Hedgehog signals inhibit postnatal beta cell neogenesis from adult rat exocrine pancreas in vitro

Diabetologia

Volumn 55, Issue 4, 2012, Pages 1024-1034

  Mfopou, J K ^a   Baeyens, L ^a   Bouwens, L ^a  

^a DIABETES RESEARCH CENTER   (Belgium)

Author keywords

Acinar cell; Acinar to ductal metaplasia; Beta cell; Cyclopamine; Hedgehog; Insulin; Neogenesis; Transdifferentiation

Indexed keywords

3 KETO N ( AMINOETHYLAMINOCAPROYL DIHYDROCINNAMOYL) CYCLOPRAMINE; CYCLOPAMINE; EPIDERMAL GROWTH FACTOR; GLIOMA ASSOCIATED ONCOGENE HOMOLOGUE 1; INSULIN; LEUKEMIA INHIBITORY FACTOR; NOTCH RECEPTOR; PROTEIN; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ACINAR CELL; ADULT ANIMAL; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL THERAPY; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; EMBRYOID BODY; EXOCRINE CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; INCUBATION TIME; METAPLASIA; NONHUMAN; PANCREAS CELL; PANCREAS ISLET; PANCREAS ISLET BETA CELL; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ACINAR CELLS; ANIMALS; CELL TRANSDIFFERENTIATION; EPIDERMAL GROWTH FACTOR; HEDGEHOG PROTEINS; INSULIN-SECRETING CELLS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LEUKEMIA INHIBITORY FACTOR; MICE; PANCREAS, EXOCRINE; RATS; RATS, WISTAR; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 84862556002     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2434-8     Document Type: Article

References (41)

1. Hruban RH, Adsay NV, Albores-Saavedra J et al (2006) Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res 66:95-106
2. Rooman I, Heremans Y, Heimberg H, Bouwens L (2000) Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro. Diabetologia 43:907-914
3. Jensen JN, Cameron E, Garay MV, Starkey TW, Gianani R, Jensen J (2005) Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration. Gastroenterology 128:728-741
4. Lardon J, Bouwens L (2005) Metaplasia in the pancreas. Differentiation 73:278-286
5. Pinho AV, Rooman I, Reichert M et al (2011) Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis. Gut 60:958-966
6. Baeyens L, Bonne S, German MS, Ravassard P, Heimberg H, Bouwens L (2006) Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway. Cell Death Differ 13:1892-1899
7. Baeyens L, de Breuck S, Lardon J, Mfopou JK, Rooman I, Bouwens L (2005) In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia 48:49-57
8. Baeyens L, Bonne S, Bos T et al (2009) Notch signaling as gatekeeper of rat acinar-to-beta cell conversion in vitro. Gastroen-terology 136:1750-1760e13
9. Houbracken I, Waele ED, Lardon J, et al. (2011) Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas. Gastroenterology 141: 731-741.e4
10. Hebrok M, Kim SK, Melton DA (1998) Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev 12:1705-1713
11. Kim SK, Hebrok M, Melton DA (1997) Notochord to endoderm signaling is required for pancreas development. Development 124:4243-4252
12. Kim SK, Melton DA (1998) Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc Natl Acad Sci USA 95:13036-13041
13. Hebrok M, Kim SK, St Jacques B, McMahon AP, Melton DA (2000) Regulation of pancreas development by hedgehog signaling. Development 127:4905-4913
14. Ramalho-Santos M, Melton DA, McMahon AP (2000) Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127:2763-2772
15. Apelqvist A, Ahlgren U, Edlund H (1997) Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr Biol 7:801-804
16. Kawahira H, Scheel DW, Smith SB, German MS, Hebrok M (2005) Hedgehog signaling regulates expansion of pancreatic epithelial cells. Dev Biol 280:111-121
17. Hebrok M (2003) Hedgehog signaling in pancreas development. Mech Dev 120:45-57
18. Kawahira H, Ma NH, Tzanakakis ES, McMahon AP, Chuang PT, Hebrok M (2003) Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development 130:4871-4879
19. Nakayama S, Arakawa M, Uchida T et al (2008) Dose-dependent requirement of patched homologue 1 in mouse pancreatic beta cell mass. Diabetologia 51:1883-1892
20. Thomas MK, Lee JH, Rastalsky N, Habener JF (2001) Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells. Endocrinology 142:1033-1040
21. Thomas MK, Rastalsky N, Lee JH, Habener JF (2000) Hedgehog signaling regulation of insulin production by pancreatic beta-cells. Diabetes 49:2039-2047
22. Lau J, Hebrok M (2010) Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function. Diabetes 59:1211-1221
23. Fendrich V, Esni F, Garay MV et al (2008) Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroen-terology 135:621-631
24. Landsman L, Parent A, Hebrok M (2011) Elevated hedgehog/Gli signaling causes {beta}-cell dedifferentiation in mice. Proc Natl Acad Sci USA 108:17010-17015
25. Mfopou JK, de Groote V, Xu X, Heimberg H, Bouwens L (2007) Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development. Stem Cells 25:1156-1165
26. Mfopou JK, Willems E, Leyns L, Bouwens L (2005) Expression of regulatory genes for pancreas development during murine embryonic stem cell differentiation. Int J Dev Biol 49:915-922
27. Rooman I, Lardon J, Flamez D, Schuit F, Bouwens L (2001) Mitogenic effect of gastrin and expression of gastrin receptors in duct-like cells of rat pancreas. Gastroenterology 121:940-949
28. Mfopou JK, Chen B, Mateizel I, Sermon K, Bouwens L (2010) Noggin, retinoids, and fibroblast growth factor regulate hepatic or pancreatic fate of human embryonic stem cells. Gastroenterology 138:2233-2245.e14
29. Kayed H, Kleeff J, Keleg S, Buchler MW, Friess H (2003) Distribution of Indian hedgehog and its receptors patched and smooth-ened in human chronic pancreatitis. J Endocrinol 178:467-478
30. Morton JP, Mongeau ME, Klimstra DS et al (2007) Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci USA 104:5103-5108
31. Pasca di Magliano M, Sekine S, Ermilov A, Ferris J, Dlugosz AA, Hebrok M (2006) Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev 20:3161-3173
32. Thayer SP, di Magliano MP, Heiser PW et al (2003) Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425:851-856
33. Cano DA, Hebrok M (2008) Hedgehog spikes pancreas regeneration. Gastroenterology 135:347-351
34. Taylor FR, Wen D, Garber EA et al (2001) Enhanced potency of human Sonic hedgehog by hydrophobic modification. Biochemistry 40:4359-4371
35. Morrow D, Cullen JP, Liu W et al (2009) Sonic hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A. Arterioscler Thromb Vasc Biol 29:1112-1118
36. Lawson ND, Vogel AM, Weinstein BM (2002) Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell 3:127-136
37. Rooman I, de Medts N, Baeyens L et al (2006) Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas. Am J Pathol 169:1206-1214
38. Wicksteed B, Alarcon C, Briaud I, Lingohr MK, Rhodes CJ (2003) Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin. J Biol Chem 278:42080-42090
39. -/mice. Diabetes 47:1046-1052
40. Wang Y, Perfetti R, Greig NH et al (1997) Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats. J Clin Invest 99:2883-2889
41. D'Alessio DA, Vahl TP (2004) Glucagon-like peptide 1: evolution of an incretin into a treatment for diabetes. Am J Physiol Endo-crinol Metab 286:E882-E890