-
1
-
-
84863869789
-
Human limb abnormalities caused by disruption of Hedgehog signaling
-
Anderson E., Peluso S., Lettice L.A., Hill R.E. Human limb abnormalities caused by disruption of Hedgehog signaling. Trends Genet 2012, 28:364-373.
-
(2012)
Trends Genet
, vol.28
, pp. 364-373
-
-
Anderson, E.1
Peluso, S.2
Lettice, L.A.3
Hill, R.E.4
-
2
-
-
80054022786
-
Gli proteins in development and disease
-
Hui C.C., Angers S. Gli proteins in development and disease. Annu Rev Cell Dev Biol 2011, 27:513-537.
-
(2011)
Annu Rev Cell Dev Biol
, vol.27
, pp. 513-537
-
-
Hui, C.C.1
Angers, S.2
-
3
-
-
57049089995
-
Hedgehog signaling in development and cancer
-
Jiang J., Hui C.C. Hedgehog signaling in development and cancer. Dev Cell 2008, 15:801-812.
-
(2008)
Dev Cell
, vol.15
, pp. 801-812
-
-
Jiang, J.1
Hui, C.C.2
-
4
-
-
73349130440
-
Drosophila genome-wide obesity screen reveals Hedgehog as a determinant of brown versus white adipose cell fate
-
Pospisilik J.A., Schramek D., Schnidar H., Cronin S.J., Nehme N.T., Zhang X., Knauf C., Cani P.D., Aumayr K., Todoric J., Bayer M., Haschemi A., Puviindran V., Tar K., Orthofer M., Neely G.G., Dietzl G., Manoukian A., Funovics M., Prager G., Wagner O., Ferrandon D., Aberger F., Hui C.C., Esterbauer H., Penninger J.M. Drosophila genome-wide obesity screen reveals Hedgehog as a determinant of brown versus white adipose cell fate. Cell 2010, 140:148-160.
-
(2010)
Cell
, vol.140
, pp. 148-160
-
-
Pospisilik, J.A.1
Schramek, D.2
Schnidar, H.3
Cronin, S.J.4
Nehme, N.T.5
Zhang, X.6
Knauf, C.7
Cani, P.D.8
Aumayr, K.9
Todoric, J.10
Bayer, M.11
Haschemi, A.12
Puviindran, V.13
Tar, K.14
Orthofer, M.15
Neely, G.G.16
Dietzl, G.17
Manoukian, A.18
Funovics, M.19
Prager, G.20
Wagner, O.21
Ferrandon, D.22
Aberger, F.23
Hui, C.C.24
Esterbauer, H.25
Penninger, J.M.26
more..
-
5
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
Reya T., Morrison S.J., Clarke M.F., Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature 2001, 414:105-111.
-
(2001)
Nature
, vol.414
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
6
-
-
84875953755
-
Stem cell metabolism in tissue development and aging
-
Shyh-Chang N., Daley G.Q., Cantley L.C. Stem cell metabolism in tissue development and aging. Development 2013, 140:2535-2547.
-
(2013)
Development
, vol.140
, pp. 2535-2547
-
-
Shyh-Chang, N.1
Daley, G.Q.2
Cantley, L.C.3
-
7
-
-
0037223971
-
The evolution of signalling pathways in animal development
-
Pires-daSilva A., Sommer R.J. The evolution of signalling pathways in animal development. Nat Rev Genet 2003, 4:39-49.
-
(2003)
Nat Rev Genet
, vol.4
, pp. 39-49
-
-
Pires-daSilva, A.1
Sommer, R.J.2
-
8
-
-
34848901657
-
The Gli code: an information nexus regulating cell fate, stemness and cancer
-
Ruiz i Altaba A., Mas C., Stecca B. The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol 2007, 17:438-447.
-
(2007)
Trends Cell Biol
, vol.17
, pp. 438-447
-
-
Ruiz i Altaba, A.1
Mas, C.2
Stecca, B.3
-
9
-
-
77952898697
-
Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals
-
Stecca B., Ruiz A., Altaba I. Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals. J Mol Cell Biol 2010, 2:84-95.
-
(2010)
J Mol Cell Biol
, vol.2
, pp. 84-95
-
-
Stecca, B.1
Ruiz, A.2
Altaba, I.3
-
10
-
-
84883457798
-
Morphogen interpretation: the transcriptional logic of neural tube patterning
-
Cohen M., Briscoe J., Blassberg R. Morphogen interpretation: the transcriptional logic of neural tube patterning. Curr Opin Genet Dev 2013, 23:423-428.
-
(2013)
Curr Opin Genet Dev
, vol.23
, pp. 423-428
-
-
Cohen, M.1
Briscoe, J.2
Blassberg, R.3
-
12
-
-
66149131842
-
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein
-
Beauchamp E., Bulut G., Abaan O., Chen K., Merchant A., Matsui W., Endo Y., Rubin J.S., Toretsky J., Uren A. GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J Biol Chem 2009, 284:9074-9082.
-
(2009)
J Biol Chem
, vol.284
, pp. 9074-9082
-
-
Beauchamp, E.1
Bulut, G.2
Abaan, O.3
Chen, K.4
Merchant, A.5
Matsui, W.6
Endo, Y.7
Rubin, J.S.8
Toretsky, J.9
Uren, A.10
-
13
-
-
34547120220
-
Induction of sonic Hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo
-
Dennler S., André J., Alexaki I., Li A., Magnaldo T., ten Dijke P., Wang X.J., Verrecchia F., Mauviel A. Induction of sonic Hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res 2007, 67:6981-6986.
-
(2007)
Cancer Res
, vol.67
, pp. 6981-6986
-
-
Dennler, S.1
André, J.2
Alexaki, I.3
Li, A.4
Magnaldo, T.5
ten Dijke, P.6
Wang, X.J.7
Verrecchia, F.8
Mauviel, A.9
-
14
-
-
84858142098
-
Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells
-
Eberl M., Klingler S., Mangelberger D., Loipetzberger A., Damhofer H., Zoidl K., Schnidar H., Hache H., Bauer H.C., Solca F., Hauser-Kronberger C., Ermilov A.N., Verhaegen M.E., Bichakjian C.K., Dlugosz A.A., Nietfeld W., Sibilia M., Lehrach H., Wierling C., Aberger F. Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells. EMBO Mol Med 2012, 4:218-233.
-
(2012)
EMBO Mol Med
, vol.4
, pp. 218-233
-
-
Eberl, M.1
Klingler, S.2
Mangelberger, D.3
Loipetzberger, A.4
Damhofer, H.5
Zoidl, K.6
Schnidar, H.7
Hache, H.8
Bauer, H.C.9
Solca, F.10
Hauser-Kronberger, C.11
Ermilov, A.N.12
Verhaegen, M.E.13
Bichakjian, C.K.14
Dlugosz, A.A.15
Nietfeld, W.16
Sibilia, M.17
Lehrach, H.18
Wierling, C.19
Aberger, F.20
more..
-
15
-
-
33847314199
-
Fibroblast growth factor blocks Sonic Hedgehog signaling in neuronal precursors and tumor cells
-
Fogarty M.P., Emmenegger B.A., Grasfeder L.L., Oliver T.G., Wechsler-Reya R.J. Fibroblast growth factor blocks Sonic Hedgehog signaling in neuronal precursors and tumor cells. Proc Natl Acad Sci U S A 2007, 104:2973-2978.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 2973-2978
-
-
Fogarty, M.P.1
Emmenegger, B.A.2
Grasfeder, L.L.3
Oliver, T.G.4
Wechsler-Reya, R.J.5
-
16
-
-
34249878895
-
Phorbol esters inhibit the Hedgehog signalling pathway downstream of Suppressor of Fused, but upstream of Gli
-
Lauth M., Bergström A., Toftgård R. Phorbol esters inhibit the Hedgehog signalling pathway downstream of Suppressor of Fused, but upstream of Gli. Oncogene 2007, 26:5163-5168.
-
(2007)
Oncogene
, vol.26
, pp. 5163-5168
-
-
Lauth, M.1
Bergström, A.2
Toftgård, R.3
-
17
-
-
58149506283
-
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
-
Nolan-Stevaux O., Lau J., Truitt M.L., Chu G.C., Hebrok M., Fernández-Zapico M.E., Hanahan D. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev 2009, 23:24-36.
-
(2009)
Genes Dev
, vol.23
, pp. 24-36
-
-
Nolan-Stevaux, O.1
Lau, J.2
Truitt, M.L.3
Chu, G.C.4
Hebrok, M.5
Fernández-Zapico, M.E.6
Hanahan, D.7
-
18
-
-
31544461492
-
Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in Hedgehog signaling
-
Riobo N.A., Haines G.M., Emerson C.P. Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in Hedgehog signaling. Cancer Res 2006, 66:839-845.
-
(2006)
Cancer Res
, vol.66
, pp. 839-845
-
-
Riobo, N.A.1
Haines, G.M.2
Emerson, C.P.3
-
19
-
-
33645220566
-
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
-
Riobó N.A., Lu K., Ai X., Haines G.M., Emerson C.P. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc Natl Acad Sci U S A 2006, 103:4505-4510.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 4505-4510
-
-
Riobó, N.A.1
Lu, K.2
Ai, X.3
Haines, G.M.4
Emerson, C.P.5
-
20
-
-
60549104260
-
Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway
-
Schnidar H., Eberl M., Klingler S., Mangelberger D., Kasper M., Hauser-Kronberger C., Regl G., Kroismayr R., Moriggl R., Sibilia M., Aberger F. Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway. Cancer Res 2009, 69:1284-1292.
-
(2009)
Cancer Res
, vol.69
, pp. 1284-1292
-
-
Schnidar, H.1
Eberl, M.2
Klingler, S.3
Mangelberger, D.4
Kasper, M.5
Hauser-Kronberger, C.6
Regl, G.7
Kroismayr, R.8
Moriggl, R.9
Sibilia, M.10
Aberger, F.11
-
21
-
-
34347226348
-
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
-
Stecca B., Mas C., Clement V., Zbinden M., Correa R., Piguet V., Beermann F., Ruiz A., Altaba I. Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc Natl Acad Sci U S A 2007, 104:5895-5900.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 5895-5900
-
-
Stecca, B.1
Mas, C.2
Clement, V.3
Zbinden, M.4
Correa, R.5
Piguet, V.6
Beermann, F.7
Ruiz, A.8
Altaba, I.9
-
22
-
-
84865528807
-
Glucocorticoid compounds modify smoothened localization and Hedgehog pathway activity
-
Wang Y., Davidow L., Arvanites A.C., Blanchard J., Lam K., Xu K., Oza V., Yoo J.W., Ng J.M., Curran T., Rubin L.L., McMahon A.P. Glucocorticoid compounds modify smoothened localization and Hedgehog pathway activity. Chem Biol 2012, 19:972-982.
-
(2012)
Chem Biol
, vol.19
, pp. 972-982
-
-
Wang, Y.1
Davidow, L.2
Arvanites, A.C.3
Blanchard, J.4
Lam, K.5
Xu, K.6
Oza, V.7
Yoo, J.W.8
Ng, J.M.9
Curran, T.10
Rubin, L.L.11
McMahon, A.P.12
-
23
-
-
78049444595
-
Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors
-
Whisenant T.C., Ho D.T., Benz R.W., Rogers J.S., Kaake R.M., Gordon E.A., Huang L., Baldi P., Bardwell L. Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors. PLoS Comput Biol 2010, 6.
-
(2010)
PLoS Comput Biol
, vol.6
-
-
Whisenant, T.C.1
Ho, D.T.2
Benz, R.W.3
Rogers, J.S.4
Kaake, R.M.5
Gordon, E.A.6
Huang, L.7
Baldi, P.8
Bardwell, L.9
-
24
-
-
84863252342
-
Noncanonical Hedgehog signaling
-
Brennan D., Chen X., Cheng L., Mahoney M., Riobo N.A. Noncanonical Hedgehog signaling. Vitam Horm 2012, 88:55-72.
-
(2012)
Vitam Horm
, vol.88
, pp. 55-72
-
-
Brennan, D.1
Chen, X.2
Cheng, L.3
Mahoney, M.4
Riobo, N.A.5
-
25
-
-
0035577854
-
Hedgehog signaling in animal development: paradigms and principles
-
Ingham P.W., McMahon A.P. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001, 15:3059-3087.
-
(2001)
Genes Dev
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
27
-
-
0019133661
-
Mutations affecting segment number and polarity in Drosophila
-
Nüsslein-Volhard C., Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980, 287:795-801.
-
(1980)
Nature
, vol.287
, pp. 795-801
-
-
Nüsslein-Volhard, C.1
Wieschaus, E.2
-
28
-
-
34547110771
-
Patched1 regulates Hedgehog signaling at the primary cilium
-
Rohatgi R., Milenkovic L., Scott M.P. Patched1 regulates Hedgehog signaling at the primary cilium. Science 2007, 317:372-376.
-
(2007)
Science
, vol.317
, pp. 372-376
-
-
Rohatgi, R.1
Milenkovic, L.2
Scott, M.P.3
-
29
-
-
31744451535
-
Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
-
Svärd J., Heby-Henricson K., Henricson K.H., Persson-Lek M., Rozell B., Lauth M., Bergström A., Ericson J., Toftgård R., Teglund S. Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell 2006, 10:187-197.
-
(2006)
Dev Cell
, vol.10
, pp. 187-197
-
-
Svärd, J.1
Heby-Henricson, K.2
Henricson, K.H.3
Persson-Lek, M.4
Rozell, B.5
Lauth, M.6
Bergström, A.7
Ericson, J.8
Toftgård, R.9
Teglund, S.10
-
30
-
-
31744436876
-
Divergence of Hedgehog signal transduction mechanism between Drosophila and mammals
-
Varjosalo M., Li S.P., Taipale J. Divergence of Hedgehog signal transduction mechanism between Drosophila and mammals. Dev Cell 2006, 10:177-186.
