Mutations in the sterol-sensing domain of patched suggest a role for vesicular trafficking in smoothened regulation

Current Biology

Volumn 11, Issue 8, 2001, Pages 608-613

  Strutt, H ^a   Thomas, C ^a   Nakano, Y ^a   Stark, D ^a   Neave, B ^a   Taylor, A M ^a   Ingham, P W ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; ERINACEIDAE; INSECTA;

EID: 0035901572     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00179-8     Document Type: Article

References (30)

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2. Dual roles for Patched in sequestering and transducing Hedgehog
3. Subcellular localisation of the segment polarity protein Patched suggests an interaction with the Wingless reception complex in Drosophila embryos
4. Contrasting distributions of Ppatched and Hedgehog proteins in the Drosophila embryo
5. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
6. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified Hedgehog from signaling cells
7. Receptor-mediated endocytosis of soluble and membrane-tethered sonic hedgehog by patched-1
8. The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development
9. Biochemical-evidence that patched is the hedgehog receptor
10. Setting the standards: Quality control in the secretory pathway
11. Niemann-Pick C1 Disease gene: Homology to mediators of cholesterol homeostasis
12. Murine model of Niemann-Pick C disease: Mutation in a cholesterol homeostasis gene
13. Multiple roles of cholesterol in Hedgehog protein biogenesis and signaling
14. Hedgehog induces opposite changes in turnover and subcellular localization of Patched and Smoothened
15. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein
16. Mutations in the leucine zipper motif and sterol-sensing domain inactivate the Niemann-Pick C1 glycoprotein
17. The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginal discs
18. Patched overexpression alters wing disc size and pattern-transcriptional and posttranscriptional effects on Hedgehog targets
19. Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins
20. In vivo functions of the Patched protein: Requirement of the C terminus for target gene inactivation but not Hedgehog sequestration
21. Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system
22. Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein
23. Niemann-Pick disease type C
24. The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo
25. Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi
26. The Serrate locus of Drosophila and its role in morphogenesis of imaginal discs: Control of cell proliferation
27. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
28. Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing