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Volumn 27, Issue , 2011, Pages 513-537

Gli proteins in development and disease

Author keywords

Cancer; Hedgehog signaling; Primary cilium; Stem cell; Transcription factor; Ubiquitin proteasome system

Indexed keywords

GLIOMA ASSOCIATED ONCOGENE FAMILY MEMBER 1 PROTEIN; GLIOMA ASSOCIATED ONCOGENE FAMILY MEMBER 2 PROTEIN; GLIOMA ASSOCIATED ONCOGENE FAMILY MEMBER 3 PROTEIN; GLIOMA ASSOCIATED ONCOGENE FAMILY MEMBER PROTEIN; PROTEASOME; PROTEIN KIF7; REGULATOR PROTEIN; SONIC HEDGEHOG PROTEIN; SUPPRESSOR OF FUSED PROTEIN; TRANSCRIPTION FACTOR; UBIQUITIN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

EID: 80054022786     PISSN: 10810706     EISSN: 15308995     Source Type: Book Series    
DOI: 10.1146/annurev-cellbio-092910-154048     Document Type: Article
Times cited : (577)

References (175)
  • 1
    • 1842839986 scopus 로고    scopus 로고
    • Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site
    • DOI 10.1016/j.gene.2004.01.010, PII S0378111904000368
    • Agren M, Kogerman P, Kleman MI, Wessling M, Toftgard R. 2004. Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site. Gene 330:101-14 (Pubitemid 38490423)
    • (2004) Gene , vol.330 , Issue.1-2 , pp. 101-114
    • Agren, M.1    Kogerman, P.2    Kleman, M.I.3    Wessling, M.4    Toftgard, R.5
  • 2
    • 12344305145 scopus 로고    scopus 로고
    • Drosophila smoothened phosphorylation sites essential for Hedgehog signal transduction
    • DOI 10.1038/ncb1210
    • Apionishev S, Katanayeva NM, Marks SA, Kalderon D, Tomlinson A. 2005. Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nat. Cell Biol. 7:86-92 (Pubitemid 40123387)
    • (2005) Nature Cell Biology , vol.7 , Issue.1 , pp. 86-92
    • Apionishev, S.1    Katanayeva, N.M.2    Marks, S.A.3    Kalderon, D.4    Tomlinson, A.5
  • 3
    • 0031587830 scopus 로고    scopus 로고
    • Proteolysis that is inhibited by hedgehog targets cubitus interruptus protein to the nucleus and converts it to a repressor
    • Aza-Blanc P, Ramirez-Weber FA, Laget MP, Schwartz C, Kornberg TB. 1997. Proteolysis that is inhibited by Hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89:1043-1053 (Pubitemid 127678738)
    • (1997) Cell , vol.89 , Issue.7 , pp. 1043-1053
    • Aza-Blanc, P.1    Ramirez- Weber, F.-A.2    Laget, M.-P.3    Schwartz, C.4    Kornberg, T.B.5
  • 4
    • 0036801765 scopus 로고    scopus 로고
    • Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
    • Bai CB, Auerbach W, Lee JS, Stephen D, Joyner AL. 2002. Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development 129:4753-61 (Pubitemid 35277202)
    • (2002) Development , vol.129 , Issue.20 , pp. 4753-4761
    • Bai, C.B.1    Auerbach, W.2    Lee, J.S.3    Stephen, D.4    Joyner, A.L.5
  • 5
    • 0347764480 scopus 로고    scopus 로고
    • All mouse ventral spinal cord patterning by Hedgehog is Gli dependent and involves an activator function of Gli3
    • DOI 10.1016/S1534-5807(03)00394-0, PII S1534580703003940
    • Bai CB, Stephen D, Joyner AL. 2004. All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev. Cell 6:103-15 (Pubitemid 38089209)
    • (2004) Developmental Cell , vol.6 , Issue.1 , pp. 103-115
    • Bai, C.B.1    Stephen, D.2    Joyner, A.L.3
  • 6
    • 31744450041 scopus 로고    scopus 로고
    • Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms
    • DOI 10.1111/j.1432-0436.2005.00042.x
    • Barnfield PC, Zhang X, Thanabalasingham V, Yoshida M, Hui C-c. 2005. Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 73:397-405 (Pubitemid 43922158)
    • (2005) Differentiation , vol.73 , Issue.8 , pp. 397-405
    • Barnfield, P.C.1    Zhang, X.2    Thanabalasingham, V.3    Yoshida, M.4    Hui, C.-C.5
  • 7
    • 66149131842 scopus 로고    scopus 로고
    • GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein
    • Beauchamp E, Bulut G, Abaan O, Chen K, Merchant A, et al. 2009. GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J. Biol. Chem. 284:9074-82
    • (2009) J. Biol. Chem. , vol.284 , pp. 9074-9082
