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Volumn 10, Issue 7, 2009, Pages 689-695

Foxp3+ regulatory T cells: Differentiation, specification, subphenotypes

Author keywords

[No Author keywords available]

Indexed keywords

CD103 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR;

EID: 67649170980     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1760     Document Type: Review
Times cited : (425)

References (112)
  • 1
    • 33746342994 scopus 로고    scopus 로고
    • + natural regulatory T cells in dominant self-tolerance and autoimmune disease
    • + natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol. Rev. 212, 8-27 (2006).
    • (2006) Immunol. Rev , vol.212 , pp. 8-27
    • Sakaguchi, S.1
  • 2
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi, S., Yamaguchi, T., Nomura, T. & Ono, M. Regulatory T cells and immune tolerance. Cell 133, 775-787 (2008).
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 3
    • 67649138829 scopus 로고    scopus 로고
    • Regulatory T cells in the control of host-microorganism interactions
    • Belkaid, Y. & Tarbell, K. Regulatory T cells in the control of host-microorganism interactions. Annu. Rev. Immunol. 27, 551-589 (2009).
    • (2009) Annu. Rev. Immunol , vol.27 , pp. 551-589
    • Belkaid, Y.1    Tarbell, K.2
  • 4
    • 31644432589 scopus 로고    scopus 로고
    • Regulatory T cells in immune surveillance and treatment of cancer
    • Yamaguchi, T. & Sakaguchi, S. Regulatory T cells in immune surveillance and treatment of cancer. Semin. Cancer Biol. 16, 115-123 (2006).
    • (2006) Semin. Cancer Biol , vol.16 , pp. 115-123
    • Yamaguchi, T.1    Sakaguchi, S.2
  • 5
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155, 1151-1164 (1995).
    • (1995) J. Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 6
    • 0029659056 scopus 로고    scopus 로고
    • The physiological role of regulatory T cells in the prevention of autoimmunity: The function of the thymus in the generation of the regulatory T cell subset
    • Saoudi, A., Seddon, B., Heath, V., Fowell, D. & Mason, D. The physiological role of regulatory T cells in the prevention of autoimmunity: The function of the thymus in the generation of the regulatory T cell subset. Immunol. Rev. 149, 195-216 (1996).
    • (1996) Immunol. Rev , vol.149 , pp. 195-216
    • Saoudi, A.1    Seddon, B.2    Heath, V.3    Fowell, D.4    Mason, D.5
  • 7
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow, M.E. et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27, 68-73 (2001).
    • (2001) Nat. Genet , vol.27 , pp. 68-73
    • Brunkow, M.E.1
  • 10
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori, S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061 (2003).
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 11
    • 33646168597 scopus 로고    scopus 로고
    • FOXP3: Of mice and men
    • Ziegler, S.F. FOXP3: Of mice and men. Annu. Rev. Immunol. 24 209-226 (2006).
    • (2006) Annu. Rev. Immunol , vol.24 , pp. 209-226
    • Ziegler, S.F.1
  • 12
    • 33645102841 scopus 로고    scopus 로고
    • An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
    • Hsieh, C.S., Zheng, Y., Liang, Y., Fontenot, J.D. & Rudensky, A.Y. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 7, 401-410 (2006).
    • (2006) Nat. Immunol , vol.7 , pp. 401-410
    • Hsieh, C.S.1    Zheng, Y.2    Liang, Y.3    Fontenot, J.D.4    Rudensky, A.Y.5
  • 14
    • 34249814016 scopus 로고    scopus 로고
    • + T cells
    • + T cells. J. Immunol. 178, 7032-7041 (2007).
    • (2007) J. Immunol , vol.178 , pp. 7032-7041
    • Wong, J.1
  • 16
    • 15244354286 scopus 로고    scopus 로고
    • Regulatory T cell lineage specification by the forkhead transcription factor Foxp3
    • Fontenot, J.D. et al. Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 22, 329-341 (2005).
    • (2005) Immunity , vol.22 , pp. 329-341
    • Fontenot, J.D.1
  • 17
    • 10744221289 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. J. Exp. Med. 199, 303-313 (2004).
    • (2004) J. Exp. Med , vol.199 , pp. 303-313
    • Huehn, J.1
  • 18
    • 2942692037 scopus 로고    scopus 로고
    • + T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J. Exp. Med. 199, 1479-1489 (2004).
    • + T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J. Exp. Med. 199, 1479-1489 (2004).
  • 19
    • 33748460087 scopus 로고    scopus 로고
    • + natural regulatory T cells revealed by DNA microarray analysis
    • + natural regulatory T cells revealed by DNA microarray analysis. Int. Immunol. 18, 1197-1209 (2006).
    • (2006) Int. Immunol , vol.18 , pp. 1197-1209
    • Sugimoto, N.1
  • 20
    • 33947600584 scopus 로고    scopus 로고
    • Regulatory T cell development in the absence of functional Foxp3
    • Lin, W. et al. Regulatory T cell development in the absence of functional Foxp3. Nat. Immunol. 8, 359-368 (2007).
    • (2007) Nat. Immunol , vol.8 , pp. 359-368
    • Lin, W.1
  • 21
    • 58149501687 scopus 로고    scopus 로고
    • Foxp3-dependent and independent regulation of the Treg transcriptional signature
    • Hill, J. et al. Foxp3-dependent and independent regulation of the Treg transcriptional signature. Immunity 25, 693-695 (2007).
    • (2007) Immunity , vol.25 , pp. 693-695
    • Hill, J.1
  • 22
    • 33847220736 scopus 로고    scopus 로고
    • Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    • Zheng, Y. et al. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 445, 936-940 (2007).
    • (2007) Nature , vol.445 , pp. 936-940
    • Zheng, Y.1
  • 23
    • 33847242598 scopus 로고    scopus 로고
    • Foxp3 occupancy and regulation of key target genes during T-cell stimulation
    • Marson, A. et al. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 445, 931-935 (2007).
    • (2007) Nature , vol.445 , pp. 931-935
    • Marson, A.1
  • 24
    • 33847373481 scopus 로고    scopus 로고
    • + regulatory T-cells in type 1 diabetes
    • + regulatory T-cells in type 1 diabetes. Diabetes 56, 604-612 (2007).
    • (2007) Diabetes , vol.56 , pp. 604-612
    • Brusko, T.1
  • 26
    • 36749031198 scopus 로고    scopus 로고
    • + regulatory T cells in the NOD mouse model of autoimmune diabetes
    • + regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc. Natl. Acad. Sci. USA 104, 18181-18186 (2007).
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 18181-18186
    • Feuerer, M.1
  • 27
    • 50149099154 scopus 로고    scopus 로고
    • + T cells in the thymic cortex
    • + T cells in the thymic cortex. Proc. Natl. Acad. Sci. USA 105, 11903-11908 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 11903-11908
    • Liston, A.1
  • 28
    • 21244433093 scopus 로고    scopus 로고
    • + T lymphocytes from MHC class II-deficient mice exhibit regulatory activity
    • + T lymphocytes from MHC class II-deficient mice exhibit regulatory activity. J. Immunol. 175, 246-253 (2005).
    • (2005) J. Immunol , vol.175 , pp. 246-253
    • Bienvenu, B.1
  • 29
    • 34249806715 scopus 로고    scopus 로고
    • + regulatory T cells participate in the control of immune responses
    • + regulatory T cells participate in the control of immune responses. J. Immunol. 178, 6901-6911 (2007).
    • (2007) J. Immunol , vol.178 , pp. 6901-6911
    • Stephens, G.L.1    Andersson, J.2    Shevach, E.M.3
  • 31
    • 0033682056 scopus 로고    scopus 로고
    • + immunoregulatory T cells that control autoimmune diabetes
    • + immunoregulatory T cells that control autoimmune diabetes. Immunity 12, 431-440 (2000).
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1
  • 32
    • 13944260538 scopus 로고    scopus 로고
    • Tai, X., Cowan, M., Feigenbaum, L. & Singer, A. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 6 152-162 (2005).
    • Tai, X., Cowan, M., Feigenbaum, L. & Singer, A. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 6 152-162 (2005).
  • 33
    • 0035320679 scopus 로고    scopus 로고
    • + regulatory T cells induced by an agonist self-peptide
    • + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2, 283-284 (2001).
    • (2001) Nat. Immunol , vol.2 , pp. 283-284
    • Jordan, M.S.1
  • 34
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou, I., Sarukhan, A., Klein, L. & von Boehmer, H. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3, 756-763 (2002).
