메뉴 건너뛰기




Volumn 30, Issue 5, 2009, Pages 626-635

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

Author keywords

[No Author keywords available]

Indexed keywords

FOOD ALLERGEN; INTERLEUKIN 2; RETINOIC ACID; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

EID: 65549123867     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2009.05.002     Document Type: Review
Times cited : (863)

References (117)
  • 1
    • 61449152973 scopus 로고    scopus 로고
    • Regulatory T cells and viral liver disease
    • Alatrakchi N., and Koziel M. Regulatory T cells and viral liver disease. J. Viral Hepat. 16 (2009) 223-229
    • (2009) J. Viral Hepat. , vol.16 , pp. 223-229
    • Alatrakchi, N.1    Koziel, M.2
  • 3
    • 2542420993 scopus 로고    scopus 로고
    • In vivo instruction of suppressor commitment in naive T cells
    • Apostolou I., and von Boehmer H. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199 (2004) 1401-1408
    • (2004) J. Exp. Med. , vol.199 , pp. 1401-1408
    • Apostolou, I.1    von Boehmer, H.2
  • 4
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou I., Sarukhan A., Klein L., and von Boehmer H. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3 (2002) 756-763
    • (2002) Nat. Immunol. , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    von Boehmer, H.4
  • 5
    • 42149145285 scopus 로고    scopus 로고
    • Ex vivo generated regulatory T cells modulate experimental autoimmune myasthenia gravis
    • Aricha R., Feferman T., Fuchs S., and Souroujon M.C. Ex vivo generated regulatory T cells modulate experimental autoimmune myasthenia gravis. J. Immunol. 180 (2008) 2132-2139
    • (2008) J. Immunol. , vol.180 , pp. 2132-2139
    • Aricha, R.1    Feferman, T.2    Fuchs, S.3    Souroujon, M.C.4
  • 7
    • 2442660296 scopus 로고    scopus 로고
    • Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy
    • Bashir M.E., Louie S., Shi H.N., and Nagler-Anderson C. Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy. J. Immunol. 172 (2004) 6978-6987
    • (2004) J. Immunol. , vol.172 , pp. 6978-6987
    • Bashir, M.E.1    Louie, S.2    Shi, H.N.3    Nagler-Anderson, C.4
  • 8
    • 0035920510 scopus 로고    scopus 로고
    • Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells
    • Bensinger S.J., Bandeira A., Jordan M.S., Caton A.J., and Laufer T.M. Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J. Exp. Med. 194 (2001) 427-438
    • (2001) J. Exp. Med. , vol.194 , pp. 427-438
    • Bensinger, S.J.1    Bandeira, A.2    Jordan, M.S.3    Caton, A.J.4    Laufer, T.M.5
  • 9
    • 34547769253 scopus 로고    scopus 로고
    • All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
    • Benson M.J., Pino-Lagos K., Rosemblatt M., and Noelle R.J. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J. Exp. Med. 204 (2007) 1765-1774
    • (2007) J. Exp. Med. , vol.204 , pp. 1765-1774
    • Benson, M.J.1    Pino-Lagos, K.2    Rosemblatt, M.3    Noelle, R.J.4
  • 10
    • 33845935950 scopus 로고    scopus 로고
    • IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells
    • Burchill M.A., Yang J., Vogtenhuber C., Blazar B.R., and Farrar M.A. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J. Immunol. 178 (2007) 280-290
    • (2007) J. Immunol. , vol.178 , pp. 280-290
    • Burchill, M.A.1    Yang, J.2    Vogtenhuber, C.3    Blazar, B.R.4    Farrar, M.A.5
  • 12
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W., Jin W., Hardegen N., Lei K.J., Li L., Marinos N., McGrady G., and Wahl S.M. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198 (2003) 1875-1886
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 13
    • 2442425262 scopus 로고    scopus 로고
    • Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants
    • Cobbold S.P., Castejon R., Adams E., Zelenika D., Graca L., Humm S., and Waldmann H. Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J. Immunol. 172 (2004) 6003-6010
    • (2004) J. Immunol. , vol.172 , pp. 6003-6010
    • Cobbold, S.P.1    Castejon, R.2    Adams, E.3    Zelenika, D.4    Graca, L.5    Humm, S.6    Waldmann, H.7
  • 14
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • Coombes J.L., Siddiqui K.R., Arancibia-Carcamo C.V., Hall J., Sun C.M., Belkaid Y., and Powrie F. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J. Exp. Med. 204 (2007) 1757-1764
    • (2007) J. Exp. Med. , vol.204 , pp. 1757-1764
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Carcamo, C.V.3    Hall, J.4    Sun, C.M.5    Belkaid, Y.6    Powrie, F.7
  • 15
    • 44749092510 scopus 로고    scopus 로고
