-
1
-
-
0030602796
-
The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
-
Alcedo J, Ayzenzon M, Von Ohlen T, Noll M, Hooper JE. 1996. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 86: 221-232.
-
(1996)
Cell
, vol.86
, pp. 221-232
-
-
Alcedo, J.1
Ayzenzon, M.2
Von Ohlen, T.3
Noll, M.4
Hooper, J.E.5
-
2
-
-
34249007279
-
The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development
-
Allen BL, Tenzen T, McMahon AP. 2007. The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev 21: 1244-1257.
-
(2007)
Genes Dev
, vol.21
, pp. 1244-1257
-
-
Allen, B.L.1
Tenzen, T.2
McMahon, A.P.3
-
3
-
-
0035694931
-
Distinct roles of central missing and dispatched in sending the Hedgehog signal
-
Amanai K, Jiang J. 2001. Distinct roles of Central missing and Dispatched in sending the Hedgehog signal. Development 128: 5119-5127. (Pubitemid 34083037)
-
(2001)
Development
, vol.128
, Issue.24
, pp. 5119-5127
-
-
Amanai, K.1
Jiang, J.2
-
4
-
-
48649101192
-
Glypican-mediated endocytosis of Hedgehog has opposite effects in flies and mice
-
Beckett K, Franch-Marro X, Vincent JP. 2008. Glypican-mediated endocytosis of Hedgehog has opposite effects in flies and mice. Trends Cell Biol 18: 360-363.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 360-363
-
-
Beckett, K.1
Franch-Marro, X.2
Vincent, J.P.3
-
5
-
-
67650287075
-
Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP
-
Bishop B, Aricescu AR, Harlos K, O'Callaghan CA, Jones EY, Siebold C. 2009. Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP. Nat Struct Mol Biol 16: 698-703.
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 698-703
-
-
Bishop, B.1
Aricescu, A.R.2
Harlos, K.3
O'Callaghan, C.A.4
Jones, E.Y.5
Siebold, C.6
-
6
-
-
0030111258
-
Sertoli cell signaling by Desert hedgehog regulates the male germline
-
Bitgood MJ, Shen L, McMahon AP. 1996. Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol 6: 298-304.
-
(1996)
Curr Biol
, vol.6
, pp. 298-304
-
-
Bitgood, M.J.1
Shen, L.2
McMahon, A.P.3
-
7
-
-
1842611616
-
Similar active sites in lysostaphins and D-Ala-D-Ala metallopeptidases
-
DOI 10.1110/ps.03515704
-
Bochtler M, Odintsov SG, Marcyjaniak M, Sabala I. 2004. Similar active sites in lysostaphins and D-Ala-D-Ala metallopeptidases. Protein Sci 13: 854-861. (Pubitemid 38429209)
-
(2004)
Protein Science
, vol.13
, Issue.4
, pp. 854-861
-
-
Bochtler, M.1
Odintsov, S.G.2
Marcyjaniak, M.3
Sabala, I.4
-
8
-
-
67650337273
-
The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling
-
Bosanac I, Maun HR, Scales SJ, Wen X, Lingel A, Bazan JF, de Sauvage FJ, Hymowitz SG, Lazarus RA. 2009. The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. Nat Struct Mol Biol 16: 691-697.
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 691-697
-
-
Bosanac, I.1
Maun, H.R.2
Scales, S.J.3
Wen, X.4
Lingel, A.5
Bazan, J.F.6
De Sauvage, F.J.7
Hymowitz, S.G.8
Lazarus, R.A.9
-
9
-
-
0035138842
-
Extracellular calcium sensing and extracellular calcium signaling
-
Brown EM, MacLeod RJ. 2001. Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 81: 239-297.
-
(2001)
Physiol Rev
, vol.81
, pp. 239-297
-
-
Brown, E.M.1
MacLeod, R.J.2
-
10
-
-
51949097274
-
Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog
-
Buglino JA, Resh MD. 2008. Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog. J Biol Chem 283: 22076-22088.
-
(2008)
J Biol Chem
, vol.283
, pp. 22076-22088
-
-
Buglino, J.A.1
Resh, M.D.2
-
11
-
-
0028966517
-
Proteolytic processing yields two secreted forms of sonic hedgehog
-
Bumcrot DA, Takada R, McMahon AP. 1995. Proteolytic processing yields two secreted forms of sonic hedgehog. Mol Cell Biol 15: 2294-2303.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 2294-2303
-
-
Bumcrot, D.A.1
Takada, R.2
McMahon, A.P.3
-
12
-
-
0033598964
-
Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
-
Burke R, Nellen D, Bellotto M, Hafen E, Senti KA, Dickson BJ, Basler K. 1999. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell 99: 803-815.
-
(1999)
Cell
, vol.99
, pp. 803-815
-
-
Burke, R.1
Nellen, D.2
Bellotto, M.3
Hafen, E.4
Senti, K.A.5
Dickson, B.J.6
Basler, K.7
-
13
-
-
69249232260
-
Brachydactyly A-1 mutations restricted to the central region of the N-terminal active fragment of Indian Hedgehog
-
Byrnes AM, Racacho L, Grimsey A, Hudgins L, Kwan AC, Sangalli M, Kidd A, Yaron Y, Lau YL, Nikkel SM, et al. 2009. Brachydactyly A-1 mutations restricted to the central region of the N-terminal active fragment of Indian Hedgehog. Eur J Hum Genet 17: 1112-1120.
-
(2009)
Eur J Hum Genet
, vol.17
, pp. 1112-1120
-
-
Byrnes, A.M.1
Racacho, L.2
Grimsey, A.3
Hudgins, L.4
Kwan, A.C.5
Sangalli, M.6
Kidd, A.7
Yaron, Y.8
Lau, Y.L.9
Nikkel, S.M.10
-
14
-
-
43049097898
-
Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding
-
Capurro MI, Xu P, Shi W, Li F, Jia A, Filmus J. 2008. Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. Dev Cell 14: 700-711.