    • (2002) Nat. Immunol , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    von Boehmer, H.4
  • 35
    • 0036568942 scopus 로고    scopus 로고
    • + regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression
    • + regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J. Immunol. 168, 4399-4405 (2002).
    • (2002) J. Immunol , vol.168 , pp. 4399-4405
    • Kawahata, K.1
  • 37
    • 9244244736 scopus 로고    scopus 로고
    • Number of Treg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
    • Van Santen, H.M., Benoist, C. & Mathis, D. Number of Treg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 200, 1221-1230 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 1221-1230
    • Van Santen, H.M.1    Benoist, C.2    Mathis, D.3
  • 39
    • 33748866909 scopus 로고    scopus 로고
    • Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus
    • Bonasio, R. et al. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat. Immunol. 7, 1092-1100 (2006).
    • (2006) Nat. Immunol , vol.7 , pp. 1092-1100
    • Bonasio, R.1
  • 40
    • 4143066714 scopus 로고    scopus 로고
    • + T cell receptors
    • + T cell receptors. Immunity 21, 267-277 (2004).
    • (2004) Immunity , vol.21 , pp. 267-277
    • Hsieh, C.S.1
  • 41
    • 34548680545 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. Immunity 27, 493-504 (2007).
    • (2007) Immunity , vol.27 , pp. 493-504
    • Pacholczyk, R.1
  • 42
    • 60549084941 scopus 로고    scopus 로고
    • + T-cell development in a mouse expressing a transgenic TCR derived from a Treg. Eur. J. Immunol. 39, 234-240 (2009).
    • + T-cell development in a mouse expressing a transgenic TCR derived from a Treg. Eur. J. Immunol. 39, 234-240 (2009).
  • 43
    • 65749120321 scopus 로고    scopus 로고
    • Intraclonal competition limits the fate determination of regulatory T cells in the thymus
    • Bautista, J.L. et al. Intraclonal competition limits the fate determination of regulatory T cells in the thymus. Nat. Immunol. 10, 610-617 (2009).
    • (2009) Nat. Immunol , vol.10 , pp. 610-617
    • Bautista, J.L.1
  • 44
    • 0025933951 scopus 로고
    • Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice
    • Huesmann, M., Scott, B., Kisielow, P. & von Boehmer, H. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell 66, 533-540 (1991).
    • (1991) Cell , vol.66 , pp. 533-540
    • Huesmann, M.1    Scott, B.2    Kisielow, P.3    von Boehmer, H.4
  • 46
    • 37849009964 scopus 로고    scopus 로고
    • A two-step process for thymic regulatory T cell development
    • Lio, C.W. & Hsieh, C.S. A two-step process for thymic regulatory T cell development. Immunity 28, 100-111 (2008).
    • (2008) Immunity , vol.28 , pp. 100-111
    • Lio, C.W.1    Hsieh, C.S.2
  • 47
    • 37849008688 scopus 로고    scopus 로고
    • Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire
    • Burchill, M.A. et al. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 28, 112-121 (2008).
    • (2008) Immunity , vol.28 , pp. 112-121
    • Burchill, M.A.1
  • 48
    • 33748448717 scopus 로고    scopus 로고
    • Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    • Li, M.O., Sanjabi, S. & Flavell, R.A. Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 25, 455-471 (2006).
    • (2006) Immunity , vol.25 , pp. 455-471
    • Li, M.O.1    Sanjabi, S.2    Flavell, R.A.3
  • 50
    • 51649112340 scopus 로고    scopus 로고
    • T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance
    • Pesu, M. et al. T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. Nature 455, 246-250 (2008).
    • (2008) Nature , vol.455 , pp. 246-250
    • Pesu, M.1
  • 51
    • 44049087148 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. Nat. Immunol. 9, 632-640 (2008).
    • (2008) Nat. Immunol , vol.9 , pp. 632-640
    • Liu, Y.1
  • 52
    • 1842480966 scopus 로고    scopus 로고
    • + regulatory and natural killer-like T cells on signals leading to NF-κB activation
    • + regulatory and natural killer-like T cells on signals leading to NF-κB activation. Proc. Natl. Acad. Sci. USA 101, 4566-4571 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4566-4571
    • Schmidt-Supprian, M.1
  • 53
    • 54349086262 scopus 로고    scopus 로고
    • Differential requirement of PKC-θ in the development and function of natural regulatory T cells
    • Gupta, S. et al. Differential requirement of PKC-θ in the development and function of natural regulatory T cells. Mol. Immunol. 46, 213-224 (2008).
