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Volumn 9, Issue 6, 2008, Pages 632-640

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

EID: 44049087148     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1607     Document Type: Article
Times cited : (484)

References (51)
  • 1
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • Bluestone, J.A. & Abbas, A.K. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3, 253-257 (2003).
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 2
    • 16844363097 scopus 로고    scopus 로고
    • A well adapted regulatory contrivance: Regulatory T cell development and the forkhead family transcription factor Foxp3
    • Fontenot, J.D. & Rudensky, A.Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 6, 331-337 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 331-337
    • Fontenot, J.D.1    Rudensky, A.Y.2
  • 3
    • 33846526212 scopus 로고    scopus 로고
    • reg cells: Guardians for life. Nat. Immunol. 8, 124-125 (2007).
    • reg cells: Guardians for life. Nat. Immunol. 8, 124-125 (2007).
  • 4
    • 0034716925 scopus 로고    scopus 로고
    • Sakaguchi, S. Regulatory T cells: Key controllers of immunologic self-tolerance. Cell 101, 455-458 (2000).
    • Sakaguchi, S. Regulatory T cells: Key controllers of immunologic self-tolerance. Cell 101, 455-458 (2000).
  • 5
    • 34547749066 scopus 로고    scopus 로고
    • Emerging challenges in regulatory T cell function and biology
    • Sakaguchi, S. & Powrie, F. Emerging challenges in regulatory T cell function and biology. Science 317, 627-629 (2007).
    • (2007) Science , vol.317 , pp. 627-629
    • Sakaguchi, S.1    Powrie, F.2
  • 6
    • 16844378209 scopus 로고    scopus 로고
    • Natural regulatory T cells and self-tolerance
    • Schwartz, R.H. Natural regulatory T cells and self-tolerance. Nat. Immunol. 6, 327-330 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 327-330
    • Schwartz, R.H.1
  • 7
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • + suppressor T cells: More questions than answers. Nat. Rev. Immunol. 2, 389-400 (2002).
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 8
    • 16844362608 scopus 로고    scopus 로고
    • Mechanisms of suppression by suppressor T cells
    • von Boehmer, H. Mechanisms of suppression by suppressor T cells. Nat. Immunol. 6, 338-344 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 338-344
    • von Boehmer, H.1
  • 9
    • 33746342782 scopus 로고    scopus 로고
    • Infectious tolerance and the long-term acceptance of transplanted tissue
    • Waldmann, H., Adams, E., Fairchild, P. & Cobbold, S. Infectious tolerance and the long-term acceptance of transplanted tissue. Immunol. Rev. 212, 301-313 (2006).
    • (2006) Immunol. Rev , vol.212 , pp. 301-313
    • Waldmann, H.1    Adams, E.2    Fairchild, P.3    Cobbold, S.4
  • 13
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou, I., Sarukhan, A., Klein, L. & von Boehmer, H. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3, 756-763 (2002).
    • (2002) Nat. Immunol , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    von Boehmer, H.4
  • 14
    • 0035320679 scopus 로고    scopus 로고
    • + regulatory T cells induced by an agonist self-peptide
    • + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2, 301-306 (2001).
    • (2001) Nat. Immunol , vol.2 , pp. 301-306
    • Jordan, M.S.1
  • 15
    • 9244244736 scopus 로고    scopus 로고
    • Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
    • van Santen, H.M., Benoist, C. & Mathis, D. Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 200, 1221-1230 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 1221-1230
    • van Santen, H.M.1    Benoist, C.2    Mathis, D.3
  • 17
    • 0033682056 scopus 로고    scopus 로고
    • + immunoregulatory T cells that control autoimmune diabetes
    • + immunoregulatory T cells that control autoimmune diabetes. Immunity 12, 431-440 (2000).
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1
  • 18
    • 13944260538 scopus 로고    scopus 로고
    • Tai, X., Cowan, M., Feigenbaum, L. & Singer, A. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 6 152-162 (2005).
    • Tai, X., Cowan, M., Feigenbaum, L. & Singer, A. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 6 152-162 (2005).
