The hedgehog-induced smoothened conformational switch assembles a signaling complex that activates fused by promoting its dimerization and phosphorylation

Development

Volumn 138, Issue 19, 2011, Pages 4219-4231

  Shi, Qing ^a   Li, Shuang ^a   Jia, Jianhang ^b   Jiang, Jin ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Ci; Cos2; Drosophila; Fu; Hedgehog; Smo; Sufu

Indexed keywords

COSTAL2 PROTEIN; CUBITUS INTERRUPTUS PROTEIN; FUSED PROTEIN; HYBRID PROTEIN; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME REGULATION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

ALLELES; ANIMALS; DIMERIZATION; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEDGEHOG PROTEINS; KINESIN; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, G-PROTEIN-COUPLED; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

CUBITUS INTERRUPTUS; ERINACEIDAE;

EID: 80052515585     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.067959     Document Type: Article

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