    • Beauchamp, E.1    Bulut, G.2    Abaan, O.3    Chen, K.4    Merchant, A.5
  • 8
    • 70549110151 scopus 로고    scopus 로고
    • Vertebrate limb development: Moving from classical morphogen gradients to an integrated 4-dimensional patterning system. Cold Spring Harb
    • B́enazet J-D, Zeller R. 2009. Vertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning system. Cold Spring Harb. Perspect. Biol. 1:a001339
    • (2009) Perspect. Biol. , vol.1
    • B́enazet, J.-D.1    Zeller, R.2
  • 10
    • 0036566575 scopus 로고    scopus 로고
    • Pallister-Hall syndrome phenotype in mice mutant for Gli3
    • B̈ ose J, Grotewold L, R̈ uther U. 2002. Pallister-Hall syndrome phenotype in mice mutant for Gli3. Hum. Mol. Genet. 11:1129-35
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 1129-1135
    • Böse, J.1    Grotewold, L.2    Rüther, U.3
  • 11
    • 0034640087 scopus 로고    scopus 로고
    • A homeodoamin protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
    • Briscoe J, Pierani A, Jessell TM, Ericson J. 2000. A homeodoamin protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube. Cell 101:435-45
    • (2000) Cell , vol.101 , pp. 435-445
    • Briscoe, J.1    Pierani, A.2    Jessell, T.M.3    Ericson, J.4
  • 12
    • 0346888543 scopus 로고    scopus 로고
    • Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction
    • DOI 10.1242/dev.00851
    • Buttitta L, Mo R, Hui C-c, Fan CM. 2003. Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 130:6233-43 (Pubitemid 38008822)
    • (2003) Development , vol.130 , Issue.25 , pp. 6233-6243
    • Buttitta, L.1    Mo, R.2    Hui, C.-C.3    Fan, C.-M.4
  • 13
    • 75949106376 scopus 로고    scopus 로고
    • Histone deacetylase and Cullin3-RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signaling through Gli acetylation
    • Canettieri G, DiMarcotullio L, Greco A, Coni S, Antonucci L, et al. 2010. Histone deacetylase and Cullin3-RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signaling through Gli acetylation. Nat. Cell Biol. 12:132-42
    • (2010) Nat. Cell Biol. , vol.12 , pp. 132-142
    • Canettieri, G.1    Dimarcotullio, L.2    Greco, A.3    Coni, S.4    Antonucci, L.5
  • 14
    • 23344453462 scopus 로고    scopus 로고
    • Mice deficient in the Fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development
    • DOI 10.1128/MCB.25.16.7042-7053.2005
    • Chen MH, Gao N, Kawakami T, Chuang PT. 2005. Mice deficient in the Fused homolog do not exhibit phenotypes indicative of perturbed Hedgehog signaling during embryonic development. Mol. Cell. Biol. 25:7042-53 (Pubitemid 41105903)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.16 , pp. 7042-7053
    • Chen, M.-H.1    Gao, N.2    Kawakami, T.3    Chuang, P.-T.4
  • 15
    • 69249245332 scopus 로고    scopus 로고
    • Cilium-independent regulation of Gli protein by Sufu in Hedgehog signaling is evolutionarily conserved
    • Chen MH, Wilson CW, Li JY, Law KK, Lu CS, et al. 2009. Cilium-independent regulation of Gli protein by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23:1910-28
    • (2009) Genes Dev , vol.23 , pp. 1910-1928
    • Chen, M.H.1    Wilson, C.W.2    Li, J.Y.3    Law, K.K.4    Lu, C.S.5
  • 17
    • 69449084098 scopus 로고    scopus 로고
    • The kinesin proteinKif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling
    • Cheung HO L, Zhang X, Ribeiro A, Mo R, Makino S, et al. 2009. The kinesin proteinKif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling. Sci. Signal. 2:1-7
    • (2009) Sci. Signal. , vol.2 , pp. 1-7
    • Cheung, H.O.L.1    Zhang, X.2    Ribeiro, A.3    Mo, R.4    Makino, S.5
  • 18
    • 0033580269 scopus 로고    scopus 로고
    • Vertebrate Hedgehog signaling modulated by induction of a Hedgehogbinding protein
    • Chuang PT, McMahon AP. 1999. Vertebrate Hedgehog signaling modulated by induction of a Hedgehogbinding protein. Nature 397:617-21
    • (1999) Nature , vol.397 , pp. 617-621
    • Chuang, P.T.1    McMahon, A.P.2
  • 19
    • 27644584608 scopus 로고    scopus 로고
    • Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused
    • DOI 10.1242/dev.02021
    • Cooper AF, Yu KP, Brueckner M, Brailey LL, Johnson L, et al. 2005. Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Development 132:4407-17 (Pubitemid 41576701)
    • (2005) Development , vol.132 , Issue.19 , pp. 4407-4417
    • Cooper, A.F.1    Yu, K.P.2    Brueckner, M.3    Brailey, L.L.4    Johnson, L.5    McGrath, J.M.6    Bale, A.E.7
  • 20
    • 26644460824 scopus 로고    scopus 로고
    • Vertebrate Smoothened functions at the primary cilium
    • DOI 10.1038/nature04117, PII N04117
    • Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, Reiter JF. 2005. Vertebrate Smoothened functions at the primary cilium. Nature 437:1018-21 (Pubitemid 41486982)
    • (2005) Nature , vol.437 , Issue.7061 , pp. 1018-1021
    • Corbit, K.C.1    Aanstad, P.2    Singla, V.3    Norman, A.R.4    Stainier, D.Y.R.5    Reiter, J.F.6
  • 21
    • 77957774529 scopus 로고    scopus 로고
    • SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors
    • Cox B, Briscoe J, Ulloa F. 2010. SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors. PLoS ONE 5:e11996
    • (2010) PLoS ONE , vol.5
    • Cox, B.1    Briscoe, J.2    Ulloa, F.3
  • 22
    • 78650211909 scopus 로고    scopus 로고
    • Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signaling
    • Cruz C, Ribes V, Kutejova E, Cayuso J, Lawson V, et al. 2010. Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signaling. Development 137:4271-82
    • (2010) Development , vol.137 , pp. 4271-4282
    • Cruz, C.1    Ribes, V.2    Kutejova, E.3    Cayuso, J.4    Lawson, V.5
  • 23
    • 0033583035 scopus 로고    scopus 로고
    • Sonic hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
    • Dai P, Akimaru H, Tanaka Y, Maekawa T, Nakafuku M, et al. 1999. Sonic hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 274:8143-52
    • (1999) J. Biol. Chem. , vol.274 , pp. 8143-8152
    • Dai, P.1    Akimaru, H.2    Tanaka, Y.3    Maekawa, T.4    Nakafuku, M.5
  • 25
    • 0034682719 scopus 로고    scopus 로고
    • Hedgehog induces opposite changes in turnover and subcellular localization of Patched and Smoothened
    • Denef N, Neubuser D, Perez L, Cohen SM. 2000. Hedgehog induces opposite changes in turnover and subcellular localization of Patched and Smoothened. Cell 102:521-31
    • (2000) Cell , vol.102 , pp. 521-531
    • Denef, N.1    Neubuser, D.2    Perez, L.3    Cohen, S.M.4
  • 26
    • 34547120220 scopus 로고    scopus 로고
    • Induction of sonic hedgehog mediators by transforming growth factor-β: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo
    • DOI 10.1158/0008-5472.CAN-07-0491
    • Dennler S, Andŕe J, Alexaki I, Li A, Magnaldo T, et al. 2007. Induction of Sonic hedgehog mediators by transforming growth factor-β: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res. 67:6981-86 (Pubitemid 47105546)
    • (2007) Cancer Research , vol.67 , Issue.14 , pp. 6981-6986
    • Dennler, S.1    Andre, J.2    Alexaki, I.3    Li, A.4    Magnaldo, T.5    Ten Dijke, P.6    Wang, X.-J.7    Verrecchia, F.8    Mauviel, A.9
  • 27
    • 50649088457 scopus 로고    scopus 로고
    • Pattern formation in the vertebrate neural tube: A sonic hedgehog morphogen-regulated transcriptional network
    • Dessaud E, McMahon AP, Briscoe J. 2008. Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development 135:2489-503
    • (2008) Development , vol.135 , pp. 2489-503
    • Dessaud, E.1    McMahon, A.P.2    Briscoe, J.3
  • 29
    • 0033533714 scopus 로고    scopus 로고
    • Mouse suppressor of fused is a negative regulator of Sonic hedgehog signaling and alters the subcellular distribution of Gli1
    • DOI 10.1016/S0960-9822(99)80482-5
    • Ding Q, Fukami S, Meng X, Nishizaki Y, Zhang X, Sasaki H, et al. 1999. Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1. Curr. Biol. 9:1119-22 (Pubitemid 29504483)
    • (1999) Current Biology , vol.9 , Issue.19 , pp. 1119-1122
    • Ding, Q.1    Fukami, S.-I.2    Meng, X.3    Nishizaki, Y.4    Zhang, X.5    Sasaki, H.6    Dlugosz, A.7    Nakafuku, M.8    Hui, C.-C.9
  • 30
    • 0031855859 scopus 로고    scopus 로고
    • Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
    • Ding Q, Motoyama J, Gasca S, Mo R, Sasaki H, et al. 1998. Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125:2533-43 (Pubitemid 28396152)
    • (1998) Development , vol.125 , Issue.14 , pp. 2533-2543
    • Ding, Q.1    Motoyama, J.2    Gasca, S.3    Mo, R.4    Sasaki, H.5    Rossant, J.6    Hui, C.-C.7
  • 31
    • 0036850976 scopus 로고    scopus 로고
    • De novo GLI3 mutation in acrocallosal syndrome: Broadening the phenotypic spectrum of GLI3 defects and overlap with murine models
    • Elson E, Perveen R, Donnai D, Wall S, Black GCM. 2002. De novo GLI3 mutation in acrocallosal syndrome: broadening the phenotypic spectrum of GLI3 defects and overlap with murine models. J. Med. Genet. 39:804-6 (Pubitemid 35346948)
    • (2002) Journal of Medical Genetics , vol.39 , Issue.11 , pp. 804-806
    • Elson, E.1    Perveen, R.2    Donnai, D.3    Wall, S.4    Black, G.C.M.5
  • 32
    • 68149178664 scopus 로고    scopus 로고
    • The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development
    • Endoh-Yamagami S, Evangelista M, Wilson D, Wen X, Theunissen JW, et al. 2009. The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr. Biol. 19:1320-26
    • (2009) Curr. Biol. , vol.19 , pp. 1320-1326
    • Endoh-Yamagami, S.1    Evangelista, M.2    Wilson, D.3    Wen, X.4    Theunissen, J.W.5
  • 33
    • 55649103338 scopus 로고    scopus 로고
    • Kinome siRNA screen identifies regulators of ciliogenesis and Hedgehog signal transduction
    • Evangelista M, Lim TY, Lee J, Parker L, Ashique A, et al. 2008. Kinome siRNA screen identifies regulators of ciliogenesis and Hedgehog signal transduction. Sci. Signal. 1:ra7
    • (2008) Sci. Signal. , vol.1
    • Evangelista, M.1    Lim, T.Y.2    Lee, J.3    Parker, L.4    Ashique, A.5
  • 34
    • 29444439981 scopus 로고    scopus 로고
    • Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification
    • DOI 10.1038/ng1684
    • Ferrante MI, Zullo A, Barra A, Bimonte S, Messaddeq N, et al. 2006. Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification. Nat. Genet. 38:112-17 (Pubitemid 43011891)
    • (2006) Nature Genetics , vol.38 , Issue.1 , pp. 112-117
    • Ferrante, M.I.1    Zullo, A.2    Barra, A.3    Bimonte, S.4    Messaddeq, N.5    Studer, M.6    Dolle, P.7    Franco, B.8
  • 35
    • 71549138077 scopus 로고    scopus 로고
    • Deletion of Atoh1 disrupts Sonic hedgehog signaling in the developing cerebellum and prevents medulloblastoma
    • Flora A, Klisch TJ, Schuster G, Zoghbi HY. 2009. Deletion of Atoh1 disrupts Sonic hedgehog signaling in the developing cerebellum and prevents medulloblastoma. Science 326:1424-27
    • (2009) Science , vol.326 , pp. 1424-1427
    • Flora, A.1    Klisch, T.J.2    Schuster, G.3    Zoghbi, H.Y.4
  • 36
    • 77952350426 scopus 로고    scopus 로고
    • Distinct roles ofHand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development
    • Galli A, Robay D, Osterwalder M, Bao X, B́enazet J-D, et al. 2010. Distinct roles ofHand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet. 6:e1000901
    • (2010) PLoS Genet , vol.6
    • Galli, A.1    Robay, D.2    Osterwalder, M.3    Bao, X.4    B́enazet, J.-D.5
  • 37
    • 69249203574 scopus 로고    scopus 로고
    • SUMO association with repressor complexes, emerging routes for transcriptional control
    • Garcia-Dominguez M, Reyes JC. 2009. SUMO association with repressor complexes, emerging routes for transcriptional control. Biochim. Biophys. Acta 1789:451-59
    • (2009) Biochim. Biophys. Acta , vol.1789 , pp. 451-459
    • Garcia-Dominguez, M.1    Reyes, J.C.2
  • 39
    • 77951101203 scopus 로고    scopus 로고
    • The primary cilium: A signaling centre during vertebrate development
    • Goetz SC, Anderson KV. 2010. The primary cilium: a signaling centre during vertebrate development. Nat. Rev. Genet. 11:331-44
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 331-344
    • Goetz, S.C.1    Anderson, K.V.2
  • 40
    • 30344439849 scopus 로고    scopus 로고
    • Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity
    • DOI 10.1016/j.cell.2005.10.042, PII S0092867405013954
    • Hallikas O, Palin K, Sinjushina N, Rautiainen R, Partanen J, et al. 2006. Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell 124:47-59 (Pubitemid 43069309)
    • (2006) Cell , vol.124 , Issue.1 , pp. 47-59
    • Hallikas, O.1    Palin, K.2    Sinjushina, N.3    Rautiainen, R.4    Partanen, J.5    Ukkonen, E.6    Taipale, J.7
  • 41
    • 69949166247 scopus 로고    scopus 로고
    • Dual and opposing roles of primary cilia in medulloblastoma development
    • Han YG, Kim HJ, Dlugosz AA, Ellison DW, Gilbertson RJ, et al. 2009. Dual and opposing roles of primary cilia in medulloblastoma development. Nat. Med. 15:1062-65
    • (2009) Nat. Med. , vol.15 , pp. 1062-1065
    • Han, Y.G.1    Kim, H.J.2    Dlugosz, A.A.3    Ellison, D.W.4    Gilbertson, R.J.5
  • 42
    • 40749144679 scopus 로고    scopus 로고
    • Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
    • Haycraft CJ, Banizs B, Aydin-Son Y, Zhang Q, Michaud EJ, et al. 2005. Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 1:e53
    • (2005) PLoS Genet , vol.1
    • Haycraft, C.J.1    Banizs, B.2    Aydin-Son, Y.3    Zhang, Q.4    Michaud, E.J.5
  • 43
    • 63349088603 scopus 로고    scopus 로고
    • A Shh-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud
    • Hill P, Gotz K, Ruther U. 2009. A Shh-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud. Dev. Biol. 328:506-16
    • (2009) Dev. Biol. , vol.328 , pp. 506-516
    • Hill, P.1    Gotz, K.2    Ruther, U.3
  • 44
    • 33244463281 scopus 로고    scopus 로고
    • GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis
    • DOI 10.1242/dev.02220
    • Hu MC, Mo R, Bhella S, Wilson CW, Chuang P-T, et al. 2006. GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133:569-78 (Pubitemid 43273842)
    • (2006) Development , vol.133 , Issue.3 , pp. 569-578
    • Hu, M.C.1    Mo, R.2    Bhella, S.3    Wilson, C.W.4    Chuang, P.-T.5    Hui, C.-C.6    Rosenblum, N.D.7
  • 46
    • 0242581681 scopus 로고    scopus 로고
    • Hedgehog signalling in the mouse requires intraflagellar transport proteins
    • DOI 10.1038/nature02061
    • Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, et al. 2003. Hedgehog signaling in the mouse requires intraflagellar transport proteins. Nature 426:83-87 (Pubitemid 37432545)
    • (2003) Nature , vol.426 , Issue.6962 , pp. 83-87
    • Huangfu, D.1    Liu, A.2    Rakeman, A.S.3    Murcia, N.S.4    Niswander, L.5    Anderson, K.V.6
  • 47
    • 0027478216 scopus 로고
    • A mouse model of Greig cephalopolysyndactyly syndrome: The extra-toes(J) mutation contains an intragenic deletion of the Gli3 gene
    • DOI 10.1038/ng0393-241
    • Hui C-c, Joyner AL. 1993. Amousemodel ofGreig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat. Genet. 3:241-46 (Pubitemid 23096560)
    • (1993) Nature Genetics , vol.3 , Issue.3 , pp. 241-246
    • Hui, C.1    Joyner, A.L.2
  • 48
    • 0028281306 scopus 로고
    • Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2 and Gli-3, in ectoderm-and mesodermderived tissues suggests multiple roles during postimplantation development
    • Hui C-c, Slusarski D, Platt KA, Holmgren R, Joyner AL. 1994. Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2 and Gli-3, in ectoderm-and mesodermderived tissues suggests multiple roles during postimplantation development. Dev. Biol. 162:402-413
    • (1994) Dev. Biol. , vol.162 , pp. 402-413
    • C-C, H.1    Slusarski, D.2    Platt, K.A.3    Holmgren, R.4    Joyner, A.L.5
  • 49
    • 77950463564 scopus 로고    scopus 로고
    • The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of fused and the Gli proteins
    • Humke EW, Dorn KV, Milenkovic L, Scott MP, Rohatgi R. 2010. The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of fused and the Gli proteins. Genes Dev. 24:670-82
    • (2010) Genes Dev , vol.24 , pp. 670-682
    • Humke, E.W.1    Dorn, K.V.2    Milenkovic, L.3    Scott, M.P.4    Rohatgi, R.5
  • 51
    • 76849113570 scopus 로고    scopus 로고