-
(2008)
Dev Cell
, vol.14
, pp. 700-711
-
-
Capurro, M.I.1
Xu, P.2
Shi, W.3
Li, F.4
Jia, A.5
Filmus, J.6
-
15
-
-
0035860538
-
Skinny Hedgehog, an acyltransferase required for palmitoylation and activity of the Hedgehog signal
-
DOI 10.1126/science.1064437
-
Chamoun Z, Mann RK, Nellen D, von Kessler DP, Bellotto M, Beachy PA, Basler K. 2001. Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science 293: 2080-2084. (Pubitemid 32848055)
-
(2001)
Science
, vol.293
, Issue.5537
, pp. 2080-2084
-
-
Chamoun, Z.1
Mann, R.K.2
Nellen, D.3
Von Kessler, D.P.4
Bellotto, M.5
Beachy, P.A.6
Basler, K.7
-
16
-
-
0027939318
-
Products, genetic linkage and limb patterning activity of a murine hedgehog gene
-
Chang DT, Lopez A, von Kessler DP, Chiang C, Simandl BK, Zhao R, Seldin MF, Fallon JF, Beachy PA. 1994. Products, genetic linkage and limb patterning activity of a murine hedgehog gene. Development 120: 3339-3353.
-
(1994)
Development
, vol.120
, pp. 3339-3353
-
-
Chang, D.T.1
Lopez, A.2
Von Kessler, D.P.3
Chiang, C.4
Simandl, B.K.5
Zhao, R.6
Seldin, M.F.7
Fallon, J.F.8
Beachy, P.A.9
-
17
-
-
13344284648
-
An immunological approach reveals biological differences between the two NDF/heregulin receptors, ErbB-3 and ErbB-4
-
Chen X, Levkowitz G, Tzahar E, Karunagaran D, Lavi S, Ben-Baruch N, Leitner O, Ratzkin BJ, Bacus SS, Yarden Y. 1996. An immunological approach reveals biological differences between the two NDF/heregulin receptors, ErbB-3 and ErbB-4. J Biol Chem 271: 7620-7629.
-
(1996)
J Biol Chem
, vol.271
, pp. 7620-7629
-
-
Chen, X.1
Levkowitz, G.2
Tzahar, E.3
Karunagaran, D.4
Lavi, S.5
Ben-Baruch, N.6
Leitner, O.7
Ratzkin, B.J.8
Bacus, S.S.9
Yarden, Y.10
-
18
-
-
1842853184
-
Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
-
Chen MH, Li YJ, Kawakami T, Xu SM, Chuang PT. 2004. Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev 18: 641-659.
-
(2004)
Genes Dev
, vol.18
, pp. 641-659
-
-
Chen, M.H.1
Li, Y.J.2
Kawakami, T.3
Xu, S.M.4
Chuang, P.T.5
-
19
-
-
0029777408
-
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
-
Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA. 1996. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383: 407-413.
-
(1996)
Nature
, vol.383
, pp. 407-413
-
-
Chiang, C.1
Litingtung, Y.2
Lee, E.3
Young, K.E.4
Corden, J.L.5
Westphal, H.6
Beachy, P.A.7
-
20
-
-
0033580269
-
Vertebrate hedgehog signalling modulated by induction of a hedgehog- Binding protein
-
DOI 10.1038/17611
-
Chuang PT, McMahon AP. 1999. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 397: 617-621. (Pubitemid 29091947)
-
(1999)
Nature
, vol.397
, Issue.6720
, pp. 617-621
-
-
Chuang, P.-T.1
McMahon, A.P.2
-
21
-
-
0037314331
-
Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung
-
Chuang PT, Kawcak T, McMahon AP. 2003. Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev 17: 342-347.
-
(2003)
Genes Dev
, vol.17
, pp. 342-347
-
-
Chuang, P.T.1
Kawcak, T.2
McMahon, A.P.3
-
22
-
-
0037418593
-
Microform holoprosencephaly in mice that lack the Ig superfamily member Cdon
-
Cole F, Krauss RS. 2003. Microform holoprosencephaly in mice that lack the Ig superfamily member Cdon. Curr Biol 13: 411-415.
-
(2003)
Curr Biol
, vol.13
, pp. 411-415
-
-
Cole, F.1
Krauss, R.S.2
-
23
-
-
26644460824
-
Vertebrate Smoothened functions at the primary cilium
-
Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, Reiter JF. 2005. Vertebrate Smoothened functions at the primary cilium. Nature 437: 1018-1021.
-
(2005)
Nature
, vol.437
, pp. 1018-1021
-
-
Corbit, K.C.1
Aanstad, P.2
Singla, V.3
Norman, A.R.4
Stainier, D.Y.5
Reiter, J.F.6
-
24
-
-
0033539473
-
Zinc-dependent structural stability of human Sonic hedgehog
-
Day ES, Wen D, Garber EA, Hong J, Avedissian LS, Rayhorn P, Shen W, Zeng C, Bailey VR, Reilly JO, et al. 1999. Zinc-dependent structural stability of human Sonic hedgehog. Biochemistry 38: 14868-14880.
-
(1999)
Biochemistry
, vol.38
, pp. 14868-14880
-
-
Day, E.S.1
Wen, D.2
Garber, E.A.3
Hong, J.4
Avedissian, L.S.5
Rayhorn, P.6
Shen, W.7
Zeng, C.8
Bailey, V.R.9
Reilly, J.O.10
-
25
-
-
0034682719
-
Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
-
Denef N, Neubuser D, Perez L, Cohen SM. 2000. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 102: 521-531.
-
(2000)
Cell
, vol.102
, pp. 521-531
-
-
Denef, N.1
Neubuser, D.2
Perez, L.3
Cohen, S.M.4
-
26
-
-
0346258165
-
The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila
-
DOI 10.1242/dev.00874
-
Desbordes SC, Sanson B. 2003. The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila. Development 130: 6245-6255. (Pubitemid 38008823)
-
(2003)
Development
, vol.130
, Issue.25
, pp. 6245-6255
-
-
Desbordes, S.C.1
Sanson, B.2
-
28
-
-
0030611387
-
Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity
-
Duan X, Gimble FS, Quiocho FA. 1997. Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity. Cell 89: 555-564.