    • Regulatory T cells and treatment of cancer
    • Curiel T.J. Regulatory T cells and treatment of cancer. Curr. Opin. Immunol. 20 (2008) 241-246
    • (2008) Curr. Opin. Immunol. , vol.20 , pp. 241-246
    • Curiel, T.J.1
  • 16
    • 10344220512 scopus 로고    scopus 로고
    • CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion
    • Curotto de Lafaille M.A., Lino A.C., Kutchukhidze N., and Lafaille J.J. CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion. J. Immunol. 173 (2004) 7259-7268
    • (2004) J. Immunol. , vol.173 , pp. 7259-7268
    • Curotto de Lafaille, M.A.1    Lino, A.C.2    Kutchukhidze, N.3    Lafaille, J.J.4
  • 17
    • 46749126890 scopus 로고    scopus 로고
    • Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation
    • Curotto de Lafaille M.A., Kutchukhidze N., Shen S., Ding Y., Yee H., and Lafaille J.J. Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation. Immunity 29 (2008) 114-126
    • (2008) Immunity , vol.29 , pp. 114-126
    • Curotto de Lafaille, M.A.1    Kutchukhidze, N.2    Shen, S.3    Ding, Y.4    Yee, H.5    Lafaille, J.J.6
  • 18
    • 27544446622 scopus 로고    scopus 로고
    • Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling
    • D'Cruz L.M., and Klein L. Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat. Immunol. 6 (2005) 1152-1159
    • (2005) Nat. Immunol. , vol.6 , pp. 1152-1159
    • D'Cruz, L.M.1    Klein, L.2
  • 19
    • 33947644716 scopus 로고    scopus 로고
    • Cutting edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells
    • Davidson T.S., DiPaolo R.J., Andersson J., and Shevach E.M. Cutting edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells. J. Immunol. 178 (2007) 4022-4026
    • (2007) J. Immunol. , vol.178 , pp. 4022-4026
    • Davidson, T.S.1    DiPaolo, R.J.2    Andersson, J.3    Shevach, E.M.4
  • 21
    • 44649144463 scopus 로고    scopus 로고
    • Autoantigen-specific TGFbeta-induced Foxp3+ regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells
    • DiPaolo R.J., Brinster C., Davidson T.S., Andersson J., Glass D., and Shevach E.M. Autoantigen-specific TGFbeta-induced Foxp3+ regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells. J. Immunol. 179 (2007) 4685-4693
    • (2007) J. Immunol. , vol.179 , pp. 4685-4693
    • DiPaolo, R.J.1    Brinster, C.2    Davidson, T.S.3    Andersson, J.4    Glass, D.5    Shevach, E.M.6
  • 22
    • 50849115190 scopus 로고    scopus 로고
    • T cells with regulatory activity in hepatitis C virus infection: What we know and what we don't
    • Dolganiuc A., and Szabo G. T cells with regulatory activity in hepatitis C virus infection: What we know and what we don't. J. Leukoc. Biol. 84 (2008) 614-622
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 614-622
    • Dolganiuc, A.1    Szabo, G.2
  • 23
    • 43249107955 scopus 로고    scopus 로고
    • Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection
    • Ebinuma H., Nakamoto N., Li Y., Price D.A., Gostick E., Levine B.L., Tobias J., Kwok W.W., and Chang K.M. Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection. J. Virol. 82 (2008) 5043-5053
    • (2008) J. Virol. , vol.82 , pp. 5043-5053
    • Ebinuma, H.1    Nakamoto, N.2    Li, Y.3    Price, D.A.4    Gostick, E.5    Levine, B.L.6    Tobias, J.7    Kwok, W.W.8    Chang, K.M.9
  • 24
    • 64849116608 scopus 로고    scopus 로고
    • Selective priming and expansion of antigen-specific Foxp3- CD4+ T cells during Listeria monocytogenes infection
    • Ertelt J.M., Rowe J.H., Johanns T.M., Lai J.C., McLachlan J.B., and Way S.S. Selective priming and expansion of antigen-specific Foxp3- CD4+ T cells during Listeria monocytogenes infection. J. Immunol. 182 (2009) 3032-3038
    • (2009) J. Immunol. , vol.182 , pp. 3032-3038
    • Ertelt, J.M.1    Rowe, J.H.2    Johanns, T.M.3    Lai, J.C.4    McLachlan, J.B.5    Way, S.S.6
  • 25
    • 15444363794 scopus 로고    scopus 로고
    • T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells
    • Fahlen L., Read S., Gorelik L., Hurst S.D., Coffman R.L., Flavell R.A., and Powrie F. T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J. Exp. Med. 201 (2005) 737-746
    • (2005) J. Exp. Med. , vol.201 , pp. 737-746
    • Fahlen, L.1    Read, S.2    Gorelik, L.3    Hurst, S.D.4    Coffman, R.L.5    Flavell, R.A.6    Powrie, F.7
  • 26
    • 2142645808 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
    • Fantini M.C., Becker C., Monteleone G., Pallone F., Galle P.R., and Neurath M.F. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 172 (2004) 5149-5153
