The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury

Journal of Hepatology

Volumn 60, Issue 1, 2014, Pages 143-151

  Grzelak, Candice Alexandra ^a   Martelotto, Luciano Gastón ^d,f   Sigglekow, Nicholas David ^a   Patkunanathan, Bramilla ^a   Ajami, Katerina ^a   Calabro, Sarah Ruth ^a   Dwyer, Benjamin James ^e   Tirnitz Parker, Janina Elke Eleonore ^e   Watkins, D Neil ^d   Warner, Fiona Jane ^a   Shackel, Nicholas Adam ^a,b,c   McCaughan, Geoffrey William ^a,b,c  

^a CENTENARY INSTITUTE   (Australia)

^b RPAH   (Australia)

^c University of Sydney   (Australia)

^d MONASH UNIVERSITY   (Australia)

^e CURTIN UNIVERSITY   (Australia)

^f MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

GLI; Hedgehog signalling pathway; Liver progenitor cells; Non canonical cell signalling; Primary cilia; Smoothened; Thioacetamide

Indexed keywords

EPITHELIAL CELL ADHESION MOLECULE; MESSENGER RNA; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; THIOACETAMIDE; TRANSCRIPTION FACTOR GLI2; LIGAND;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELL PROLIFERATION; CILIATED EPITHELIUM; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; KNOCKOUT GENE; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STEM CELL NICHE; WILD TYPE; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; CHRONIC DISEASE; EUKARYOTIC FLAGELLUM; GENE SILENCING; LEUKOCYTE; MALE; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; STEM CELL;

ALANINE AMINOTRANSFERASE; ALCOHOLIC LIVER DISEASE; ALD; ALT; CK; CYTOKERATIN; DESERT HEDGEHOG; DHH; EGF; EMT; EPCAM; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELL ADHESION MOLECULE; EPITHELIAL-TO-MESENCHYMAL TRANSITION; GLI; GLI CLEAVED REPRESSOR; GLI FULL-LENGTH ACTIVATOR; GLI-A; GLI-KRUPPEL FAMILY OF TRANSCRIPTION FACTORS; GLI-R; HEDGEHOG; HEDGEHOG SIGNALLING PATHWAY; HEPATIC STELLATE CELL; HEPATOCYTE GROWTH FACTOR; HGF; HH; HSC; IHH; INDIAN HEDGEHOG; LIVER PROGENITOR CELL; LIVER PROGENITOR CELLS; LPC; MCDE; METHIONINE CHOLINE-DEFICIENT DIET+ETHIONINE; N-HH; N-TERMINAL HEDGEHOG SIGNALLING PEPTIDE; NON-CANONICAL CELL SIGNALLING; NON-TARGETING CONTROL; NT2; PATCHED 1; PC; PRIMARY CILIA; PTC1(+/-); PTC1-LACZ REPORTER; PTCH1; SHH; SMO; SMOOTHENED; SONIC HEDGEHOG; TAA; THIOACETAMIDE; Α-SMA; Α-SMOOTH MUSCLE ACTIN;

ANIMALS; CHRONIC DISEASE; CILIA; DRUG-INDUCED LIVER INJURY; EPITHELIAL-MESENCHYMAL TRANSITION; HEDGEHOG PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIVER; MALE; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; THIOACETAMIDE;

EID: 84890567500     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.08.012     Document Type: Article

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