  • 19
  • 20
    • 27544446622 scopus 로고    scopus 로고
    • + regulatory T cells in the absence of interleukin 2 signaling
    • + regulatory T cells in the absence of interleukin 2 signaling. Nat. Immunol. 6, 1152-1159 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 1152-1159
    • D'Cruz, L.M.1    Klein, L.2
  • 21
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot, J.D., Rasmussen, J.P., Gavin, M.A. & Rudensky, A.Y. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6, 1142-1151 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 22
    • 4544241811 scopus 로고    scopus 로고
    • Tolerance, not immunity, crucially depends on IL-2
    • Malek, T.R. & Bayer, A.L. Tolerance, not immunity, crucially depends on IL-2. Nat. Rev. Immunol. 4, 665-674 (2004).
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 665-674
    • Malek, T.R.1    Bayer, A.L.2
  • 23
    • 0027531528 scopus 로고
    • Transforming growth factor-β null mutation in mice causes excessive inflammatory response and early death
    • Kulkarni, A.B. et al. Transforming growth factor-β null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. USA 90, 770-774 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 770-774
    • Kulkarni, A.B.1
  • 24
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
    • Shull, M.M. et al. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature 359, 693-699 (1992).
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1
  • 25
    • 33646577466 scopus 로고    scopus 로고
    • H17 and regulatory T cells
    • H17 and regulatory T cells. Nature 441, 235-238 (2006).
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1
  • 26
    • 33845942398 scopus 로고    scopus 로고
    • Th3 cells in peripheral tolerance. II. TGF-β-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity
    • Carrier, Y., Yuan, J., Kuchroo, V.K. & Weiner, H.L. Th3 cells in peripheral tolerance. II. TGF-β-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity. J. Immunol. 178, 172-178 (2007).
    • (2007) J. Immunol , vol.178 , pp. 172-178
    • Carrier, Y.1    Yuan, J.2    Kuchroo, V.K.3    Weiner, H.L.4
  • 27
    • 0348223787 scopus 로고    scopus 로고
    • + regulatory T cells by TGF-β induction of transcription factor Foxp3
    • + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
    • (2003) J. Exp. Med , vol.198 , pp. 1875-1886
    • Chen, W.1
  • 29
    • 2142645808 scopus 로고    scopus 로고
    • - T cells through Foxp3 induction and down-regulation of Smad7
    • - T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 172, 5149-5153 (2004).
    • (2004) J. Immunol , vol.172 , pp. 5149-5153
    • Fantini, M.C.1
  • 30
    • 4744356110 scopus 로고    scopus 로고
    • - precursors
    • - precursors. Am. J. Transplant. 4, 1614-1627 (2004).
    • (2004) Am. J. Transplant , vol.4 , pp. 1614-1627
    • Fu, S.1
  • 32
    • 17044430217 scopus 로고    scopus 로고
    • Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter
    • Wan, Y.Y. & Flavell, R.A. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc. Natl. Acad. Sci. USA 102, 5126-5131 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5126-5131
    • Wan, Y.Y.1    Flavell, R.A.2
  • 34
    • 29244435493 scopus 로고    scopus 로고
    • Inducing and expanding regulatory T cell populations by foreign antigen
    • Kretschmer, K. et al. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 6, 1219-1227 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 1219-1227
    • Kretschmer, K.1
  • 36
    • 15444363794 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. J. Exp. Med. 201, 737-746 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 737-746
    • Fahlen, L.1
  • 37
    • 33748448717 scopus 로고    scopus 로고
    • Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    • Li, M.O., Sanjabi, S. & Flavell, R.A. Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 25, 455-471 (2006).
    • (2006) Immunity , vol.25 , pp. 455-471
    • Li, M.O.1    Sanjabi, S.2    Flavell, R.A.3
  • 38
    • 33748465396 scopus 로고    scopus 로고
    • Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-β receptor
    • Marie, J.C., Liggitt, D. & Rudensky, A.Y. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-β receptor. Immunity 25, 441-454 (2006).
