    • Koonpaew, S., Shen, S., Flowers, L. & Zhang, W. LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J. Exp. Med. 203, 119-129 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 119-129
    • Koonpaew, S.1    Shen, S.2    Flowers, L.3    Zhang, W.4
  • 45
    • 33746111852 scopus 로고    scopus 로고
    • The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
    • Wan, Y.Y., Chi, H., Xie, M., Schneider, M.D. & Flavell, R.A. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat. Immunol. 7, 851-858 (2006).
    • (2006) Nat. Immunol. , vol.7 , pp. 851-858
    • Wan, Y.Y.1    Chi, H.2    Xie, M.3    Schneider, M.D.4    Flavell, R.A.5
  • 46
    • 60549113390 scopus 로고    scopus 로고
    • Differential requirement for CARMA1 in agonist-selected T-cell development
    • Medoff, B.D. et al. Differential requirement for CARMA1 in agonist-selected T-cell development. Eur. J. Immunol. 39, 78-84 (2009).
    • (2009) Eur. J. Immunol. , vol.39 , pp. 78-84
    • Medoff, B.D.1
  • 47
    • 1842480966 scopus 로고    scopus 로고
    • Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation
    • Schmidt-Supprian, M. et al. Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation. Proc. Natl. Acad. Sci. USA 101, 4566-4571 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4566-4571
    • Schmidt-Supprian, M.1
  • 48
    • 0141678951 scopus 로고    scopus 로고
    • Mature T cells depend on signaling through the IKK complex
    • Schmidt-Supprian, M. et al. Mature T cells depend on signaling through the IKK complex. Immunity 19, 377-389 (2003).
    • (2003) Immunity , vol.19 , pp. 377-389
    • Schmidt-Supprian, M.1
  • 49
    • 54349086262 scopus 로고    scopus 로고
    • Differential requirement of PKC-θ in the development and function of natural regulatory T cells
    • Gupta, S. et al. Differential requirement of PKC-θ in the development and function of natural regulatory T cells. Mol. Immunol. 46, 213-224 (2008).
    • (2008) Mol. Immunol. , vol.46 , pp. 213-224
    • Gupta, S.1
  • 50
    • 72449191782 scopus 로고    scopus 로고
    • Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons
    • Kadkhodaei, B. et al. Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons. J. Neurosci. 29, 15923-15932 (2009).
    • (2009) J. Neurosci , vol.29 , pp. 15923-15932
    • Kadkhodaei, B.1


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