-
(1997)
Cell
, vol.89
, pp. 555-564
-
-
Duan, X.1
Gimble, F.S.2
Quiocho, F.A.3
-
29
-
-
0027756145
-
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
-
Echelard Y, Epstein DJ, St-Jacques B, Shen L, Mohler J, McMahon JA, McMahon AP. 1993. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75: 1417-1430.
-
(1993)
Cell
, vol.75
, pp. 1417-1430
-
-
Echelard, Y.1
Epstein, D.J.2
St-Jacques, B.3
Shen, L.4
Mohler, J.5
McMahon, J.A.6
McMahon, A.P.7
-
30
-
-
0030584081
-
Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity
-
Ericson J, Morton S, Kawakami A, Roelink H, Jessell TM. 1996. Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell 87: 661-673.
-
(1996)
Cell
, vol.87
, pp. 661-673
-
-
Ericson, J.1
Morton, S.2
Kawakami, A.3
Roelink, H.4
Jessell, T.M.5
-
31
-
-
66249084507
-
Glypicans
-
doi: 10.1186/gb-2008-9-5-224
-
Filmus J, Capurro M, Rast J. 2008. Glypicans. Genome Biol 9: 224. doi: 10.1186/gb-2008-9-5-224.
-
(2008)
Genome Biol
, vol.9
, pp. 224
-
-
Filmus, J.1
Capurro, M.2
Rast, J.3
-
32
-
-
0033613253
-
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched
-
Fuse N, Maiti T, Wang B, Porter JA, Hall TM, Leahy DJ, Beachy PA. 1999. Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proc Natl Acad Sci 96: 10992-10999.
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 10992-10999
-
-
Fuse, N.1
Maiti, T.2
Wang, B.3
Porter, J.A.4
Hall, T.M.5
Leahy, D.J.6
Beachy, P.A.7
-
33
-
-
43049138477
-
Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and wingless transcytosis
-
Gallet A, Staccini-Lavenant L, Therond PP. 2008. Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and wingless transcytosis. Dev Cell 14: 712-725.
-
(2008)
Dev Cell
, vol.14
, pp. 712-725
-
-
Gallet, A.1
Staccini-Lavenant, L.2
Therond, P.P.3
-
34
-
-
0034935075
-
Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1
-
Gao B, Guo J, She C, Shu A, Yang M, Tan Z, Yang X, Guo S, Feng G, He L. 2001. Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. Nat Genet 28: 386-388.
-
(2001)
Nat Genet
, vol.28
, pp. 386-388
-
-
Gao, B.1
Guo, J.2
She, C.3
Shu, A.4
Yang, M.5
Tan, Z.6
Yang, X.7
Guo, S.8
Feng, G.9
He, L.10
-
35
-
-
67349243876
-
A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range
-
Gao B, Hu J, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L, et al. 2009. A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature 458: 1196-1200.
-
(2009)
Nature
, vol.458
, pp. 1196-1200
-
-
Gao, B.1
Hu, J.2
Stricker, S.3
Cheung, M.4
Ma, G.5
Law, K.F.6
Witte, F.7
Briscoe, J.8
Mundlos, S.9
He, L.10
-
36
-
-
13244292984
-
Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog
-
Glise B, Miller CA, Crozatier M, Halbisen MA, Wise S, Olson DJ, Vincent A, Blair SS. 2005. Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog. Dev Cell 8: 255-266.
-
(2005)
Dev Cell
, vol.8
, pp. 255-266
-
-
Glise, B.1
Miller, C.A.2
Crozatier, M.3
Halbisen, M.A.4
Wise, S.5
Olson, D.J.6
Vincent, A.7
Blair, S.S.8
-
37
-
-
0030027059
-
Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
-
Goodrich LV, Johnson RL, Milenkovic L, McMahon JA, Scott MP. 1996. Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog. Genes Dev 10: 301-312.
-
(1996)
Genes Dev
, vol.10
, pp. 301-312
-
-
Goodrich, L.V.1
Johnson, R.L.2
Milenkovic, L.3
McMahon, J.A.4
Scott, M.P.5
-
38
-
-
13244257603
-
The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog
-
Gorfinkiel N, Sierra J, Callejo A, Ibanez C, Guerrero I. 2005. The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog. Dev Cell 8: 241-253.
-
(2005)
Dev Cell
, vol.8
, pp. 241-253
-
-
Gorfinkiel, N.1
Sierra, J.2
Callejo, A.3
Ibanez, C.4
Guerrero, I.5
-
40
-
-
0028841677
-
A potential catalytic site revealed by the 1.7-Å crystal structure of the amino-terminal signalling domain of Sonic hedgehog
-
Hall TM, Porter JA, Beachy PA, Leahy DJ. 1995. A potential catalytic site revealed by the 1.7-Å crystal structure of the amino-terminal signalling domain of Sonic hedgehog. Nature 378: 212-216.
-
(1995)
Nature
, vol.378
, pp. 212-216
-
-
Hall, T.M.1
Porter, J.A.2
Beachy, P.A.3
Leahy, D.J.4
-
41
-
-
0342813091
-
Crystal structure of a Hedgehog autoprocessing domain: Homology between Hedgehog and self-splicing proteins
-
Hall TM, Porter JA, Young KE, Koonin EV, Beachy PA, Leahy DJ. 1997. Crystal structure of a Hedgehog autoprocessing domain: Homology between Hedgehog and self-splicing proteins. Cell 91: 85-97.
-
(1997)
Cell
, vol.91
, pp. 85-97
-
-
Hall, T.M.1
Porter, J.A.2
Young, K.E.3
Koonin, E.V.4
Beachy, P.A.5
Leahy, D.J.6
-
42
-
-
1242329977
-
Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process
-
Han C, Belenkaya TY, Wang B, Lin X. 2004. Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process. Development 131: 601-611.
-
(2004)
Development
, vol.131
, pp. 601-611
-
-
Han, C.1
Belenkaya, T.Y.2
Wang, B.3
Lin, X.4
-
43
-
-
70350008258
-
Selection and structure of hyperactive inteins: Peripheral changes relayed to the catalytic center
-
Hiraga K, Soga I, Dansereau JT, Pereira B, Derbyshire V, Du Z, Wang C, Van Roey P, Belfort G, Belfort M. 2009. Selection and structure of hyperactive inteins: Peripheral changes relayed to the catalytic center. J Mol Biol 393: 1106-1117.
