메뉴 건너뛰기




Volumn 32, Issue 5, 2010, Pages 642-653

Transforming growth factor-β signaling curbs thymic negative selection promoting regulatory T cell development

Author keywords

Cellimmuno; Molimmuno

Indexed keywords

BIM PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

EID: 77953267301     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2010.04.012     Document Type: Article
Times cited : (202)

References (51)
  • 2
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou I., Sarukhan A., Klein L., von Boehmer H. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 2002, 3:756-763.
    • (2002) Nat. Immunol. , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    von Boehmer, H.4
  • 5
    • 0034507693 scopus 로고    scopus 로고
    • Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion
    • Bouneaud C., Kourilsky P., Bousso P. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity 2000, 13:829-840.
    • (2000) Immunity , vol.13 , pp. 829-840
    • Bouneaud, C.1    Kourilsky, P.2    Bousso, P.3
  • 6
    • 0037103223 scopus 로고    scopus 로고
    • Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo
    • Brewer J.A., Kanagawa O., Sleckman B.P., Muglia L.J. Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J. Immunol. 2002, 169:1837-1843.
    • (2002) J. Immunol. , vol.169 , pp. 1837-1843
    • Brewer, J.A.1    Kanagawa, O.2    Sleckman, B.P.3    Muglia, L.J.4
  • 7
    • 33845935950 scopus 로고    scopus 로고
    • IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells
    • Burchill M.A., Yang J., Vogtenhuber C., Blazar B.R., Farrar M.A. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J. Immunol. 2007, 178:280-290.
    • (2007) J. Immunol. , vol.178 , pp. 280-290
    • Burchill, M.A.1    Yang, J.2    Vogtenhuber, C.3    Blazar, B.R.4    Farrar, M.A.5
  • 9
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W., Jin W., Hardegen N., Lei K.J., Li L., Marinos N., McGrady G., Wahl S.M. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 2003, 198:1875-1886.
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 10
    • 26844450449 scopus 로고    scopus 로고
    • How defects in central tolerance impinge on a deficiency in regulatory T cells
    • Chen Z., Benoist C., Mathis D. How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc. Natl. Acad. Sci. USA 2005, 102:14735-14740.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 14735-14740
    • Chen, Z.1    Benoist, C.2    Mathis, D.3
  • 11
    • 65549123867 scopus 로고    scopus 로고
    • Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?
    • Curotto de Lafaille M.A., Lafaille J.J. Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?. Immunity 2009, 30:626-635.
    • (2009) Immunity , vol.30 , pp. 626-635
    • Curotto de Lafaille, M.A.1    Lafaille, J.J.2
  • 13
    • 60549084941 scopus 로고    scopus 로고
    • CD4+ T-cell development in a mouse expressing a transgenic TCR derived from a Treg
    • DiPaolo R.J., Shevach E.M. CD4+ T-cell development in a mouse expressing a transgenic TCR derived from a Treg. Eur. J. Immunol. 2009, 39:234-240.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 234-240
    • DiPaolo, R.J.1    Shevach, E.M.2
  • 15
    • 67649170980 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells: Differentiation, specification, subphenotypes
    • Feuerer M., Hill J.A., Mathis D., Benoist C. Foxp3+ regulatory T cells: Differentiation, specification, subphenotypes. Nat. Immunol. 2009, 10:689-695.
    • (2009) Nat. Immunol. , vol.10 , pp. 689-695
    • Feuerer, M.1    Hill, J.A.2    Mathis, D.3    Benoist, C.4
  • 16
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot J.D., Rasmussen J.P., Gavin M.A., Rudensky A.Y. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 2005, 6:1142-1151.
    • (2005) Nat. Immunol. , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 17
    • 7244227645 scopus 로고    scopus 로고
    • Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
    • Gallegos A.M., Bevan M.J. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J. Exp. Med. 2004, 200:1039-1049.
    • (2004) J. Exp. Med. , vol.200 , pp. 1039-1049
    • Gallegos, A.M.1    Bevan, M.J.2
  • 18
  • 19
    • 33645102841 scopus 로고    scopus 로고
    • An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
    • Hsieh C.S., Zheng Y., Liang Y., Fontenot J.D., Rudensky A.Y. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 2006, 7:401-410.
