T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

Immunity

Volumn 37, Issue 5, 2012, Pages 785-799

  Ohkura, Naganari ^a,b   Hamaguchi, Masahide ^a,b   Morikawa, Hiromasa ^a,b   Sugimura, Kyoko ^b   Tanaka, Atsushi ^b   Ito, Yoshinaga ^b   Osaki, Motonao ^a,b   Tanaka, Yoshiaki ^c   Yamashita, Riu ^c   Nakano, Naoko ^d   Huehn, Jochen ^e   Fehling, Hans Joerg ^f   Sparwasser, Tim ^g   Nakai, Kenta ^c,h   Sakaguchi, Shimon ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d TOKYO UNIVERSITY OF SCIENCE   (Japan)

^e HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^f UNIVERSITY HOSPITAL ULM   (Germany)

^g INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^h JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL FATE; CELL LINEAGE; CELL MATURATION; CELL TYPE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION; GENETIC REGULATION; GENETIC TRANSCRIPTION; HISTONE MODIFICATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; THYMUS;

ANIMALS; DNA METHYLATION; EPIGENESIS, GENETIC; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; HISTONES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, REGULATORY; THYMUS GLAND;

EID: 84869148187     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2012.09.010     Document Type: Article

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