-
(2009)
J Mol Biol
, vol.393
, pp. 1106-1117
-
-
Hiraga, K.1
Soga, I.2
Dansereau, J.T.3
Pereira, B.4
Derbyshire, V.5
Du, Z.6
Wang, C.7
Van Roey, P.8
Belfort, G.9
Belfort, M.10
-
44
-
-
0024468746
-
The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
-
Hooper JE, Scott MP. 1989. The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 59: 751-765.
-
(1989)
Cell
, vol.59
, pp. 751-765
-
-
Hooper, J.E.1
Scott, M.P.2
-
45
-
-
0025815911
-
Role of the Drosophila patched gene in positional signalling
-
Ingham PW, Taylor AM, Nakano Y. 1991. Role of the Drosophila patched gene in positional signaling. Nature 353: 184-187. (Pubitemid 21912487)
-
(1991)
Nature
, vol.353
, Issue.6340
, pp. 184-187
-
-
Ingham, P.W.1
Taylor, A.M.2
Nakano, Y.3
-
46
-
-
0034687244
-
Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein
-
Ingham PW, Nystedt S, Nakano Y, Brown W, Stark D, van den Heuvel M, Taylor AM. 2000. Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein. Curr Biol 10: 1315-1318.
-
(2000)
Curr Biol
, vol.10
, pp. 1315-1318
-
-
Ingham, P.W.1
Nystedt, S.2
Nakano, Y.3
Brown, W.4
Stark, D.5
Van Den Heuvel, M.6
Taylor, A.M.7
-
47
-
-
15844381336
-
Human homolog of patched, a candidate gene for the basal cell nevus syndrome
-
Johnson RL, Rothman AL, Xie J, Goodrich LV, Bare JW, Bonifas JM, Quinn AG, Myers RM, Cox DR, Epstein EH Jr, et al. 1996. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272: 1668-1671.
-
(1996)
Science
, vol.272
, pp. 1668-1671
-
-
Johnson, R.L.1
Rothman, A.L.2
Xie, J.3
Goodrich, L.V.4
Bare, J.W.5
Bonifas, J.M.6
Quinn, A.G.7
Myers, R.M.8
Cox, D.R.9
Epstein Jr., E.H.10
-
48
-
-
0037080787
-
BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation
-
Kang JS, Mulieri PJ, Hu Y, Taliana L, Krauss RS. 2002. BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. EMBO J 21: 114-124.
-
(2002)
EMBO J
, vol.21
, pp. 114-124
-
-
Kang, J.S.1
Mulieri, P.J.2
Hu, Y.3
Taliana, L.4
Krauss, R.S.5
-
49
-
-
77955298373
-
All mammalian Hedgehog proteins interact with CDO and BOC in a conserved manner
-
Kavran JM, Ward MD, Oladosu OO, Mulepati S, Leahy DJ. 2010. All mammalian Hedgehog proteins interact with CDO and BOC in a conserved manner. J Biol Chem 285: 24584-24590.
-
(2010)
J Biol Chem
, vol.285
, pp. 24584-24590
-
-
Kavran, J.M.1
Ward, M.D.2
Oladosu, O.O.3
Mulepati, S.4
Leahy, D.J.5
-
50
-
-
0031975772
-
Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing
-
DOI 10.1038/nsb0198-31
-
Klabunde T, Sharma S, Telenti A, Jacobs WR Jr, Sacchettini JC. 1998. Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing. Nat Struct Biol 5: 31-36. (Pubitemid 28048974)
-
(1998)
Nature Structural Biology
, vol.5
, Issue.1
, pp. 31-36
-
-
Klabunde, T.1
Sharma, S.2
Telenti, A.3
Jacobs Jr., W.R.4
Sacchettini, J.C.5
-
51
-
-
0027749249
-
A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
-
Krauss S, Concordet JP, Ingham PW. 1993. A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell 75: 1431-1444.
-
(1993)
Cell
, vol.75
, pp. 1431-1444
-
-
Krauss, S.1
Concordet, J.P.2
Ingham, P.W.3
-
52
-
-
0026783674
-
Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
-
Lee JJ, von Kessler DP, Parks S, Beachy PA. 1992. Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell 71: 33-50.
-
(1992)
Cell
, vol.71
, pp. 33-50
-
-
Lee, J.J.1
Von Kessler, D.P.2
Parks, S.3
Beachy, P.A.4
-
53
-
-
0028641336
-
Autoproteolysis in hedgehog protein biogenesis
-
Lee JJ, Ekker SC, von Kessler DP, Porter JA, Sun BI, Beachy PA. 1994. Autoproteolysis in hedgehog protein biogenesis. Science 266: 1528-1537.
-
(1994)
Science
, vol.266
, pp. 1528-1537
-
-
Lee, J.J.1
Ekker, S.C.2
Von Kessler, D.P.3
Porter, J.A.4
Sun, B.I.5
Beachy, P.A.6
-
54
-
-
0035337027
-
An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development
-
Lee JD, Kraus P, Gaiano N, Nery S, Kohtz J, Fishell G, Loomis CA, Treisman JE. 2001. An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development. Dev Biol 233: 122-136.
-
(2001)
Dev Biol
, vol.233
, pp. 122-136
-
-
Lee, J.D.1
Kraus, P.2
Gaiano, N.3
Nery, S.4
Kohtz, J.5
Fishell, G.6
Loomis, C.A.7
Treisman, J.E.8
-
55
-
-
77952883331
-
A novel heterozygous mutation in the Indian hedgehog gene (IHH) is associated with brachydactyly type A1 in a Chinese family
-
Liu M, Wang X, Cai Z, Tang Z, Cao K, Liang B, Ren X, Liu JY, Wang QK. 2006. A novel heterozygous mutation in the Indian hedgehog gene (IHH) is associated with brachydactyly type A1 in a Chinese family. J Hum Genet 51: 727-731.