    • Distinctive expression patterns of Hedgehog pathway genes in the Ciona intestinalis larva: Implications for a role of Hedgehog signaling in postembryonic development and chordate evolution
    • Islam AF, Moly PK, Miyamoto Y, Kusakabe TG. 2010. Distinctive expression patterns of Hedgehog pathway genes in the Ciona intestinalis larva: implications for a role of Hedgehog signaling in postembryonic development and chordate evolution. Zool. Sci. 27:84-90
    • (2010) Zool. Sci. , vol.27 , pp. 84-90
    • Islam, A.F.1    Moly, P.K.2    Miyamoto, Y.3    Kusakabe, T.G.4
  • 52
    • 78649999605 scopus 로고    scopus 로고
    • Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway
    • Jagani Z, Mora-Blanco EL, Sansam CG, McKenna ES, Wilson B, et al. 2010. Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway. Nat. Med. 16:1429-33
    • (2010) Nat. Med. , vol.16 , pp. 1429-1433
    • Jagani, Z.1    Mora-Blanco, E.L.2    Sansam, C.G.3    McKenna, E.S.4    Wilson, B.5
  • 53
    • 34347253037 scopus 로고    scopus 로고
    • Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells
    • DOI 10.1074/jbc.M611089200
    • Ji Z, Mei FC, Xie J, Cheng Z. 2007. Oncogenic KRAS activates Hedgehog signaling pathway in pancreatic cancer cells. J. Biol. Chem. 282:14048-55 (Pubitemid 47100411)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.19 , pp. 14048-14055
    • Ji, Z.1    Mei, F.C.2    Xie, J.3    Cheng, X.4
  • 54
    • 67349198593 scopus 로고    scopus 로고
    • Suppressor of fused inhibits mammalian Hedgehog signaling in the absence of cilia
    • Jia J, Kolterud A, Zeng H, Hoover A, Teglund S, et al. 2009. Suppressor of fused inhibits mammalian Hedgehog signaling in the absence of cilia. Dev. Biol. 330:452-60
    • (2009) Dev. Biol. , vol.330 , pp. 452-460
    • Jia, J.1    Kolterud, A.2    Zeng, H.3    Hoover, A.4    Teglund, S.5
  • 55
    • 11144237279 scopus 로고    scopus 로고
    • Hedgehog signalling activity of smoothened requires phosphorylation by protein kinase A and casein kinase I
    • DOI 10.1038/nature03179
    • Jia J, Tong C, Wang B, Luo L, Jiang J. 2004. Hedgehog signaling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature 432:1045-50 (Pubitemid 40052237)
    • (2004) Nature , vol.432 , Issue.7020 , pp. 1045-1050
    • Jia, J.1    Tong, C.2    Wang, B.3    Luo, L.4    Jiang, J.5
  • 56
    • 28444449828 scopus 로고    scopus 로고
    • Phosphorylation of double-time/CKI and CKIα targetes Cubitus interruptus for Slimb/β-TrCP-mediated proteolytic processing
    • Jia J, Zhang L, Zhang Q, Tong C, Wang B, et al. 2005. Phosphorylation of double-time/CKI and CKIα targetes Cubitus interruptus for Slimb/β-TrCP-mediated proteolytic processing. Dev. Cell 9:19-30
    • (2005) Dev. Cell , vol.9 , pp. 19-30
    • Jia, J.1    Zhang, L.2    Zhang, Q.3    Tong, C.4    Wang, B.5
  • 57
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • Jiang J, Hui C-c. 2008. Hedgehog signaling in development and cancer. Dev. Cell 15:801-12
    • (2008) Dev. Cell , vol.15 , pp. 801-812
    • Jiang, J.1    C-C, H.2
  • 58
    • 0032576777 scopus 로고    scopus 로고
    • Regulation of the Hedgehog and Wingless signalling pathways by the F- box/WD40-repeat protein Slimb
    • DOI 10.1038/35154
    • Jiang J, Struhl G. 1998. Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40 repeat protein Slimb. Nature 391:493-96 (Pubitemid 28086550)
    • (1998) Nature , vol.391 , Issue.6666 , pp. 493-496
    • Jiang, J.1    Struhl, G.2
  • 59
    • 79251474031 scopus 로고    scopus 로고
    • Molecular analysis expands the spectrum of phenotypes associated with GLI3 mutations
    • Johnston JJ, Sapp JC, Turner JT, Amor D, Aftimos S, et al. 2010. Molecular analysis expands the spectrum of phenotypes associated with GLI3 mutations. Hum. Mutat. 31:1142-54
    • (2010) Hum. Mutat. , vol.31 , pp. 1142-1154
    • Johnston, J.J.1    Sapp, J.C.2    Turner, J.T.3    Amor, D.4    Aftimos, S.5
  • 60
    • 0031019090 scopus 로고    scopus 로고
    • GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome
    • DOI 10.1038/ng0397-266
