GLI transcription factors: Mediators of oncogenic Hedgehog signalling

European Journal of Cancer

Volumn 42, Issue 4, 2006, Pages 437-445

  Kasper, Maria ^a   Regl, Gerhard ^a   Frischauf, Anna Maria ^a   Aberger, Fritz ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Gene expression regulation; GLI proteins; Hedgehog proteins; Neoplasms; Oncogenes; Signal transduction

Indexed keywords

SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

CANCER; CANCER STEM CELL; CARCINOGENESIS; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL SURVIVAL; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; GENETIC ANALYSIS; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 32444449871     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2005.08.039     Document Type: Article

References (88)

1. P.W. Ingham, and A.P. McMahon Hedgehog signaling in animal development: paradigms and principles Genes Dev 15 2001 3059 3087
2. M. Pasca di Magliano, and M. Hebrok Hedgehog signalling in cancer formation and maintenance Nat Rev Cancer 3 2003 903 911
3. P. Sanchez, V. Clement, and A.R. i Altaba Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer Cancer Res 65 2005 2990 2992
4. L. Lum, and P.A. Beachy The Hedgehog response network: sensors, switches, and routers Science 304 2004 1755 1759
5. J.E. Hooper, and M.P. Scott Developmental cell biology: communicating with hedgehogs Nat Rev Mol Cell Biol 6 2005 306 317
6. A. Ruiz i Altaba, P. Sanchez, and N. Dahmane Gli and hedgehog in cancer: tumours, embryos and stem cells Nat Rev Cancer 2 2002 361 372
7. N.P. Pavletich, and C.O. Pabo Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers Science 261 1993 1701 1707
8. K.W. Kinzler, and B. Vogelstein The GLI gene encodes a nuclear protein which binds specific sequences in the human genome Mol Cell Biol 10 1990 634 642
9. H. Sasaki, Y. Nishizaki, and C. Hui Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of SHH signaling Development 126 1999 3915 3924
10. B. Wang, J.F. Fallon, and P.A. Beachy Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb Cell 100 2000 423 434
11. S.H. Shin, P. Kogerman, and E. Lindstrom GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization Proc Natl Acad Sci USA 96 1999 2880 2884
12. A.R. Altaba Gli proteins encode context-dependent positive and negative functions: implications for development and disease Development 126 1999 3205 3216
13. C.B. Bai, D. Stephen, and A.L. Joyner All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3 Dev Cell 6 2004 103 115
14. L. Buttitta, R. Mo, and C.C. Hui Interplays of Gli2 and Gli3 and their requirement in mediating SHH-dependent sclerotome induction Development 130 2003 6233 6243
15. J. Motoyama, L. Milenkovic, and M. Iwama Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification Dev Biol 259 2003 150 161
16. P. Dai, H. Akimaru, and Y. Tanaka Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3 J Biol Chem 274 1999 8143 8152
17. M.S. Ikram, G.W. Neill, and G. Regl GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter J Invest Dermatol 122 2004 1503 1509
18. P. Aza-Blanc, F.A. Ramirez-Weber, and M.P. Laget Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor Cell 89 1997 1043 1053
19. C.H. Chen, D.P. von Kessler, and W. Park Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression Cell 98 1999 305 316
20. J. Jia, K. Amanai, and G. Wang Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus Nature 416 2002 548 552
21. M.A. Price, and D. Kalderon Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A Development 126 1999 4331 4339
22. M.A. Price, and D. Kalderon Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1 Cell 108 2002 823 835
23. J. Jiang, and G. Struhl Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb Nature 391 1998 493 496
24. L. Lum, C. Zhang, and S. Oh Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2 Mol Cell 12 2003 1261 1274
25. P. Kogerman, T. Grimm, and L. Kogerman Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1 Nat Cell Biol 1 1999 312 319
26. M.D. Taylor, L. Liu, and C. Raffel Mutations in SUFU predispose to medulloblastoma Nat Genet 31 2002 306 310