-
(2006)
J Hum Genet
, vol.51
, pp. 727-731
-
-
Liu, M.1
Wang, X.2
Cai, Z.3
Tang, Z.4
Cao, K.5
Liang, B.6
Ren, X.7
Liu, J.Y.8
Wang, Q.K.9
-
56
-
-
0037470952
-
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells
-
DOI 10.1126/science.1081403
-
Lum L, Yao S, Mozer B, Rovescalli A, Von Kessler D, Nirenberg M, Beachy PA. 2003. Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science 299: 2039-2045. (Pubitemid 36383726)
-
(2003)
Science
, vol.299
, Issue.5615
, pp. 2039-2045
-
-
Lum, L.1
Yao, S.2
Mozer, B.3
Rovescalli, A.4
Von Kessler, D.5
Nirenberg, M.6
Beachy, P.A.7
-
57
-
-
28044441095
-
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly
-
Maity T, Fuse N, Beachy PA. 2005. Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly. Proc Natl Acad Sci 102: 17026-17031.
-
(2005)
Proc Natl Acad Sci
, vol.102
, pp. 17026-17031
-
-
Maity, T.1
Fuse, N.2
Beachy, P.A.3
-
58
-
-
2942742564
-
Novel lipid modifications of secreted protein signals
-
Mann RK, Beachy PA. 2004. Novel lipid modifications of secreted protein signals. Annu Rev Biochem 73: 891-923.
-
(2004)
Annu Rev Biochem
, vol.73
, pp. 891-923
-
-
Mann, R.K.1
Beachy, P.A.2
-
59
-
-
0029948270
-
Biochemical evidence that patched is the hedgehog receptor
-
DOI 10.1038/384176a0
-
Marigo V, Davey RA, Zuo Y, Cunningham JM, Tabin CJ. 1996. Biochemical evidence that patched is the Hedgehog receptor. Nature 384: 176-179. (Pubitemid 26386474)
-
(1996)
Nature
, vol.384
, Issue.6605
, pp. 176-179
-
-
Marigo, V.1
Davey, R.A.2
Zuo, Y.3
Cunningham, J.M.4
Tabin, C.J.5
-
60
-
-
34249011892
-
Gas1 extends the range of Hedgehog action by facilitating its signaling
-
Martinelli DC, Fan CM. 2007. Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev 21: 1231-1243.
-
(2007)
Genes Dev
, vol.21
, pp. 1231-1243
-
-
Martinelli, D.C.1
Fan, C.M.2
-
61
-
-
77955953035
-
The Hedgehog pathway antagonist 5E1 binds Hedgehog at the pseudo-active site
-
Maun HR, Wen X, Lingel A, de Sauvage FJ, Lazarus RA, Scales SJ, Hymowitz SG. 2010. The Hedgehog pathway antagonist 5E1 binds Hedgehog at the pseudo-active site. J Biol Chem 285: 26570-26580.
-
(2010)
J Biol Chem
, vol.285
, pp. 26570-26580
-
-
Maun, H.R.1
Wen, X.2
Lingel, A.3
De Sauvage, F.J.4
Lazarus, R.A.5
Scales, S.J.6
Hymowitz, S.G.7
-
62
-
-
0030779872
-
Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX
-
McCafferty DG, Lessard IA, Walsh CT. 1997. Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX. Biochemistry 36: 10498-10505.
-
(1997)
Biochemistry
, vol.36
, pp. 10498-10505
-
-
McCafferty, D.G.1
Lessard, I.A.2
Walsh, C.T.3
-
63
-
-
0037067722
-
Megalin functions as an endocytic sonic hedgehog receptor
-
McCarthy RA, Barth JL, Chintalapudi MR, Knaak C, Argraves WS. 2002. Megalin functions as an endocytic sonic hedgehog receptor. J Biol Chem 277: 25660-25667.
-
(2002)
J Biol Chem
, vol.277
, pp. 25660-25667
-
-
McCarthy, R.A.1
Barth, J.L.2
Chintalapudi, M.R.3
Knaak, C.4
Argraves, W.S.5
-
64
-
-
33751241154
-
Structure of a heparin-dependent complex of hedgehog and Ihog
-
DOI 10.1073/pnas.0606738103
-
McLellan JS, Yao S, Zheng X, Geisbrecht BV, Ghirlando R, Beachy PA, Leahy DJ. 2006. Structure of a heparin-dependent complex of Hedgehog and Ihog. Proc Natl Acad Sci 103: 17208-17213. (Pubitemid 44788948)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.46
, pp. 17208-17213
-
-
McLellan, J.S.1
Yao, S.2
Zheng, X.3
Geisbrecht, B.V.4
Ghirlando, R.5
Beachy, P.A.6
Leahy, D.J.7
-
65
-
-
54049122121
-
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla
-
McLellan JS, Zheng X, Hauk G, Ghirlando R, Beachy PA, Leahy DJ. 2008. The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature 455: 979-983.
-
(2008)
Nature
, vol.455
, pp. 979-983
-
-
McLellan, J.S.1
Zheng, X.2
Hauk, G.3
Ghirlando, R.4
Beachy, P.A.5
Leahy, D.J.6
-
67
-
-
0036339605
-
Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling
-
Micchelli CA, The I, Selva E, Mogila V, Perrimon N. 2002. Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. Development 129: 843-851.
-
(2002)
Development
, vol.129
, pp. 843-851
-
-
Micchelli, C.A.1
The, I.2
Selva, E.3
Mogila, V.4
Perrimon, N.5
-
68
-
-
0026474841
-
Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila
-
Mohler J, Vani K. 1992. Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila. Development 115: 957-971.
