메뉴 건너뛰기




Volumn 435, Issue 7038, 2005, Pages 58-65

Lipoprotein particles are required for Hedgehog and Wingless signalling

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH KINETICS; HYDROPHOBICITY; LIPIDS; NATURAL SCIENCES; SIGNALING;

EID: 18344378499     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03504     Document Type: Article
Times cited : (563)

References (48)
  • 1
    • 0030663064 scopus 로고    scopus 로고
    • A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
    • Strigini, M. & Cohen, S. M. A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development 124, 4697-1705 (1997).
    • (1997) Development , vol.124 , pp. 4697-1705
    • Strigini, M.1    Cohen, S.M.2
  • 2
    • 0031020656 scopus 로고    scopus 로고
    • Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing
    • Neumann, C. J. & Cohen, S. M. Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing. Development 124, 861-870 (1997).
    • (1997) Development , vol.124 , pp. 861-870
    • Neumann, C.J.1    Cohen, S.M.2
  • 3
    • 15844386540 scopus 로고    scopus 로고
    • Hedgehog patterning activity; role of a lipophilic modification mediated by the carboxy-terminal auto processing domain
    • Porter, J. A. et al. Hedgehog patterning activity; role of a lipophilic modification mediated by the carboxy-terminal auto processing domain. Cell 86, 21-34 (1996).
    • (1996) Cell , vol.86 , pp. 21-34
    • Porter, J.A.1
  • 4
    • 0037737726 scopus 로고    scopus 로고
    • Wnt proteins are lipid-modified and can act as stern cell growth factors
    • Willert, K. et al. Wnt proteins are lipid-modified and can act as stern cell growth factors. Nature 423, 448-452 (2003).
    • (2003) Nature , vol.423 , pp. 448-452
    • Willert, K.1
  • 5
    • 15444359695 scopus 로고    scopus 로고
    • Identification of a palmitic acid-modified form of human Sonic hedgehog
    • Pepinsky, R. B. et al. Identification of a palmitic acid-modified form of human Sonic hedgehog. J. Biol. Chem. 273, 14037-14045 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 14037-14045
    • Pepinsky, R.B.1
  • 6
    • 0033490535 scopus 로고    scopus 로고
    • Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity
    • Williams, K. P. et al. Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity. J. Cell Sci. 112, 4405-4414 (1999).
    • (1999) J. Cell Sci. , vol.112 , pp. 4405-4414
    • Williams, K.P.1
  • 7
    • 0035860538 scopus 로고    scopus 로고
    • Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
    • Chamoun, Z. et al. Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science 293, 2080-2084 (2001).
    • (2001) Science , vol.293 , pp. 2080-2084
    • Chamoun, Z.1
  • 8
    • 0036339605 scopus 로고    scopus 로고
    • Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling
    • Micchelli, C. A., The, I., Selva, E., Mogila, V. & Perrimon, N. Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. Development 129, 843-851 (2002).
    • (2002) Development , vol.129 , pp. 843-851
    • Micchelli, C.A.1    The, I.2    Selva, E.3    Mogila, V.4    Perrimon, N.5
  • 9
    • 0035337027 scopus 로고    scopus 로고
    • An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development
    • Lee, J. D. et al. An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development. Dev. Biol. 233, 122-136 (2001).
    • (2001) Dev. Biol. , vol.233 , pp. 122-136
    • Lee, J.D.1
  • 10
    • 0037033033 scopus 로고    scopus 로고
    • Intercellular transfer of the cellular prion protein
    • Liu, T. et al. Intercellular transfer of the cellular prion protein. J. Biol. Chem. 277, 47671-47678 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 47671-47678
    • Liu, T.1
  • 11
    • 0029824262 scopus 로고    scopus 로고
    • A knock-out model of paroxysmal nocturnal hemoglobinuria: Pig-a(-) hematopoiesis is reconstituted following intercellular transfer of GPI-anchored proteins
    • Dunn, D. E. et al. A knock-out model of paroxysmal nocturnal hemoglobinuria: Pig-a(-) hematopoiesis is reconstituted following intercellular transfer of GPI-anchored proteins. Proc. Natl Acad. Sci. USA 93, 7938-7943 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 7938-7943
    • Dunn, D.E.1
  • 12
    • 0030014912 scopus 로고    scopus 로고
    • Intercellular transfer of a glycosylphosphatidylinositol (GPI)-Iinked protein: Release and uptake of CD4-GPI from recombinant adeno-associated virus-transduced HeLa cells
    • Anderson, S. M., Yu, G., Giattina, M. & Miller, J. L. Intercellular transfer of a glycosylphosphatidylinositol (GPI)-Iinked protein: release and uptake of CD4-GPI from recombinant adeno-associated virus-transduced HeLa cells. Proc. Natl Acad. Sci. USA 93, 5894-5898 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 5894-5898
    • Anderson, S.M.1    Yu, G.2    Giattina, M.3    Miller, J.L.4
  • 13
    • 0035823004 scopus 로고    scopus 로고
    • Argosomes: A potential vehicle for the spread of morphogens through epithelia
    • Greco, V., Hannus, M. & Eaton, S. Argosomes: a potential vehicle for the spread of morphogens through epithelia. Cell 106, 633-645 (2001).
