Functional impairment of CD8+ T cells by regulatory T cells during persistent retroviral infection

Immunity

Volumn 20, Issue 3, 2004, Pages 293-303

  Dittmer, Ulf ^b   He, Hong ^a   Messer, Ronald J ^a   Schimmer, Simone ^b   Olbrich, Anke R M ^b   Ohlen, Claes ^c   Greenberg, Philip D ^c   Stromnes, Ingunn M ^a,c   Iwashiro, Michihiro ^a,e   Sakaguchi, Shimon ^d   Evans, Leonard H ^a   Peterson, Karin E ^a   Yang, Guojun ^a   Hasenkrug, Kim J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c UNIVERSITY OF WASHINGTON   (United States)

^d KYOTO UNIVERSITY   (Japan)

^e Tango Furusato Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR ANTIBODY; RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; FEMALE; FRIEND LEUKEMIA VIRUS; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; RETROVIRUS INFECTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VIRUS LOAD;

ACUTE DISEASE; ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; EPITOPES, T-LYMPHOCYTE; FRIEND MURINE LEUKEMIA VIRUS; GENE PRODUCTS, GAG; INTERFERON TYPE II; MICE; MICE, INBRED C57BL; MUTATION; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; RETROVIRIDAE INFECTIONS; TUMOR VIRUS INFECTIONS; VIRUS LATENCY;

EID: 12144287345     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(04)00054-8     Document Type: Article

References (52)