-
(1992)
Development
, vol.115
, pp. 957-971
-
-
Mohler, J.1
Vani, K.2
-
70
-
-
0024440611
-
A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched
-
DOI 10.1038/341508a0
-
Nakano Y, Guerrero I, Hidalgo A, Taylor A, Whittle JR, Ingham PW. 1989. A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched. Nature 341: 508-513. (Pubitemid 19252523)
-
(1989)
Nature
, vol.341
, Issue.6242
, pp. 508-513
-
-
Nakano, Y.1
Guerrero, I.2
Hidalgo, A.3
Taylor, A.4
Whittle, J.R.S.5
Ingham, P.W.6
-
71
-
-
0019133661
-
Mutations affecting segment number and polarity in Drosophila
-
DOI 10.1038/287795a0
-
Nusslein-Volhard C, Wieschaus E. 1980. Mutations affecting segment number and polarity in Drosophila. Nature 287: 795-801. (Pubitemid 11214475)
-
(1980)
Nature
, vol.287
, Issue.5785
, pp. 795-801
-
-
Nusslein-Volhard, C.1
Wieschaus, E.2
-
72
-
-
33751078546
-
Boc is a receptor for sonic hedgehog in the guidance of commissural axons
-
DOI 10.1038/nature05246, PII NATURE05246
-
Okada A, Charron F, Morin S, Shin DS, Wong K, Fabre PJ, Tessier-Lavigne M, McConnell SK. 2006. Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature 444: 369-373. (Pubitemid 44764112)
-
(2006)
Nature
, vol.444
, Issue.7117
, pp. 369-373
-
-
Okada, A.1
Charron, F.2
Morin, S.3
Shin, D.S.4
Wong, K.5
Fabre, P.J.6
Tessier-Lavigne, M.7
McConnell, S.K.8
-
73
-
-
18344378499
-
Lipoprotein particles are required for Hedgehog and Wingless signalling
-
DOI 10.1038/nature03504
-
Panakova D, Sprong H, Marois E, Thiele C, Eaton S. 2005. Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature 435: 58-65. (Pubitemid 40655904)
-
(2005)
Nature
, vol.435
, Issue.7038
, pp. 58-65
-
-
Panakova, D.1
Sprong, H.2
Marois, E.3
Thiele, C.4
Eaton, S.5
-
74
-
-
0037440459
-
Drosophila Perlecan modulates FGF and Hedgehog signals to activate neural stem cell division
-
DOI 10.1016/S0012-1606(02)00019-2, PII S0012160602000192
-
Park Y, Rangel C, Reynolds MM, Caldwell MC, Johns M, Nayak M, Welsh CJ, McDermott S, Datta S. 2003. Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division. Dev Biol 253: 247-257. (Pubitemid 36259885)
-
(2003)
Developmental Biology
, vol.253
, Issue.2
, pp. 247-257
-
-
Park, Y.1
Rangel, C.2
Reynolds, M.M.3
Caldwell, M.C.4
Johns, M.5
Nayak, M.6
Welsh, C.J.R.7
McDermott, S.8
Datta, S.9
-
75
-
-
0033179931
-
Schwann cell-derived desert hedgehog controls the development of peripheral nerve sheaths
-
DOI 10.1016/S0896-6273(01)80030-1
-
Parmantier E, Lynn B, Lawson D, Turmaine M, Namini SS, Chakrabarti L, McMahon AP, Jessen KR, Mirsky R. 1999. Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Neuron 23: 713-724. (Pubitemid 29411561)
-
(1999)
Neuron
, vol.23
, Issue.4
, pp. 713-724
-
-
Parmantier, E.1
Lynn, B.2
Lawson, D.3
Turmaine, M.4
Namini, S.S.5
Chakrabarti, L.6
McMahon, A.P.7
Jessen, K.R.8
Mirsky, R.9
-
76
-
-
15444359695
-
Identification of a palmitic acid-modified form of human Sonic hedgehog
-
Pepinsky RB, Zeng C, Wen D, Rayhorn P, Baker DP, Williams KP, Bixler SA, Ambrose CM, Garber EA, Miatkowski K, et al. 1998. Identification of a palmitic acid-modified form of human Sonic hedgehog. J Biol Chem 273: 14037-14045.
-
(1998)
J Biol Chem
, vol.273
, pp. 14037-14045
-
-
Pepinsky, R.B.1
Zeng, C.2
Wen, D.3
Rayhorn, P.4
Baker, D.P.5
Williams, K.P.6
Bixler, S.A.7
Ambrose, C.M.8
Garber, E.A.9
Miatkowski, K.10
-
77
-
-
0034646625
-
Mapping Sonic hedgehog-receptor interactions by steric interference
-
DOI 10.1074/jbc.275.15.10995
-
Pepinsky RB, Rayhorn P, Day ES, Dergay A, Williams KP, Galdes A, Taylor FR, Boriack-Sjodin PA, Garber EA. 2000. Mapping sonic hedgehog-receptor interactions by steric interference. J Biol Chem 275: 10995-11001. (Pubitemid 30212738)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.15
, pp. 10995-11001
-
-
Pepinsky, R.B.1
Rayhorn, P.2
Day, E.S.3
Dergay, A.4
Williams, K.P.5
Galdes, A.6
Taylor, F.R.7
Boriack-Sjodin, P.A.8
Garber, E.A.9
-
78
-
-
0032498234
-
Protein splicing of inteins and hedgehog autoproteolysis: Structure, function, and evolution
-
Perler FB. 1998. Protein splicing of inteins and hedgehog autoproteolysis: Structure, function, and evolution. Cell 92: 1-4.
-
(1998)
Cell
, vol.92
, pp. 1-4
-
-
Perler, F.B.1
-
79
-
-
0033520472
-
Structural basis for FGF receptor dimerization and activation
-
DOI 10.1016/S0092-8674(00)80051-3
-
Plotnikov AN, Schlessinger J, Hubbard SR, Mohammadi M. 1999. Structural basis for FGF receptor dimerization and activation. Cell 98: 641-650. (Pubitemid 29418955)
-
(1999)
Cell
, vol.98
, Issue.5
, pp. 641-650
-
-
Plotnikov, A.N.1
Schlessinger, J.2
Hubbard, S.R.3
Mohammadi, M.4
-
80
-
-
0033959532
-
Sonic hedgehog synergizes with the extracellular matrix protein Vitronectin to induce spinal motor neuron differentiation
-
Pons S, Marti E. 2000. Sonic hedgehog synergizes with the extracellular matrix protein vitronectin to induce spinal motor neuron differentiation. Development 127: 333-342. (Pubitemid 30087969)
-
(2000)
Development
, vol.127
, Issue.2
, pp. 333-342
-
-
Pons, S.1
Marti, E.2
-
81
-
-
0028948811
-
The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
-
Porter JA, von Kessler DP, Ekker SC, Young KE, Lee JJ, Moses K, Beachy PA. 1995. The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature 374: 363-366.