    • (2006) Nat. Immunol. , vol.7 , pp. 401-410
    • Hsieh, C.S.1    Zheng, Y.2    Liang, Y.3    Fontenot, J.D.4    Rudensky, A.Y.5
  • 21
    • 65549145814 scopus 로고    scopus 로고
    • Control of regulatory T cell lineage commitment and maintenance
    • Josefowicz S.Z., Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity 2009, 30:616-625.
    • (2009) Immunity , vol.30 , pp. 616-625
    • Josefowicz, S.Z.1    Rudensky, A.2
  • 22
    • 0036568942 scopus 로고    scopus 로고
    • Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression
    • Kawahata K., Misaki Y., Yamauchi M., Tsunekawa S., Setoguchi K., Miyazaki J., Yamamoto K. Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J. Immunol. 2002, 168:4399-4405.
    • (2002) J. Immunol. , vol.168 , pp. 4399-4405
    • Kawahata, K.1    Misaki, Y.2    Yamauchi, M.3    Tsunekawa, S.4    Setoguchi, K.5    Miyazaki, J.6    Yamamoto, K.7
  • 24
  • 26
    • 70350440009 scopus 로고    scopus 로고
    • TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes
    • Leung M.W., Shen S., Lafaille J.J. TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes. J. Exp. Med. 2009, 206:2121-2130.
    • (2009) J. Exp. Med. , vol.206 , pp. 2121-2130
    • Leung, M.W.1    Shen, S.2    Lafaille, J.J.3
  • 27
    • 48449086316 scopus 로고    scopus 로고
    • TGF-beta: A master of all T cell trades
    • Li M.O., Flavell R.A. TGF-beta: A master of all T cell trades. Cell 2008, 134:392-404.
    • (2008) Cell , vol.134 , pp. 392-404
    • Li, M.O.1    Flavell, R.A.2
  • 28
    • 33748448717 scopus 로고    scopus 로고
    • Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    • Li M.O., Sanjabi S., Flavell R.A. Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 2006, 25:455-471.
    • (2006) Immunity , vol.25 , pp. 455-471
    • Li, M.O.1    Sanjabi, S.2    Flavell, R.A.3
  • 29
    • 34248592104 scopus 로고    scopus 로고
    • T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation
    • Li M.O., Wan Y.Y., Flavell R.A. T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 2007, 26:579-591.
    • (2007) Immunity , vol.26 , pp. 579-591
    • Li, M.O.1    Wan, Y.Y.2    Flavell, R.A.3
  • 30
    • 44049087148 scopus 로고    scopus 로고
    • A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells
    • Liu Y., Zhang P., Li J., Kulkarni A.B., Perruche S., Chen W. A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat. Immunol. 2008, 9:632-640.
    • (2008) Nat. Immunol. , vol.9 , pp. 632-640
    • Liu, Y.1    Zhang, P.2    Li, J.3    Kulkarni, A.B.4    Perruche, S.5    Chen, W.6
  • 32
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    • Malek T.R., Yu A., Vincek V., Scibelli P., Kong L. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 2002, 17:167-178.
    • (2002) Immunity , vol.17 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 33
    • 33748465396 scopus 로고    scopus 로고
    • Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor
    • Marie J.C., Liggitt D., Rudensky A.Y. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 2006, 25:441-454.
    • (2006) Immunity , vol.25 , pp. 441-454
    • Marie, J.C.1    Liggitt, D.2    Rudensky, A.Y.3
  • 34
    • 2442567829 scopus 로고    scopus 로고
    • Back to central tolerance
    • Mathis D., Benoist C. Back to central tolerance. Immunity 2004, 20:509-516.
    • (2004) Immunity , vol.20 , pp. 509-516
    • Mathis, D.1    Benoist, C.2
  • 35
    • 0038725685 scopus 로고    scopus 로고
    • Negative selection-clearing out the bad apples from the T-cell repertoire
    • Palmer E. Negative selection-clearing out the bad apples from the T-cell repertoire. Nat. Rev. Immunol. 2003, 3:383-391.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 383-391
    • Palmer, E.1
  • 36
    • 4143085811 scopus 로고    scopus 로고
    • Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival
    • Park J.H., Yu Q., Erman B., Appelbaum J.S., Montoya-Durango D., Grimes H.L., Singer A. Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity 2004, 21:289-302.
    • (2004) Immunity , vol.21 , pp. 289-302
    • Park, J.H.1    Yu, Q.2    Erman, B.3    Appelbaum, J.S.4    Montoya-Durango, D.5    Grimes, H.L.6    Singer, A.7
  • 38
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S., Yamaguchi T., Nomura T., Ono M. Regulatory T cells and immune tolerance. Cell 2008, 133:775-787.
