Mature T cells depend on signaling through the IKK complex

Immunity

Volumn 19, Issue 3, 2003, Pages 377-389

  Schmidt Supprian, Marc ^a,b   Courtois, Gilles ^c   Tian, Jane ^d   Coyle, Anthony J ^d   Israël, Alain ^c   Rajewsky, Klaus ^a,b   Pasparakis, Manolis ^b,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF COLOGNE   (Germany)

^c INSTITUT PASTEUR   (France)

^d MILLENNIUM PHARMACEUTICALS INC   (United States)

^e EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOENZYME; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL LINE; CELL MATURATION; CELL SURVIVAL; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INDUCTION; ENZYME SUBUNIT; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0141678951     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(03)00237-1     Document Type: Article

References (49)

1. Anest V., Hanson J.L., Cogswell P.C., Steinbrecher K.A., Strahl B.D., Baldwin A.S. A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Nature. 423:2003;659-663.
2. Attar R.M., Macdonald-Bravo H., Raventos-Suarez C., Durham S.K., Bravo R. Expression of constitutively active IkappaB beta in T cells of transgenic mice. persistent NF-kappaB activity is required for T-cell immune responses Mol. Cell. Biol. 18:1998;477-487.
3. Aune T.M., Mora A.L., Kim S., Boothby M., Lichtman A.H. Costimulation reverses the defect in IL-2 but not effector cytokine production by T cells with impaired IkappaBalpha degradation. J. Immunol. 162:1999;5805-5812.
4. Barkett M., Gilmore T.D. Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene. 18:1999;6910-6924.
5. Boothby M.R., Mora A.L., Scherer D.C., Brockman J.A., Ballard D.W. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB. J. Exp. Med. 185:1997;1897-1907.
6. Caamano J., Hunter C.A. NF-kappaB family of transcription factors. central regulators of innate and adaptive immune functions Clin. Microbiol. Rev. 15:2002;414-429.
7. Cao Y., Bonizzi G., Seagroves T.N., Greten F.R., Johnson R., Schmidt E.V., Karin M. IKKα provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell. 107:2001;763-775.
8. Denk A., Wirth T., Baumann B. NF-kappaB transcription factors. critical regulators of hematopoiesis and neuronal survival Cytokine Growth Factor Rev. 11:2000;303-320.
9. Dorfman J.R., Germain R.N. MHC-dependent survival of naive T cells? A complicated answer to a simple question. Microbes Infect. 4:2002;547-554.
10. Esslinger C.W., Wilson A., Sordat B., Beermann F., Jongeneel C.V. Abnormal T lymphocyte development induced by targeted overexpression of IkappaB alpha. J. Immunol. 158:1997;5075-5078.
11. Esslinger C.W., Jongeneel C.V., MacDonald H.R. Survival-independent function of NF-kappaB/Rel during late stages of thymocyte differentiation. Mol. Immunol. 35:1998;847-852.
12. Ferreira V., Sidenius N., Tarantino N., Hubert P., Chatenoud L., Blasi F., Korner M. In vivo inhibition of NF-kappa B in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis. J. Immunol. 162:1999;6442-6450.
13. Fischer C., Page S., Weber M., Eisele T., Neumeier D., Brand K. Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IkappaB kinase signalsome activation and IkappaB proteolysis. J. Biol. Chem. 274:1999;24625-24632.
14. Franzoso G., Carlson L., Xing L., Poljak L., Shores E.W., Brown K.D., Leonardi A., Tran T., Boyce B.F., Siebenlist U. Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev. 11:1997;3482-3496.
15. Ghosh S., Karin M. Missing pieces in the NF-κB puzzle. Cell Suppl. 109:2002;S81-S96.
16. Goldrath A.W. Maintaining the status quo. T-cell homeostasis Microbes Infect. 4:2002;539-545.
17. Grossmann M., O'Reilly L.A., Gugasyan R., Strasser A., Adams J.M., Gerondakis S. The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression. EMBO J. 19:2000;6351-6360.
18. Guermonprez P., Valladeau J., Zitvogel L., Thery C., Amigorena S. Antigen presentation and T cell stimulation by dendritic cells. Annu. Rev. Immunol. 20:2002;621-667.
19. Hettmann T., DiDonato J., Karin M., Leiden J.M. An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis. J. Exp. Med. 189:1999;145-158.
20. Horwitz B.H., Scott M.L., Cherry S.R., Bronson R.T., Baltimore D. Failure of lymphopoiesis after adoptive transfer of NF-κB-deficient fetal liver cells. Immunity. 6:1997;765-772.
21. Israel A. The IKK complex. an integrator of all signals that activate NF-kappaB? Trends Cell Biol. 10:2000;129-133.
