A Two-Step Process for Thymic Regulatory T Cell Development

Immunity

Volumn 28, Issue 1, 2008, Pages 100-111

  Lio, Chan Wang Joaquim ^a   Hsieh, Chyi Song ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CELLIMMUNO; MOLIMMUNO

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 15; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; STEM CELL; STOCHASTIC MODEL; THYMOCYTE;

ANIMALS; CELL DIFFERENTIATION; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; SELF TOLERANCE; STAT5 TRANSCRIPTION FACTOR; STEM CELLS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; THYMUS GLAND;

EID: 37849009964     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2007.11.021     Document Type: Article

References (45)

1. Apostolou I., Sarukhan A., Klein L., and von Boehmer H. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3 (2002) 756-763
2. Bassiri H., and Carding S.R. A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection. J. Immunol. 166 (2001) 5945-5954
3. + T regulatory cells. J. Immunol. 178 (2007) 4062-4071
4. Bennett C.L., Christie J., Ramsdell F., Brunkow M.E., Ferguson P.J., Whitesell L., Kelly T.E., Saulsbury F.T., Chance P.F., and Ochs H.D. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27 (2001) 20-21
5. + regulatory T cells. J. Immunol. 178 (2007) 280-290
6. Burchill M.A., Yang J., Vang K.B., Moon J.J., Chu H.H., Lio C.-W.J., Vegoe A.L., Hsieh C.-S., Jenkins M.K., and Farrar M.A. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 28 (2008) 112-121 this issue
7. + T cell homeostasis. J. Exp. Med. 200 (2004) 825-834
8. + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198 (2003) 1875-1886
9. + regulatory T cells in the absence of interleukin 2 signaling. Nat. Immunol. 6 (2005) 1152-1159
10. Fontenot J.D., and Rudensky A.Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 6 (2005) 331-337
11. + regulatory T cells. Nat. Immunol. 4 (2003) 330-336
12. Fontenot J.D., Dooley J.L., Farr A.G., and Rudensky A.Y. Developmental regulation of Foxp3 expression during ontogeny. J. Exp. Med. 202 (2005) 901-906
13. Fontenot J.D., Rasmussen J.P., Gavin M.A., and Rudensky A.Y. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6 (2005) 1142-1151
14. Fontenot J.D., Rasmussen J.P., Williams L.M., Dooley J.L., Farr A.G., and Rudensky A.Y. Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 22 (2005) 329-341
15. Gavin M.A., Rasmussen J.P., Fontenot J.D., Vasta V., Manganiello V.C., Beavo J.A., and Rudensky A.Y. Foxp3-dependent programme of regulatory T-cell differentiation. Nature 445 (2007) 771-775
16. Hori S., Nomura T., and Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299 (2003) 1057-1061
17. + T cell receptors. Immunity 21 (2004) 267-277
18. Hsieh C.S., Zheng Y., Liang Y., Fontenot J.D., and Rudensky A.Y. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 7 (2006) 401-410
19. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162 (1999) 5317-5326
20. Izcue A., Coombes J.L., and Powrie F. Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol. Rev. 212 (2006) 256-271
21. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2 (2001) 301-306
22. Kim J.M., Rasmussen J.P., and Rudensky A.Y. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8 (2007) 191-197
23. Kishimoto H., and Sprent J. Negative selection in the thymus includes semimature T cells. J. Exp. Med. 185 (1997) 263-271
24. Kishimoto H., Surh C.D., and Sprent J. Upregulation of surface markers on dying thymocytes. J. Exp. Med. 181 (1995) 649-655
25. + regulatory T cells induces a scurfy-like disease. J. Exp. Med. 204 (2007) 57-63
26. Li M.O., Sanjabi S., and Flavell R.A. Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 25 (2006) 455-471
27. Lin W., Haribhai D., Relland L.M., Truong N., Carlson M.R., Williams C.B., and Chatila T.A. Regulatory T cell development in the absence of functional Foxp3. Nat. Immunol. 8 (2007) 359-368
28. Malek T.R., Yu A., Vincek V., Scibelli P., and Kong L. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17 (2002) 167-178
29. Marie J.C., Liggitt D., and Rudensky A.Y. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25 (2006) 441-454
30. + T cells. Immunity 25 (2006) 249-259
31. Pacholczyk R., Kern J., Singh N., Iwashima M., Kraj P., and Ignatowicz L. Nonself-antigens are the cognate specificities of foxp3(+) regulatory T cells. Immunity 27 (2007) 493-504
32. Pennington D.J., Silva-Santos B., Silberzahn T., Escorcio-Correia M., Woodward M.J., Roberts S.J., Smith A.L., Dyson P.J., and Hayday A.C. Early events in the thymus affect the balance of effector and regulatory T cells. Nature 444 (2006) 1073-1077
33. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22 (2004) 531-562
34. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12 (2000) 431-440
35. Samy E.T., Setiady Y.Y., Ohno K., Pramoonjago P., Sharp C., and Tung K.S. The role of physiological self-antigen in the acquisition and maintenance of regulatory T-cell function. Immunol. Rev. 212 (2006) 170-184
36. Seddon B., and Mason D. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J. Exp. Med. 189 (1999) 877-882
37. Sharon M., Klausner R.D., Cullen B.R., Chizzonite R., and Leonard W.J. Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions. Science 234 (1986) 859-863
38. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3 (2002) 135-142
39. Taguchi O., Kontani K., Ikeda H., Kezuka T., Takeuchi M., and Takahashi T. Tissue-specific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens. Immunology 82 (1994) 365-369
40. Tai X., Cowan M., Feigenbaum L., and Singer A. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 6 (2005) 152-162
41. Tang Q., Henriksen K.J., Bi M., Finger E.B., Szot G., Ye J., Masteller E.L., McDevitt H., Bonyhadi M., and Bluestone J.A. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J. Exp. Med. 199 (2004) 1455-1465
42. Van De Wiele C.J., Marino J.H., Murray B.W., Vo S.S., Whetsell M.E., and Teague T.K. Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation. J. Immunol. 172 (2004) 4235-4244
43. Van Santen H.-M., Benoist C., and Mathis D. Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 200 (2004) 1221-1230
44. + T cells. J. Immunol. 178 (2007) 7032-7041
45. Yao Z., Kanno Y., Kerenyi M., Stephens G., Durant L., Watford W.T., Laurence A., Robinson G.W., Shevach E.M., Moriggl R., et al. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 109 (2007) 4368-4375