-
(2006)
Dev Cell
, vol.10
, pp. 177-186
-
-
Varjosalo, M.1
Li, S.P.2
Taipale, J.3
-
31
-
-
77951101203
-
The primary cilium: a signalling centre during vertebrate development
-
Goetz S.C., Anderson K.V. The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet 2010, 11:331-344.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 331-344
-
-
Goetz, S.C.1
Anderson, K.V.2
-
32
-
-
84899921559
-
Cilia-mediated Hedgehog signaling in Drosophila
-
Kuzhandaivel A., Schultz S.W., Alkhori L., Alenius M. Cilia-mediated Hedgehog signaling in Drosophila. Cell Rep 2014, 7:1-9.
-
(2014)
Cell Rep
, vol.7
, pp. 1-9
-
-
Kuzhandaivel, A.1
Schultz, S.W.2
Alkhori, L.3
Alenius, M.4
-
33
-
-
0030866154
-
Altered neural cell fates and medulloblastoma in mouse patched mutants
-
Goodrich L.V., Milenković L., Higgins K.M., Scott M.P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 1997, 277:1109-1113.
-
(1997)
Science
, vol.277
, pp. 1109-1113
-
-
Goodrich, L.V.1
Milenković, L.2
Higgins, K.M.3
Scott, M.P.4
-
34
-
-
15844386165
-
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
-
Hahn H., Wicking C., Zaphiropoulous P.G., Gailani M.R., Shanley S., Chidambaram A., Vorechovsky I., Holmberg E., Unden A.B., Gillies S., Negus K., Smyth I., Pressman C., Leffell D.J., Gerrard B., Goldstein A.M., Dean M., Toftgard R., Chenevix-Trench G., Wainwright B., Bale A.E. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996, 85:841-851.
-
(1996)
Cell
, vol.85
, pp. 841-851
-
-
Hahn, H.1
Wicking, C.2
Zaphiropoulous, P.G.3
Gailani, M.R.4
Shanley, S.5
Chidambaram, A.6
Vorechovsky, I.7
Holmberg, E.8
Unden, A.B.9
Gillies, S.10
Negus, K.11
Smyth, I.12
Pressman, C.13
Leffell, D.J.14
Gerrard, B.15
Goldstein, A.M.16
Dean, M.17
Toftgard, R.18
Chenevix-Trench, G.19
Wainwright, B.20
Bale, A.E.21
more..
-
35
-
-
0025072659
-
Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched
-
Hidalgo A., Ingham P. Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched. Development 1990, 110:291-301.
-
(1990)
Development
, vol.110
, pp. 291-301
-
-
Hidalgo, A.1
Ingham, P.2
-
36
-
-
0025815911
-
Role of the Drosophila patched gene in positional signalling
-
Ingham P.W., Taylor A.M., Nakano Y. Role of the Drosophila patched gene in positional signalling. Nature 1991, 353:184-187.
-
(1991)
Nature
, vol.353
, pp. 184-187
-
-
Ingham, P.W.1
Taylor, A.M.2
Nakano, Y.3
-
37
-
-
15844381336
-
Human homolog of patched, a candidate gene for the basal cell nevus syndrome
-
Johnson R.L., Rothman A.L., Xie J., Goodrich L.V., Bare J.W., Bonifas J.M., Quinn A.G., Myers R.M., Cox D.R., Epstein E.H., Scott M.P. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996, 272:1668-1671.
-
(1996)
Science
, vol.272
, pp. 1668-1671
-
-
Johnson, R.L.1
Rothman, A.L.2
Xie, J.3
Goodrich, L.V.4
Bare, J.W.5
Bonifas, J.M.6
Quinn, A.G.7
Myers, R.M.8
Cox, D.R.9
Epstein, E.H.10
Scott, M.P.11
-
38
-
-
34249007279
-
The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development
-
Allen B.L., Tenzen T., McMahon A.P. The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev 2007, 21:1244-1257.
-
(2007)
Genes Dev
, vol.21
, pp. 1244-1257
-
-
Allen, B.L.1
Tenzen, T.2
McMahon, A.P.3
-
39
-
-
77956814604
-
Interactions between Hedgehog proteins and their binding partners come into view
-
Beachy P.A., Hymowitz S.G., Lazarus R.A., Leahy D.J., Siebold C. Interactions between Hedgehog proteins and their binding partners come into view. Genes Dev 2010, 24:2001-2012.
-
(2010)
Genes Dev
, vol.24
, pp. 2001-2012
-
-
Beachy, P.A.1
Hymowitz, S.G.2
Lazarus, R.A.3
Leahy, D.J.4
Siebold, C.5
-
40
-
-
34249011892
-
Gas1 extends the range of Hedgehog action by facilitating its signaling
-
Martinelli D.C., Fan C.M. Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev 2007, 21:1231-1243.
-
(2007)
Genes Dev
, vol.21
, pp. 1231-1243
-
-
Martinelli, D.C.1
Fan, C.M.2
-
41
-
-
54049122121
-
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla
-
McLellan J.S., Zheng X., Hauk G., Ghirlando R., Beachy P.A., Leahy D.J. The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature 2008, 455:979-983.
-
(2008)
Nature
, vol.455
, pp. 979-983
-
-
McLellan, J.S.1
Zheng, X.2
Hauk, G.3
Ghirlando, R.4
Beachy, P.A.5
Leahy, D.J.6
-
42
-
-
33646035770
-
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation
-
Yao S., Lum L., Beachy P. The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell 2006, 125:343-357.
-
(2006)
Cell
, vol.125
, pp. 343-357
-
-
Yao, S.1
Lum, L.2
Beachy, P.3
-
43
-
-
0029784223
-
Smoothened encodes a receptor-like serpentine protein required for Hedgehog signalling
-
van den Heuvel M., Ingham P.W. smoothened encodes a receptor-like serpentine protein required for Hedgehog signalling. Nature 1996, 382:547-551.
-
(1996)
Nature
, vol.382
, pp. 547-551
-
-
van den Heuvel, M.1
Ingham, P.W.2
-
44
-
-
75549090700
-
Lateral transport of smoothened from the plasma membrane to the membrane of the cilium
-
Milenkovic L., Scott M.P., Rohatgi R. Lateral transport of smoothened from the plasma membrane to the membrane of the cilium. J Cell Biol 2009, 187:365-374.
-
(2009)
J Cell Biol
, vol.187
, pp. 365-374
-
-
Milenkovic, L.1
Scott, M.P.2
Rohatgi, R.3
-
45
-
-
62549159642
-
Hedgehog signal transduction by smoothened: pharmacologic evidence for a 2-step activation process
-
Rohatgi R., Milenkovic L., Corcoran R.B., Scott M.P. Hedgehog signal transduction by smoothened: pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci U S A 2009, 106:3196-3201.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 3196-3201
-
-
Rohatgi, R.1
Milenkovic, L.2
Corcoran, R.B.3
Scott, M.P.4
-
46
-
-
0037158748
-
Patched acts catalytically to suppress the activity of smoothened
-
Taipale J., Cooper M.K., Maiti T., Beachy P.A. Patched acts catalytically to suppress the activity of smoothened. Nature 2002, 418:892-897.
-
(2002)
Nature
, vol.418
, pp. 892-897
-
-
Taipale, J.1
Cooper, M.K.2
Maiti, T.3
Beachy, P.A.4
-
47
-
-
33744788672
-
Oxysterols stimulate sonic Hedgehog signal transduction and proliferation of medulloblastoma cells
-
Corcoran R.B., Scott M.P. Oxysterols stimulate sonic Hedgehog signal transduction and proliferation of medulloblastoma cells. Proc Natl Acad Sci U S A 2006, 103:8408-8413.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 8408-8413
-
-
Corcoran, R.B.1
Scott, M.P.2
-
48
-
-
34247844371
-
Oxysterols are novel activators of the Hedgehog signaling pathway in pluripotent mesenchymal cells
-
Dwyer J.R., Sever N., Carlson M., Nelson S.F., Beachy P.A., Parhami F. Oxysterols are novel activators of the Hedgehog signaling pathway in pluripotent mesenchymal cells. J Biol Chem 2007, 282:8959-8968.
-
(2007)
J Biol Chem
, vol.282
, pp. 8959-8968
-
-
Dwyer, J.R.1
Sever, N.2
Carlson, M.3
Nelson, S.F.4
Beachy, P.A.5
Parhami, F.6
-
49
-
-
84856098531
-
Oxysterols are allosteric activators of the oncoprotein Smoothened
-
Nachtergaele S., Mydock L.K., Krishnan K., Rammohan J., Schlesinger P.H., Covey D.F., Rohatgi R. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol 2012, 8:211-220.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 211-220
-
-
Nachtergaele, S.1
Mydock, L.K.2
Krishnan, K.3
Rammohan, J.4
Schlesinger, P.H.5
Covey, D.F.6
Rohatgi, R.7
-
50
-
-
84887326705
-
Structure and function of the smoothened extracellular domain in vertebrate Hedgehog signaling
-
Nachtergaele S., Whalen D.M., Mydock L.K., Zhao Z., Malinauskas T., Krishnan K., Ingham P.W., Covey D.F., Siebold C., Rohatgi R. Structure and function of the smoothened extracellular domain in vertebrate Hedgehog signaling. Elife 2013, 2:e01340.
-
(2013)
Elife
, vol.2
-
-
Nachtergaele, S.1
Whalen, D.M.2
Mydock, L.K.3
Zhao, Z.4
Malinauskas, T.5
Krishnan, K.6
Ingham, P.W.7
Covey, D.F.8
Siebold, C.9
Rohatgi, R.10
-
51
-
-
38949218488
-
Patched, the receptor of Hedgehog, is a lipoprotein receptor
-
Callejo A., Culi J., Guerrero I. Patched, the receptor of Hedgehog, is a lipoprotein receptor. Proc Natl Acad Sci U S A 2008, 105:912-917.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 912-917
-
-
Callejo, A.1
Culi, J.2
Guerrero, I.3
-
52
-
-
71449084811
-
Patched regulates smoothened trafficking using lipoprotein-derived lipids
-
Khaliullina H., Panáková D., Eugster C., Riedel F., Carvalho M., Eaton S. Patched regulates smoothened trafficking using lipoprotein-derived lipids. Development 2009, 136:4111-4121.
-
(2009)
Development
, vol.136
, pp. 4111-4121
-
-
Khaliullina, H.1
Panáková, D.2
Eugster, C.3
Riedel, F.4
Carvalho, M.5
Eaton, S.6
-
53
-
-
32444449871
-
GLI transcription factors: mediators of oncogenic Hedgehog signalling
-
Kasper M., Regl G., Frischauf A.M., Aberger F. GLI transcription factors: mediators of oncogenic Hedgehog signalling. Eur J Cancer 2006, 42:437-445.
-
(2006)
Eur J Cancer
, vol.42
, pp. 437-445
-
-
Kasper, M.1
Regl, G.2
Frischauf, A.M.3
Aberger, F.4
-
54
-
-
84892542938
-
Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling
-
Niewiadomski P., Kong J.H., Ahrends R., Ma Y., Humke E.W., Khan S., Teruel M.N., Novitch B.G., Rohatgi R. Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling. Cell Rep 2013, 6:1-14.
-
(2013)
Cell Rep
, vol.6
, pp. 1-14
-
-
Niewiadomski, P.1
Kong, J.H.2
Ahrends, R.3
Ma, Y.4
Humke, E.W.5
Khan, S.6
Teruel, M.N.7
Novitch, B.G.8
Rohatgi, R.9
-
55
-
-
77950463564
-
The output of Hedgehog signaling is controlled by the dynamic association between suppressor of fused and the gli proteins
-
Humke E.W., Dorn K.V., Milenkovic L., Scott M.P., Rohatgi R. The output of Hedgehog signaling is controlled by the dynamic association between suppressor of fused and the gli proteins. Genes Dev 2010, 24:670-682.
-
(2010)
Genes Dev
, vol.24
, pp. 670-682
-
-
Humke, E.W.1
Dorn, K.V.2
Milenkovic, L.3
Scott, M.P.4
Rohatgi, R.5
-
56
-
-
76049114315
-
Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
-
Kim J., Kato M., Beachy P.A. Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proc Natl Acad Sci U S A 2009, 106:21666-21671.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 21666-21671
-
-
Kim, J.1
Kato, M.2
Beachy, P.A.3
-
57
-
-
0032756914
-
Proteolysis of Cubitus interruptus in Drosophila requires phosphorylation by protein kinase A
-
Price M.A., Kalderon D. Proteolysis of Cubitus interruptus in Drosophila requires phosphorylation by protein kinase A. Development 1999, 126:4331-4339.
-
(1999)
Development
, vol.126
, pp. 4331-4339
-
-
Price, M.A.1
Kalderon, D.2
-
58
-
-
23144466931
-
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
-
Liu A., Wang B., Niswander L.A. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 2005, 132:3103-3111.
-
(2005)
Development
, vol.132
, pp. 3103-3111
-
-
Liu, A.1
Wang, B.2
Niswander, L.A.3
-
59
-
-
0034681266
-
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
-
Wang B., Fallon J.F., Beachy P.A. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 2000, 100:423-434.
-
(2000)
Cell
, vol.100
, pp. 423-434
-
-
Wang, B.1
Fallon, J.F.2
Beachy, P.A.3
-
60
-
-
77958508124
-
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes
-
Tukachinsky H., Lopez L.V., Salic A. A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. J Cell Biol 2010, 191:415-428.
-
(2010)
J Cell Biol
, vol.191
, pp. 415-428
-
-
Tukachinsky, H.1
Lopez, L.V.2
Salic, A.3
-
61
-
-
77950671813
-
Kinetics of Hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation
-
Wen X., Lai C.K., Evangelista M., Hongo J.A., de Sauvage F.J., Scales S.J. Kinetics of Hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation. Mol Cell Biol 2010, 30:1910-1922.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 1910-1922
-
-
Wen, X.1
Lai, C.K.2
Evangelista, M.3
Hongo, J.A.4
de Sauvage, F.J.5
Scales, S.J.6
-
62
-
-
84872508509
-
The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic Hedgehog pathway via cAMP signaling
-
Mukhopadhyay S., Wen X., Ratti N., Loktev A., Rangell L., Scales S.J., Jackson P.K. The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic Hedgehog pathway via cAMP signaling. Cell 2013, 152:210-223.