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 39
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon B., Lenschow D.J., Rhee L., Ashourian N., Singh B., Sharpe A., Bluestone J.A. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000, 12:431-440.
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3    Ashourian, N.4    Singh, B.5    Sharpe, A.6    Bluestone, J.A.7
  • 40
    • 68249141869 scopus 로고    scopus 로고
    • Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells
    • Sanjabi S., Mosaheb M.M., Flavell R.A. Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells. Immunity 2009, 31:131-144.
    • (2009) Immunity , vol.31 , pp. 131-144
    • Sanjabi, S.1    Mosaheb, M.M.2    Flavell, R.A.3
  • 41
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T regulatory cell-mediated suppression
    • Shevach E.M. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 2009, 30:636-645.
    • (2009) Immunity , vol.30 , pp. 636-645
    • Shevach, E.M.1
  • 42
    • 0024492086 scopus 로고
    • Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures
    • Smith C.A., Williams G.T., Kingston R., Jenkinson E.J., Owen J.J. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature 1989, 337:181-184.
    • (1989) Nature , vol.337 , pp. 181-184
    • Smith, C.A.1    Williams, G.T.2    Kingston, R.3    Jenkinson, E.J.4    Owen, J.J.5
  • 43
    • 13944260538 scopus 로고    scopus 로고
    • CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    • Tai X., Cowan M., Feigenbaum L., Singer A. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 2005, 6:152-162.
    • (2005) Nat. Immunol. , vol.6 , pp. 152-162
    • Tai, X.1    Cowan, M.2    Feigenbaum, L.3    Singer, A.4
  • 44
    • 68249152608 scopus 로고    scopus 로고
    • Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo
    • Tinoco R., Alcalde V., Yang Y., Sauer K., Zuniga E.I. Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity 2009, 31:145-157.
    • (2009) Immunity , vol.31 , pp. 145-157
    • Tinoco, R.1    Alcalde, V.2    Yang, Y.3    Sauer, K.4    Zuniga, E.I.5
  • 46
    • 9244244736 scopus 로고    scopus 로고
    • Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
    • van Santen H.M., Benoist C., Mathis D. Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 2004, 200:1221-1230.
    • (2004) J. Exp. Med. , vol.200 , pp. 1221-1230
    • van Santen, H.M.1    Benoist, C.2    Mathis, D.3
  • 47
    • 51549104932 scopus 로고    scopus 로고
    • IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development
    • Vang K.B., Yang J., Mahmud S.A., Burchill M.A., Vegoe A.L., Farrar M.A. IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development. J. Immunol. 2008, 181:3285-3290.
    • (2008) J. Immunol. , vol.181 , pp. 3285-3290
    • Vang, K.B.1    Yang, J.2    Mahmud, S.A.3    Burchill, M.A.4    Vegoe, A.L.5    Farrar, M.A.6
  • 48
    • 0043244867 scopus 로고    scopus 로고
    • Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo
    • Walker L.S., Chodos A., Eggena M., Dooms H., Abbas A.K. Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. J. Exp. Med. 2003, 198:249-258.
    • (2003) J. Exp. Med. , vol.198 , pp. 249-258
    • Walker, L.S.1    Chodos, A.2    Eggena, M.3    Dooms, H.4    Abbas, A.K.5
  • 49
    • 17044430217 scopus 로고    scopus 로고
    • Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter
    • Wan Y.Y., Flavell R.A. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc. Natl. Acad. Sci. USA 2005, 102:5126-5131.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5126-5131
    • Wan, Y.Y.1    Flavell, R.A.2
  • 50
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: Opposing activities that mediate cell death
    • Youle R.J., Strasser A. The BCL-2 protein family: Opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 2008, 9:47-59.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 51
    • 1242290580 scopus 로고    scopus 로고
    • Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: The role of IL-2, TGF-beta, and IL-10
    • Zheng S.G., Wang J.H., Gray J.D., Soucier H., Horwitz D.A. Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: The role of IL-2, TGF-beta, and IL-10. J. Immunol. 2004, 172:5213-5221.
    • (2004) J. Immunol. , vol.172 , pp. 5213-5221
    • Zheng, S.G.1    Wang, J.H.2    Gray, J.D.3    Soucier, H.4    Horwitz, D.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.