    • Kang S, Graham JM, Olney AH, Bisecker LG. 1997. GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome. Nat. Genet. 15:266-68 (Pubitemid 27098719)
    • (1997) Nature Genetics , vol.15 , Issue.3 , pp. 266-268
    • Kang, S.1    Graham Jr., J.M.2    Olney, A.H.3    Biesecker, L.G.4
  • 61
    • 0012843926 scopus 로고    scopus 로고
    • Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development
    • DOI 10.1242/dev.00364
    • Karlstrom RO, Tyurina OV, Kawakami A, Nishioka N, Talbot WS, et al. 2003. Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development. Development 130:1549-64 (Pubitemid 36527516)
    • (2003) Development , vol.130 , Issue.8 , pp. 1549-1564
    • Karlstrom, R.O.1    Tyurina, O.V.2    Kawakami, A.3    Nishioka, N.4    Talbot, W.S.5    Sasaki, H.6    Schier, A.F.7
  • 62
    • 54249162413 scopus 로고    scopus 로고
    • SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of Suppressor of fused in pancreatic cancer cell
    • Kasai K, Inaguma S, Yoneyama A, Yoshikawa K, Ikeda H. 2008. SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of Suppressor of fused in pancreatic cancer cell. Cancer Res. 68:7723-29
    • (2008) Cancer Res , vol.68 , pp. 7723-7729
    • Kasai, K.1    Inaguma, S.2    Yoneyama, A.3    Yoshikawa, K.4    Ikeda, H.5
  • 63
    • 38649121715 scopus 로고    scopus 로고
    • Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment
    • DOI 10.1016/j.mcn.2007.10.013, PII S1044743107002576
    • Ke Z, Kondrichin I, Gong Z, Korzh V. 2008. Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment. Mol. Cell. Neurosci. 37:388-401 (Pubitemid 351173857)
    • (2008) Molecular and Cellular Neuroscience , vol.37 , Issue.2 , pp. 388-401
    • Ke, Z.1    Kondrichin, I.2    Gong, Z.3    Korzh, V.4
  • 64
    • 33646875414 scopus 로고    scopus 로고
    • Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus
    • DOI 10.1242/dev.02370
    • Kent D, Bush EW, Hooper JE. 2006. Roadkill attenuates Hedgehog responses through degradation ofCubitus interruptus. Development 133:2001-10 (Pubitemid 43881265)
    • (2006) Development , vol.133 , Issue.10 , pp. 2001-2010
    • Kent, D.1    Bush, E.W.2    Hooper, J.E.3
  • 65
    • 76049114315 scopus 로고    scopus 로고
    • Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
    • Kim J, Kato M, Beachy PA. 2009. Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proc. Natl. Acad. Sci. USA 106:21666-71
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 21666-21671
    • Kim, J.1    Kato, M.2    Beachy, P.A.3
  • 66
    • 0023930186 scopus 로고
    • The GLI gene is a member of the Kruppel family of zinc finger proteins
    • DOI 10.1038/332371a0
    • Kinzler KW, Ruppert JM, Bigner SH, Vogelstein B. 1988. The GLI gene is a member of the Kr̈ uppel family of zinc finger proteins. Nature 332:371-74 (Pubitemid 18091079)
    • (1988) Nature , vol.332 , Issue.6162 , pp. 371-374
    • Kinzler, K.W.1    Ruppert, J.M.2    Bigner, S.H.3    Vogelstein, B.4
  • 67
    • 0025156778 scopus 로고
    • The GLI gene encodes a nuclear protein which binds specific sequences in the human genome
    • Kinzler KW, Vogelstein B. 1990. The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol. Cell. Biol. 10:634-42
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 634-642
    • Kinzler, K.W.1    Vogelstein, B.2
  • 70
    • 70449449853 scopus 로고    scopus 로고
    • Pointmutations in GLI3 lead to misregulation of its subcellular localization
    • Krauss S, So J, Hambrock M, K̈ ohler A, Kunath M, et al. 2009. Pointmutations in GLI3 lead to misregulation of its subcellular localization. PLoS ONE 4:e7471
    • (2009) PLoS ONE , vol.4
    • Krauss, S.1    So, J.2    Hambrock, M.3    Köhler, A.4    Kunath, M.5
  • 71
  • 72
    • 33846192047 scopus 로고    scopus 로고
    • Gli2 and Gli3 play distinct roles in the dorsoventral patterning of the mouse hindbrain
    • DOI 10.1016/j.ydbio.2006.08.005, PII S0012160606010748
    • LebelM, Mo R, Shimamura K, Hui C-c. 2007. Gli2 andGli3 play distinct roles in the dorsoventral patterning of the mouse hindbrain. Dev. Biol. 302:345-55 (Pubitemid 46099039)