    • (2008) Mol. Immunol , vol.46 , pp. 213-224
    • Gupta, S.1
  • 54
    • 65549114796 scopus 로고    scopus 로고
    • Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery
    • Barnes, M.J. et al. Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery. PLoS Biol. 7, e51 (2009).
    • (2009) PLoS Biol , vol.7
    • Barnes, M.J.1
  • 55
    • 65549146581 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. J. Immunol. 182, 6736-6743 (2009).
    • (2009) J. Immunol , vol.182 , pp. 6736-6743
    • Molinero, L.L.1
  • 56
    • 60549113390 scopus 로고    scopus 로고
    • Differential requirement for CARMA1 in agonist-selected T-cell development
    • Medoff, B.D. et al. Differential requirement for CARMA1 in agonist-selected T-cell development. Eur. J. Immunol. 39, 78-84 (2009).
    • (2009) Eur. J. Immunol , vol.39 , pp. 78-84
    • Medoff, B.D.1
  • 57
    • 0141678951 scopus 로고    scopus 로고
    • Mature T cells depend on signaling through the IKK complex
    • Schmidt-Supprian, M. et al. Mature T cells depend on signaling through the IKK complex. Immunity 19, 377-389 (2003).
    • (2003) Immunity , vol.19 , pp. 377-389
    • Schmidt-Supprian, M.1
  • 58
    • 33748999526 scopus 로고    scopus 로고
    • TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells
    • Sato, S. et al. TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int. Immunol. 18, 1405-1411 (2006).
    • (2006) Int. Immunol , vol.18 , pp. 1405-1411
    • Sato, S.1
  • 59
    • 33746111852 scopus 로고    scopus 로고
    • The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
    • Wan, Y.Y., Chi, H., Xie, M., Schneider, M.D. & Flavell, R.A. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat. Immunol. 7, 851-858 (2006).
    • (2006) Nat. Immunol , vol.7 , pp. 851-858
    • Wan, Y.Y.1    Chi, H.2    Xie, M.3    Schneider, M.D.4    Flavell, R.A.5
  • 61
    • 45549098562 scopus 로고    scopus 로고
    • T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
    • Sauer, S. et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc. Natl. Acad. Sci. USA 105, 7797-7802 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 7797-7802
    • Sauer, S.1
  • 62
    • 10744228165 scopus 로고    scopus 로고
    • Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance
    • Zheng, X.X. et al. Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance. Immunity 19, 503-514 (2003).
    • (2003) Immunity , vol.19 , pp. 503-514
    • Zheng, X.X.1
  • 64
    • 33845915103 scopus 로고    scopus 로고
    • + regulatory T cells cultured with rapamycin
    • + regulatory T cells cultured with rapamycin. J. Immunol. 178, 320-329 (2007).
    • (2007) J. Immunol , vol.178 , pp. 320-329
    • Strauss, L.1
  • 65
    • 33847218321 scopus 로고    scopus 로고
    • + T cells in mice
    • + T cells in mice. Transpl. Immunol. 17, 153-161 (2007).
    • (2007) Transpl. Immunol , vol.17 , pp. 153-161
    • Qu, Y.1
  • 66
    • 66949173728 scopus 로고    scopus 로고
    • mTor diferentially regulates effector and regulatory T cell lineage commitment
    • in the press
    • Delgoffe, G.M. mTor diferentially regulates effector and regulatory T cell lineage commitment. Immunity (in the press).
    • Immunity
    • Delgoffe, G.M.1
  • 67
    • 58849118836 scopus 로고    scopus 로고
    • Epigenetic control of FOXP3 expression: The key to a stable regulatory T-cell lineage?
    • Huehn, J., Polansky, J.K. & Hamann, A. Epigenetic control of FOXP3 expression: The key to a stable regulatory T-cell lineage? Nat. Rev. Immunol. 9, 83-89 (2009).
    • (2009) Nat. Rev. Immunol , vol.9 , pp. 83-89
    • Huehn, J.1    Polansky, J.K.2    Hamann, A.3
  • 68
    • 44849118564 scopus 로고    scopus 로고
    • Rethinking the molecular definition of regulatory T cells
    • Hori, S. Rethinking the molecular definition of regulatory T cells. Eur. J. Immunol. 38, 928-930 (2008).