-
(1995)
Nature
, vol.374
, pp. 363-366
-
-
Porter, J.A.1
Von Kessler, D.P.2
Ekker, S.C.3
Young, K.E.4
Lee, J.J.5
Moses, K.6
Beachy, P.A.7
-
82
-
-
0029844192
-
Cholesterol modification of hedgehog signaling proteins in animal development
-
Porter JA, Young KE, Beachy PA. 1996. Cholesterol modification of hedgehog signaling proteins in animal development. Science 274: 255-259.
-
(1996)
Science
, vol.274
, pp. 255-259
-
-
Porter, J.A.1
Young, K.E.2
Beachy, P.A.3
-
83
-
-
0027760995
-
Sonic hedgehog mediates the polarizing activity of the ZPA
-
DOI 10.1016/0092-8674(93)90626-2
-
Riddle RD, Johnson RL, Laufer E, Tabin C. 1993. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75: 1401-1416. (Pubitemid 24021914)
-
(1993)
Cell
, vol.75
, Issue.7
, pp. 1401-1416
-
-
Riddle, R.D.1
Johnson, R.L.2
Laufer, E.3
Tabin, C.4
-
84
-
-
23444440157
-
Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
-
Roelink H, Augsburger A, Heemskerk J, Korzh V, Norlin S, Ruiz i Altaba A, Tanabe Y, Placzek M, Edlund T, Jessell TM, et al. 1994. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell 76: 761-775.
-
(1994)
Cell
, vol.76
, pp. 761-775
-
-
Roelink, H.1
Augsburger, A.2
Heemskerk, J.3
Korzh, V.4
Norlin, S.5
Ruiz I Altaba, A.6
Tanabe, Y.7
Placzek, M.8
Edlund, T.9
Jessell, T.M.10
-
85
-
-
34547110771
-
Patched1 regulates hedgehog signaling at the primary cilium
-
DOI 10.1126/science.1139740
-
Rohatgi R, Milenkovic L, Scott MP. 2007. Patched1 regulates hedgehog signaling at the primary cilium. Science 317: 372-376. (Pubitemid 47106377)
-
(2007)
Science
, vol.317
, Issue.5836
, pp. 372-376
-
-
Rohatgi, R.1
Milenkovic, L.2
Scott, M.P.3
-
86
-
-
0033567213
-
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
-
St-Jacques B, Hammerschmidt M, McMahon AP. 1999. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 13: 2072-2086.
-
(1999)
Genes Dev
, vol.13
, pp. 2072-2086
-
-
St-Jacques, B.1
Hammerschmidt, M.2
McMahon, A.P.3
-
87
-
-
0011102935
-
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
-
Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL, Scott MP, Pennica D, Goddard A, Phillips H, et al. 1996. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384: 129-134.
-
(1996)
Nature
, vol.384
, pp. 129-134
-
-
Stone, D.M.1
Hynes, M.2
Armanini, M.3
Swanson, T.A.4
Gu, Q.5
Johnson, R.L.6
Scott, M.P.7
Pennica, D.8
Goddard, A.9
Phillips, H.10
-
88
-
-
0027096741
-
The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation
-
Tabata T, Eaton S, Kornberg TB. 1992. The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes Dev 6: 2635-2645. (Pubitemid 23052890)
-
(1992)
Genes and Development
, vol.6
, Issue.12 B
, pp. 2635-2645
-
-
Tabata, T.1
Eaton, S.2
Kornberg, T.B.3
-
89
-
-
0037158748
-
Patched acts catalytically to suppress the activity of Smoothened
-
Taipale J, Cooper MK, Maiti T, Beachy PA. 2002. Patched acts catalytically to suppress the activity of Smoothened. Nature 418: 892-897.
-
(2002)
Nature
, vol.418
, pp. 892-897
-
-
Taipale, J.1
Cooper, M.K.2
Maiti, T.3
Beachy, P.A.4
-
90
-
-
0027474898
-
Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication
-
Tashiro S, Michiue T, Higashijima S, Zenno S, Ishimaru S, Takahashi F, Orihara M, Kojima T, Saigo K. 1993. Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication.Gene 124: 183-189.
-
(1993)
Gene
, vol.124
, pp. 183-189
-
-
Tashiro, S.1
Michiue, T.2
Higashijima, S.3
Zenno, S.4
Ishimaru, S.5
Takahashi, F.6
Orihara, M.7
Kojima, T.8
Saigo, K.9
-
91
-
-
33646103902
-
The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice
-
Tenzen T, Allen BL, Cole F, Kang JS, Krauss RS, McMahon AP. 2006. The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell 10: 647-656.
-
(2006)
Dev Cell
, vol.10
, pp. 647-656
-
-
Tenzen, T.1
Allen, B.L.2
Cole, F.3
Kang, J.S.4
Krauss, R.S.5
McMahon, A.P.6
-
92
-
-
0033212987
-
Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan
-
The I, Bellaiche Y, Perrimon N. 1999. Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan. Mol Cell 4: 633-639.
-
(1999)
Mol Cell
, vol.4
, pp. 633-639
-
-
The, I.1
Bellaiche, Y.2
Perrimon, N.3
-
93
-
-
68749106005
-
Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans
-
Tsai MT, Cheng CJ, Lin YC, Chen CC, Wu AR, Wu MT, Hsu CC, Yang RB. 2009. Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans. Biochem J 422: 119-128.
-
(2009)
Biochem J
, vol.422
, pp. 119-128
-
-
Tsai, M.T.1
Cheng, C.J.2
Lin, Y.C.3
Chen, C.C.4
Wu, A.R.5
Wu, M.T.6
Hsu, C.C.7
Yang, R.B.8
-
94
-
-
0029784223
-
Smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
-
van den Heuvel M, Ingham PW. 1996. smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 382: 547-551.
-
(1996)
Nature
, vol.382
, pp. 547-551
-
-
Van Den Heuvel, M.1
Ingham, P.W.2
-
95
-
-
51949085076
-
Hedgehog: Functions and mechanisms
-
Varjosalo M, Taipale J. 2008. Hedgehog: Functions and mechanisms. Genes Dev 22: 2454-2472.