27. S.Y. Cheng, and J.M. Bishop Suppressor of fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex Proc Natl Acad Sci USA 99 2002 5442 5447
28. P. Mill, R. Mo, and H. Fu Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development Genes Dev 17 2003 282 294
29. Q. Ding, J. Motoyama, and S. Gasca Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice Development 125 1998 2533 2543
30. J. Mao, P. Maye, and P. Kogerman Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1 J Biol Chem 22 2002 22
31. C.A. Callahan, T. Ofstad, and L. Horng MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription Genes Dev 18 2004 2724 2729
32. H. Akimaru, Y. Chen, and P. Dai Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling Nature 386 1997 735 738
33. Y. Chen, R.H. Goodman, and S.M. Smolik Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo Mol Cell Biol 20 2000 1616 1625
34. D. Huangfu, A. Liu, and A.S. Rakeman Hedgehog signalling in the mouse requires intraflagellar transport proteins Nature 426 2003 83 87
35. D. Huangfu, and K.V. Anderson Cilia and Hedgehog responsiveness in the mouse Proc Natl Acad Sci USA 2005
36. A. Liu, B. Wang, and L.A. Niswander Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors Development 132 2005 3103 3111
37. V. Nguyen, A.L. Chokas, and B. Stecca Cooperative requirement of the Gli proteins in neurogenesis Development 132 2005 3267 3279
38. R.J. Gorlin Nevoid basal cell carcinoma syndrome Dermatol Clin 13 1995 113 125
39. H. Hahn, L. Wojnowski, and G. Miller The patched signaling pathway in tumourigenesis and development: lessons from animal models J Mol Med 77 1999 459 468 [in process citation]
40. A.E. Bale, and K.P. Yu The hedgehog pathway and basal cell carcinomas Hum Mol Genet 10 2001 757 762
41. L.V. Goodrich, and M.P. Scott Hedgehog and patched in neural development and disease Neuron 21 1998 1243 1257
42. H. Hahn, C. Wicking, and P.G. Zaphiropoulous Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome Cell 85 1996 841 851
43. M.R. Gailani, M. Stahle-Backdahl, and D.J. Leffell The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas Nat Genet 14 1996 78 81 [see comments]
44. R.L. Johnson, A.L. Rothman, and J. Xie Human homolog of patched, a candidate gene for the basal cell nevus syndrome Science 272 1996 1668 1671
45. J. Xie, M. Murone, and S.M. Luoh Activating smoothened mutations in sporadic basal-cell carcinoma Nature 391 1998 90 92
46. A.E. Oro, K.M. Higgins, and Z. Hu Basal cell carcinomas in mice overexpressing Sonic hedgehog Science 276 1997 817 821
47. H. Fan, A.E. Oro, and M.P. Scott Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog Nat Med 3 1997 788 792
48. M. Aszterbaum, J. Epstein, and A. Oro Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice Nat Med 5 1999 1285 1291
49. M. Nilsson, A.B. Unden, and D. Krause Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1 Proc Natl Acad Sci USA 97 2000 3438 3443
50. M. Grachtchouk, R. Mo, and S. Yu Basal cell carcinomas in mice overexpressing Gli2 in skin Nat Genet 24 2000 216 217
51. M.E. Hutchin, M.S. Kariapper, and M. Grachtchouk Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumourigenesis recapitulates the hair growth cycle Genes Dev 19 2005 214 223
52. D.M. Berman, S.S. Karhadkar, and A. Maitra Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours Nature 425 2003 846 851
53. S.S. Karhadkar, G.S. Bova, and N. Abdallah Hedgehog signalling in prostate regeneration, neoplasia and metastasis Nature 431 2004 707 712
54. D.N. Watkins, D.M. Berman, and S.G. Burkholder Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer Nature 422 2003 313 317
55. S.P. Thayer, M.P. di Magliano, and P.W. Heiser Hedgehog is an early and late mediator of pancreatic cancer tumourigenesis Nature 425 2003 851 856
56. T. Sheng, C. Li, and X. Zhang Activation of the hedgehog pathway in advanced prostate cancer Mol Cancer 3 2004 29
57. P. Sanchez, A.M. Hernandez, and B. Stecca Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling Proc Natl Acad Sci USA 101 2004 12561 12566
58. L. Fan, C.V. Pepicelli, and C.C. Dibble Hedgehog signaling promotes prostate xenograft tumour growth Endocrinology 145 2004 3961 3970