    • (2006) Immunity , vol.25 , pp. 441-454
    • Marie, J.C.1    Liggitt, D.2    Rudensky, A.Y.3
  • 39
    • 0029556979 scopus 로고
    • T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination
    • Hennet, T., Hagen, F.K., Tabak, L.A. & Marth, J.D. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc. Natl. Acad. Sci. USA 92 12070-12074 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 12070-12074
    • Hennet, T.1    Hagen, F.K.2    Tabak, L.A.3    Marth, J.D.4
  • 40
    • 0142245613 scopus 로고    scopus 로고
    • TGF-β signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro
    • Larsson, J. et al. TGF-β signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro. Blood 102, 3129-3135 (2003).
    • (2003) Blood , vol.102 , pp. 3129-3135
    • Larsson, J.1
  • 41
    • 0029788211 scopus 로고    scopus 로고
    • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    • Asano, M., Toda, M., Sakaguchi, N. & Sakaguchi, S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184, 387-396 (1996).
    • (1996) J. Exp. Med , vol.184 , pp. 387-396
    • Asano, M.1    Toda, M.2    Sakaguchi, N.3    Sakaguchi, S.4
  • 42
    • 25844504653 scopus 로고    scopus 로고
    • Developmental regulation of Foxp3 expression during ontogeny
    • Fontenot, J.D., Dooley, J.L., Farr, A.G. & Rudensky, A.Y. Developmental regulation of Foxp3 expression during ontogeny. J. Exp. Med. 202, 901-906 (2005).
    • (2005) J. Exp. Med , vol.202 , pp. 901-906
    • Fontenot, J.D.1    Dooley, J.L.2    Farr, A.G.3    Rudensky, A.Y.4
  • 43
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188, 287-296 (1998).
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188, 287-296 (1998).
  • 44
    • 0027405356 scopus 로고
    • Exclusion of circulating T cells from the thymus does not apply in the neonatal period
    • Surh, C.D., Sprent, J. & Webb, S.R. Exclusion of circulating T cells from the thymus does not apply in the neonatal period. J. Exp. Med. 177, 379-385 (1993).
    • (1993) J. Exp. Med , vol.177 , pp. 379-385
    • Surh, C.D.1    Sprent, J.2    Webb, S.R.3
  • 45
    • 33748866909 scopus 로고    scopus 로고
    • Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus
    • Bonasio, R. et al. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat. Immunol. 7, 1092-1100 (2006).
    • (2006) Nat. Immunol , vol.7 , pp. 1092-1100
    • Bonasio, R.1
  • 46
    • 0035920554 scopus 로고    scopus 로고
    • Requirement for transforming growth factor beta1 in controlling T cell apoptosis
    • Chen, W. et al. Requirement for transforming growth factor beta1 in controlling T cell apoptosis. J. Exp. Med. 194, 439-454 (2001).
    • (2001) J. Exp. Med , vol.194 , pp. 439-454
    • Chen, W.1
  • 47
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • Shi, Y. & Massague, J. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113, 685-700 (2003).
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 48
    • 0028070715 scopus 로고
    • Maternal rescue of transforming growth factor-β null mice
    • Letterio, J.J. et al. Maternal rescue of transforming growth factor-β null mice. Science 264, 1936-1938 (1994).
    • (1994) Science , vol.264 , pp. 1936-1938
    • Letterio, J.J.1
  • 50
    • 34247564147 scopus 로고    scopus 로고
    • Nonredundant roles for Stat5a/b in directly regulating Foxp3
    • Yao, Z. et al. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 109, 4368-4375 (2007).
    • (2007) Blood , vol.109 , pp. 4368-4375
    • Yao, Z.1
  • 51
    • 33845879342 scopus 로고    scopus 로고
    • Early events in the thymus affect the balance of effector and regulatory T cells
    • Pennington, D.J. et al. Early events in the thymus affect the balance of effector and regulatory T cells. Nature 444, 1073-1077 (2006).
    • (2006) Nature , vol.444 , pp. 1073-1077
    • Pennington, D.J.1


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