-
(2013)
Cell
, vol.152
, pp. 210-223
-
-
Mukhopadhyay, S.1
Wen, X.2
Ratti, N.3
Loktev, A.4
Rangell, L.5
Scales, S.J.6
Jackson, P.K.7
-
63
-
-
72449171640
-
Sonic-Hedgehog-mediated proliferation requires the localization of PKA to the cilium base
-
Barzi M., Berenguer J., Menendez A., Alvarez-Rodriguez R., Pons S. Sonic-Hedgehog-mediated proliferation requires the localization of PKA to the cilium base. J Cell Sci 2010, 123:62-69.
-
(2010)
J Cell Sci
, vol.123
, pp. 62-69
-
-
Barzi, M.1
Berenguer, J.2
Menendez, A.3
Alvarez-Rodriguez, R.4
Pons, S.5
-
64
-
-
0033194243
-
Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1
-
Kogerman P., Grimm T., Kogerman L., Krause D., Undén A.B., Sandstedt B., Toftgård R., Zaphiropoulos P.G. Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1. Nat Cell Biol 1999, 1:312-319.
-
(1999)
Nat Cell Biol
, vol.1
, pp. 312-319
-
-
Kogerman, P.1
Grimm, T.2
Kogerman, L.3
Krause, D.4
Undén, A.B.5
Sandstedt, B.6
Toftgård, R.7
Zaphiropoulos, P.G.8
-
65
-
-
0033583035
-
Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
-
Dai P., Akimaru H., Tanaka Y., Maekawa T., Nakafuku M., Ishii S. Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J Biol Chem 1999, 274:8143-8152.
-
(1999)
J Biol Chem
, vol.274
, pp. 8143-8152
-
-
Dai, P.1
Akimaru, H.2
Tanaka, Y.3
Maekawa, T.4
Nakafuku, M.5
Ishii, S.6
-
66
-
-
2942618679
-
GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter
-
Ikram M.S., Neill G.W., Regl G., Eichberger T., Frischauf A.M., Aberger F., Quinn A., Philpott M. GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. J Invest Dermatol 2004, 122:1503-1509.
-
(2004)
J Invest Dermatol
, vol.122
, pp. 1503-1509
-
-
Ikram, M.S.1
Neill, G.W.2
Regl, G.3
Eichberger, T.4
Frischauf, A.M.5
Aberger, F.6
Quinn, A.7
Philpott, M.8
-
67
-
-
0037103909
-
Human GLI2 and GLI1 are part of a positive feedback mechanism in basal cell carcinoma
-
Regl G., Neill G.W., Eichberger T., Kasper M., Ikram M.S., Koller J., Hintner H., Quinn A.G., Frischauf A.M., Aberger F. Human GLI2 and GLI1 are part of a positive feedback mechanism in basal cell carcinoma. Oncogene 2002, 21:5529-5539.
-
(2002)
Oncogene
, vol.21
, pp. 5529-5539
-
-
Regl, G.1
Neill, G.W.2
Eichberger, T.3
Kasper, M.4
Ikram, M.S.5
Koller, J.6
Hintner, H.7
Quinn, A.G.8
Frischauf, A.M.9
Aberger, F.10
-
68
-
-
0033214342
-
Gli proteins and Hedgehog signaling: development and cancer
-
Ruiz i Altaba A. Gli proteins and Hedgehog signaling: development and cancer. Trends Genet 1999, 15:418-425.
-
(1999)
Trends Genet
, vol.15
, pp. 418-425
-
-
Ruiz i Altaba, A.1
-
69
-
-
0036559186
-
Gli and Hedgehog in cancer: tumours, embryos and stem cells
-
Ruiz i Altaba A., Sánchez P., Dahmane N. Gli and Hedgehog in cancer: tumours, embryos and stem cells. Nat Rev Cancer 2002, 2:361-372.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 361-372
-
-
Ruiz i Altaba, A.1
Sánchez, P.2
Dahmane, N.3
-
70
-
-
3042798261
-
Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function
-
Kristiansen K. Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function. Pharmacol Ther 2004, 103:21-80.
-
(2004)
Pharmacol Ther
, vol.103
, pp. 21-80
-
-
Kristiansen, K.1
-
71
-
-
84878112106
-
Structure of the human smoothened receptor bound to an antitumour agent
-
Wang C., Wu H., Katritch V., Han G.W., Huang X.P., Liu W., Siu F.Y., Roth B.L., Cherezov V., Stevens R.C. Structure of the human smoothened receptor bound to an antitumour agent. Nature 2013, 497:338-343.
-
(2013)
Nature
, vol.497
, pp. 338-343
-
-
Wang, C.1
Wu, H.2
Katritch, V.3
Han, G.W.4
Huang, X.P.5
Liu, W.6
Siu, F.Y.7
Roth, B.L.8
Cherezov, V.9
Stevens, R.C.10
-
72
-
-
84867536639
-
Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat
-
Teperino R., Amann S., Bayer M., McGee S.L., Loipetzberger A., Connor T., Jaeger C., Kammerer B., Winter L., Wiche G., Dalgaard K., Selvaraj M., Gaster M., Lee-Young R.S., Febbraio M.A., Knauf C., Cani P.D., Aberger F., Penninger J.M., Pospisilik J.A., Esterbauer H. Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell 2012, 151:414-426.
-
(2012)
Cell
, vol.151
, pp. 414-426
-
-
Teperino, R.1
Amann, S.2
Bayer, M.3
McGee, S.L.4
Loipetzberger, A.5
Connor, T.6
Jaeger, C.7
Kammerer, B.8
Winter, L.9
Wiche, G.10
Dalgaard, K.11
Selvaraj, M.12
Gaster, M.13
Lee-Young, R.S.14
Febbraio, M.A.15
Knauf, C.16
Cani, P.D.17
Aberger, F.18
Penninger, J.M.19
Pospisilik, J.A.20
Esterbauer, H.21
more..
-
73
-
-
84883051342
-
Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response
-
Myers B.R., Sever N., Chong Y.C., Kim J., Belani J.D., Rychnovsky S., Bazan J.F., Beachy P.A. Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. Dev Cell 2013, 26:346-357.
-
(2013)
Dev Cell
, vol.26
, pp. 346-357
-
-
Myers, B.R.1
Sever, N.2
Chong, Y.C.3
Kim, J.4
Belani, J.D.5
Rychnovsky, S.6
Bazan, J.F.7
Beachy, P.A.8
-
74
-
-
84883185477
-
Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling
-
Nedelcu D., Liu J., Xu Y., Jao C., Salic A. Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling. Nat Chem Biol 2013, 9:557-564.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 557-564
-
-
Nedelcu, D.1
Liu, J.2
Xu, Y.3
Jao, C.4
Salic, A.5
-
75
-
-
36049033946
-
Hedgehog regulates smoothened activity by inducing a conformational switch
-
Zhao Y., Tong C., Jiang J. Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 2007, 450:252-258.
-
(2007)
Nature
, vol.450
, pp. 252-258
-
-
Zhao, Y.1
Tong, C.2
Jiang, J.3
-
76
-
-
84874290371
-
Smoothened is a fully competent activator of the heterotrimeric G protein G(i)
-
Shen F., Cheng L., Douglas A.E., Riobo N.A., Manning D.R. Smoothened is a fully competent activator of the heterotrimeric G protein G(i). Mol Pharmacol 2013, 83:691-697.
-
(2013)
Mol Pharmacol
, vol.83
, pp. 691-697
-
-
Shen, F.1
Cheng, L.2
Douglas, A.E.3
Riobo, N.A.4
Manning, D.R.5
-
77
-
-
79957613017
-
Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration
-
Polizio A.H., Chinchilla P., Chen X., Kim S., Manning D.R., Riobo N.A. Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration. J Biol Chem 2011, 286:19589-19596.
-
(2011)
J Biol Chem
, vol.286
, pp. 19589-19596
-
-
Polizio, A.H.1
Chinchilla, P.2
Chen, X.3
Kim, S.4
Manning, D.R.5
Riobo, N.A.6
-
78
-
-
11144256194
-
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2
-
Chen W., Ren X.R., Nelson C.D., Barak L.S., Chen J.K., Beachy P.A., de Sauvage F., Lefkowitz R.J. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science 2004, 306:2257-2260.
-
(2004)
Science
, vol.306
, pp. 2257-2260
-
-
Chen, W.1
Ren, X.R.2
Nelson, C.D.3
Barak, L.S.4
Chen, J.K.5
Beachy, P.A.6
de Sauvage, F.7
Lefkowitz, R.J.8
-
79
-
-
77956805860
-
G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
-
Chen Y., Li S., Tong C., Zhao Y., Wang B., Liu Y., Jia J., Jiang J. G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes Dev 2010, 24:2054-2067.
-
(2010)
Genes Dev
, vol.24
, pp. 2054-2067
-
-
Chen, Y.1
Li, S.2
Tong, C.3
Zhao, Y.4
Wang, B.5
Liu, Y.6
Jia, J.7
Jiang, J.8
-
80
-
-
26644460824
-
Vertebrate smoothened functions at the primary cilium
-
Corbit K.C., Aanstad P., Singla V., Norman A.R., Stainier D.Y., Reiter J.F. Vertebrate smoothened functions at the primary cilium. Nature 2005, 437:1018-1021.
-
(2005)
Nature
, vol.437
, pp. 1018-1021
-
-
Corbit, K.C.1
Aanstad, P.2
Singla, V.3
Norman, A.R.4
Stainier, D.Y.5
Reiter, J.F.6
-
81
-
-
46449127054
-
Beta-arrestin-mediated localization of smoothened to the primary cilium
-
Kovacs J.J., Whalen E.J., Liu R., Xiao K., Kim J., Chen M., Wang J., Chen W., Lefkowitz R.J. Beta-arrestin-mediated localization of smoothened to the primary cilium. Science 2008, 320:1777-1781.
-
(2008)
Science
, vol.320
, pp. 1777-1781
-
-
Kovacs, J.J.1
Whalen, E.J.2
Liu, R.3
Xiao, K.4
Kim, J.5
Chen, M.6
Wang, J.7
Chen, W.8
Lefkowitz, R.J.9
-
82
-
-
10744233219
-
Hedgehog signal transduction via smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2
-
Lum L., Zhang C., Oh S., Mann R.K., von Kessler D.P., Taipale J., Weis-Garcia F., Gong R., Wang B., Beachy P.A. Hedgehog signal transduction via smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell 2003, 12:1261-1274.
-
(2003)
Mol Cell
, vol.12
, pp. 1261-1274
-
-
Lum, L.1
Zhang, C.2
Oh, S.3
Mann, R.K.4
von Kessler, D.P.5
Taipale, J.6
Weis-Garcia, F.7
Gong, R.8
Wang, B.9
Beachy, P.A.10
-
83
-
-
80052515585
-
The Hedgehog-induced smoothened conformational switch assembles a signaling complex that activates fused by promoting its dimerization and phosphorylation
-
Shi Q., Li S., Jia J., Jiang J. The Hedgehog-induced smoothened conformational switch assembles a signaling complex that activates fused by promoting its dimerization and phosphorylation. Development 2011, 138:4219-4231.
-
(2011)
Development
, vol.138
, pp. 4219-4231
-
-
Shi, Q.1
Li, S.2
Jia, J.3
Jiang, J.4
-
84
-
-
11144285406
-
Beta-arrestin 2 regulates zebrafish development through the Hedgehog signaling pathway
-
Wilbanks A.M., Fralish G.B., Kirby M.L., Barak L.S., Li Y.X., Caron M.G. Beta-arrestin 2 regulates zebrafish development through the Hedgehog signaling pathway. Science 2004, 306:2264-2267.
-
(2004)
Science
, vol.306
, pp. 2264-2267
-
-
Wilbanks, A.M.1
Fralish, G.B.2
Kirby, M.L.3
Barak, L.S.4
Li, Y.X.5
Caron, M.G.6
-
85
-
-
57049085407
-
G protein Galphai functions immediately downstream of smoothened in Hedgehog signalling
-
Ogden S.K., Fei D.L., Schilling N.S., Ahmed Y.F., Hwa J., Robbins D.J. G protein Galphai functions immediately downstream of smoothened in Hedgehog signalling. Nature 2008, 456:967-970.
-
(2008)
Nature
, vol.456
, pp. 967-970
-
-
Ogden, S.K.1
Fei, D.L.2
Schilling, N.S.3
Ahmed, Y.F.4
Hwa, J.5
Robbins, D.J.6
-
86
-
-
0032519906
-
The effect of pertussis toxin on zebrafish development: a possible role for inhibitory G-proteins in Hedgehog signaling
-
Hammerschmidt M., McMahon A.P. The effect of pertussis toxin on zebrafish development: a possible role for inhibitory G-proteins in Hedgehog signaling. Dev Biol 1998, 194:166-171.
-
(1998)
Dev Biol
, vol.194
, pp. 166-171
-
-
Hammerschmidt, M.1
McMahon, A.P.2
-
87
-
-
49049108307
-
The decoupling of smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning
-
Low W.C., Wang C., Pan Y., Huang X.Y., Chen J.K., Wang B. The decoupling of smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning. Dev Biol 2008, 321:188-196.
-
(2008)
Dev Biol
, vol.321
, pp. 188-196
-
-
Low, W.C.1
Wang, C.2
Pan, Y.3
Huang, X.Y.4
Chen, J.K.5
Wang, B.6
-
88
-
-
79953138390
-
Sonic Hedgehog-induced proliferation requires specific Gα inhibitory proteins
-
Barzi M., Kostrz D., Menendez A., Pons S. Sonic Hedgehog-induced proliferation requires specific Gα inhibitory proteins. J Biol Chem 2011, 286:8067-8074.
-
(2011)
J Biol Chem
, vol.286
, pp. 8067-8074
-
-
Barzi, M.1
Kostrz, D.2
Menendez, A.3
Pons, S.4
-
89
-
-
77951932085
-
Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways
-
Chinchilla P., Xiao L., Kazanietz M.G., Riobo N.A. Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways. Cell Cycle 2010, 9:570-579.