1. Aandahl E.M., Michaelsson J., Moretto W.J., Hecht F.M., Nixon D.F. Human CD4+CD25+ regulatory T cells control T cell responses to HIV and CMV Antigens. J. Virol. 78:2004;2454-2459.
2. Andersson J., Kinloch S., Sonnerborg A., Nilsson J., Fehniger T.E., Spetz A.L., Behbahani H., Goh L.E., McDade H., Gazzard B.et al. Low levels of perforin expression in CD8+ T lymphocyte granules in lymphoid tissue during acute human immunodeficiency virus type 1 infection. J. Infect. Dis. 185:2002;1355-1358.
3. Appay V., Nixon D.F., Donahoe S.M., Gillespie G.M., Dong T., King A., Ogg G.S., Spiegel H.M., Conlon C., Spina C.A.et al. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med. 192:2000;63-75.
4. Belkaid Y., Hoffmann K.F., Mendez S., Kamhawi S., Udey M.C., Wynn T.A., Sacks D.L. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J. Exp. Med. 194:2001;1497-1506.
5. Belkaid Y., Piccirillo C.A., Mendez S., Shevach E.M., Sacks D.L. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature. 420:2002;502-507.
6. Bluestone J.A., Abbas A.K. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3:2003;253-257.
7. Bynoe M.S., Evans J.T., Viret C., Janeway C.A. Jr. Epicutaneous immunization with autoantigenic peptides induces T suppressor cells that prevent experimental allergic encephalomyelitis. Immunity. 19:2003;317-328.
8. Chen W., Qin H., Chesebro B., Cheever M.A. Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors. J. Virol. 70:1996;7773-7782.
9. Dittmer U., Brooks D.M., Hasenkrug K.J. Characterization of a live-attenuated retroviral vaccine demonstrates protection via immune mechanisms. J. Virol. 72:1998;6554-6558.
10. Dittmer U., Brooks D.M., Hasenkrug K.J. Requirement for multiple lymphocyte subsets in protection against retroviral infection by a live attenuated vaccine. Nat. Med. 5:1999;189-193.
11. Dittmer U., Race B., Peterson K.E., Stromnes I.M., Messer R.J., Hasenkrug K.J. Essential roles for CD8+ T cells and gamma interferon in protection of mice against retrovirus-induced immunosuppression. J. Virol. 76:2002;450-454.
12. Gandhi R.T., Walker B.D. Immunologic control of HIV-1. Annu. Rev. Med. 53:2002;149-172.
13. Geertsma M.F., van Wengen-Stevenhagen A., van Dam E.M., Risberg K., Kroon F.P., Groeneveld P.H., Nibbering P.H. Decreased expression of zeta molecules by T lymphocytes is correlated with disease progression in human immunodeficiency virus-infected persons. J. Infect. Dis. 180:1999;649-658.
14. Gruener N.H., Lechner F., Jung M.C., Diepolder H., Gerlach T., Lauer G., Walker B., Sullivan J., Phillips R., Pape G.R., Klenerman P. Sustained dysfunction of antiviral CD8+ T lymphocytes after infection with hepatitis C virus. J. Virol. 75:2001;5550-5558.
15. Hasenkrug K.J. Lymphocyte deficiencies increase susceptibility to Friend virus-induced erythroleukemia in Fv-2 genetically resistant mice. J. Virol. 73:1999;6468-6473.
16. Hasenkrug K.J., Brooks D.M., Chesebro B. Passive immunotherapy for retroviral disease. influence of major histocompatibility complex type and T-cell responsiveness Proc. Natl. Acad. Sci. USA. 92:1995;10492-10495.
17. Hasenkrug K.J., Brooks D.M., Dittmer U. Critical role for CD4+ T cells in controlling retrovirus replication and spread in persistently infected mice. J. Virol. 72:1998;6559-6564.
18. Hughes J.F., Coffin J.M. Evidence for genomic rearrangements mediated by human endogenous retroviruses during primate evolution. Nat. Genet. 29:2001;487-489.
19. International Human Genome Sequencing Consortium Initial sequencing and analysis of the human genome. Nature. 409:2001;860-921.
20. Iwashiro M., Messer R.J., Peterson K.E., Stromnes I.M., Sugie T., Hasenkrug K.J. Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection. Proc. Natl. Acad. Sci. USA. 98:2001;9226-9230. a.
21. Iwashiro M., Peterson K., Messer R.J., Stromnes I.M., Hasenkrug K.J. CD4(+) T cells and gamma interferon in the long-term control of persistent friend retrovirus infection. J. Virol. 75:2001;52-60. b.
22. Johnson W.E., Desrosiers R.C. Viral persistance. HIV's strategies of immune system evasion Annu. Rev. Med. 53:2002;499-518.
23. Kim J.D., Choi B.K., Bae J.S., Lee U.H., Han I.S., Lee H.W., Youn B.S., Vinay D.S., Kwon B.S. Cloning and characterization of GITR ligand. Genes Immun. 4:2003;564-569.
24. Lieberman J., Shankar P., Manjunath N., Andersson J. Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection. Blood. 98:2001;1667-1677.
25. Lilly F., Steeves R.A. B-tropic Friend virus. a host-range pseudotype of spleen focus-forming virus (SFFV) Virology. 55:1973;363-370.
26. Lucas M., Karrer U., Lucas A., Klenerman P. Viral escape mechanisms - escapology taught by viruses. Int. J. Exp. Pathol. 82:2001;269-286.
27. MacDonald A.J., Duffy M., Brady M.T., McKiernan S., Hall W., Hegarty J., Curry M., Mills K.H. CD4 T helper type 1 and regulatory T cells induced against the same epitopes on the core protein in hepatitis C virus-infected persons. J. Infect. Dis. 185:2002;720-727.
