G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

Genes and Development

Volumn 24, Issue 18, 2010, Pages 2054-2067

  Chen, Yongbin ^a   Li, Shuang ^a   Tong, Chao ^a,d   Zhao, Yun ^a,e   Wang, Bing ^a   Liu, Yajuan ^b,c   Jia, Jianhang ^b,c   Jiang, Jin ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Conformation; GPCR; Gprk2 GRK2; Hedgehog; Phosphorylation; Smo

Indexed keywords

G PROTEIN COUPLED RECEPTOR KINASE 2; SONIC HEDGEHOG PROTEIN; DROSOPHILA PROTEIN; G PROTEIN COUPLED RECEPTOR; GPRK2 PROTEIN, DROSOPHILA; HEDGEHOG PROTEIN, DROSOPHILA; SMOOTHENED PROTEIN, DROSOPHILA;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATION; DIMERIZATION; DROSOPHILA; NONHUMAN; OLIGOMERIZATION; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; ENZYMOLOGY; GENETICS; METABOLISM; PHOSPHORYLATION;

ERINACEIDAE;

ANIMALS; CELLS, CULTURED; DROSOPHILA; DROSOPHILA PROTEINS; G-PROTEIN-COUPLED RECEPTOR KINASE 2; HEDGEHOG PROTEINS; PHOSPHORYLATION; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 77956805860     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1948710     Document Type: Article

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