    • (2001) Cell , vol.106 , pp. 633-645
    • Greco, V.1    Hannus, M.2    Eaton, S.3
  • 14
    • 0033767690 scopus 로고    scopus 로고
    • Exosome: From internal vesicle of the multivesicular body to intercellular signaling device
    • Denzer, K., Kleijmeer, M. J., Heijnen, H. F., Stoorvogel, W. & Geuze, H. J. Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J. Cell Sci. 113, 3365-3374 (2000).
    • (2000) J. Cell Sci. , vol.113 , pp. 3365-3374
    • Denzer, K.1    Kleijmeer, M.J.2    Heijnen, H.F.3    Stoorvogel, W.4    Geuze, H.J.5
  • 15
    • 0035182083 scopus 로고    scopus 로고
    • Lipid storage and mobilization in insects: Current status and future directions
    • Arrese, E. L. et al. Lipid storage and mobilization in insects: current status and future directions. Insect Biochem. Mol. Biol. 31, 7-17 (2001).
    • (2001) Insect Biochem. Mol. Biol. , vol.31 , pp. 7-17
    • Arrese, E.L.1
  • 17
    • 0032493658 scopus 로고    scopus 로고
    • Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
    • Escola, J. M. et al. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J. Biol. Chem. 273, 20121-20127 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 20121-20127
    • Escola, J.M.1
  • 18
    • 0013495952 scopus 로고    scopus 로고
    • Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation
    • Wubbolts, R. et al. Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. J. Biol. Chem. 278, 10963-10972 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 10963-10972
    • Wubbolts, R.1
  • 19
    • 0030239984 scopus 로고    scopus 로고
    • The precursor protein of the structural apolipoproteins of lipophorin: cDNA and deduced amino acid sequence
    • Sundermeyer, K., Hendricks, I. K., Prasad, S. V. & Wells, M. A. The precursor protein of the structural apolipoproteins of lipophorin: cDNA and deduced amino acid sequence. Insect Biochem. Mol. Biol. 26, 735-738 (1996).
    • (1996) Insect Biochem. Mol. Biol. , vol.26 , pp. 735-738
    • Sundermeyer, K.1    Hendricks, I.K.2    Prasad, S.V.3    Wells, M.A.4
  • 20
    • 0029810885 scopus 로고    scopus 로고
    • Molecular characterization and developmental expression of a retinoid- and fatty acid-binding glycoprotein from Drosophila. A putative lipophorin
    • Kutty, R. K. et al. Molecular characterization and developmental expression of a retinoid- and fatty acid-binding glycoprotein from Drosophila. A putative lipophorin. J. Biol. Chem. 271, 20641-20649 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 20641-20649
    • Kutty, R.K.1
  • 21
    • 0025106007 scopus 로고
    • Drosophila fasciclin I, a neural cell adhesion molecule, has a phosphatidylinositol lipid membrane anchor that is developmental regulated
    • Hortsch, M. & Goodman, C. S. Drosophila fasciclin I, a neural cell adhesion molecule, has a phosphatidylinositol lipid membrane anchor that is developmental regulated. J. Biol. Chem. 265, 15104-15109 (1990).
    • (1990) J. Biol. Chem. , vol.265 , pp. 15104-15109
    • Hortsch, M.1    Goodman, C.S.2
  • 22
    • 0026688573 scopus 로고
    • Connectin: A homophilic cell adhesion molecule expressed on a subset of muscles and the motoneurons that innervate them in Drosophila
    • Nose, A., Mahajan, V. B. & Goodman, C. S. Connectin: a homophilic cell adhesion molecule expressed on a subset of muscles and the motoneurons that innervate them in Drosophila. Cell 70, 553-567 (1992).
    • (1992) Cell , vol.70 , pp. 553-567
    • Nose, A.1    Mahajan, V.B.2    Goodman, C.S.3
  • 23
    • 0031033107 scopus 로고    scopus 로고
    • Klingon, a novel member of the Drosophila immunoglobulin superfamily, is required for the development of the R7 photoreceptor neuron
    • Butler, S. J., Ray, S. & Hiromi, Y. klingon, a novel member of the Drosophila immunoglobulin superfamily, is required for the development of the R7 photoreceptor neuron. Development 124, 781-792 (1997).
    • (1997) Development , vol.124 , pp. 781-792
    • Butler, S.J.1    Ray, S.2    Hiromi, Y.3
  • 24
    • 0029923812 scopus 로고    scopus 로고
    • Replacement of the glycoinositol phospholipid anchor of Drosophila acetylcholinesterase with a transmembrane domain does not alter sorting in neurons and epithelia but results in behavioral defects
    • Incardona, J. P. & Rosenberry, T. L. Replacement of the glycoinositol phospholipid anchor of Drosophila acetylcholinesterase with a transmembrane domain does not alter sorting in neurons and epithelia but results in behavioral defects. Mol. Biol. Cell 7, 613-630 (1996).
    • (1996) Mol. Biol. Cell , vol.7 , pp. 613-630
    • Incardona, J.P.1    Rosenberry, T.L.2
  • 25
    • 0026632816 scopus 로고
    • The bride of seven less and sevenless interaction: Internalization of a transmembrane ligand
    • Cagan, R. L., Kramer, H., Hart, A. C. & Zipursky, S. L. The bride of seven less and sevenless interaction: Internalization of a transmembrane ligand. Cell 69, 393-399 (1992).
    • (1992) Cell , vol.69 , pp. 393-399
    • Cagan, R.L.1    Kramer, H.2    Hart, A.C.3    Zipursky, S.L.4
  • 26
    • 0032705926 scopus 로고    scopus 로고
    • Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: Members of the Notch signalling pathway in Drosophila
    • Klueg, K. M. & Muskavitch, M. A. Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: members of the Notch signalling pathway in Drosophila. J. Cell Sci. 112, 3289-3297 (1999).
    • (1999) J. Cell Sci. , vol.112 , pp. 3289-3297
    • Klueg, K.M.1    Muskavitch, M.A.2
  • 27
    • 0037423256 scopus 로고    scopus 로고
    • Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila
    • Culi, I. & Mann, R. S. Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila. Cell 112, 343-354 (2003).
    • (2003) Cell , vol.112 , pp. 343-354
    • Culi, I.1    Mann, R.S.2
  • 28
    • 0021923858 scopus 로고
    • Nile red: A selective fluorescent stain for intracellular lipid droplets
    • Greenspan, P., Mayer, E. P. & Fowler, S. D. Nile red: a selective fluorescent stain for intracellular lipid droplets. J. Cell Biol. 100, 965-973 (1985).
    • (1985) J. Cell Biol. , vol.100 , pp. 965-973
    • Greenspan, P.1    Mayer, E.P.2    Fowler, S.D.3
  • 29
    • 0036484062 scopus 로고    scopus 로고
    • Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions
    • Britton, J. S., Lockwood, W. K., Li, L., Cohen, S. M. & Edgar, B. A. Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev. Cell 2, 239-249 (2002).
    • (2002) Dev. Cell , vol.2 , pp. 239-249
    • Britton, J.S.1    Lockwood, W.K.2    Li, L.3    Cohen, S.M.4    Edgar, B.A.5
  • 30
    • 0034118006 scopus 로고    scopus 로고
    • Hedgehog and wing development in Drosophila: A morphogen at work?
    • Vervoort, M. hedgehog and wing development in Drosophila: a morphogen at work? Bioessays 22, 460-468 (2000).
    • (2000) Bioessays , vol.22 , pp. 460-468
    • Vervoort, M.1
  • 31
    • 0033578020 scopus 로고    scopus 로고
    • The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing
    • Vervoort, M., Crozatier, M., Valle, D. & Vincent, A. The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing. Curr. Biol. 9, 632-639 (1999).
    • (1999) Curr. Biol. , vol.9 , pp. 632-639
    • Vervoort, M.1    Crozatier, M.2    Valle, D.3    Vincent, A.4
  • 32
    • 3042799334 scopus 로고    scopus 로고
    • Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction
    • Torroja, C., Gorfinkiel, N. & Guerrero, I. Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction. Development 131, 2395-2408 (2004).