    • (2004) J. Immunol. , vol.172 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3    Pallone, F.4    Galle, P.R.5    Neurath, M.F.6
  • 29
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot J.D., Gavin M.A., and Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4 (2003) 330-336
    • (2003) Nat. Immunol. , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 30
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot J.D., Rasmussen J.P., Gavin M.A., and Rudensky A.Y. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6 (2005) 1142-1151
    • (2005) Nat. Immunol. , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 33
    • 1642335813 scopus 로고    scopus 로고
    • Demonstration of strong enterobacterial reactivity of CD4+CD25- T cells from conventional and germ-free mice which is counter-regulated by CD4+CD25+ T cells
    • Gad M., Pedersen A.E., Kristensen N.N., and Claesson M.H. Demonstration of strong enterobacterial reactivity of CD4+CD25- T cells from conventional and germ-free mice which is counter-regulated by CD4+CD25+ T cells. Eur. J. Immunol. 34 (2004) 695-704
    • (2004) Eur. J. Immunol. , vol.34 , pp. 695-704
    • Gad, M.1    Pedersen, A.E.2    Kristensen, N.N.3    Claesson, M.H.4
  • 34
    • 0015172562 scopus 로고
    • Infectious immunological tolerance
    • Gershon R.K., and Kondo K. Infectious immunological tolerance. Immunology 21 (1971) 903-914
    • (1971) Immunology , vol.21 , pp. 903-914
    • Gershon, R.K.1    Kondo, K.2
  • 35
    • 0033785339 scopus 로고    scopus 로고
    • Identification of tgh-2, a filarial nematode homolog of Caenorhabditis elegans daf-7 and human transforming growth factor beta, expressed in microfilarial and adult stages of Brugia malayi
    • Gomez-Escobar N., Gregory W.F., and Maizels R.M. Identification of tgh-2, a filarial nematode homolog of Caenorhabditis elegans daf-7 and human transforming growth factor beta, expressed in microfilarial and adult stages of Brugia malayi. Infect. Immun. 68 (2000) 6402-6410
    • (2000) Infect. Immun. , vol.68 , pp. 6402-6410
    • Gomez-Escobar, N.1    Gregory, W.F.2    Maizels, R.M.3
  • 38
    • 36048978911 scopus 로고    scopus 로고
    • Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
    • Hill J.A., Feuerer M., Tash K., Haxhinasto S., Perez J., Melamed R., Mathis D., and Benoist C. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 27 (2007) 786-800
    • (2007) Immunity , vol.27 , pp. 786-800
    • Hill, J.A.1    Feuerer, M.2    Tash, K.3    Haxhinasto, S.4    Perez, J.5    Melamed, R.6    Mathis, D.7    Benoist, C.8
  • 40
    • 0036919854 scopus 로고    scopus 로고
    • Peripheral expansion of thymus-derived regulatory cells in anti-myelin basic protein T cell receptor transgenic mice
    • Hori S., Haury M., Lafaille J.J., Demengeot J., and Coutinho A. Peripheral expansion of thymus-derived regulatory cells in anti-myelin basic protein T cell receptor transgenic mice. Eur. J. Immunol. 32 (2002) 3729-3735
    • (2002) Eur. J. Immunol. , vol.32 , pp. 3729-3735
    • Hori, S.1    Haury, M.2    Lafaille, J.J.3    Demengeot, J.4    Coutinho, A.5
  • 41
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S., Nomura T., and Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299 (2003) 1057-1061
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 42
    • 49849094011 scopus 로고    scopus 로고
    • Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other
    • Horwitz D.A., Zheng S.G., and Gray J.D. Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other. Trends Immunol. 29 (2008) 429-435
    • (2008) Trends Immunol. , vol.29 , pp. 429-435
    • Horwitz, D.A.1    Zheng, S.G.2    Gray, J.D.3
  • 43
    • 4143066714 scopus 로고    scopus 로고
    • Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors
    • Hsieh C.S., Liang Y., Tyznik A.J., Self S.G., Liggitt D., and Rudensky A.Y. Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 21 (2004) 267-277
    • (2004) Immunity , vol.21 , pp. 267-277
    • Hsieh, C.S.1    Liang, Y.2    Tyznik, A.J.3    Self, S.G.4    Liggitt, D.5    Rudensky, A.Y.6
  • 44
    • 33645102841 scopus 로고    scopus 로고
    • An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
    • Hsieh C.S., Zheng Y., Liang Y., Fontenot J.D., and Rudensky A.Y. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 7 (2006) 401-410
    • (2006) Nat. Immunol. , vol.7 , pp. 401-410
    • Hsieh, C.S.1    Zheng, Y.2    Liang, Y.3    Fontenot, J.D.4    Rudensky, A.Y.5
  • 45
    • 58849118836 scopus 로고    scopus 로고
    • Epigenetic control of FOXP3 expression: The key to a stable regulatory T-cell lineage?