-
(2008)
Genes Dev
, vol.22
, pp. 2454-2472
-
-
Varjosalo, M.1
Taipale, J.2
-
96
-
-
0034183346
-
Conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration
-
DOI 10.1046/j.1523-1747.2000.00951.x
-
Wang LC, Liu ZY, Gambardella L, Delacour A, Shapiro R, Yang J, Sizing I, Rayhorn P, Garber EA, Benjamin CD, et al. 2000. Conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration. J Invest Dermatol 114: 901-908. (Pubitemid 30252709)
-
(2000)
Journal of Investigative Dermatology
, vol.114
, Issue.5
, pp. 901-908
-
-
Wang, L.C.1
Liu, Z.-Y.2
Gambardella, L.3
Delacour, A.4
Shapiro, R.5
Yang, J.6
Sizing, I.7
Rayhorn, P.8
Garber, E.A.9
Benjamin, C.D.10
Williams, K.P.11
Taylor, F.R.12
Barrandon, Y.13
Ling, L.14
Burkly, L.C.15
-
97
-
-
77950538817
-
Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response
-
Williams EH, Pappano WN, Saunders AM, Kim MS, Leahy DJ, Beachy PA. 2010. Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Proc Natl Acad Sci 107: 5869-5874.
-
(2010)
Proc Natl Acad Sci
, vol.107
, pp. 5869-5874
-
-
Williams, E.H.1
Pappano, W.N.2
Saunders, A.M.3
Kim, M.S.4
Leahy, D.J.5
Beachy, P.A.6
-
98
-
-
33646127578
-
New 'hogs' in Hedgehog transport and signal reception
-
Wilson CW, Chuang PT. 2006. New 'hogs' in Hedgehog transport and signal reception. Cell 125: 435-438.
-
(2006)
Cell
, vol.125
, pp. 435-438
-
-
Wilson, C.W.1
Chuang, P.T.2
-
99
-
-
65549101582
-
Sonic hedgehog guides axons through a noncanonical, Src-family-kinase- dependent signaling pathway
-
Yam PT, Langlois SD, Morin S, Charron F. 2009. Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway. Neuron 62: 349-362.
-
(2009)
Neuron
, vol.62
, pp. 349-362
-
-
Yam, P.T.1
Langlois, S.D.2
Morin, S.3
Charron, F.4
-
100
-
-
46449083570
-
Opposing roles for glypicans in Hedgehog signalling
-
Yan D, Lin X. 2008. Opposing roles for glypicans in Hedgehog signalling. Nat Cell Biol 10: 761-763.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 761-763
-
-
Yan, D.1
Lin, X.2
-
101
-
-
77954055939
-
Shaping morphogen gradients by proteoglycans
-
doi: 10.1101/cshperspect.a002493
-
Yan D, Lin X. 2009. Shaping morphogen gradients by proteoglycans. Cold Spring Harb Perspect Biol 1: a002493. doi: 10.1101/cshperspect.a002493.
-
(2009)
Cold Spring Harb Perspect Biol
, vol.1
-
-
Yan, D.1
Lin, X.2
-
102
-
-
77953080875
-
The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development
-
Yan D, Wu Y, Yang Y, Belenkaya TY, Tang X, Lin X. 2010. The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development. Development 137: 2033-2044.
-
(2010)
Development
, vol.137
, pp. 2033-2044
-
-
Yan, D.1
Wu, Y.2
Yang, Y.3
Belenkaya, T.Y.4
Tang, X.5
Lin, X.6
-
103
-
-
33646035770
-
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation
-
Yao S, Lum L, Beachy P. 2006. The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell 125: 343-357.
-
(2006)
Cell
, vol.125
, pp. 343-357
-
-
Yao, S.1
Lum, L.2
Beachy, P.3
-
104
-
-
0035822098
-
A freely diffusible form of Sonic hedgehog mediates long-range signalling
-
DOI 10.1038/35079648
-
Zeng X, Goetz JA, Suber LM, Scott WJ Jr, Schreiner CM, Robbins DJ. 2001. A freely diffusible form of Sonic hedgehog mediates long-range signalling. Nature 411: 716-720. (Pubitemid 32531680)
-
(2001)
Nature
, vol.411
, Issue.6838
, pp. 716-720
-
-
Zeng, X.1
Goetz, J.A.2
Suber, L.M.3
Scott Jr., W.J.4
Schreiner, C.M.5
Robbins, D.J.6
-
105
-
-
0035958941
-
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node
-
Zhang XM, Ramalho-Santos M, McMahon AP. 2001. Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106: 781-792.
-
(2001)
Cell
, vol.106
, pp. 781-792
-
-
Zhang, X.M.1
Ramalho-Santos, M.2
McMahon, A.P.3
-
106
-
-
33646120095
-
Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
-
ZhangW, Kang JS, Cole F, Yi MJ, Krauss RS. 2006. Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev Cell 10: 657-665.
-
(2006)
Dev Cell
, vol.10
, pp. 657-665
-
-
Zhang, W.1
Kang, J.S.2
Cole, F.3
Yi, M.J.4
Krauss, R.S.5
-
107
-
-
34047241063
-
Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway
-
DOI 10.1021/bi6025424
-
Zhang F, McLellan JS, Ayala AM, Leahy DJ, Linhardt RJ. 2007. Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway. Biochemistry 46: 3933-3941. (Pubitemid 46536057)
-
(2007)
Biochemistry
, vol.46
, Issue.13
, pp. 3933-3941
-
-
Zhang, F.1
McLellan, J.S.2
Ayala, A.M.3
Leahy, D.J.4
Linhardt, R.J.5
-
108
-
-
73549083198
-
Genetic and biochemical definition of the Hedgehog receptor
-
Zheng X, Mann RK, Sever N, Beachy PA. 2010. Genetic and biochemical definition of the Hedgehog receptor. Genes Dev 24: 57-71.
-
(2010)
Genes Dev
, vol.24
, pp. 57-71
-
-
Zheng, X.1
Mann, R.K.2
Sever, N.3
Beachy, P.A.4
|