59. J. Taipale, J.K. Chen, and M.K. Cooper Effects of oncogenic mutations in smoothened and patched can be reversed by cyclopamine Nature 406 2000 1005 1009
60. M. Frank-Kamenetsky, X.M. Zhang, and S. Bottega Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists J Biol 1 2002 10
61. P. Sanchez, and A. Ruiz i Altaba In vivo inhibition of endogenous brain tumours through systemic interference of Hedgehog signaling in mice Mech Dev 122 2005 223 230
62. J.A. Williams, O.M. Guicherit, and B.I. Zaharian Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions Proc Natl Acad Sci USA 100 2003 4616 4621
63. J.T. Romer, H. Kimura, and S. Magdaleno Suppression of the SHH pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-) p53(-/-) mice Cancer Cell 6 2004 229 240
64. M. Athar, C. Li, and X. Tang Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis Cancer Res 64 2004 7545 7552
65. J.M. Ruppert, B. Vogelstein, and K.W. Kinzler The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A Mol Cell Biol 11 1991 1724 1728
66. G. Regl, G.W. Neill, and T. Eichberger Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma Oncogene 21 2002 5529 5539
67. H. Kimura, D. Stephen, and A. Joyner Gli1 is important for medulloblastoma formation in Ptc1(+/-) mice Oncogene 24 2005 4026 4036
68. H.L. Park, C. Bai, and K.A. Platt Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation Development 127 2000 1593 1605
69. C. Niemann, A.B. Unden, and S. Lyle Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis Proc Natl Acad Sci USA 100 Suppl. 1 2003 11873 11880
70. B. St-Jacques, H.R. Dassule, and I. Karavanova Sonic hedgehog signaling is essential for hair development Curr Biol 8 1998 1058 1068
71. P.A. Beachy, S.S. Karhadkar, and D.M. Berman Tissue repair and stem cell renewal in carcinogenesis Nature 432 2004 324 331
72. T. Reya, S.J. Morrison, and M.F. Clarke Stem cells, cancer, and cancer stem cells Nature 414 2001 105 111
73. M. Dean, T. Fojo, and S. Bates Tumour stem cells and drug resistance Nat Rev Cancer 5 2005 275 284
74. G. Regl, M. Kasper, and H. Schnidar The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells Oncogene 23 2004 1263 1274
75. A.M. Kenney, and D.H. Rowitch Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors Mol Cell Biol 20 2000 9055 9067
76. F. Long, X.M. Zhang, and S. Karp Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation Development 128 2001 5099 5108
77. Y. Li, H. Zhang, and S.C. Choi Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis Dev Biol 270 2004 214 231
78. J.W. Yoon, Y. Kita, and D.J. Frank Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation J Biol Chem 277 2002 5548 5555
79. M. Duman-Scheel, L. Weng, and S. Xin Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E Nature 417 2002 299 304
80. A.M. Kenney, M.D. Cole, and D.H. Rowitch Nmyc upregulation by Sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors Development 130 2003 15 28
81. G. Regl, M. Kasper, and H. Schnidar Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2 Cancer Res 64 2004 7724 7731
82. R.L. Bigelow, N.S. Chari, and A.B. Unden Transcriptional regulation of bcl-2 mediated by the Sonic hedgehog signaling pathway through Gli-1 J Biol Chem 279 2004 1197 1205
83. I.D. Louro, E.C. Bailey, and X. Li Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation Cancer Res 62 2002 5867 5873
84. M. van den Heuvel, and P.W. Ingham Smoothened encodes a receptor-like serpentine protein required for hedgehog signalling Nature 382 1996 547 551
85. X.M. Zhang, M. Ramalho-Santos, and A.P. McMahon Smoothened mutants reveal redundant roles for SHH and IHH signaling including regulation of L/R symmetry by the mouse node Cell 106 2001 781 792
86. J. Soutschek, A. Akinc, and B. Bramlage Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs Nature 432 2004 173 178
87. E. Song, P. Zhu, and S.K. Lee Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors Nat Biotechnol 23 2005 709 717
88. S.Y. Tay, P.W. Ingham, and S. Roy A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo Development 132 2005 625 634