Elevated Hedgehog/Gli signaling causes β-cell dedifferentiation in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 41, 2011, Pages 17010-17015

  Landsman, Limor ^a   Parent, Audrey ^a   Hebrok, Matthias ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Embryogenesis; Glucose stimulated insulin secretion; Progenitor; Signaling pathways

Indexed keywords

GLUCOSE; INSULIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR SOX9;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEDIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO DEVELOPMENT; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEM CELL; TRANSGENIC MOUSE;

ANIMALS; CELL DEDIFFERENTIATION; CILIA; GLUCOSE INTOLERANCE; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; INSULIN-SECRETING CELLS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MICE; MICE, TRANSGENIC; NUCLEAR PROTEINS; PANCREATIC NEOPLASMS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SOX9 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTOME; UP-REGULATION;

ERINACEIDAE; MUS; MUS MUSCULUS;

EID: 80054743186     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1105404108     Document Type: Article

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