    • Huehn J., Polansky J.K., and Hamann A. Epigenetic control of FOXP3 expression: The key to a stable regulatory T-cell lineage?. Nat. Rev. Immunol. 9 (2009) 83-89
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 83-89
    • Huehn, J.1    Polansky, J.K.2    Hamann, A.3
  • 49
    • 65549145814 scopus 로고    scopus 로고
    • Control of regulatory T cell lineage commitment and maintenance
    • this issue
    • Josefowicz S.Z., and Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity 30 (2009) 616-625 this issue
    • (2009) Immunity , vol.30 , pp. 616-625
    • Josefowicz, S.Z.1    Rudensky, A.2
  • 50
    • 51049084027 scopus 로고    scopus 로고
    • Naturally occurring regulatory T cells (CD4+, CD25high, FOXP3+) in the antrum and cardia are associated with higher H. pylori colonization and increased gene expression of TGF-beta1
    • Kandulski A., Wex T., Kuester D., Peitz U., Gebert I., Roessner A., and Malfertheiner P. Naturally occurring regulatory T cells (CD4+, CD25high, FOXP3+) in the antrum and cardia are associated with higher H. pylori colonization and increased gene expression of TGF-beta1. Helicobacter 13 (2008) 295-303
    • (2008) Helicobacter , vol.13 , pp. 295-303
    • Kandulski, A.1    Wex, T.2    Kuester, D.3    Peitz, U.4    Gebert, I.5    Roessner, A.6    Malfertheiner, P.7
  • 51
    • 63649108380 scopus 로고    scopus 로고
    • The roles of TLRs, RLRs and NLRs in pathogen recognition
    • Kawai T., and Akira S. The roles of TLRs, RLRs and NLRs in pathogen recognition. Int. Immunol. 21 (2009) 317-337
    • (2009) Int. Immunol. , vol.21 , pp. 317-337
    • Kawai, T.1    Akira, S.2
  • 52
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri R., Cox T., Yasayko S.A., and Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4 (2003) 337-342
    • (2003) Nat. Immunol. , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 53
    • 27944455288 scopus 로고    scopus 로고
    • Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen
    • Knoechel B., Lohr J., Kahn E., Bluestone J.A., and Abbas A.K. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J. Exp. Med. 202 (2005) 1375-1386
    • (2005) J. Exp. Med. , vol.202 , pp. 1375-1386
    • Knoechel, B.1    Lohr, J.2    Kahn, E.3    Bluestone, J.A.4    Abbas, A.K.5
  • 56
    • 0028102655 scopus 로고
    • High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
    • Lafaille J.J., Nagashima K., Katsuki M., and Tonegawa S. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell 78 (1994) 399-408
    • (1994) Cell , vol.78 , pp. 399-408
    • Lafaille, J.J.1    Nagashima, K.2    Katsuki, M.3    Tonegawa, S.4
  • 57
    • 42149137398 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cell repertoire formation shaped by differential presentation of peptides from a self-antigen
    • Larkin III J., Rankin A.L., Picca C.C., Riley M.P., Jenks S.A., Sant A.J., and Caton A.J. CD4+CD25+ regulatory T cell repertoire formation shaped by differential presentation of peptides from a self-antigen. J. Immunol. 180 (2008) 2149-2157
    • (2008) J. Immunol. , vol.180 , pp. 2149-2157
    • Larkin III, J.1    Rankin, A.L.2    Picca, C.C.3    Riley, M.P.4    Jenks, S.A.5    Sant, A.J.6    Caton, A.J.7
  • 58
    • 41549169557 scopus 로고    scopus 로고
    • Contextual regulation of inflammation: A duet by transforming growth factor-beta and interleukin-10
    • Li M.O., and Flavell R.A. Contextual regulation of inflammation: A duet by transforming growth factor-beta and interleukin-10. Immunity 28 (2008) 468-476
    • (2008) Immunity , vol.28 , pp. 468-476
    • Li, M.O.1    Flavell, R.A.2
  • 59
    • 33748448717 scopus 로고    scopus 로고
    • Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    • Li M.O., Sanjabi S., and Flavell R.A. Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 25 (2006) 455-471
    • (2006) Immunity , vol.25 , pp. 455-471