-
(2010)
Cell Cycle
, vol.9
, pp. 570-579
-
-
Chinchilla, P.1
Xiao, L.2
Kazanietz, M.G.3
Riobo, N.A.4
-
90
-
-
81855183838
-
Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins
-
Sonic, pt7
-
Polizio A.H., Chinchilla P., Chen X., Manning D.R., Riobo N.A., Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins. Sci Signal 2011, 4:pt7.
-
(2011)
Sci Signal
, vol.4
-
-
Polizio, A.H.1
Chinchilla, P.2
Chen, X.3
Manning, D.R.4
Riobo, N.A.5
-
91
-
-
84894106141
-
Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma
-
Razumilava N., Gradilone S.A., Smoot R.L., Mertens J.C., Bronk S.F., Sirica A.E., Gores G.J. Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma. J Hepatol 2013, 60(3):599-605.
-
(2013)
J Hepatol
, vol.60
, Issue.3
, pp. 599-605
-
-
Razumilava, N.1
Gradilone, S.A.2
Smoot, R.L.3
Mertens, J.C.4
Bronk, S.F.5
Sirica, A.E.6
Gores, G.J.7
-
92
-
-
84865306296
-
Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium
-
Bijlsma M.F., Damhofer H., Roelink H. Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium. Sci Signal 2012, 5:ra60.
-
(2012)
Sci Signal
, vol.5
-
-
Bijlsma, M.F.1
Damhofer, H.2
Roelink, H.3
-
93
-
-
79952733097
-
Sonic Hedgehog signaling is decoded by calcium spike activity in the developing spinal cord
-
Belgacem Y.H., Borodinsky L.N. Sonic Hedgehog signaling is decoded by calcium spike activity in the developing spinal cord. Proc Natl Acad Sci U S A 2011, 108:4482-4487.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 4482-4487
-
-
Belgacem, Y.H.1
Borodinsky, L.N.2
-
94
-
-
84881082520
-
Trimeric G protein-CARMA1 axis links smoothened, the Hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma
-
Qu C., Liu Y., Kunkalla K., Singh R.R., Blonska M., Lin X., Agarwal N.K., Vega F. Trimeric G protein-CARMA1 axis links smoothened, the Hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma. Blood 2013, 121:4718-4728.
-
(2013)
Blood
, vol.121
, pp. 4718-4728
-
-
Qu, C.1
Liu, Y.2
Kunkalla, K.3
Singh, R.R.4
Blonska, M.5
Lin, X.6
Agarwal, N.K.7
Vega, F.8
-
95
-
-
0347623882
-
The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic Hedgehog signalling
-
Kasai K., Takahashi M., Osumi N., Sinnarajah S., Takeo T., Ikeda H., Kehrl J.H., Itoh G., Arnheiter H. The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic Hedgehog signalling. Genes Cells 2004, 9:49-58.
-
(2004)
Genes Cells
, vol.9
, pp. 49-58
-
-
Kasai, K.1
Takahashi, M.2
Osumi, N.3
Sinnarajah, S.4
Takeo, T.5
Ikeda, H.6
Kehrl, J.H.7
Itoh, G.8
Arnheiter, H.9
-
96
-
-
80052204865
-
The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened
-
Douglas A.E., Heim J.A., Shen F., Almada L.L., Riobo N.A., Fernández-Zapico M.E., Manning D.R. The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened. J Biol Chem 2011, 286:30714-30722.
-
(2011)
J Biol Chem
, vol.286
, pp. 30714-30722
-
-
Douglas, A.E.1
Heim, J.A.2
Shen, F.3
Almada, L.L.4
Riobo, N.A.5
Fernández-Zapico, M.E.6
Manning, D.R.7
-
97
-
-
0036829397
-
Inhibition of Hedgehog signaling by direct binding of cyclopamine to smoothened
-
Chen J.K., Taipale J., Cooper M.K., Beachy P.A. Inhibition of Hedgehog signaling by direct binding of cyclopamine to smoothened. Genes Dev 2002, 16:2743-2748.
-
(2002)
Genes Dev
, vol.16
, pp. 2743-2748
-
-
Chen, J.K.1
Taipale, J.2
Cooper, M.K.3
Beachy, P.A.4
-
98
-
-
0037195074
-
Small molecule modulation of smoothened activity
-
Chen J.K., Taipale J., Young K.E., Maiti T., Beachy P.A. Small molecule modulation of smoothened activity. Proc Natl Acad Sci U S A 2002, 99:14071-14076.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 14071-14076
-
-
Chen, J.K.1
Taipale, J.2
Young, K.E.3
Maiti, T.4
Beachy, P.A.5
-
99
-
-
33645211374
-
Purmorphamine activates the Hedgehog pathway by targeting smoothened
-
Sinha S., Chen J.K. Purmorphamine activates the Hedgehog pathway by targeting smoothened. Nat Chem Biol 2006, 2:29-30.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 29-30
-
-
Sinha, S.1
Chen, J.K.2
-
100
-
-
84858258693
-
A genome-wide RNAi screen identifies regulators of cholesterol-modified Hedgehog secretion in Drosophila
-
Aikin R., Cervantes A., D'Angelo G., Ruel L., Lacas-Gervais S., Schaub S., Thérond P. A genome-wide RNAi screen identifies regulators of cholesterol-modified Hedgehog secretion in Drosophila. PLoS ONE 2012, 7:e33665.
-
(2012)
PLoS ONE
, vol.7
-
-
Aikin, R.1
Cervantes, A.2
D'Angelo, G.3
Ruel, L.4
Lacas-Gervais, S.5
Schaub, S.6
Thérond, P.7
-
101
-
-
79951850782
-
Processing-dependent trafficking of Sonic Hedgehog to the regulated secretory pathway in neurons
-
Beug S.T., Parks R.J., McBride H.M., Wallace V.A. Processing-dependent trafficking of Sonic Hedgehog to the regulated secretory pathway in neurons. Mol Cell Neurosci 2011, 46:583-596.
-
(2011)
Mol Cell Neurosci
, vol.46
, pp. 583-596
-
-
Beug, S.T.1
Parks, R.J.2
McBride, H.M.3
Wallace, V.A.4
-
102
-
-
0035860538
-
Skinny Hedgehog, an acyltransferase required for palmitoylation and activity of the Hedgehog signal
-
Chamoun Z., Mann R.K., Nellen D., von Kessler D.P., Bellotto M., Beachy P.A., Basler K. Skinny Hedgehog, an acyltransferase required for palmitoylation and activity of the Hedgehog signal. Science 2001, 293:2080-2084.
-
(2001)
Science
, vol.293
, pp. 2080-2084
-
-
Chamoun, Z.1
Mann, R.K.2
Nellen, D.3
von Kessler, D.P.4
Bellotto, M.5
Beachy, P.A.6
Basler, K.7
-
103
-
-
84862594879
-
Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form
-
Creanga A., Glenn T.D., Mann R.K., Saunders A.M., Talbot W.S., Beachy P.A. Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. Genes Dev 2012, 26:1312-1325.
-
(2012)
Genes Dev
, vol.26
, pp. 1312-1325
-
-
Creanga, A.1
Glenn, T.D.2
Mann, R.K.3
Saunders, A.M.4
Talbot, W.S.5
Beachy, P.A.6
-
104
-
-
81855183845
-
Barcoding Hedgehog for intracellular transport
-
Kornberg T.B. Barcoding Hedgehog for intracellular transport. Sci Signal 2011, 4:pe44.
-
(2011)
Sci Signal
, vol.4
-
-
Kornberg, T.B.1
-
105
-
-
33847607092
-
Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling
-
Li Y.X., Yang H.T., Zdanowicz M., Sicklick J.K., Qi Y., Camp T.J., Diehl A.M. Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling. Lab Invest 2007, 87:231-240.
-
(2007)
Lab Invest
, vol.87
, pp. 231-240
-
-
Li, Y.X.1
Yang, H.T.2
Zdanowicz, M.3
Sicklick, J.K.4
Qi, Y.5
Camp, T.J.6
Diehl, A.M.7
-
106
-
-
2942742564
-
Novel lipid modifications of secreted protein signals
-
Mann R.K., Beachy P.A. Novel lipid modifications of secreted protein signals. Annu Rev Biochem 2004, 73:891-923.
-
(2004)
Annu Rev Biochem
, vol.73
, pp. 891-923
-
-
Mann, R.K.1
Beachy, P.A.2
-
107
-
-
84861837671
-
Release and transportation of Hedgehog molecules
-
Thérond P.P. Release and transportation of Hedgehog molecules. Curr Opin Cell Biol 2012, 24:173-180.
-
(2012)
Curr Opin Cell Biol
, vol.24
, pp. 173-180
-
-
Thérond, P.P.1
-
108
-
-
78951481661
-
Human adipose-derived stromal cells stimulate autogenous skeletal repair via paracrine Hedgehog signaling with calvarial osteoblasts
-
Levi B., James A.W., Nelson E.R., Li S., Peng M., Commons G.W., Lee M., Wu B., Longaker M.T. Human adipose-derived stromal cells stimulate autogenous skeletal repair via paracrine Hedgehog signaling with calvarial osteoblasts. Stem Cells Dev 2011, 20:243-257.
-
(2011)
Stem Cells Dev
, vol.20
, pp. 243-257
-
-
Levi, B.1
James, A.W.2
Nelson, E.R.3
Li, S.4
Peng, M.5
Commons, G.W.6
Lee, M.7
Wu, B.8
Longaker, M.T.9
-
109
-
-
61349174523
-
Sonic Hedgehog ligand partners with caveolin-1 for intracellular transport
-
Mao H., Diehl A.M., Li Y.X. Sonic Hedgehog ligand partners with caveolin-1 for intracellular transport. Lab Invest 2009, 89:290-300.
-
(2009)
Lab Invest
, vol.89
, pp. 290-300
-
-
Mao, H.1
Diehl, A.M.2
Li, Y.X.3
-
110
-
-
84891742744
-
Hedgehog pathway agonism: therapeutic potential and small-molecule development
-
Hadden M.K. Hedgehog pathway agonism: therapeutic potential and small-molecule development. ChemMedChem 2013, 9(1):27-37.
-
(2013)
ChemMedChem
, vol.9
, Issue.1
, pp. 27-37
-
-
Hadden, M.K.1
-
111
-
-
3242804594
-
Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat
-
Kha H.T., Basseri B., Shouhed D., Richardson J., Tetradis S., Hahn T.J., Parhami F. Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat. J Bone Miner Res 2004, 19:830-840.
-
(2004)
J Bone Miner Res
, vol.19
, pp. 830-840
-
-
Kha, H.T.1
Basseri, B.2
Shouhed, D.3
Richardson, J.4
Tetradis, S.5
Hahn, T.J.6
Parhami, F.7
-
112
-
-
0344953585
-
A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis
-
Cooper M.K., Wassif C.A., Krakowiak P.A., Taipale J., Gong R., Kelley R.I., Porter F.D., Beachy P.A. A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nat Genet 2003, 33:508-513.
-
(2003)
Nat Genet
, vol.33
, pp. 508-513
-
-
Cooper, M.K.1
Wassif, C.A.2
Krakowiak, P.A.3
Taipale, J.4
Gong, R.5
Kelley, R.I.6
Porter, F.D.7
Beachy, P.A.8
-
113
-
-
0035901616
-
The sterol-sensing domain of patched protein seems to control smoothened activity through patched vesicular trafficking
-
Martín V., Carrillo G., Torroja C., Guerrero I. The sterol-sensing domain of patched protein seems to control smoothened activity through patched vesicular trafficking. Curr Biol 2001, 11:601-607.
-
(2001)
Curr Biol
, vol.11
, pp. 601-607
-
-
Martín, V.1
Carrillo, G.2
Torroja, C.3
Guerrero, I.4
-
114
-
-
0035901572
-
Mutations in the sterol-sensing domain of patched suggest a role for vesicular trafficking in smoothened regulation
-
Strutt H., Thomas C., Nakano Y., Stark D., Neave B., Taylor A.M., Ingham P.W. Mutations in the sterol-sensing domain of patched suggest a role for vesicular trafficking in smoothened regulation. Curr Biol 2001, 11:608-613.
-
(2001)
Curr Biol
, vol.11
, pp. 608-613
-
-
Strutt, H.1
Thomas, C.2
Nakano, Y.3
Stark, D.4
Neave, B.5
Taylor, A.M.6
Ingham, P.W.7
-
115
-
-
0037083492
-
Distinct consequences of sterol sensor mutations in Drosophila and mouse patched homologs
-
Johnson R.L., Zhou L., Bailey E.C. Distinct consequences of sterol sensor mutations in Drosophila and mouse patched homologs. Dev Biol 2002, 242:224-235.
-
(2002)
Dev Biol
, vol.242
, pp. 224-235
-
-
Johnson, R.L.1
Zhou, L.2
Bailey, E.C.3
-
116
-
-
84857003746
-
LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals
-
Christ A., Christa A., Kur E., Lioubinski O., Bachmann S., Willnow T.E., Hammes A. LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals. Dev Cell 2012, 22:268-278.
-
(2012)
Dev Cell
, vol.22
, pp. 268-278
-
-
Christ, A.1
Christa, A.2
Kur, E.3
Lioubinski, O.4
Bachmann, S.5
Willnow, T.E.6
Hammes, A.7
-
117
-
-
0028019068
-
Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family
-
Saito A., Pietromonaco S., Loo A.K., Farquhar M.G. Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. Proc Natl Acad Sci U S A 1994, 91:9725-9729.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 9725-9729
-
-
Saito, A.1
Pietromonaco, S.2
Loo, A.K.3
Farquhar, M.G.4
-
118
-
-
84984766757
-
Megalin and cubilin: multifunctional endocytic receptors
-
Christensen E.I., Birn H. Megalin and cubilin: multifunctional endocytic receptors. Nat Rev Mol Cell Biol 2002, 3:256-266.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 256-266
-
-
Christensen, E.I.1
Birn, H.2
-
119
-
-
34247557490
-
The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions
-
May P., Woldt E., Matz R.L., Boucher P. The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions. Ann Med 2007, 39:219-228.