    • (2008) Eur. J. Immunol , vol.38 , pp. 928-930
    • Hori, S.1
  • 69
    • 33847153417 scopus 로고    scopus 로고
    • Foxp3-dependent programme of regulatory T-cell differentiation
    • Gavin, M.A. et al. Foxp3-dependent programme of regulatory T-cell differentiation. Nature 445, 771-775 (2007).
    • (2007) Nature , vol.445 , pp. 771-775
    • Gavin, M.A.1
  • 70
    • 33745211931 scopus 로고    scopus 로고
    • Defective regulatory and effector T cell functions in patients with FOXP3 mutations
    • Bacchetta, R. et al. Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J. Clin. Invest. 116, 1713-1722 (2006).
    • (2006) J. Clin. Invest , vol.116 , pp. 1713-1722
    • Bacchetta, R.1
  • 71
    • 65449136307 scopus 로고    scopus 로고
    • A central role for induced regulatory T cells in tolerance induction in experimental colitis
    • Haribhai, D. et al. A central role for induced regulatory T cells in tolerance induction in experimental colitis. J. Immunol. 182 3461-3468 (2009).
    • (2009) J. Immunol , vol.182 , pp. 3461-3468
    • Haribhai, D.1
  • 72
    • 59749103715 scopus 로고    scopus 로고
    • Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3
    • Allan, S.E., Song-Zhao, G.X., Abraham, T., McMurchy, A.N. & Levings, M.K. Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3. Eur. J. Immunol. 38, 3282-3289 (2008).
    • (2008) Eur. J. Immunol , vol.38 , pp. 3282-3289
    • Allan, S.E.1    Song-Zhao, G.X.2    Abraham, T.3    McMurchy, A.N.4    Levings, M.K.5
  • 74
    • 33846980131 scopus 로고    scopus 로고
    • Epigenetic control of the foxp3 locus in regulatory T cells
    • Floess, S. et al. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol. 5, e38 (2007).
    • (2007) PLoS Biol , vol.5
    • Floess, S.1
  • 75
    • 60149085254 scopus 로고    scopus 로고
    • A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells
    • Yu, A., Zhu, L., Altman, N.H. & Malek, T.R. A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells. Immunity 30, 204-217 (2009).
    • (2009) Immunity , vol.30 , pp. 204-217
    • Yu, A.1    Zhu, L.2    Altman, N.H.3    Malek, T.R.4
  • 76
    • 0348223787 scopus 로고    scopus 로고
    • + regulatory T cells by TGF-β induction of transcription factor Foxp3
    • + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
    • (2003) J. Exp. Med , vol.198 , pp. 1875-1886
    • Chen, W.1
  • 77
    • 2142645808 scopus 로고    scopus 로고
    • - T cells through Foxp3 induction and down-regulation of Smad7
    • - T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 172, 5149-5153 (2004).
    • (2004) J. Immunol , vol.172 , pp. 5149-5153
    • Fantini, M.C.1
  • 78
    • 29244435493 scopus 로고    scopus 로고
    • Inducing and expanding regulatory T cell populations by foreign antigen
    • Kretschmer, K. et al. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 6, 1219-1227 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 1219-1227
    • Kretschmer, K.1
  • 79
    • 2542420993 scopus 로고    scopus 로고
    • In vivo instruction of suppressor commitment in naive T cells
    • Apostolou, I. & von Boehmer, H. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199, 1401-1408 (2004).
    • (2004) J. Exp. Med , vol.199 , pp. 1401-1408
    • Apostolou, I.1    von Boehmer, H.2
  • 80
    • 42149141724 scopus 로고    scopus 로고
    • Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppression
    • Verginis, P., McLaughlin, K.A., Wucherpfennig, K.W., von, B.H. & Apostolou, I. Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppression. Proc. Natl. Acad. Sci. USA 105, 3479-3484 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 3479-3484
    • Verginis, P.1    McLaughlin, K.A.2    Wucherpfennig, K.W.3    von, B.H.4    Apostolou, I.5
  • 81
    • 22144479379 scopus 로고    scopus 로고
    • Oral tolerance in the absence of naturally occurring Tregs
    • Mucida, D. et al. Oral tolerance in the absence of naturally occurring Tregs. J. Clin. Invest. 115, 1923-1933 (2005).
