Selective recruitment of regulatory T cell through CCR6-CCL20 in hepatocellular carcinoma fosters tumor progression and predicts poor prognosis

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Chen, Kang Jie ^a   Lin, Sheng Zhang ^a,b   Zhou, Lin ^a   Xie, Hai Yang ^a   Zhou, Wu Hua ^a   Taki Eldin, Ahmed ^a   Zheng, Shu Sen ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b THE SECOND AFFILIATED HOSPITAL AND YUYING CHILDREN S HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD69 ANTIGEN; CHEMOKINE RECEPTOR CCR6; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; TRANSCRIPTION FACTOR FOXP3; CCR6 PROTEIN, HUMAN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER INFILTRATION; CD4+ T LYMPHOCYTE; CELL AGGREGATION; CELL MIGRATION; CELL TRANSPORT; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE FREE SURVIVAL; FEMALE; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PHENOTYPE; PREDICTION; PROGNOSIS; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; TUMOR DIFFERENTIATION; TUMOR GROWTH; TUMOR LOCALIZATION; TUMOR MICROENVIRONMENT; CELL CULTURE; CYTOLOGY; GENETICS; IMMUNOLOGY; LIVER TUMOR; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; CELLS, CULTURED; CHEMOKINE CCL20; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RECEPTORS, CCR6; T-LYMPHOCYTES, REGULATORY;

EID: 80052827580     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024671     Document Type: Article

References (37)

1. Zou W, (2006) Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 6: 295-307.
2. Sakaguchi S, Yamaguchi T, Nomura T, Ono M, (2008) Regulatory T cells and immune tolerance. Cell 133: 775-787.
3. Sakaguchi S, Miyara M, Costantino CM, Hafler DA, (2010) FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 10: 490-500.
4. Wei S, Kryczek I, Zou W, (2006) Regulatory T-cell compartmentalization and trafficking. blood 108: 426-431.
5. Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, et al. (2004) Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 10: 942-949.
6. Gao Q, Qiu SJ, Fan J, Zhou J, Wang XY, et al. (2007) Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol 25: 2586-2593.
7. Beyer M, Schultze JL, (2006) Regulatory T cells in cancer. Blood 108: 804-811.
8. Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL, (2002) CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. nature 420: 502-507.
9. Sakaguchi S, (2005) Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 6: 345-352.
10. Jemal A, Siegel R, Xu J, Ward E, (2010) Cancer statistics, 2010. CA Cancer J Clin 60: 277-300.
11. Ormandy LA, Hillemann T, Wedemeyer H, Manns MP, Greten TF, et al. (2005) Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res 65: 2457-2464.
12. Yang XH, Yamagiwa S, Ichida T, Matsuda Y, Sugahara S, et al. (2006) Increase of CD4+ CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma. J Hepatol 45: 254-262.
13. Fu J, Xu D, Liu Z, Shi M, Zhao P, et al. (2007) Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology 132: 2328-2339.
14. Unitt E, Rushbrook SM, Marshall A, Davies S, Gibbs P, et al. (2005) Compromised lymphocytes infiltrate hepatocellular carcinoma: the role of T-regulatory cells. Hepatology 41: 722-730.
15. Mackay CR, (2008) Moving targets: cell migration inhibitors as new anti-inflammatory therapies. Nat Immunol 9: 988-998.
16. Bromley SK, Mempel TR, Luster AD, (2008) Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat Immunol 9: 970-980.
17. Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, et al. (2006) The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J Immunol 177: 4488-4494.
18. Huehn J, Hamann A, (2005) Homing to suppress: address codes for Treg migration. Trends Immunol 26: 632-636.
19. Gobert M, Treilleux I, Bendriss-Vermare N, Bachelot T, Goddard-Leon S, et al. (2009) Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome. Cancer Res 69: 2000-2009.
20. Wilke CM, Wu K, Zhao E, Wang G, Zou W, (2010) Prognostic significance of regulatory T cells in tumor. Int J Cancer 127: 748-758.
21. Campbell DJ, Koch MA, (2011) Phenotypical and functional specialization of FOXP3(+) regulatory T cells. Nat Rev Immunol 11: 119-130.
22. Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, et al. (2009) C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol 10: 514-523.
23. Sallusto F, Baggiolini M, (2008) Chemokines and leukocyte traffic. Nat Immunol 9: 949-952.
24. Butcher EC, Picker LJ, (1996) Lymphocyte homing and homeostasis. Science 272: 60-66.
25. Warnock RA, Askari S, Butcher EC, von Andrian UH, (1998) Molecular mechanisms of lymphocyte homing to peripheral lymph nodes. J Exp Med 187: 205-216.
26. Nishikawa H, Sakaguchi S, (2010) Regulatory T cells in tumor immunity. Int J Cancer 127: 759-767.
27. Pang YL, Zhang HG, Peng JR, Pang XW, Yu S, et al. (2009) The immunosuppressive tumor microenvironment in hepatocellular carcinoma. Cancer Immunol Immunother 58: 877-886.
28. Vignali DA, Collison LW, Workman CJ, (2008) How regulatory T cells work. Nat Rev Immunol 8: 523-532.
29. Enarsson K, Lundgren A, Kindlund B, Hermansson M, Roncador G, et al. (2006) Function and recruitment of mucosal regulatory T cells in human chronic Helicobacter pylori infection and gastric adenocarcinoma. Clin Immunol 121: 358-368.
30. Yang ZZ, Novak AJ, Stenson MJ, Witzig TE, Ansell SM, (2006) Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma. blood 107: 3639-3646.
31. Yamazaki T, Yang XO, Chung Y, Fukunaga A, Nurieva R, et al. (2008) CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol 181: 8391-8401.
32. Xu L, Xu W, Qiu S, Xiong S, (2010) Enrichment of CCR6+Foxp3+ regulatory T cells in the tumor mass correlates with impaired CD8+ T cell function and poor prognosis of breast cancer. Clin Immunol 135: 466-475.
33. Liu JL, Zhang N, Li Q, Zhang WW, Ke F, et al. (2011) Tumor-Associated Macrophages Recruit CCR6+ Regulatory T Cells and Promote the Development of Colorectal Cancer via Enhancing CCL20 Production in Mice. PLoS One 6: e19495.
34. Siegmund K, Feuerer M, Siewert C, Ghani S, Haubold U, et al. (2005) Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood 106: 3097-3104.
35. Zhou J, Ding T, Pan W, Zhu LY, Li L, et al. (2009) Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients. Int J Cancer 125: 1640-1648.
36. Lu J, Wu DM, Zheng YL, Hu B, Zhang ZF, et al. (2010) Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity. J Pathol 222: 199-212.
37. Yoong KF, Afford SC, Jones R, Aujla P, Qin S, et al. (1999) Expression and function of CXC and CC chemokines in human malignant liver tumors: a role for human monokine induced by gamma-interferon in lymphocyte recruitment to hepatocellular carcinoma. Hepatology 30: 100-111.