-
(2007)
Ann Med
, vol.39
, pp. 219-228
-
-
May, P.1
Woldt, E.2
Matz, R.L.3
Boucher, P.4
-
120
-
-
77954949822
-
Role of lipid metabolism in smoothened derepression in Hedgehog signaling
-
Yavari A., Nagaraj R., Owusu-Ansah E., Folick A., Ngo K., Hillman T., Call G., Rohatgi R., Scott M.P., Banerjee U. Role of lipid metabolism in smoothened derepression in Hedgehog signaling. Dev Cell 2010, 19:54-65.
-
(2010)
Dev Cell
, vol.19
, pp. 54-65
-
-
Yavari, A.1
Nagaraj, R.2
Owusu-Ansah, E.3
Folick, A.4
Ngo, K.5
Hillman, T.6
Call, G.7
Rohatgi, R.8
Scott, M.P.9
Banerjee, U.10
-
121
-
-
80052186347
-
Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network
-
Santiago-Tirado F.H., Bretscher A. Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network. Trends Cell Biol 2011, 21:515-525.
-
(2011)
Trends Cell Biol
, vol.21
, pp. 515-525
-
-
Santiago-Tirado, F.H.1
Bretscher, A.2
-
122
-
-
84864848873
-
PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity
-
Hammond G.R., Fischer M.J., Anderson K.E., Holdich J., Koteci A., Balla T., Irvine R.F. PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity. Science 2012, 337:727-730.
-
(2012)
Science
, vol.337
, pp. 727-730
-
-
Hammond, G.R.1
Fischer, M.J.2
Anderson, K.E.3
Holdich, J.4
Koteci, A.5
Balla, T.6
Irvine, R.F.7
-
123
-
-
18344378499
-
Lipoprotein particles are required for Hedgehog and Wingless signalling
-
Panáková D., Sprong H., Marois E., Thiele C., Eaton S. Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature 2005, 435:58-65.
-
(2005)
Nature
, vol.435
, pp. 58-65
-
-
Panáková, D.1
Sprong, H.2
Marois, E.3
Thiele, C.4
Eaton, S.5
-
124
-
-
84885419722
-
Lipoproteins and Hedgehog signalling - possible implications for the adrenal gland function
-
Swierczynska M.M., Lamounier-Zepter V., Bornstein S.R., Eaton S. Lipoproteins and Hedgehog signalling - possible implications for the adrenal gland function. Eur J Clin Invest 2013, 43:1178-1183.
-
(2013)
Eur J Clin Invest
, vol.43
, pp. 1178-1183
-
-
Swierczynska, M.M.1
Lamounier-Zepter, V.2
Bornstein, S.R.3
Eaton, S.4
-
125
-
-
35548983852
-
Lipoproteins and their receptors in embryonic development: more than cholesterol clearance
-
Willnow T.E., Hammes A., Eaton S. Lipoproteins and their receptors in embryonic development: more than cholesterol clearance. Development 2007, 134:3239-3249.
-
(2007)
Development
, vol.134
, pp. 3239-3249
-
-
Willnow, T.E.1
Hammes, A.2
Eaton, S.3
-
126
-
-
44349159118
-
Multiple roles for lipids in the Hedgehog signalling pathway
-
Eaton S. Multiple roles for lipids in the Hedgehog signalling pathway. Nat Rev Mol Cell Biol 2008, 9:437-445.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 437-445
-
-
Eaton, S.1
-
127
-
-
84875452685
-
Secretion and signaling activities of lipoprotein-associated Hedgehog and non-sterol-modified Hedgehog in flies and mammals
-
Palm W., Swierczynska M.M., Kumari V., Ehrhart-Bornstein M., Bornstein S.R., Eaton S. Secretion and signaling activities of lipoprotein-associated Hedgehog and non-sterol-modified Hedgehog in flies and mammals. PLoS Biol 2013, 11:e1001505.
-
(2013)
PLoS Biol
, vol.11
-
-
Palm, W.1
Swierczynska, M.M.2
Kumari, V.3
Ehrhart-Bornstein, M.4
Bornstein, S.R.5
Eaton, S.6
-
128
-
-
78149400975
-
Human plasma very low density lipoprotein carries Indian Hedgehog
-
Queiroz K.C., Tio R.A., Zeebregts C.J., Bijlsma M.F., Zijlstra F., Badlou B., de Vries M., Ferreira C.V., Spek C.A., Peppelenbosch M.P., Rezaee F. Human plasma very low density lipoprotein carries Indian Hedgehog. J Proteome Res 2010, 9:6052-6059.
-
(2010)
J Proteome Res
, vol.9
, pp. 6052-6059
-
-
Queiroz, K.C.1
Tio, R.A.2
Zeebregts, C.J.3
Bijlsma, M.F.4
Zijlstra, F.5
Badlou, B.6
de Vries, M.7
Ferreira, C.V.8
Spek, C.A.9
Peppelenbosch, M.P.10
Rezaee, F.11
-
129
-
-
84879414522
-
The mechanisms of Hedgehog signalling and its roles in development and disease
-
Briscoe J., Thérond P.P. The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol 2013, 14(7):416-429.
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, Issue.7
, pp. 416-429
-
-
Briscoe, J.1
Thérond, P.P.2
-
130
-
-
33645046358
-
Hedgehog signaling plays a conserved role in inhibiting fat formation
-
Suh J.M., Gao X., McKay J., McKay R., Salo Z., Graff J.M. Hedgehog signaling plays a conserved role in inhibiting fat formation. Cell Metab 2006, 3:25-34.
-
(2006)
Cell Metab
, vol.3
, pp. 25-34
-
-
Suh, J.M.1
Gao, X.2
McKay, J.3
McKay, R.4
Salo, Z.5
Graff, J.M.6
-
131
-
-
79959445462
-
Cross-talk between interferon-γ and Hedgehog signaling regulates adipogenesis
-
Todoric J., Strobl B., Jais A., Boucheron N., Bayer M., Amann S., Lindroos J., Teperino R., Prager G., Bilban M., Ellmeier W., Krempler F., Müller M., Wagner O., Patsch W., Pospisilik J.A., Esterbauer H. Cross-talk between interferon-γ and Hedgehog signaling regulates adipogenesis. Diabetes 2011, 60:1668-1676.
-
(2011)
Diabetes
, vol.60
, pp. 1668-1676
-
-
Todoric, J.1
Strobl, B.2
Jais, A.3
Boucheron, N.4
Bayer, M.5
Amann, S.6
Lindroos, J.7
Teperino, R.8
Prager, G.9
Bilban, M.10
Ellmeier, W.11
Krempler, F.12
Müller, M.13
Wagner, O.14
Patsch, W.15
Pospisilik, J.A.16
Esterbauer, H.17
-
132
-
-
0037065356
-
A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells
-
Wu X., Ding S., Ding Q., Gray N.S., Schultz P.G. A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. J Am Ceram Soc 2002, 124:14520-14521.
-
(2002)
J Am Ceram Soc
, vol.124
, pp. 14520-14521
-
-
Wu, X.1
Ding, S.2
Ding, Q.3
Gray, N.S.4
Schultz, P.G.5
-
133
-
-
0033861095
-
BMP-2 and sonic Hedgehog have contrary effects on adipocyte-like differentiation of C3H10T1/2 cells
-
Zehentner B.K., Leser U., Burtscher H. BMP-2 and sonic Hedgehog have contrary effects on adipocyte-like differentiation of C3H10T1/2 cells. DNA Cell Biol 2000, 19:275-281.
-
(2000)
DNA Cell Biol
, vol.19
, pp. 275-281
-
-
Zehentner, B.K.1
Leser, U.2
Burtscher, H.3
-
134
-
-
84867596741
-
A mouse model of rhabdomyosarcoma originating from the adipocyte lineage
-
Hatley M.E., Tang W., Garcia M.R., Finkelstein D., Millay D.P., Liu N., Graff J., Galindo R.L., Olson E.N. A mouse model of rhabdomyosarcoma originating from the adipocyte lineage. Cancer Cell 2012, 22:536-546.
-
(2012)
Cancer Cell
, vol.22
, pp. 536-546
-
-
Hatley, M.E.1
Tang, W.2
Garcia, M.R.3
Finkelstein, D.4
Millay, D.P.5
Liu, N.6
Graff, J.7
Galindo, R.L.8
Olson, E.N.9
-
135
-
-
84865711698
-
BBS-induced ciliary defect enhances adipogenesis, causing paradoxical higher-insulin sensitivity, glucose usage, and decreased inflammatory response
-
Marion V., Mockel A., De Melo C., Obringer C., Claussmann A., Simon A., Messaddeq N., Durand M., Dupuis L., Loeffler J.P., King P., Mutter-Schmidt C., Petrovsky N., Stoetzel C., Dollfus H. BBS-induced ciliary defect enhances adipogenesis, causing paradoxical higher-insulin sensitivity, glucose usage, and decreased inflammatory response. Cell Metab 2012, 16:363-377.
-
(2012)
Cell Metab
, vol.16
, pp. 363-377
-
-
Marion, V.1
Mockel, A.2
De Melo, C.3
Obringer, C.4
Claussmann, A.5
Simon, A.6
Messaddeq, N.7
Durand, M.8
Dupuis, L.9
Loeffler, J.P.10
King, P.11
Mutter-Schmidt, C.12
Petrovsky, N.13
Stoetzel, C.14
Dollfus, H.15
-
136
-
-
84879165722
-
Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma
-
Blotta S., Jakubikova J., Calimeri T., Roccaro A.M., Amodio N., Azab A.K., Foresta U., Mitsiades C.S., Rossi M., Todoerti K., Molica S., Morabito F., Neri A., Tagliaferri P., Tassone P., Anderson K.C., Munshi N.C. Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma. Blood 2012, 120:5002-5013.
-
(2012)
Blood
, vol.120
, pp. 5002-5013
-
-
Blotta, S.1
Jakubikova, J.2
Calimeri, T.3
Roccaro, A.M.4
Amodio, N.5
Azab, A.K.6
Foresta, U.7
Mitsiades, C.S.8
Rossi, M.9
Todoerti, K.10
Molica, S.11
Morabito, F.12
Neri, A.13
Tagliaferri, P.14
Tassone, P.15
Anderson, K.C.16
Munshi, N.C.17
-
137
-
-
84871191893
-
Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma
-
Chan I.S., Guy C.D., Chen Y., Lu J., Swiderska-Syn M., Michelotti G.A., Karaca G., Xie G., Krüger L., Syn W.K., Anderson B.R., Pereira T.A., Choi S.S., Baldwin A.S., Diehl A.M. Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma. Cancer Res 2012, 72:6344-6350.
-
(2012)
Cancer Res
, vol.72
, pp. 6344-6350
-
-
Chan, I.S.1
Guy, C.D.2
Chen, Y.3
Lu, J.4
Swiderska-Syn, M.5
Michelotti, G.A.6
Karaca, G.7
Xie, G.8
Krüger, L.9
Syn, W.K.10
Anderson, B.R.11
Pereira, T.A.12
Choi, S.S.13
Baldwin, A.S.14
Diehl, A.M.15
-
138
-
-
80955181031
-
The Hedgehog's tale: developing strategies for targeting cancer
-
Ng J.M., Curran T. The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer 2011, 11:493-501.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 493-501
-
-
Ng, J.M.1
Curran, T.2
-
139
-
-
33751209187
-
Hedgehog/Ras interactions regulate early stages of pancreatic cancer
-
Pasca di Magliano M., Sekine S., Ermilov A., Ferris J., Dlugosz A.A., Hebrok M. Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev 2006, 20:3161-3173.
-
(2006)
Genes Dev
, vol.20
, pp. 3161-3173
-
-
Pasca di Magliano, M.1
Sekine, S.2
Ermilov, A.3
Ferris, J.4
Dlugosz, A.A.5
Hebrok, M.6
-
140
-
-
67650289584
-
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
-
Scales S.J., de Sauvage F.J. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 2009, 30:303-312.
-
(2009)
Trends Pharmacol Sci
, vol.30
, pp. 303-312
-
-
Scales, S.J.1
de Sauvage, F.J.2
-
141
-
-
77649337790
-
Hedgehog beyond medulloblastoma and basal cell carcinoma
-
Teglund S., Toftgård R. Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta 2010, 1805:181-208.
-
(2010)
Biochim Biophys Acta
, vol.1805
, pp. 181-208
-
-
Teglund, S.1
Toftgård, R.2
-
142
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
Thayer S.P., di Magliano M.P., Heiser P.W., Nielsen C.M., Roberts D.J., Lauwers G.Y., Qi Y.P., Gysin S., Fernández-del Castillo C., Yajnik V., Antoniu B., McMahon M., Warshaw A.L., Hebrok M. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003, 425:851-856.
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
di Magliano, M.P.2
Heiser, P.W.3
Nielsen, C.M.4
Roberts, D.J.5
Lauwers, G.Y.6
Qi, Y.P.7
Gysin, S.8
Fernández-del Castillo, C.9
Yajnik, V.10
Antoniu, B.11
McMahon, M.12
Warshaw, A.L.13
Hebrok, M.14
-
143
-
-
0030874617
-
Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours
-
Vorechovský I., Tingby O., Hartman M., Strömberg B., Nister M., Collins V.P., Toftgård R. Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours. Oncogene 1997, 15:361-366.
-
(1997)
Oncogene
, vol.15
, pp. 361-366
-
-
Vorechovský, I.1
Tingby, O.2
Hartman, M.3
Strömberg, B.4
Nister, M.5
Collins, V.P.6
Toftgård, R.7
-
144
-
-
65549101582
-
Sonic Hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway
-
Yam P.T., Langlois S.D., Morin S., Charron F. Sonic Hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway. Neuron 2009, 62:349-362.
-
(2009)
Neuron
, vol.62
, pp. 349-362
-
-
Yam, P.T.1
Langlois, S.D.2
Morin, S.3
Charron, F.4
-
145
-
-
0029766983
-
Regulation of VLDL synthesis and secretion in the liver
-
Gruffat D., Durand D., Graulet B., Bauchart D. Regulation of VLDL synthesis and secretion in the liver. Reprod Nutr Dev 1996, 36:375-389.