    • (2005) J. Clin. Invest , vol.115 , pp. 1923-1933
    • Mucida, D.1
  • 82
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun, C.M. et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204, 1775-1785 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 1775-1785
    • Sun, C.M.1
  • 83
    • 46749126890 scopus 로고    scopus 로고
    • + regulatory T cell-dependent and -independent control of allergic inflammation
    • + regulatory T cell-dependent and -independent control of allergic inflammation. Immunity 29, 114-126 (2008).
    • (2008) Immunity , vol.29 , pp. 114-126
    • Curotto de Lafaille, M.A.1
  • 84
    • 27944455288 scopus 로고    scopus 로고
    • Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen
    • Knoechel, B., Lohr, J., Kahn, E., Bluestone, J.A. & Abbas, A.K. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J. Exp. Med. 202, 1375-1386 (2005).
    • (2005) J. Exp. Med , vol.202 , pp. 1375-1386
    • Knoechel, B.1    Lohr, J.2    Kahn, E.3    Bluestone, J.A.4    Abbas, A.K.5
  • 86
    • 0035180067 scopus 로고    scopus 로고
    • Control of intestinal inflammation by regulatory T cells
    • Singh, B. et al. Control of intestinal inflammation by regulatory T cells. Immunol. Rev. 182, 190-200 (2001).
    • (2001) Immunol. Rev , vol.182 , pp. 190-200
    • Singh, B.1
  • 87
    • 0041884743 scopus 로고    scopus 로고
    • + regulatory T cells in the steady state
    • + regulatory T cells in the steady state. J. Exp. Med. 198, 737-746 (2003).
    • (2003) J. Exp. Med , vol.198 , pp. 737-746
    • Fisson, S.1
  • 88
    • 59649118664 scopus 로고    scopus 로고
    • Antigen-specific peripheral shaping of the natural regulatory T cell population
    • Lathrop, S.K., Santacruz, N.A., Pham, D., Luo, J. & Hsieh, C.S. Antigen-specific peripheral shaping of the natural regulatory T cell population. J. Exp. Med. 205, 3105-3117 (2008).
    • (2008) J. Exp. Med , vol.205 , pp. 3105-3117
    • Lathrop, S.K.1    Santacruz, N.A.2    Pham, D.3    Luo, J.4    Hsieh, C.S.5
  • 89
    • 34548381245 scopus 로고    scopus 로고
    • TCR-based lineage tracing: No evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets
    • Wong, J., Mathis, D. & Benoist, C. TCR-based lineage tracing: No evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets. J. Exp. Med. 204, 2039-2045 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 2039-2045
    • Wong, J.1    Mathis, D.2    Benoist, C.3
  • 90
    • 34147128572 scopus 로고    scopus 로고
    • Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
    • Korn, T. et al. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat. Med. 13, 423-431 (2007).
    • (2007) Nat. Med , vol.13 , pp. 423-431
    • Korn, T.1
  • 92
    • 60549089435 scopus 로고    scopus 로고
    • + Treg cells by infective larvae determines the outcome of filarial infection
    • + Treg cells by infective larvae determines the outcome of filarial infection. Eur. J. Immunol. 39, 192-206 (2009).
    • (2009) Eur. J. Immunol , vol.39 , pp. 192-206
    • Taylor, M.D.1
  • 93
    • 32244442562 scopus 로고    scopus 로고
    • TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M. & Stockinger, B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 179-189 (2006).
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 94
    • 33646577466 scopus 로고    scopus 로고
    • H17 and regulatory T cells
    • H17 and regulatory T cells. Nature 441, 235-238 (2006).
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1
  • 95
    • 34547188748 scopus 로고    scopus 로고
    • H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8, 967-974 (2007).
    • (2007) Nat. Immunol , vol.8 , pp. 967-974
    • Zhou, L.1
  • 96
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • Yang, X.O. et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29, 44-56 (2008).
    • (2008) Immunity , vol.29 , pp. 44-56
    • Yang, X.O.1
  • 97
    • 43449135305 scopus 로고    scopus 로고
    • H17 cell differentiation by antagonizing RORγt function
    • H17 cell differentiation by antagonizing RORγt function. Nature 453, 236-240 (2008).
    • (2008) Nature , vol.453 , pp. 236-240
    • Zhou, L.1
  • 98
    • 62449202866 scopus 로고    scopus 로고
    • Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches
    • Tsuji, M. et al. Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science 323 1488-1492 (2009).