22. Kaisho T., Takeda K., Tsujimura T., Kawai T., Nomura F., Terada N., Akira S. IkappaB kinase alpha is essential for mature B cell development and function. J. Exp. Med. 193:2001;417-426.
23. Karin M., Ben-Neriah Y. Phosphorylation meets ubiquitination. the control of NF-κB activity Annu. Rev. Immunol. 18:2000;621-663.
24. Lee P.P., Fitzpatrick D.R., Beard C., Jessup H.K., Lehar S., Makar K.W., Perez-Melgosa M., Sweetser M.T., Schlissel M.S., Nguyen S.et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity. 15:2001;763-774.
25. Li Q., Verma I.M. NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2:2002;725-734.
26. Li Q., Van Antwerp D., Mercurio F., Lee K.F., Verma I.M. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science. 284:1999;321-325.
27. Li Q., Estepa G., Memet S., Israel A., Verma I.M. Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice. additional defect in neurulation Genes Dev. 14:2000;1729-1733.
28. Li X., Massa P.E., Hanidu A., Peet G.W., Aro P., Savitt A., Mische S., Li J., Marcu K.B. IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program. J. Biol. Chem. 277:2002;45129-45140.
29. Mackay F., Browning J.L. Baff. a fundamental survival factor for b cells Nat. Rev. Immunol. 2:2002;465-475.
30. Mercurio F., Zhu H., Murray B.W., Shevchenko A., Bennett B.L., Li J., Young D.B., Barbosa M., Mann M., Manning A., Rao A. IKK-1 and IKK-2. cytokine-activated IkappaB kinases essential for NF-kappaB activation Science. 278:1997;860-866.
31. Orban P.C., Chui D., Marth J.D. Tissue- and site-specific DNA recombination in transgenic mice. Proc. Natl. Acad. Sci. USA. 89:1992;6861-6865.
32. Pasparakis M., Courtois G., Hafner M., Schmidt-Supprian M., Nenci A., Toksoy A., Krampert M., Goebeler M., Gillitzer R., Israel A.et al. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature. 417:2002;861-866. a.
33. Pasparakis M., Schmidt-Supprian M., Rajewsky K. IkappaB kinase signaling is essential for maintenance of mature B cells. J. Exp. Med. 196:2002;743-752. b.
34. Polic B., Kunkel D., Scheffold A., Rajewsky K. How alpha beta T cells deal with induced TCR alpha ablation. Proc. Natl. Acad. Sci. USA. 98:2001;8744-8749.
35. Read S., Powrie F. CD4(+) regulatory T cells. Curr. Opin. Immunol. 13:2001;644-649.
36. Ren H., Schmalstieg A., van Oers N.S., Gaynor R.B. I-kappa B kinases alpha and beta have distinct roles in regulating murine T cell function. J. Immunol. 168:2002;3721-3731.
37. Roes J., Rajewsky K. Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells. J. Exp. Med. 177:1993;45-55.
38. Ruland J., Duncan G.S., Elia A., del Barco Barrantes I., Nguyen L., Plyte S., Millar D.G., Bouchard D., Wakeham A., Ohashi P.S., Mak T.W. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-κB and neural tube closure. Cell. 104:2001;33-42.
39. Schmidt-Supprian M., Bloch W., Courtois G., Addicks K., Israel A., Rajewsky K., Pasparakis M. NEMO/IKK γ-deficient mice model incontinentia pigmenti. Mol. Cell. 5:2000;981-992.
40. Schwenk F., Baron U., Rajewsky K. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23:1995;5080-5081.
41. Senftleben U., Cao Y., Xiao G., Greten F.R., Krahn G., Bonizzi G., Chen Y., Hu Y., Fong A., Sun S.C., Karin M. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science. 293:2001;1495-1499. a.
42. Senftleben U., Li Z.W., Baud V., Karin M. IKKβ is essential for protecting T cells from TNFα-induced apoptosis. Immunity. 14:2001;217-230. b.
43. Shevach E.M. CD4+ CD25+ suppressor T cells. more questions than answers Nat. Rev. Immunol. 2:2002;389-400.
44. Shortman K., Wilson A., Egerton M., Pearse M., Scollay R. Immature CD4- CD8+ murine thymocytes. Cell. Immunol. 113:1988;462-479.
45. Tanaka M., Fuentes M.E., Yamaguchi K., Durnin M.H., Dalrymple S.A., Hardy K.L., Goeddel D.V. Embryonic lethality, liver degeneration, and impaired NF-κB activation in IKK-β-deficient mice. Immunity. 10:1999;421-429.
46. Tian T., Zhang J., Gao L., Qian X.P., Chen W.F. Heterogeneity within medullary-type TCRalphabeta(+)CD3(+)CD4(-)CD8(+) thymocytes in normal mouse thymus. Int. Immunol. 13:2001;313-320.
47. Yamamoto Y., Verma U.N., Prajapati S., Kwak Y.T., Gaynor R.B. Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. Nature. 423:2003;655-659.
48. Yamaoka S., Courtois G., Bessia C., Whiteside S.T., Weil R., Agou F., Kirk H.E., Kay R.J., Israel A. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell. 93:1998;1231-1240.
49. Zheng Y., Vig M., Lyons J., Van Parijs L., Beg A.A. Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function. J. Exp. Med. 197:2003;861-874.