-
(1996)
Reprod Nutr Dev
, vol.36
, pp. 375-389
-
-
Gruffat, D.1
Durand, D.2
Graulet, B.3
Bauchart, D.4
-
146
-
-
84860197759
-
Intracellular trafficking and secretion of VLDL
-
Tiwari S., Siddiqi S.A. Intracellular trafficking and secretion of VLDL. Arterioscler Thromb Vasc Biol 2012, 32:1079-1086.
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 1079-1086
-
-
Tiwari, S.1
Siddiqi, S.A.2
-
147
-
-
77951228960
-
Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion
-
Sundaram M., Yao Z. Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion. Nutr Metab (Lond) 2010, 7:35.
-
(2010)
Nutr Metab (Lond)
, vol.7
, pp. 35
-
-
Sundaram, M.1
Yao, Z.2
-
148
-
-
34247369797
-
Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation
-
Omenetti A., Yang L., Li Y.X., McCall S.J., Jung Y., Sicklick J.K., Huang J., Choi S., Suzuki A., Diehl A.M. Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. Lab Invest 2007, 87:499-514.
-
(2007)
Lab Invest
, vol.87
, pp. 499-514
-
-
Omenetti, A.1
Yang, L.2
Li, Y.X.3
McCall, S.J.4
Jung, Y.5
Sicklick, J.K.6
Huang, J.7
Choi, S.8
Suzuki, A.9
Diehl, A.M.10
-
149
-
-
68949194359
-
Repair-related activation of Hedgehog signaling promotes cholangiocyte chemokine production
-
Omenetti A., Syn W.K., Jung Y., Francis H., Porrello A., Witek R.P., Choi S.S., Yang L., Mayo M.J., Gershwin M.E., Alpini G., Diehl A.M. Repair-related activation of Hedgehog signaling promotes cholangiocyte chemokine production. Hepatology 2009, 50:518-527.
-
(2009)
Hepatology
, vol.50
, pp. 518-527
-
-
Omenetti, A.1
Syn, W.K.2
Jung, Y.3
Francis, H.4
Porrello, A.5
Witek, R.P.6
Choi, S.S.7
Yang, L.8
Mayo, M.J.9
Gershwin, M.E.10
Alpini, G.11
Diehl, A.M.12
-
150
-
-
78449240951
-
Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the Hedgehog pathway
-
Choi S.S., Syn W.K., Karaca G.F., Omenetti A., Moylan C.A., Witek R.P., Agboola K.M., Jung Y., Michelotti G.A., Diehl A.M. Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the Hedgehog pathway. J Biol Chem 2010, 285:36551-36560.
-
(2010)
J Biol Chem
, vol.285
, pp. 36551-36560
-
-
Choi, S.S.1
Syn, W.K.2
Karaca, G.F.3
Omenetti, A.4
Moylan, C.A.5
Witek, R.P.6
Agboola, K.M.7
Jung, Y.8
Michelotti, G.A.9
Diehl, A.M.10
-
151
-
-
84868102616
-
Hedgehog controls hepatic stellate cell fate by regulating metabolism
-
1319.e1-1329.e11
-
Chen Y., Choi S.S., Michelotti G.A., Chan I.S., Swiderska-Syn M., Karaca G.F., Xie G., Moylan C.A., Garibaldi F., Premont R., Suliman H.B., Piantadosi C.A., Diehl A.M. Hedgehog controls hepatic stellate cell fate by regulating metabolism. Gastroenterology 2012, 143. 1319.e1-1329.e11.
-
(2012)
Gastroenterology
, vol.143
-
-
Chen, Y.1
Choi, S.S.2
Michelotti, G.A.3
Chan, I.S.4
Swiderska-Syn, M.5
Karaca, G.F.6
Xie, G.7
Moylan, C.A.8
Garibaldi, F.9
Premont, R.10
Suliman, H.B.11
Piantadosi, C.A.12
Diehl, A.M.13
-
152
-
-
84896316878
-
Alcohol activates the Hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis
-
Chan I.S., Guy C.D., Machado M.V., Wank A., Kadiyala V., Michelotti G., Choi S., Swiderska-Syn M., Karaca G., Pereira T.A., Yip-Schneider M.T., Max Schmidt C., Diehl A.M. Alcohol activates the Hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis. Alcohol Clin Exp Res 2013, 38(3):787-800.
-
(2013)
Alcohol Clin Exp Res
, vol.38
, Issue.3
, pp. 787-800
-
-
Chan, I.S.1
Guy, C.D.2
Machado, M.V.3
Wank, A.4
Kadiyala, V.5
Michelotti, G.6
Choi, S.7
Swiderska-Syn, M.8
Karaca, G.9
Pereira, T.A.10
Yip-Schneider, M.T.11
Max Schmidt, C.12
Diehl, A.M.13
-
153
-
-
84890567500
-
The intrahepatic signalling niche of Hedgehog is defined by primary cilia positive cells during chronic liver injury
-
Grzelak C.A., Martelotto L.G., Sigglekow N.D., Patkunanathan B., Ajami K., Calabro S.R., Dwyer B.J., Tirnitz-Parker J.E., Neil Watkins D., Warner F.J., Shackel N.A., McCaughan G.W. The intrahepatic signalling niche of Hedgehog is defined by primary cilia positive cells during chronic liver injury. J Hepatol 2013, 60(1):143-151.
-
(2013)
J Hepatol
, vol.60
, Issue.1
, pp. 143-151
-
-
Grzelak, C.A.1
Martelotto, L.G.2
Sigglekow, N.D.3
Patkunanathan, B.4
Ajami, K.5
Calabro, S.R.6
Dwyer, B.J.7
Tirnitz-Parker, J.E.8
Neil Watkins, D.9
Warner, F.J.10
Shackel, N.A.11
McCaughan, G.W.12
-
154
-
-
84875614093
-
Hedgehog signalling pathway in adult liver: a major new player in hepatocyte metabolism and zonation?
-
Matz-Soja M., Hovhannisyan A., Gebhardt R. Hedgehog signalling pathway in adult liver: a major new player in hepatocyte metabolism and zonation?. Med Hypotheses 2013, 80:589-594.
-
(2013)
Med Hypotheses
, vol.80
, pp. 589-594
-
-
Matz-Soja, M.1
Hovhannisyan, A.2
Gebhardt, R.3
-
155
-
-
36549011761
-
Sonic Hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells
-
Yang L., Wang Y., Mao H., Fleig S., Omenetti A., Brown K.D., Sicklick J.K., Li Y.X., Diehl A.M. Sonic Hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol 2008, 48:98-106.
-
(2008)
J Hepatol
, vol.48
, pp. 98-106
-
-
Yang, L.1
Wang, Y.2
Mao, H.3
Fleig, S.4
Omenetti, A.5
Brown, K.D.6
Sicklick, J.K.7
Li, Y.X.8
Diehl, A.M.9
-
156
-
-
84878527104
-
Smoothened is a master regulator of adult liver repair
-
Michelotti G.A., Xie G., Swiderska M., Choi S.S., Karaca G., Krüger L., Premont R., Yang L., Syn W.K., Metzger D., Diehl A.M. Smoothened is a master regulator of adult liver repair. J Clin Invest 2013, 123(6):2380-2394.
-
(2013)
J Clin Invest
, vol.123
, Issue.6
, pp. 2380-2394
-
-
Michelotti, G.A.1
Xie, G.2
Swiderska, M.3
Choi, S.S.4
Karaca, G.5
Krüger, L.6
Premont, R.7
Yang, L.8
Syn, W.K.9
Metzger, D.10
Diehl, A.M.11
-
157
-
-
74849087878
-
The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
-
Pavlides S., Whitaker-Menezes D., Castello-Cros R., Flomenberg N., Witkiewicz A.K., Frank P.G., Casimiro M.C., Wang C., Fortina P., Addya S., Pestell R.G., Martinez-Outschoorn U.E., Sotgia F., Lisanti M.P. The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle 2009, 8:3984-4001.
-
(2009)
Cell Cycle
, vol.8
, pp. 3984-4001
-
-
Pavlides, S.1
Whitaker-Menezes, D.2
Castello-Cros, R.3
Flomenberg, N.4
Witkiewicz, A.K.5
Frank, P.G.6
Casimiro, M.C.7
Wang, C.8
Fortina, P.9
Addya, S.10
Pestell, R.G.11
Martinez-Outschoorn, U.E.12
Sotgia, F.13
Lisanti, M.P.14
-
158
-
-
84860333164
-
Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue
-
Sotgia F., Whitaker-Menezes D., Martinez-Outschoorn U.E., Flomenberg N., Birbe R.C., Witkiewicz A.K., Howell A., Philp N.J., Pestell R.G., Lisanti M.P. Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue. Cell Cycle 2012, 11:1445-1454.
-
(2012)
Cell Cycle
, vol.11
, pp. 1445-1454
-
-
Sotgia, F.1
Whitaker-Menezes, D.2
Martinez-Outschoorn, U.E.3
Flomenberg, N.4
Birbe, R.C.5
Witkiewicz, A.K.6
Howell, A.7
Philp, N.J.8
Pestell, R.G.9
Lisanti, M.P.10
-
159
-
-
84865335195
-
Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and l-lactate production
-
Guido C., Whitaker-Menezes D., Capparelli C., Balliet R., Lin Z., Pestell R.G., Howell A., Aquila S., Andò S., Martinez-Outschoorn U., Sotgia F., Lisanti M.P. Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and l-lactate production. Cell Cycle 2012, 11:3019-3035.
-
(2012)
Cell Cycle
, vol.11
, pp. 3019-3035
-
-
Guido, C.1
Whitaker-Menezes, D.2
Capparelli, C.3
Balliet, R.4
Lin, Z.5
Pestell, R.G.6
Howell, A.7
Aquila, S.8
Andò, S.9
Martinez-Outschoorn, U.10
Sotgia, F.11
Lisanti, M.P.12
-
160
-
-
79954504372
-
Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment
-
Martinez-Outschoorn U.E., Pavlides S., Howell A., Pestell R.G., Tanowitz H.B., Sotgia F., Lisanti M.P. Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment. Int J Biochem Cell Biol 2011, 43:1045-1051.
-
(2011)
Int J Biochem Cell Biol
, vol.43
, pp. 1045-1051
-
-
Martinez-Outschoorn, U.E.1
Pavlides, S.2
Howell, A.3
Pestell, R.G.4
Tanowitz, H.B.5
Sotgia, F.6
Lisanti, M.P.7
-
161
-
-
77956419439
-
Ketones and lactate "fuel" tumor growth and metastasis: evidence that epithelial cancer cells use oxidative mitochondrial metabolism
-
Bonuccelli G., Tsirigos A., Whitaker-Menezes D., Pavlides S., Pestell R.G., Chiavarina B., Frank P.G., Flomenberg N., Howell A., Martinez-Outschoorn U.E., Sotgia F., Lisanti M.P. Ketones and lactate "fuel" tumor growth and metastasis: evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle 2010, 9:3506-3514.
-
(2010)
Cell Cycle
, vol.9
, pp. 3506-3514
-
-
Bonuccelli, G.1
Tsirigos, A.2
Whitaker-Menezes, D.3
Pavlides, S.4
Pestell, R.G.5
Chiavarina, B.6
Frank, P.G.7
Flomenberg, N.8
Howell, A.9
Martinez-Outschoorn, U.E.10
Sotgia, F.11
Lisanti, M.P.12
-
162
-
-
78649641423
-
Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma
-
Pereira T.d.e.A., Witek R.P., Syn W.K., Choi S.S., Bradrick S., Karaca G.F., Agboola K.M., Jung Y., Omenetti A., Moylan C.A., Yang L., Fernandez-Zapico M.E., Jhaveri R., Shah V.H., Pereira F.E., Diehl A.M. Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma. Lab Invest 2010, 90:1690-1703.
-
(2010)
Lab Invest
, vol.90
, pp. 1690-1703
-
-
Pereira, T.1
Witek, R.P.2
Syn, W.K.3
Choi, S.S.4
Bradrick, S.5
Karaca, G.F.6
Agboola, K.M.7
Jung, Y.8
Omenetti, A.9
Moylan, C.A.10
Yang, L.11
Fernandez-Zapico, M.E.12
Jhaveri, R.13
Shah, V.H.14
Pereira, F.E.15
Diehl, A.M.16
-
163
-
-
80055042635
-
Up-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication
-
Choi S.S., Bradrick S., Qiang G., Mostafavi A., Chaturvedi G., Weinman S.A., Diehl A.M., Jhaveri R. Up-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication. Hepatology 2011, 54:1580-1590.
-
(2011)
Hepatology
, vol.54
, pp. 1580-1590
-
-
Choi, S.S.1
Bradrick, S.2
Qiang, G.3
Mostafavi, A.4
Chaturvedi, G.5
Weinman, S.A.6
Diehl, A.M.7
Jhaveri, R.8
-
164
-
-
79952091871
-
Lipid metabolism and HCV infection
-
Targett-Adams P., Boulant S., Douglas M.W., McLauchlan J. Lipid metabolism and HCV infection. Viruses 2010, 2:1195-1217.
-
(2010)
Viruses
, vol.2
, pp. 1195-1217
-
-
Targett-Adams, P.1
Boulant, S.2
Douglas, M.W.3
McLauchlan, J.4
-
165
-
-
84890553992
-
Hepatitis C virus infection alters lipid metabolism depending on IL28B polymorphism and viral genotype and modulates gene expression in vivo and in vitro
-
Rojas Á., del Campo J.A., Maraver M., Aparcero R., García-Valdecasas M., Diago M., Carmona I., Andrade R.J., Solà R., Romero-Gómez M. Hepatitis C virus infection alters lipid metabolism depending on IL28B polymorphism and viral genotype and modulates gene expression in vivo and in vitro. J Viral Hepat 2014, 21:19-24.
-
(2014)
J Viral Hepat
, vol.21
, pp. 19-24
-
-
Rojas, Á.1
del Campo, J.A.2
Maraver, M.3
Aparcero, R.4
García-Valdecasas, M.5
Diago, M.6
Carmona, I.7
Andrade, R.J.8
Solà, R.9
Romero-Gómez, M.10
-
166
-
-
84887602906
-
HCV and host lipids: an intimate connection
-
Schaefer E.A., Chung R.T. HCV and host lipids: an intimate connection. Semin Liver Dis 2013, 33:358-368.