28. McGuirk P., Mills K.H. Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases. Trends Immunol. 23:2002;450-455.
29. McGuirk P., McCann C., Mills K.H. Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells. a novel strategy for evasion of protective T helper type 1 tesponses by Bordetella pertussis J. Exp. Med. 195:2002;221-231.
30. Mellors J.W., Kingsley L.A., Rinaldo C.R. Jr., Todd J.A., Hoo B.S., Kokka R.P., Gupta P. Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann. Intern. Med. 122:1995;573-579.
31. Mellors J.W., Rinaldo C.R. Jr., Gupta P., White R.M., Todd J.A., Kingsley L.A. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science. 272:1996;1167-1170.
32. Migueles S.A., Laborico A.C., Shupert W.L., Sabbaghian M.S., Rabin R., Hallahan C.W., Van Baarle D., Kostense S., Miedema F., McLaughlin M.et al. HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat. Immunol. 3:2002;1061-1068.
33. Moskophidis D., Lechner F., Pircher H., Zinkernagel R.M. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature. 362:1993;758-761.
34. Ohlen C., Kalos M., Cheng L.E., Shur A.C., Hong D.J., Carson B.D., Kokot N.C., Lerner C.G., Sather B.D., Huseby E.S., Greenberg P.D. CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function. J. Exp. Med. 195:2002;1407-1418.
35. Oldstone M.B. How viruses escape from cytotoxic T lymphocytes. molecular parameters and players Virology. 234:1997;179-185.
36. Onami T.M., Harrington L.E., Williams M.A., Galvan M., Larsen C.P., Pearson T.C., Manjunath N., Baum L.G., Pearce B.D., Ahmed R. Dynamic regulation of T cell immunity by CD43. J. Immunol. 168:2002;6022-6031.
37. Ostrowski M.A., Gu J.X., Kovacs C., Freedman J., Luscher M.A., MacDonald K.S. Quantitative and qualitative assessment of human immunodeficiency virus type 1 (HIV-1)-specific CD4+ T cell immunity to gag in HIV-1-infected individuals with differential disease progression. reciprocal interferon-gamma and interleukin-10 responses J. Infect. Dis. 184:2001;1268-1278.
38. Rich R.F., Green W.R. Inhibition of antiviral CTL responses by virus-infected cells. line item veto (cells) revisited Virology. 272:2000;237-243.
39. Robertson M.N., Spangrude G.J., Hasenkrug K., Perry L., Nishio J., Wehrly K., Chesebro B. Role and specificity of T-cell subsets in spontaneous recovery from Friend virus-induced leukemia in mice. J. Virol. 66:1992;3271-3277.
40. Sakaguchi S. Regulatory T cells. mediating compromises between host and parasite Nat. Immunol. 4:2003;10-11.
41. Schepers K., Toebes M., Sotthewes G., Vyth-Dreese F.A., Dellemijn T.A., Melief C.J., Ossendorp F., Schumacher T.N. Differential kinetics of antigen-specific CD4+ and CD8+ T cell responses in the regression of retrovirus-induced sarcomas. J. Immunol. 169:2002;3191-3199.
42. Shimizu J., Yamazaki S., Takahashi T., Ishida Y., Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3:2002;135-142.
43. Stromnes I.M., Dittmer U., Schumacher T.N., Schepers K., Messer R.J., Evans L.H., Peterson K.E., Race B., Hasenkrug K.J. Temporal effects of gamma interferon deficiency on the course of Friend retrovirus infection in mice. J. Virol. 76:2002;2225-2232.
44. Suvas S., Kumaraguru U., Pack C.D., Lee S., Rouse B.T. CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses. J. Exp. Med. 198:2003;889-901.
45. Tone M., Tone Y., Adams E., Yates S.F., Frewin M.R., Cobbold S.P., Waldmann H. Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc. Natl. Acad. Sci. USA. 100:2003;15059-15064.
46. Trimble L.A., Lieberman J. Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 zeta, the signaling chain of the T-cell receptor complex. Blood. 91:1998;585-594.
47. Uraushihara K., Kanai T., Ko K., Totsuka T., Makita S., Iiyama R., Nakamura T., Watanabe M. Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells. J. Immunol. 171:2003;708-716.
48. Urbani S., Boni C., Missale G., Elia G., Cavallo C., Massari M., Raimondo G., Ferrari C. Virus-specific CD8+ lymphocytes share the same effector-memory phenotype but exhibit functional differences in acute hepatitis B and C. J. Virol. 76:2002;12423-12434.
49. Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A.et al. The sequence of the human genome. Science. 291:2001;1304-1351.
50. Vingerhoets J., Bisalinkumi E., Penne G., Colebunders R., Bosmans E., Kestens L., Vanham G. Altered receptor expression and decreased sensitivity of T-cells to the stimulatory cytokines IL-2, IL-7 and IL-12 in HIV infection. Immunol. Lett. 61:1998;53-61.
51. Wedemeyer H., He X.S., Nascimbeni M., Davis A.R., Greenberg H.B., Hoofnagle J.H., Liang T.J., Alter H., Rehermann B. Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection. J. Immunol. 169:2002;3447-3458.
52. Xu X.N., Screaton G.R., McMichael A.J. Virus infections. escape, resistance, and counterattack Immunity. 15:2001;867-870.