    • Li, M.O.1    Sanjabi, S.2    Flavell, R.A.3
  • 60
  • 61
    • 12344307563 scopus 로고    scopus 로고
    • Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus
    • Liang S., Alard P., Zhao Y., Parnell S., Clark S.L., and Kosiewicz M.M. Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus. J. Exp. Med. 201 (2005) 127-137
    • (2005) J. Exp. Med. , vol.201 , pp. 127-137
    • Liang, S.1    Alard, P.2    Zhao, Y.3    Parnell, S.4    Clark, S.L.5    Kosiewicz, M.M.6
  • 62
    • 0031595503 scopus 로고    scopus 로고
    • The beta7 integrin gene (Itgb-7) promoter is responsive to TGF-beta1: Defining control regions
    • Lim S.P., Leung E., and Krissansen G.W. The beta7 integrin gene (Itgb-7) promoter is responsive to TGF-beta1: Defining control regions. Immunogenetics 48 (1998) 184-195
    • (1998) Immunogenetics , vol.48 , pp. 184-195
    • Lim, S.P.1    Leung, E.2    Krissansen, G.W.3
  • 63
    • 37849009964 scopus 로고    scopus 로고
    • A two-step process for thymic regulatory T cell development
    • Lio C.W., and Hsieh C.S. A two-step process for thymic regulatory T cell development. Immunity 28 (2008) 100-111
    • (2008) Immunity , vol.28 , pp. 100-111
    • Lio, C.W.1    Hsieh, C.S.2
  • 64
    • 33847337912 scopus 로고    scopus 로고
    • Tumor evasion of the immune system by converting CD4+CD25- T cells into CD4+CD25+ T regulatory cells: role of tumor-derived TGF-beta
    • Liu V.C., Wong L.Y., Jang T., Shah A.H., Park I., Yang X., Zhang Q., Lonning S., Teicher B.A., and Lee C. Tumor evasion of the immune system by converting CD4+CD25- T cells into CD4+CD25+ T regulatory cells: role of tumor-derived TGF-beta. J. Immunol. 178 (2007) 2883-2892
    • (2007) J. Immunol. , vol.178 , pp. 2883-2892
    • Liu, V.C.1    Wong, L.Y.2    Jang, T.3    Shah, A.H.4    Park, I.5    Yang, X.6    Zhang, Q.7    Lonning, S.8    Teicher, B.A.9    Lee, C.10
  • 65
    • 44049087148 scopus 로고    scopus 로고
    • A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells
    • Liu Y., Zhang P., Li J., Kulkarni A.B., Perruche S., and Chen W. A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat. Immunol. 9 (2008) 632-640
    • (2008) Nat. Immunol. , vol.9 , pp. 632-640
    • Liu, Y.1    Zhang, P.2    Li, J.3    Kulkarni, A.B.4    Perruche, S.5    Chen, W.6
  • 66
    • 0344405680 scopus 로고    scopus 로고
    • Helicobacter pylori-specific CD4+ CD25high regulatory T cells suppress memory T-cell responses to H. pylori in infected individuals
    • Lundgren A., Suri-Payer E., Enarsson K., Svennerholm A.M., and Lundin B.S. Helicobacter pylori-specific CD4+ CD25high regulatory T cells suppress memory T-cell responses to H. pylori in infected individuals. Infect. Immun. 71 (2003) 1755-1762
    • (2003) Infect. Immun. , vol.71 , pp. 1755-1762
    • Lundgren, A.1    Suri-Payer, E.2    Enarsson, K.3    Svennerholm, A.M.4    Lundin, B.S.5
  • 67
    • 35948937088 scopus 로고    scopus 로고
    • Regulation of the immune system in metazoan parasite infections
    • Maizels R. Regulation of the immune system in metazoan parasite infections. Novartis Found. Symp. 281 (2007) 192-204
    • (2007) Novartis Found. Symp. , vol.281 , pp. 192-204
    • Maizels, R.1
  • 68
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    • Malek T.R., Yu A., Vincek V., Scibelli P., and Kong L. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17 (2002) 167-178
    • (2002) Immunity , vol.17 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 69
    • 33748465396 scopus 로고    scopus 로고
    • Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor
    • Marie J.C., Liggitt D., and Rudensky A.Y. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25 (2006) 441-454
    • (2006) Immunity , vol.25 , pp. 441-454
    • Marie, J.C.1    Liggitt, D.2    Rudensky, A.Y.3
  • 70
    • 57449084307 scopus 로고    scopus 로고
    • Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi
    • McSorley H.J., Harcus Y.M., Murray J., Taylor M.D., and Maizels R.M. Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi. J. Immunol. 181 (2008) 6456-6466
    • (2008) J. Immunol. , vol.181 , pp. 6456-6466
    • McSorley, H.J.1    Harcus, Y.M.2    Murray, J.3    Taylor, M.D.4    Maizels, R.M.5
  • 71
    • 0026542168 scopus 로고
    • Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering
    • Miller A., Lider O., Roberts A.B., Sporn M.B., and Weiner H.L. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc. Natl. Acad. Sci. USA 89 (1992) 421-425
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 421-425
    • Miller, A.1    Lider, O.2    Roberts, A.B.3    Sporn, M.B.4    Weiner, H.L.5
  • 72
    • 34447580869 scopus 로고    scopus 로고
    • Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis
    • Min B., Thornton A., Caucheteux S.M., Younes S.A., Oh K., Hu-Li J., and Paul W.E. Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis. Eur. J. Immunol. 37 (2007) 1916-1923
    • (2007) Eur. J. Immunol. , vol.37 , pp. 1916-1923
    • Min, B.1    Thornton, A.2    Caucheteux, S.M.3    Younes, S.A.4    Oh, K.5    Hu-Li, J.6    Paul, W.E.7
  • 73
    • 0030073402 scopus 로고    scopus 로고
    • A model for developmentally acquired thymus-dependent tolerance to central and peripheral antigens
    • Modigliani Y., Bandeira A., and Coutinho A. A model for developmentally acquired thymus-dependent tolerance to central and peripheral antigens. Immunol. Rev. 149 (1996) 155-220
    • (1996) Immunol. Rev. , vol.149 , pp. 155-220
    • Modigliani, Y.1    Bandeira, A.2    Coutinho, A.3
  • 74
    • 0029916216 scopus 로고    scopus 로고
    • The absence of gut flora, the doses of antigen ingested and aging affect the long-term peripheral tolerance induced by ovalbumin feeding in mice
    • Moreau M.C., and Gaboriau-Routhiau V. The absence of gut flora, the doses of antigen ingested and aging affect the long-term peripheral tolerance induced by ovalbumin feeding in mice. Res. Immunol. 147 (1996) 49-59
    • (1996) Res. Immunol. , vol.147 , pp. 49-59
    • Moreau, M.C.1    Gaboriau-Routhiau, V.2
  • 76
  • 78
    • 0033168037 scopus 로고    scopus 로고
    • Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody
    • Onizuka S., Tawara I., Shimizu J., Sakaguchi S., Fujita T., and Nakayama E. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res. 59 (1999) 3128-3133
    • (1999) Cancer Res. , vol.59 , pp. 3128-3133
    • Onizuka, S.1    Tawara, I.2    Shimizu, J.3    Sakaguchi, S.4    Fujita, T.5    Nakayama, E.6
  • 80
    • 33747099523 scopus 로고    scopus 로고
    • Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells
    • Pacholczyk R., Ignatowicz H., Kraj P., and Ignatowicz L. Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells. Immunity 25 (2006) 249-259
    • (2006) Immunity , vol.25 , pp. 249-259
    • Pacholczyk, R.1    Ignatowicz, H.2    Kraj, P.3    Ignatowicz, L.4
  • 81
    • 34548680545 scopus 로고    scopus 로고
    • Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells
    • Pacholczyk R., Kern J., Singh N., Iwashima M., Kraj P., and Ignatowicz L. Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Immunity 27 (2007) 493-504
    • (2007) Immunity , vol.27 , pp. 493-504
    • Pacholczyk, R.1    Kern, J.2    Singh, N.3    Iwashima, M.4    Kraj, P.5    Ignatowicz, L.6
  • 82
    • 58049220365 scopus 로고    scopus 로고
    • Pattern recognition receptors and control of adaptive immunity
    • Palm N.W., and Medzhitov R. Pattern recognition receptors and control of adaptive immunity. Immunol. Rev. 227 (2009) 221-233
    • (2009) Immunol. Rev. , vol.227 , pp. 221-233
    • Palm, N.W.1    Medzhitov, R.2
  • 84
    • 22644443548 scopus 로고    scopus 로고
    • Mucosal immunity and allergic responses: Lack of regulation and/or lack of microbial stimulation?