-
(2013)
Semin Liver Dis
, vol.33
, pp. 358-368
-
-
Schaefer, E.A.1
Chung, R.T.2
-
167
-
-
84896138369
-
Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels
-
Matz-Soja M., Aleithe S., Marbach E., Böttger J., Arnold K., Schmidt-Heck W., Kratzsch J., Gebhardt R. Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels. Cell Commun Signal 2014, 12:11.
-
(2014)
Cell Commun Signal
, vol.12
, pp. 11
-
-
Matz-Soja, M.1
Aleithe, S.2
Marbach, E.3
Böttger, J.4
Arnold, K.5
Schmidt-Heck, W.6
Kratzsch, J.7
Gebhardt, R.8
-
168
-
-
0037108681
-
Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital
-
Loeppen S., Schneider D., Gaunitz F., Gebhardt R., Kurek R., Buchmann A., Schwarz M. Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital. Cancer Res 2002, 62:5685-5688.
-
(2002)
Cancer Res
, vol.62
, pp. 5685-5688
-
-
Loeppen, S.1
Schneider, D.2
Gaunitz, F.3
Gebhardt, R.4
Kurek, R.5
Buchmann, A.6
Schwarz, M.7
-
169
-
-
33744495398
-
Apc tumor suppressor gene is the "zonation-keeper" of mouse liver
-
Benhamouche S., Decaens T., Godard C., Chambrey R., Rickman D.S., Moinard C., Vasseur-Cognet M., Kuo C.J., Kahn A., Perret C., Colnot S. Apc tumor suppressor gene is the "zonation-keeper" of mouse liver. Dev Cell 2006, 10:759-770.
-
(2006)
Dev Cell
, vol.10
, pp. 759-770
-
-
Benhamouche, S.1
Decaens, T.2
Godard, C.3
Chambrey, R.4
Rickman, D.S.5
Moinard, C.6
Vasseur-Cognet, M.7
Kuo, C.J.8
Kahn, A.9
Perret, C.10
Colnot, S.11
-
170
-
-
14844331446
-
Hedgehog signaling regulates expansion of pancreatic epithelial cells
-
Kawahira H., Scheel D.W., Smith S.B., German M.S., Hebrok M. Hedgehog signaling regulates expansion of pancreatic epithelial cells. Dev Biol 2005, 280:111-121.
-
(2005)
Dev Biol
, vol.280
, pp. 111-121
-
-
Kawahira, H.1
Scheel, D.W.2
Smith, S.B.3
German, M.S.4
Hebrok, M.5
-
171
-
-
77953284901
-
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS
-
Lauth M., Bergström A., Shimokawa T., Tostar U., Jin Q., Fendrich V., Guerra C., Barbacid M., Toftgård R. DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. Nat Struct Mol Biol 2010, 17:718-725.
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 718-725
-
-
Lauth, M.1
Bergström, A.2
Shimokawa, T.3
Tostar, U.4
Jin, Q.5
Fendrich, V.6
Guerra, C.7
Barbacid, M.8
Toftgård, R.9
-
172
-
-
84865865508
-
Plasma Shh levels reduced in pancreatic cancer patients
-
El-Zaatari M., Daignault S., Tessier A., Kelsey G., Travnikar L.A., Cantu E.F., Lee J., Plonka C.M., Simeone D.M., Anderson M.A., Merchant J.L. Plasma Shh levels reduced in pancreatic cancer patients. Pancreas 2012, 41:1019-1028.
-
(2012)
Pancreas
, vol.41
, pp. 1019-1028
-
-
El-Zaatari, M.1
Daignault, S.2
Tessier, A.3
Kelsey, G.4
Travnikar, L.A.5
Cantu, E.F.6
Lee, J.7
Plonka, C.M.8
Simeone, D.M.9
Anderson, M.A.10
Merchant, J.L.11
-
173
-
-
0031260579
-
Sonic Hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
-
Apelqvist A., Ahlgren U., Edlund H. Sonic Hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr Biol 1997, 7:801-804.
-
(1997)
Curr Biol
, vol.7
, pp. 801-804
-
-
Apelqvist, A.1
Ahlgren, U.2
Edlund, H.3
-
174
-
-
38849196910
-
Hedgehog signals in pancreatic differentiation from embryonic stem cells: revisiting the neglected
-
Mfopou J.K., Bouwens L. Hedgehog signals in pancreatic differentiation from embryonic stem cells: revisiting the neglected. Differentiation 2008, 76:107-117.
-
(2008)
Differentiation
, vol.76
, pp. 107-117
-
-
Mfopou, J.K.1
Bouwens, L.2
-
175
-
-
84862556002
-
Hedgehog signals inhibit postnatal beta cell neogenesis from adult rat exocrine pancreas in vitro
-
Mfopou J.K., Baeyens L., Bouwens L. Hedgehog signals inhibit postnatal beta cell neogenesis from adult rat exocrine pancreas in vitro. Diabetologia 2012, 55:1024-1034.
-
(2012)
Diabetologia
, vol.55
, pp. 1024-1034
-
-
Mfopou, J.K.1
Baeyens, L.2
Bouwens, L.3
-
176
-
-
80054743186
-
Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice
-
Landsman L., Parent A., Hebrok M. Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice. Proc Natl Acad Sci U S A 2011, 108:17010-17015.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 17010-17015
-
-
Landsman, L.1
Parent, A.2
Hebrok, M.3
-
177
-
-
77951835156
-
Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function
-
Lau J., Hebrok M. Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function. Diabetes 2010, 59:1211-1221.
-
(2010)
Diabetes
, vol.59
, pp. 1211-1221
-
-
Lau, J.1
Hebrok, M.2
-
178
-
-
0033668338
-
Hedgehog signaling regulation of insulin production by pancreatic beta-cells
-
Thomas M.K., Rastalsky N., Lee J.H., Habener J.F. Hedgehog signaling regulation of insulin production by pancreatic beta-cells. Diabetes 2000, 49:2039-2047.
-
(2000)
Diabetes
, vol.49
, pp. 2039-2047
-
-
Thomas, M.K.1
Rastalsky, N.2
Lee, J.H.3
Habener, J.F.4
-
179
-
-
77953389464
-
Primary cilia regulate Gli/Hedgehog activation in pancreas
-
Cervantes S., Lau J., Cano D.A., Borromeo-Austin C., Hebrok M. Primary cilia regulate Gli/Hedgehog activation in pancreas. Proc Natl Acad Sci U S A 2010, 107:10109-10114.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 10109-10114
-
-
Cervantes, S.1
Lau, J.2
Cano, D.A.3
Borromeo-Austin, C.4
Hebrok, M.5
-
180
-
-
84892727198
-
What we talk about when we talk about fat
-
Rosen E.D., Spiegelman B.M. What we talk about when we talk about fat. Cell 2014, 156:20-44.
-
(2014)
Cell
, vol.156
, pp. 20-44
-
-
Rosen, E.D.1
Spiegelman, B.M.2
-
181
-
-
0034949211
-
Sonic Hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation
-
Spinella-Jaegle S., Rawadi G., Kawai S., Gallea S., Faucheu C., Mollat P., Courtois B., Bergaud B., Ramez V., Blanchet A.M., Adelmant G., Baron R., Roman-Roman S. Sonic Hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation. J Cell Sci 2001, 114:2085-2094.
-
(2001)
J Cell Sci
, vol.114
, pp. 2085-2094
-
-
Spinella-Jaegle, S.1
Rawadi, G.2
Kawai, S.3
Gallea, S.4
Faucheu, C.5
Mollat, P.6
Courtois, B.7
Bergaud, B.8
Ramez, V.9
Blanchet, A.M.10
Adelmant, G.11
Baron, R.12
Roman-Roman, S.13
-
182
-
-
0029936510
-
Mesenchymal dysplasia: a recessive mutation on chromosome 13 of the mouse
-
Sweet H.O., Bronson R.T., Donahue L.R., Davisson M.T. Mesenchymal dysplasia: a recessive mutation on chromosome 13 of the mouse. J Hered 1996, 87:87-95.
-
(1996)
J Hered
, vol.87
, pp. 87-95
-
-
Sweet, H.O.1
Bronson, R.T.2
Donahue, L.R.3
Davisson, M.T.4
-
183
-
-
0346996354
-
Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells
-
van der Horst G., Farih-Sips H., Löwik C.W., Karperien M. Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells. Bone 2003, 33:899-910.
-
(2003)
Bone
, vol.33
, pp. 899-910
-
-
van der Horst, G.1
Farih-Sips, H.2
Löwik, C.W.3
Karperien, M.4
-
184
-
-
0036165339
-
Disruption of Hedgehog signaling reveals a novel role in intestinal morphogenesis and intestinal-specific lipid metabolism in mice
-
Wang L.C., Nassir F., Liu Z.Y., Ling L., Kuo F., Crowell T., Olson D., Davidson N.O., Burkly L.C. Disruption of Hedgehog signaling reveals a novel role in intestinal morphogenesis and intestinal-specific lipid metabolism in mice. Gastroenterology 2002, 122:469-482.
-
(2002)
Gastroenterology
, vol.122
, pp. 469-482
-
-
Wang, L.C.1
Nassir, F.2
Liu, Z.Y.3
Ling, L.4
Kuo, F.5
Crowell, T.6
Olson, D.7
Davidson, N.O.8
Burkly, L.C.9
-
185
-
-
4644250693
-
Purmorphamine induces osteogenesis by activation of the Hedgehog signaling pathway
-
Wu X., Walker J., Zhang J., Ding S., Schultz P.G. Purmorphamine induces osteogenesis by activation of the Hedgehog signaling pathway. Chem Biol 2004, 11:1229-1238.
-
(2004)
Chem Biol
, vol.11
, pp. 1229-1238
-
-
Wu, X.1
Walker, J.2
Zhang, J.3
Ding, S.4
Schultz, P.G.5
-
186
-
-
84881554868
-
Control of muscle fibre-type diversity during embryonic development: the zebrafish paradigm
-
Jackson H.E., Ingham P.W. Control of muscle fibre-type diversity during embryonic development: the zebrafish paradigm. Mech Dev 2013, 130:447-457.
-
(2013)
Mech Dev
, vol.130
, pp. 447-457
-
-
Jackson, H.E.1
Ingham, P.W.2
-
187
-
-
46449134594
-
Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activity
-
Elworthy S., Hargrave M., Knight R., Mebus K., Ingham P.W. Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activity. Development 2008, 135:2115-2126.
-
(2008)
Development
, vol.135
, pp. 2115-2126
-
-
Elworthy, S.1
Hargrave, M.2
Knight, R.3
Mebus, K.4
Ingham, P.W.5
-
188
-
-
19544364842
-
Hedgehog signalling and the specification of muscle cell identity in the zebrafish embryo
-
Ingham P.W., Kim H.R. Hedgehog signalling and the specification of muscle cell identity in the zebrafish embryo. Exp Cell Res 2005, 306:336-342.
-
(2005)
Exp Cell Res
, vol.306
, pp. 336-342
-
-
Ingham, P.W.1
Kim, H.R.2
-
189
-
-
0033572225
-
Control of muscle cell-type specification in the zebrafish embryo by Hedgehog signalling
-
Lewis K.E., Currie P.D., Roy S., Schauerte H., Haffter P., Ingham P.W. Control of muscle cell-type specification in the zebrafish embryo by Hedgehog signalling. Dev Biol 1999, 216:469-480.
-
(1999)
Dev Biol
, vol.216
, pp. 469-480
-
-
Lewis, K.E.1
Currie, P.D.2
Roy, S.3
Schauerte, H.4
Haffter, P.5
Ingham, P.W.6
-
190
-
-
0031913613
-
Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb
-
Duprez D., Fournier-Thibault C., Le Douarin N. Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb. Development 1998, 125:495-505.
-
(1998)
Development
, vol.125
, pp. 495-505
-
-
Duprez, D.1
Fournier-Thibault, C.2
Le Douarin, N.3
-
191
-
-
34548491014
-
Sonic Hedgehog promotes proliferation and differentiation of adult muscle cells: involvement of MAPK/ERK and PI3K/Akt pathways
-
Elia D., Madhala D., Ardon E., Reshef R., Halevy O. Sonic Hedgehog promotes proliferation and differentiation of adult muscle cells: involvement of MAPK/ERK and PI3K/Akt pathways. Biochim Biophys Acta 2007, 1773:1438-1446.
-
(2007)
Biochim Biophys Acta
, vol.1773
, pp. 1438-1446
-
-
Elia, D.1
Madhala, D.2
Ardon, E.3
Reshef, R.4
Halevy, O.5
-
192
-
-
4644252171
-
Hedgehog signaling is required for commitment but not initial induction of slow muscle precursors
-
Hirsinger E., Stellabotte F., Devoto S.H., Westerfield M. Hedgehog signaling is required for commitment but not initial induction of slow muscle precursors. Dev Biol 2004, 275:143-157.
-
(2004)
Dev Biol
, vol.275
, pp. 143-157
-
-
Hirsinger, E.1
Stellabotte, F.2
Devoto, S.H.3
Westerfield, M.4
-
193
-
-
84866493965
-
Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation
-
Hu J.K., McGlinn E., Harfe B.D., Kardon G., Tabin C.J. Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. Genes Dev 2012, 26:2088-2102.
-
(2012)
Genes Dev
, vol.26
, pp. 2088-2102
-
-
Hu, J.K.1
McGlinn, E.2
Harfe, B.D.3
Kardon, G.4
Tabin, C.J.5
-
194
-
-
0038376480
-
Multiple muscle cell identities induced by distinct levels and timing of Hedgehog activity in the zebrafish embryo
-
Wolff C., Roy S., Ingham P.W. Multiple muscle cell identities induced by distinct levels and timing of Hedgehog activity in the zebrafish embryo. Curr Biol 2003, 13:1169-1181.
-
(2003)
Curr Biol
, vol.13
, pp. 1169-1181
-
-
Wolff, C.1
Roy, S.2
Ingham, P.W.3
-
195
-
-
79951693039
-
Cardiac muscle regeneration: lessons from development
-
Mercola M., Ruiz-Lozano P., Schneider M.D. Cardiac muscle regeneration: lessons from development. Genes Dev 2011, 25:299-309.