    • (2004) Development , vol.131 , pp. 2395-2408
    • Torroja, C.1    Gorfinkiel, N.2    Guerrero, I.3
  • 33
    • 0028178786 scopus 로고
    • Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
    • Tabata, T. & Kornberg, T. B. Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76, 89-102 (1994).
    • (1994) Cell , vol.76 , pp. 89-102
    • Tabata, T.1    Kornberg, T.B.2
  • 34
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing Hedgehog
    • Chen, Y. & Struhl, G. Dual roles for patched in sequestering and transducing Hedgehog. Cell 87, 553-563 (1996).
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 35
    • 0033212987 scopus 로고    scopus 로고
    • Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan
    • The, I., Bellaiche, Y. & Perrimon, N. Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan. Mol. Cell 4, 633-639 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 633-639
    • The, I.1    Bellaiche, Y.2    Perrimon, N.3
  • 36
    • 1342341864 scopus 로고    scopus 로고
    • Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglyeans
    • Takei, Y., Ozawa, Y., Sato, M., Watanabe, A. & Tabata, T. Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglyeans. Development 131, 73-82 (2004).
    • (2004) Development , vol.131 , pp. 73-82
    • Takei, Y.1    Ozawa, Y.2    Sato, M.3    Watanabe, A.4    Tabata, T.5
  • 37
    • 0032895028 scopus 로고    scopus 로고
    • Remnant lipoprotein metabolism: Key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E
    • Mahley, R. W. & Ji, Z. S. Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E. J. Lipid Res. 40, 1-16 (1999).
    • (1999) J. Lipid Res. , vol.40 , pp. 1-16
    • Mahley, R.W.1    Ji, Z.S.2
  • 38
    • 0031877416 scopus 로고    scopus 로고
    • Association of apo B lipoproteins with arterial proteoglycans: Pathological significance and molecular basis
    • Camejo, G., Hurt-Camejo, E., Wiklund, O. & Bondjers, G. Association of apo B lipoproteins with arterial proteoglycans: pathological significance and molecular basis. Atherosclerosis 139, 205-222 (1998).
    • (1998) Atherosclerosis , vol.139 , pp. 205-222
    • Camejo, G.1    Hurt-Camejo, E.2    Wiklund, O.3    Bondjers, G.4
  • 40
    • 0034727099 scopus 로고    scopus 로고
    • Arrow encodes an LDL-receptor-related protein essential for Wingless signalling
    • Wehrli, M. et al. arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 407, 527-530 (2000).
    • (2000) Nature , vol.407 , pp. 527-530
    • Wehrli, M.1
  • 41
    • 0034727104 scopus 로고    scopus 로고
    • LDL-receptor-related proteins in Wnt signal transduction
    • Tamai, K. et al. LDL-receptor-related proteins in Wnt signal transduction. Nature 407, 530-535 (2000).
    • (2000) Nature , vol.407 , pp. 530-535
    • Tamai, K.1
  • 42
    • 0033598964 scopus 로고    scopus 로고
    • Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
    • Burke, R. et al. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell 99, 803-815 (1999).
    • (1999) Cell , vol.99 , pp. 803-815
    • Burke, R.1
  • 43
    • 0024440611 scopus 로고
    • A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched
    • Nakano, Y. et al. A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched. Nature 341, 508-513 (1989).
    • (1989) Nature , vol.341 , pp. 508-513
    • Nakano, Y.1
  • 44
    • 0344953585 scopus 로고    scopus 로고
    • A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis
    • Cooper, M, K. et al. A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nature Genet. 33, 508-513 (2003).
    • (2003) Nature Genet. , vol.33 , pp. 508-513
    • Cooper, M.K.1
  • 45
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand, A. H. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415 (1993).
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 46
    • 0034704824 scopus 로고    scopus 로고
    • Wingless gradient formation in the Drosophila wing
    • Strigini, M. & Cohen, S. M. Wingless gradient formation in the Drosophila wing. Curr. Biol. 10, 293-300 (2000).
    • (2000) Curr. Biol. , vol.10 , pp. 293-300
    • Strigini, M.1    Cohen, S.M.2
  • 47
    • 0027200833 scopus 로고
    • Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo
    • Taylor, A. M., Nakano, Y., Mohler, J. & Ingham, P. W. Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo. Mech. Dev. 42, 89-96 (1993).
    • (1993) Mech. Dev. , vol.42 , pp. 89-96
    • Taylor, A.M.1    Nakano, Y.2    Mohler, J.3    Ingham, P.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.