A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells

Nature Immunology

Volumn 13, Issue 10, 2012, Pages 972-980

  Fu, Wenxian ^a   Ergun, Ayla ^a,b   Lu, Ting ^b,c   Hill, Jonathan A ^a,g   Haxhinasto, Sokol ^a,h   Fassett, Marlys S ^a   Gazit, Roi ^d   Adoro, Stanley ^e   Glimcher, Laurie ^e   Chan, Susan ^f   Kastner, Philippe ^f   Rossi, Derrick ^d   Collins, James J ^b   Mathis, Diane ^a   Benoist, Christophe ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Boston University   (United States)

^c University of Illinois at Urbana Champaign   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^g Tempero Pharmaceuticals   (United States)

^h BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON REGULATORY FACTOR 4; LYMPHOID ENHANCER FACTOR 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EOS; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 1; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; GENE EXPRESSION; GENE SWITCHING; GENE TARGETING; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD4; CELL DIFFERENTIATION; COMPUTATIONAL BIOLOGY; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GATA1 TRANSCRIPTION FACTOR; HUMANS; IKAROS TRANSCRIPTION FACTOR; INTERFERON REGULATORY FACTORS; LYMPHOCYTE ACTIVATION; LYMPHOID ENHANCER-BINDING FACTOR 1; MATRIX ATTACHMENT REGION BINDING PROTEINS; MICE; MICE, INBRED C57BL; SERINE ENDOPEPTIDASES; T-LYMPHOCYTES, REGULATORY; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84866533054     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2420     Document Type: Article

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