Foxp3 occupancy and regulation of key target genes during T-cell stimulation

Nature

Volumn 445, Issue 7130, 2007, Pages 931-935

  Marson, Alexander ^a,b   Kretschmer, Karsten ^e,f   Frampton, Garrett M ^a,b   Jacobsen, Elizabeth S ^a   Polansky, Julia K ^e   MacIsaac, Kenzie D ^c   Levine, Stuart S ^a   Fraenkel, Ernest ^b,d   Von Boehmer, Harald ^e,f   Young, Richard A ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c USA   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

CYTOGENETICS; DNA; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNE SYSTEM; MUTATION; PHENOTYPE; PROTEIN;

ARTICLE; AUTOIMMUNE DISEASE; CELL STIMULATION; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; GENE TARGETING; HUMAN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TRANSCRIPTION INITIATION;

EID: 33847242598     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05478     Document Type: Article

References (30)

1. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155, 1151-1164 (1995).
2. Baecher-Allan, C. & Hafler, D. A. Human regulatory T cells and their role in autoimmune disease. Immunol. Rev. 212, 203-216 (2006).
3. + suppressor T cells: more questions than answers. Nature Rev. Immunol. 2, 389-400 (2002).
4. von Boehmer, H. Mechanisms of suppression by suppressor T cells. Nature Immunol. 6, 338-344 (2005).
5. Hori, S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061 (2003).
6. + regulatory T cells. Nature Immunol. 4, 330-336 (2003).
7. + T regulatory cells. Nature Immunol. 4, 337-342 (2003).
8. Fontenot, J. D. et al. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22, 329-341 (2005).
9. Brunkow, M. E. et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nature Genet. 27, 68-73 (2001).
10. Bennett, C. L. et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nature Genet. 27, 20-21 (2001).
11. Wildin, R. S. et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nature Genet. 27, 18-20 (2001).
12. Wu, Y. et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126, 375-387 (2006).
13. Schubert, L. A., Jeffery, E., Zhang, Y., Ramsdell, F. & Ziegler, S. F. Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J. Biol. Chem. 276, 37672-37679 (2001).
14. Boyer, L. A. et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441, 349-353 (2006).
15. Chen, C., Rowell, E. A., Thomas, R. M., Hancock, W. W. & Wells, A. D. Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation. J. Biol. Chem. 281, 36828-36834 (2006).
16. Kanehisa, M. & Goto, S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27-30 (2000).
17. Cobb, B. S. et al. A role for Dicer in immune regulation. J. Exp. Med. 203, 2519-2527 (2006).
18. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16, 311-323 (2002).
19. Bruder, D. et al. Neuropilin-1: a surface marker of regulatory T cells. Eur. J. Immunol. 34, 623-630 (2004).
20. + regulatory T cells. J. Exp. Med. 194, 847-853 (2001).
21. Harbison, C. T. et al. Transcriptional regulatory code of a eukaryotic genome. Nature 431, 99-104 (2004).
22. Klein, L., Khazaie, K. & von Boehmer, H. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc. Natl Acad. Sci. USA 100, 8886-8892 (2003).
23. + regulatory T cells induced by an agonist self-peptide. Nature Immunol. 2, 301-306 (2001).
24. Kretschmer, K. et al. Inducing and expanding regulatory T cell populations by foreign antigen. Nature Immunol. 6, 1219-1227 (2005).
25. Stanford, W. L. et al. Altered proliferative response by T lymphocytes of Ly-6A (Sca-1) null mice. J. Exp. Med. 186, 705-717 (1997).
26. Myers, L. M. & Vella, A. T. Interfacing T-cell effector and regulatory function through CD137 (4-1BB) co-stimulation. Trends Immunol. 26, 440-446 (2005).
27. Bottini, N. et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nature Genet. 36, 337-338 (2004).
28. Wu, J. et al. Identification of substrates of human protein-tyrosine phosphatase PTPN22. J. Biol. Chem. 281, 11002-11010 (2006).
29. Bottini, N., Vang, T., Cucca, F. & Mustelin, T. Role of PTPN22 in type 1 diabetes and other autoimmune diseases. Semin. Immunol. 18, 207-213 (2006).
30. Vang, T. et al. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nature Genet. 37, 1317-1319 (2005).