Mammalian Suppressor-of-Fused modulates nuclear-cytoplasmic shuttling of GLI-1

Nature Cell Biology

Volumn 1, Issue 5, 1999, Pages 312-319

  Kogerman, Priit ^a   Grimm, Thomas ^a   Kogerman, Lembi ^a   Krause, Darren ^a   Undén, Anne Birgitte ^a,b   Sandstedt, Bengt ^b   Toftgård, Rune ^a   Zaphiropoulos, Peter G ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ERINACEIDAE; MAMMALIA;

DROSOPHILA PROTEIN; GLI PROTEIN; ONCOPROTEIN; RECOMBINANT PROTEIN; REPRESSOR PROTEIN; SUFU PROTEIN, DROSOPHILA; SUFU PROTEIN, HUMAN; SUFU PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ADULT; AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL LINE; CELL NUCLEUS; CHEMISTRY; CHICKEN; CYTOPLASM; DROSOPHILA MELANOGASTER; EMBRYO; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HUMAN; MAMMAL; METABOLISM; MOLECULAR GENETICS; MOUSE; OSTEOBLAST; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

ADULT; AMINO ACID SEQUENCE; ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELL NUCLEUS; CHICKENS; CYTOPLASM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYO; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MAMMALS; MICE; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS; OSTEOBLASTS; OSTEOGENESIS; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0033194243     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/13031     Document Type: Article

References (34)

1. Roessler, E. et al. Mutations in the C-terminal domain of Sonic Hedgehog cause holoprosencephaly. Hum. Mol. Genet. 6, 1847-1853 (1997).
2. Hahn, H. et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85, 841-851 (1996).
3. Johnson, R. L. et al. Human homolog of patched, a candidate gene for basal cell nevus syndrome. Science 272, 1668-1671 (1996).
4. Vortkamp, A., Gessler, M. & Grzeschik, K.-H. GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families. Nature 352, 539-540 (1991).
5. Ruiz i Altaba, A. Catching a gli-mpse of hedgehog. Cell 90, 193-196 (1997).
6. Monnier, V., Dussillol, F., Alves, G., Lamour-Isnard, C. & Plessis, A. Suppressor of fused links Fused and Cubitus interruptus on the hedgehog signalling pathway. Curr. Biol. 8, 583-586 (1998).
7. Methot, N. & Basler, K. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and represser forms of Cubitus interruptus. Cell 96, 819-831 (1999).
8. Ohlmeyer, J. & Kalderon, D. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 396, 749-753 (1998).
9. Shin, S. H., Kogerman, P., Lindström, E., Toftgård, R. & Biesecker, L. G. GLI3 mutations in human disorders mimic Drosophila Cubitus interruptus protein functions and localization. Proc. Natl Acad. Sci. USA 96, 2880-2884 (1999).
10. Kinzler, K. W. & Vogelstein, B. The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol. Cell. Biol. 10, 634-642 (1990).
11. Dahmane, N., Lee, J., Robins, P., Heller, P. & Ruiz i Altaba, A. Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature 389, 876-881 (1997).
12. Ruiz i Altaba, A. Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development 126, 3205-3216 (1999).
13. Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M. & Ishii, S. Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 274, 8143-8152 (1999).
14. Pham, A. et al. The Suppressor of fused gene encodes a novel PEST protein involved in Drosophila segment polarity establishment. Genetics 140, 587-598 (1995).
15. Vortkamp, A. et al. Regulation of cartilage differentiation by Indian Hedgehog and PTCH-related protein. Science 273, 613-622 (1996).
16. Vortkamp, A. et al. Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair. Mech. Dev. 71, 65-76 (1998).
17. Hynes, M. et al. Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 19, 15-26 (1997).
18. Kinzler, K. W., Ruppert, J. M., Bigner, S. H. & Vogelstein, B. The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature 332, 371-374 (1988).
19. Nakamura, T. et al. Induction of osteogenic differentiation by hedgehog proteins. Biochem. Biophys. Res. Commun. 237, 465-469 (1997).
20. Murone, M., Rosenthal, A. & de Sauvage, F. J. Sonic hedgehog signaling by the patched-smoothened receptor complex. Curr. Biol. 9, 76-84 (1999).
21. Aza-Blanc, P., Ramirez-Weber, F. A., Laget, M. P., Schwartz, C. & Kornberg, T. B. Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a represser. Cell 89, 1043-1053 (1997).
22. Bogerd, H., Echarri, A., Ross, T. M. & Cullen, B. R. Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1. J. Virol 72, 8627-8635 (1998).
23. Kudo, N. et al. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell Res. 242, 540-547 (1998).
24. Ingham, P. W. Transducing hedgehog: the story so far. EMBO J. 17, 3505-3511 (1998).
25. Hamada, F. et al. Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. Science 283, 1739-1742 (1999).
26. Ruppert, T., Vogelstein, B. & Kinzler, K. W. The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A. Mol. Cell Biol. 11, 1724-1728 (1991).
27. Zaphiropoulos, P. G. & Toftgard, R. cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region. DNA Cell Biol. 15, 1049-1056 (1996).
28. Wilkinson, D. G. In Situ Hybridization: A Practical Approach (IRL, Oxford, 1992).
29. Undén, A. B., Zaphiropoulos, P. G., Bruce, K., Toftgård, R. & Ståhle-Bäckdahl, M. Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma. Cancer Res. 57, 2336-2340 (1997).
30. Evan, G. I., Lewis, G. K., Ramsay, G. & Bishop, J. M. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol 5, 3610-3616 (1985).
31. Pati, U. K. Novel vectors for expression of cDNA encoding epitope-tagged proteins in mammalian cells. Gene 114, 285-288 (1992).
32. Almlöf, T., Gustafsson, J.-Å. & Wright, A. P. H. Role of hydrophobic amino acid clusters in the transactivation activity of the human glucocorticoid receptor. Mol. Cell. Biol. 17, 934-945 (1997).
33. Ausubel, F. M. et al. Current Protocols in Molecular Biology (John Wiley, New York, 1987).
34. Pavletich, N. P. & Pabo, C. O. Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. Science 261, 1701-1707 (1993).