    • Prioult G., and Nagler-Anderson C. Mucosal immunity and allergic responses: Lack of regulation and/or lack of microbial stimulation?. Immunol. Rev. 206 (2005) 204-218
    • (2005) Immunol. Rev. , vol.206 , pp. 204-218
    • Prioult, G.1    Nagler-Anderson, C.2
  • 86
    • 21244478209 scopus 로고    scopus 로고
    • A full flora, but not monocolonization by Escherichia coli or lactobacilli, supports tolerogenic processing of a fed antigen
    • Rask C., Evertsson S., Telemo E., and Wold A.E. A full flora, but not monocolonization by Escherichia coli or lactobacilli, supports tolerogenic processing of a fed antigen. Scand. J. Immunol. 61 (2005) 529-535
    • (2005) Scand. J. Immunol. , vol.61 , pp. 529-535
    • Rask, C.1    Evertsson, S.2    Telemo, E.3    Wold, A.E.4
  • 87
    • 33747590748 scopus 로고    scopus 로고
    • The role of virus-induced regulatory T cells in immunopathology
    • Robertson S.J., and Hasenkrug K.J. The role of virus-induced regulatory T cells in immunopathology. Springer Semin. Immunopathol. 28 (2006) 51-62
    • (2006) Springer Semin. Immunopathol. , vol.28 , pp. 51-62
    • Robertson, S.J.1    Hasenkrug, K.J.2
  • 88
    • 0035316363 scopus 로고    scopus 로고
    • Policing the regulators
    • Sakaguchi S. Policing the regulators. Nat. Immunol. 2 (2001) 283-284
    • (2001) Nat. Immunol. , vol.2 , pp. 283-284
    • Sakaguchi, S.1
  • 89
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S., Yamaguchi T., Nomura T., and Ono M. Regulatory T cells and immune tolerance. Cell 133 (2008) 775-787
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 90
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon B., Lenschow D.J., Rhee L., Ashourian N., Singh B., Sharpe A., and Bluestone J.A. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12 (2000) 431-440
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3    Ashourian, N.4    Singh, B.5    Sharpe, A.6    Bluestone, J.A.7
  • 91
    • 48249143387 scopus 로고    scopus 로고
    • Mitigation of experimental allergic encephalomyelitis by TGF-beta induced Foxp3+ regulatory T lymphocytes through the induction of anergy and infectious tolerance
    • Selvaraj R.K., and Geiger T.L. Mitigation of experimental allergic encephalomyelitis by TGF-beta induced Foxp3+ regulatory T lymphocytes through the induction of anergy and infectious tolerance. J. Immunol. 180 (2008) 2830-2838
    • (2008) J. Immunol. , vol.180 , pp. 2830-2838
    • Selvaraj, R.K.1    Geiger, T.L.2
  • 92
    • 15444374646 scopus 로고    scopus 로고
    • Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
    • Setoguchi R., Hori S., Takahashi T., and Sakaguchi S. Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 201 (2005) 723-735
    • (2005) J. Exp. Med. , vol.201 , pp. 723-735
    • Setoguchi, R.1    Hori, S.2    Takahashi, T.3    Sakaguchi, S.4
  • 94
    • 0033571105 scopus 로고    scopus 로고
    • Induction of tumor immunity by removing CD25+CD4+ T cells: A common basis between tumor immunity and autoimmunity
    • Shimizu J., Yamazaki S., and Sakaguchi S. Induction of tumor immunity by removing CD25+CD4+ T cells: A common basis between tumor immunity and autoimmunity. J. Immunol. 163 (1999) 5211-5218
    • (1999) J. Immunol. , vol.163 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 95
    • 34447572680 scopus 로고    scopus 로고
    • IL-2Rbeta links IL-2R signaling with Foxp3 expression
    • Soper D.M., Kasprowicz D.J., and Ziegler S.F. IL-2Rbeta links IL-2R signaling with Foxp3 expression. Eur. J. Immunol. 37 (2007) 1817-1826
    • (2007) Eur. J. Immunol. , vol.37 , pp. 1817-1826
    • Soper, D.M.1    Kasprowicz, D.J.2    Ziegler, S.F.3
  • 97
    • 0031571230 scopus 로고    scopus 로고
    • The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction
    • Sudo N., Sawamura S., Tanaka K., Aiba Y., Kubo C., and Koga Y. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J. Immunol. 159 (1997) 1739-1745
    • (1997) J. Immunol. , vol.159 , pp. 1739-1745
    • Sudo, N.1    Sawamura, S.2    Tanaka, K.3    Aiba, Y.4    Kubo, C.5    Koga, Y.6
  • 98
    • 33645077332 scopus 로고    scopus 로고
    • Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens
    • Suffia I.J., Reckling S.K., Piccirillo C.A., Goldszmid R.S., and Belkaid Y. Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens. J. Exp. Med. 203 (2006) 777-788
    • (2006) J. Exp. Med. , vol.203 , pp. 777-788
    • Suffia, I.J.1    Reckling, S.K.2    Piccirillo, C.A.3    Goldszmid, R.S.4    Belkaid, Y.5
  • 99
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun C.M., Hall J.A., Blank R.B., Bouladoux N., Oukka M., Mora J.R., and Belkaid Y. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204 (2007) 1775-1785
    • (2007) J. Exp. Med. , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3    Bouladoux, N.4    Oukka, M.5    Mora, J.R.6    Belkaid, Y.7
  • 101
    • 13944260538 scopus 로고    scopus 로고
    • CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    • Tai X., Cowan M., Feigenbaum L., and Singer A. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 6 (2005) 152-162