-
(2011)
Genes Dev
, vol.25
, pp. 299-309
-
-
Mercola, M.1
Ruiz-Lozano, P.2
Schneider, M.D.3
-
196
-
-
35348875982
-
Molecular signature of quiescent satellite cells in adult skeletal muscle
-
Fukada S., Uezumi A., Ikemoto M., Masuda S., Segawa M., Tanimura N., Yamamoto H., Miyagoe-Suzuki Y., Takeda S. Molecular signature of quiescent satellite cells in adult skeletal muscle. Stem Cells 2007, 25:2448-2459.
-
(2007)
Stem Cells
, vol.25
, pp. 2448-2459
-
-
Fukada, S.1
Uezumi, A.2
Ikemoto, M.3
Masuda, S.4
Segawa, M.5
Tanimura, N.6
Yamamoto, H.7
Miyagoe-Suzuki, Y.8
Takeda, S.9
-
197
-
-
84896693822
-
Sonic Hedgehog therapy in a mouse model of age-associated impairment of skeletal muscle regeneration
-
Piccioni A., Gaetani E., Neri V., Gatto I., Palladino M., Silver M., Smith R.C., Giarretta I., Pola E., Hlatky L., Pola R. Sonic Hedgehog therapy in a mouse model of age-associated impairment of skeletal muscle regeneration. J Gerontol A Biol Sci Med Sci 2013, 69(3):245-252.
-
(2013)
J Gerontol A Biol Sci Med Sci
, vol.69
, Issue.3
, pp. 245-252
-
-
Piccioni, A.1
Gaetani, E.2
Neri, V.3
Gatto, I.4
Palladino, M.5
Silver, M.6
Smith, R.C.7
Giarretta, I.8
Pola, E.9
Hlatky, L.10
Pola, R.11
-
198
-
-
72949097878
-
Sonic Hedgehog regulates angiogenesis and myogenesis during post-natal skeletal muscle regeneration
-
Straface G., Aprahamian T., Flex A., Gaetani E., Biscetti F., Smith R.C., Pecorini G., Pola E., Angelini F., Stigliano E., Castellot J.J., Losordo D.W., Pola R. Sonic Hedgehog regulates angiogenesis and myogenesis during post-natal skeletal muscle regeneration. J Cell Mol Med 2009, 13:2424-2435.
-
(2009)
J Cell Mol Med
, vol.13
, pp. 2424-2435
-
-
Straface, G.1
Aprahamian, T.2
Flex, A.3
Gaetani, E.4
Biscetti, F.5
Smith, R.C.6
Pecorini, G.7
Pola, E.8
Angelini, F.9
Stigliano, E.10
Castellot, J.J.11
Losordo, D.W.12
Pola, R.13
-
199
-
-
79751484162
-
Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma
-
Rubin B.P., Nishijo K., Chen H.I., Yi X., Schuetze D.P., Pal R., Prajapati S.I., Abraham J., Arenkiel B.R., Chen Q.R., Davis S., McCleish A.T., Capecchi M.R., Michalek J.E., Zarzabal L.A., Khan J., Yu Z., Parham D.M., Barr F.G., Meltzer P.S., Chen Y., Keller C. Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma. Cancer Cell 2011, 19:177-191.
-
(2011)
Cancer Cell
, vol.19
, pp. 177-191
-
-
Rubin, B.P.1
Nishijo, K.2
Chen, H.I.3
Yi, X.4
Schuetze, D.P.5
Pal, R.6
Prajapati, S.I.7
Abraham, J.8
Arenkiel, B.R.9
Chen, Q.R.10
Davis, S.11
McCleish, A.T.12
Capecchi, M.R.13
Michalek, J.E.14
Zarzabal, L.A.15
Khan, J.16
Yu, Z.17
Parham, D.M.18
Barr, F.G.19
Meltzer, P.S.20
Chen, Y.21
Keller, C.22
more..
-
201
-
-
84858782079
-
AMPK: a nutrient and energy sensor that maintains energy homeostasis
-
Hardie D.G., Ross F.A., Hawley S.A. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012, 13:251-262.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
202
-
-
84858604270
-
Metabolic reprogramming: a cancer hallmark even warburg did not anticipate
-
Ward P.S., Thompson C.B. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012, 21:297-308.
-
(2012)
Cancer Cell
, vol.21
, pp. 297-308
-
-
Ward, P.S.1
Thompson, C.B.2
-
203
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science 1956, 123:309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
204
-
-
84255162057
-
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism
-
Hitosugi T., Fan J., Chung T.W., Lythgoe K., Wang X., Xie J., Ge Q., Gu T.L., Polakiewicz R.D., Roesel J.L., Chen G.Z., Boggon T.J., Lonial S., Fu H., Khuri F.R., Kang S., Chen J. Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Mol Cell 2011, 44:864-877.
-
(2011)
Mol Cell
, vol.44
, pp. 864-877
-
-
Hitosugi, T.1
Fan, J.2
Chung, T.W.3
Lythgoe, K.4
Wang, X.5
Xie, J.6
Ge, Q.7
Gu, T.L.8
Polakiewicz, R.D.9
Roesel, J.L.10
Chen, G.Z.11
Boggon, T.J.12
Lonial, S.13
Fu, H.14
Khuri, F.R.15
Kang, S.16
Chen, J.17
-
205
-
-
53049087909
-
Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells
-
McFate T., Mohyeldin A., Lu H., Thakar J., Henriques J., Halim N.D., Wu H., Schell M.J., Tsang T.M., Teahan O., Zhou S., Califano J.A., Jeoung N.H., Harris R.A., Verma A. Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells. J Biol Chem 2008, 283:22700-22708.
-
(2008)
J Biol Chem
, vol.283
, pp. 22700-22708
-
-
McFate, T.1
Mohyeldin, A.2
Lu, H.3
Thakar, J.4
Henriques, J.5
Halim, N.D.6
Wu, H.7
Schell, M.J.8
Tsang, T.M.9
Teahan, O.10
Zhou, S.11
Califano, J.A.12
Jeoung, N.H.13
Harris, R.A.14
Verma, A.15
-
206
-
-
40749099894
-
Pyruvate kinase M2 is a phosphotyrosine-binding protein
-
Christofk H.R., Vander Heiden M.G., Wu N., Asara J.M., Cantley L.C. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 2008, 452:181-186.
-
(2008)
Nature
, vol.452
, pp. 181-186
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Wu, N.3
Asara, J.M.4
Cantley, L.C.5
-
207
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk H.R., Vander Heiden M.G., Harris M.H., Ramanathan A., Gerszten R.E., Wei R., Fleming M.D., Schreiber S.L., Cantley L.C. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008, 452:230-233.
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
208
-
-
84866842363
-
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
-
Anastasiou D., Yu Y., Israelsen W.J., Jiang J.K., Boxer M.B., Hong B.S., Tempel W., Dimov S., Shen M., Jha A., Yang H., Mattaini K.R., Metallo C.M., Fiske B.P., Courtney K.D., Malstrom S., Khan T.M., Kung C., Skoumbourdis A.P., Veith H., Southall N., Walsh M.J., Brimacombe K.R., Leister W., Lunt S.Y., Johnson Z.R., Yen K.E., Kunii K., Davidson S.M., Christofk H.R., Austin C.P., Inglese J., Harris M.H., Asara J.M., Stephanopoulos G., Salituro F.G., Jin S., Dang L., Auld D.S., Park H.W., Cantley L.C., Thomas C.J., Vander Heiden M.G. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol 2012, 8:839-847.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 839-847
-
-
Anastasiou, D.1
Yu, Y.2
Israelsen, W.J.3
Jiang, J.K.4
Boxer, M.B.5
Hong, B.S.6
Tempel, W.7
Dimov, S.8
Shen, M.9
Jha, A.10
Yang, H.11
Mattaini, K.R.12
Metallo, C.M.13
Fiske, B.P.14
Courtney, K.D.15
Malstrom, S.16
Khan, T.M.17
Kung, C.18
Skoumbourdis, A.P.19
Veith, H.20
Southall, N.21
Walsh, M.J.22
Brimacombe, K.R.23
Leister, W.24
Lunt, S.Y.25
Johnson, Z.R.26
Yen, K.E.27
Kunii, K.28
Davidson, S.M.29
Christofk, H.R.30
Austin, C.P.31
Inglese, J.32
Harris, M.H.33
Asara, J.M.34
Stephanopoulos, G.35
Salituro, F.G.36
Jin, S.37
Dang, L.38
Auld, D.S.39
Park, H.W.40
Cantley, L.C.41
Thomas, C.J.42
Vander Heiden, M.G.43
more..
-
209
-
-
84885589840
-
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
-
Israelsen W.J., Dayton T.L., Davidson S.M., Fiske B.P., Hosios A.M., Bellinger G., Li J., Yu Y., Sasaki M., Horner J.W., Burga L.N., Xie J., Jurczak M.J., DePinho R.A., Clish C.B., Jacks T., Kibbey R.G., Wulf G.M., Di Vizio D., Mills G.B., Cantley L.C., Vander Heiden M.G. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell 2013, 155:397-409.
-
(2013)
Cell
, vol.155
, pp. 397-409
-
-
Israelsen, W.J.1
Dayton, T.L.2
Davidson, S.M.3
Fiske, B.P.4
Hosios, A.M.5
Bellinger, G.6
Li, J.7
Yu, Y.8
Sasaki, M.9
Horner, J.W.10
Burga, L.N.11
Xie, J.12
Jurczak, M.J.13
DePinho, R.A.14
Clish, C.B.15
Jacks, T.16
Kibbey, R.G.17
Wulf, G.M.18
Di Vizio, D.19
Mills, G.B.20
Cantley, L.C.21
Vander Heiden, M.G.22
more..
-
210
-
-
84861876867
-
Inhibiting the Hedgehog pathway in patients with the basal-cell nevus syndrome
-
Tang J.Y., Mackay-Wiggan J.M., Aszterbaum M., Yauch R.L., Lindgren J., Chang K., Coppola C., Chanana A.M., Marji J., Bickers D.R., Epstein E.H. Inhibiting the Hedgehog pathway in patients with the basal-cell nevus syndrome. N Engl J Med 2012, 366:2180-2188.
-
(2012)
N Engl J Med
, vol.366
, pp. 2180-2188
-
-
Tang, J.Y.1
Mackay-Wiggan, J.M.2
Aszterbaum, M.3
Yauch, R.L.4
Lindgren, J.5
Chang, K.6
Coppola, C.7
Chanana, A.M.8
Marji, J.9
Bickers, D.R.10
Epstein, E.H.11
-
211
-
-
84861856844
-
Efficacy and safety of vismodegib in advanced basal-cell carcinoma
-
Sekulic A., Migden M.R., Oro A.E., Dirix L., Lewis K.D., Hainsworth J.D., Solomon J.A., Yoo S., Arron S.T., Friedlander P.A., Marmur E., Rudin C.M., Chang A.L., Low J.A., Mackey H.M., Yauch R.L., Graham R.A., Reddy J.C., Hauschild A. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med 2012, 366:2171-2179.
-
(2012)
N Engl J Med
, vol.366
, pp. 2171-2179
-
-
Sekulic, A.1
Migden, M.R.2
Oro, A.E.3
Dirix, L.4
Lewis, K.D.5
Hainsworth, J.D.6
Solomon, J.A.7
Yoo, S.8
Arron, S.T.9
Friedlander, P.A.10
Marmur, E.11
Rudin, C.M.12
Chang, A.L.13
Low, J.A.14
Mackey, H.M.15
Yauch, R.L.16
Graham, R.A.17
Reddy, J.C.18
Hauschild, A.19
-
212
-
-
0030955557
-
Basal cell carcinomas in mice overexpressing sonic Hedgehog
-
Oro A.E., Higgins K.M., Hu Z., Bonifas J.M., Epstein E.H., Scott M.P. Basal cell carcinomas in mice overexpressing sonic Hedgehog. Science 1997, 276:817-821.
-
(1997)
Science
, vol.276
, pp. 817-821
-
-
Oro, A.E.1
Higgins, K.M.2
Hu, Z.3
Bonifas, J.M.4
Epstein, E.H.5
Scott, M.P.6
-
213
-
-
0034091805
-
Basal cell carcinomas in mice overexpressing Gli2 in skin
-
Grachtchouk M., Mo R., Yu S., Zhang X., Sasaki H., Hui C.C., Dlugosz A.A. Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat Genet 2000, 24:216-217.
-
(2000)
Nat Genet
, vol.24
, pp. 216-217
-
-
Grachtchouk, M.1
Mo, R.2
Yu, S.3
Zhang, X.4
Sasaki, H.5
Hui, C.C.6
Dlugosz, A.A.7
-
216
-
-
33748769378
-
The ciliopathies: an emerging class of human genetic disorders
-
Badano J.L., Mitsuma N., Beales P.L., Katsanis N. The ciliopathies: an emerging class of human genetic disorders. Annu Rev Genomics Hum Genet 2006, 7:125-148.
-
(2006)
Annu Rev Genomics Hum Genet
, vol.7
, pp. 125-148
-
-
Badano, J.L.1
Mitsuma, N.2
Beales, P.L.3
Katsanis, N.4
-
217
-
-
78149259013
-
Primary cilia regulate mTORC1 activity and cell size through Lkb1
-
Boehlke C., Kotsis F., Patel V., Braeg S., Voelker H., Bredt S., Beyer T., Janusch H., Hamann C., Gödel M., Müller K., Herbst M., Hornung M., Doerken M., Köttgen M., Nitschke R., Igarashi P., Walz G., Kuehn E.W. Primary cilia regulate mTORC1 activity and cell size through Lkb1. Nat Cell Biol 2010, 12:1115-1122.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 1115-1122
-
-
Boehlke, C.1
Kotsis, F.2
Patel, V.3
Braeg, S.4
Voelker, H.5
Bredt, S.6
Beyer, T.7
Janusch, H.8
Hamann, C.9
Gödel, M.10
Müller, K.11
Herbst, M.12
Hornung, M.13
Doerken, M.14
Köttgen, M.15
Nitschke, R.16
Igarashi, P.17
Walz, G.18
Kuehn, E.W.19
|