    • (2009) Science , vol.323 , pp. 1488-1492
    • Tsuji, M.1
  • 99
    • 60549115770 scopus 로고    scopus 로고
    • + T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity
    • + T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc. Natl. Acad. Sci. USA 106, 1903-1908 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 1903-1908
    • Komatsu, N.1
  • 100
    • 65549088243 scopus 로고    scopus 로고
    • IL-17-producing human peripheral regulatory T cells retain suppressive function
    • Beriou, G. et al. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood 113, 4240-4249 (2009).
    • (2009) Blood , vol.113 , pp. 4240-4249
    • Beriou, G.1
  • 102
    • 34250336452 scopus 로고    scopus 로고
    • + regulatory T cells results in tissue-specific inflammatory disease
    • + regulatory T cells results in tissue-specific inflammatory disease. J. Exp. Med. 204, 1335-1347 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 1335-1347
    • Sather, B.D.1
  • 103
    • 40449110125 scopus 로고    scopus 로고
    • + regulatory T cells originate from both naive T cells and naturally occurring naive-like regulatory T cells
    • + regulatory T cells originate from both naive T cells and naturally occurring naive-like regulatory T cells. J. Immunol. 180, 146-155 (2008).
    • (2008) J. Immunol , vol.180 , pp. 146-155
    • Siewert, C.1
  • 104
    • 37549018472 scopus 로고    scopus 로고
    • Characterization of mouse CD4 T cell subsets defined by expression of KLRG1
    • Beyersdorf, N., Ding, X., Tietze, J.K. & Hanke, T. Characterization of mouse CD4 T cell subsets defined by expression of KLRG1. Eur. J. Immunol. 37, 3445-3454 (2007).
    • (2007) Eur. J. Immunol , vol.37 , pp. 3445-3454
    • Beyersdorf, N.1    Ding, X.2    Tietze, J.K.3    Hanke, T.4
  • 105
    • 27144524938 scopus 로고    scopus 로고
    • Migration matters: Regulatory T-cell compartmentalization determines suppressive activity in vivo
    • Siegmund, K. et al. Migration matters: Regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood 106, 3097-3104 (2005).
    • (2005) Blood , vol.106 , pp. 3097-3104
    • Siegmund, K.1
  • 106
    • 46949111560 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells maintain immune homeostasis in the skin
    • Dudda, J.C., Perdue, N., Bachtanian, E. & Campbell, D.J. Foxp3+ regulatory T cells maintain immune homeostasis in the skin. J. Exp. Med. 205, 1559-1565 (2008).
    • (2008) J. Exp. Med , vol.205 , pp. 1559-1565
    • Dudda, J.C.1    Perdue, N.2    Bachtanian, E.3    Campbell, D.J.4
  • 107
    • 62649165369 scopus 로고    scopus 로고
    • H2 responses
    • H2 responses. Nature 458 351-356 (2009).
    • (2009) Nature , vol.458 , pp. 351-356
    • Zheng, Y.1
  • 108
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch, M.A. et al. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 10, 595-602 (2009).
    • (2009) Nat. Immunol , vol.10 , pp. 595-602
    • Koch, M.A.1
  • 109
    • 34247264407 scopus 로고    scopus 로고
    • Trawling for treasure: Tales of T-bet
    • Glimcher, L.H. Trawling for treasure: Tales of T-bet. Nat. Immunol. 8, 448-450 (2007).
    • (2007) Nat. Immunol , vol.8 , pp. 448-450
    • Glimcher, L.H.1
  • 110
    • 2542442633 scopus 로고    scopus 로고
    • Transcriptional control of early B cell development
    • Busslinger, M. Transcriptional control of early B cell development. Annu. Rev. Immunol. 22, 55-79 (2004).
    • (2004) Annu. Rev. Immunol , vol.22 , pp. 55-79
    • Busslinger, M.1
  • 112
    • 0037117557 scopus 로고    scopus 로고
    • T-bet regulates IgG class switching and pathogenic autoantibody production
    • Peng, S.L., Szabo, S.J. & Glimcher, L.H. T-bet regulates IgG class switching and pathogenic autoantibody production. Proc. Natl. Acad. Sci. USA 99, 5545-5550 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 5545-5550
    • Peng, S.L.1    Szabo, S.J.2    Glimcher, L.H.3


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