    • (2005) Nat. Immunol. , vol.6 , pp. 152-162
    • Tai, X.1    Cowan, M.2    Feigenbaum, L.3    Singer, A.4
  • 102
  • 103
    • 9244244736 scopus 로고    scopus 로고
    • Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
    • van Santen H.M., Benoist C., and Mathis D. Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 200 (2004) 1221-1230
    • (2004) J. Exp. Med. , vol.200 , pp. 1221-1230
    • van Santen, H.M.1    Benoist, C.2    Mathis, D.3
  • 104
    • 17044430217 scopus 로고    scopus 로고
    • Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter
    • Wan Y.Y., and Flavell R.A. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc. Natl. Acad. Sci. USA 102 (2005) 5126-5131
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5126-5131
    • Wan, Y.Y.1    Flavell, R.A.2
  • 106
    • 0035495857 scopus 로고    scopus 로고
    • The germless theory of allergic disease: revisiting the hygiene hypothesis
    • Wills-Karp M., Santeliz J., and Karp C.L. The germless theory of allergic disease: revisiting the hygiene hypothesis. Nat. Rev. Immunol. 1 (2001) 69-75
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 69-75
    • Wills-Karp, M.1    Santeliz, J.2    Karp, C.L.3
  • 107
    • 1542721580 scopus 로고    scopus 로고
    • Regulation of allergy and autoimmunity in helminth infection
    • Wilson M.S., and Maizels R.M. Regulation of allergy and autoimmunity in helminth infection. Clin. Rev. Allergy Immunol. 26 (2004) 35-50
    • (2004) Clin. Rev. Allergy Immunol. , vol.26 , pp. 35-50
    • Wilson, M.S.1    Maizels, R.M.2
  • 108
    • 56649105150 scopus 로고    scopus 로고
    • Role of endogenous and induced regulatory T cells during infections
    • Wohlfert E., and Belkaid Y. Role of endogenous and induced regulatory T cells during infections. J. Clin. Immunol. 28 (2008) 707-715
    • (2008) J. Clin. Immunol. , vol.28 , pp. 707-715
    • Wohlfert, E.1    Belkaid, Y.2
  • 109
    • 34548381245 scopus 로고    scopus 로고
    • TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets
    • Wong J., Mathis D., and Benoist C. TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets. J. Exp. Med. 204 (2007) 2039-2045
    • (2007) J. Exp. Med. , vol.204 , pp. 2039-2045
    • Wong, J.1    Mathis, D.2    Benoist, C.3
  • 110
    • 34249814016 scopus 로고    scopus 로고
    • Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells
    • Wong J., Obst R., Correia-Neves M., Losyev G., Mathis D., and Benoist C. Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J. Immunol. 178 (2007) 7032-7041
    • (2007) J. Immunol. , vol.178 , pp. 7032-7041
    • Wong, J.1    Obst, R.2    Correia-Neves, M.3    Losyev, G.4    Mathis, D.5    Benoist, C.6
  • 112
    • 34247277666 scopus 로고    scopus 로고
    • Foxp3 in control of the regulatory T cell lineage
    • Zheng Y., and Rudensky A.Y. Foxp3 in control of the regulatory T cell lineage. Nat. Immunol. 8 (2007) 457-462
    • (2007) Nat. Immunol. , vol.8 , pp. 457-462
    • Zheng, Y.1    Rudensky, A.Y.2
  • 113
    • 33644835247 scopus 로고    scopus 로고
    • TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells
    • Zheng S.G., Wang J.H., Stohl W., Kim K.S., Gray J.D., and Horwitz D.A. TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells. J. Immunol. 176 (2006) 3321-3329
    • (2006) J. Immunol. , vol.176 , pp. 3321-3329
    • Zheng, S.G.1    Wang, J.H.2    Stohl, W.3    Kim, K.S.4    Gray, J.D.5    Horwitz, D.A.6
  • 114
    • 33846923124 scopus 로고    scopus 로고
    • IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells
    • Zheng S.G., Wang J., Wang P., Gray J.D., and Horwitz D.A. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J. Immunol. 178 (2007) 2018-2027
    • (2007) J. Immunol. , vol.178 , pp. 2018-2027
    • Zheng, S.G.1    Wang, J.2    Wang, P.3    Gray, J.D.4    Horwitz, D.A.5
  • 115
    • 33846913897 scopus 로고    scopus 로고
    • Natural regulatory T cells and de novo-induced regulatory T cells contribute independently to tumor-specific tolerance
    • Zhou G., and Levitsky H.I. Natural regulatory T cells and de novo-induced regulatory T cells contribute independently to tumor-specific tolerance. J. Immunol. 178 (2007) 2155-2162
    • (2007) J. Immunol. , vol.178 , pp. 2155-2162
    • Zhou, G.1    Levitsky, H.I.2
  • 116
    • 65549115862 scopus 로고    scopus 로고
    • Plasticity of CD4+ T cell lineage differentiation
    • this issue
    • Zhou L., Chong M.M.W., and Littman D.R. Plasticity of CD4+ T cell lineage differentiation. Immunity 30 (2009) 646-655 this issue
    • (2009) Immunity , vol.30 , pp. 646-655
    • Zhou, L.1    Chong, M.M.W.2    Littman, D.R.3
  • 117
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumour immunity and immunotherapy
    • Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat. Rev. Immunol. 6 (2006) 295-307
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 295-307
    • Zou, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.