    • (2007) Developmental Biology , vol.302 , Issue.1 , pp. 345-355
    • Lebel, M.1    Mo, R.2    Shimamura, K.3    Hui, C.-c.4
  • 73
    • 77953113675 scopus 로고    scopus 로고
    • Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis
    • Lee EY, Ji H, Ouyang Z, Zhou B, Ma W, et al. 2010. Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis. Proc. Natl. Acad. Sci. USA 107:9736-41
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 9736-9741
    • Lee, E.Y.1    Ji, H.2    Ouyang, Z.3    Zhou, B.4    Ma, W.5
  • 74
    • 0030805592 scopus 로고    scopus 로고
    • Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
    • Lee J, Platt KA, Censullo P, Ruiz i Altaba A. 1997. Gli1 is a target of Sonic hedgehog signaling that induces ventral neural tube development. Development 124:2537-52 (Pubitemid 27341754)
    • (1997) Development , vol.124 , Issue.13 , pp. 2537-2552
    • Lee, J.1    Platt, K.A.2    Censullo, P.3    Ruiz I Altaba, A.4
  • 75
    • 33747833061 scopus 로고    scopus 로고
    • Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube
    • DOI 10.1016/j.devcel.2006.06.013, PII S153458070600298X
    • Lei Q, Jeong Y, Misra K, Li S, Zelman AK, Epstein DJ, Matise MP. 2006. Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev. Cell 11:325-37 (Pubitemid 44283939)
    • (2006) Developmental Cell , vol.11 , Issue.3 , pp. 325-337
    • Lei, Q.1    Jeong, Y.2    Misra, K.3    Li, S.4    Zelman, A.K.5    Epstein, D.J.6    Matise, M.P.7
  • 76
    • 78649887219 scopus 로고    scopus 로고
    • A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning
    • Lek M, Dias JM, Marklund U, Uhde CW, Kurdija S, et al. 2010. A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development 137:4051-4060
    • (2010) Development , vol.137 , pp. 4051-4060
    • Lek, M.1    Dias, J.M.2    Marklund, U.3    Uhde, C.W.4    Kurdija, S.5
  • 77
    • 69449099121 scopus 로고    scopus 로고
    • Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling
    • Liem KF Jr, He M, Ocbina PJ R, Anderson KV. 2009. Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proc. Natl. Acad. Sci. USA 106:13377-82
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 13377-13382
    • Liem Jr., K.F.1    He, M.2    Ocbina, P.J.R.3    Anderson, K.V.4
  • 78
    • 0033808256 scopus 로고    scopus 로고
    • Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3
    • Litingtung Y, Chiang C. 2000. Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nat. Neurosci. 3:979-85
    • (2000) Nat. Neurosci. , vol.3 , pp. 979-985
    • Litingtung, Y.1    Chiang, C.2
  • 79
    • 0037194765 scopus 로고    scopus 로고
    • Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity
    • DOI 10.1038/nature01033
    • Litingtung Y, Dahn RD, Li Y, Fallon JF, Chiang C. 2002. Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature 418:979-83 (Pubitemid 34976033)
    • (2002) Nature , vol.418 , Issue.6901 , pp. 979-983
    • Litingtung, Y.1    Dahn, R.D.2    Li, Y.3    Fallon, J.F.4    Chiang, C.5
  • 80
    • 23144466931 scopus 로고    scopus 로고
    • Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
    • DOI 10.1242/dev.01894
    • Liu A, Wang B, Niswander LA. 2005. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132:3103-11 (Pubitemid 41086743)
    • (2005) Development , vol.132 , Issue.13 , pp. 3103-3111
    • Liu, A.1    Wang, B.2    Niswander, L.A.3
  • 82
    • 79951904426 scopus 로고    scopus 로고
    • Clinical experience with Hedgehog pathway inhibitors
    • Low JA, de Sauvage FJ. 2010. Clinical experience with Hedgehog pathway inhibitors. J. Clin. Oncol. 36:5321-26
    • (2010) J. Clin. Oncol. , vol.36 , pp. 5321-5326
    • Low, J.A.1    De Sauvage, F.J.2
  • 83
    • 64049091261 scopus 로고    scopus 로고
    • Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase
    • Maddika S, Chen J. 2009. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat. Cell Biol. 11:409-19
    • (2009) Nat. Cell Biol. , vol.11 , pp. 409-419
    • Maddika, S.1    Chen, J.2
  • 84
    • 77956914006 scopus 로고    scopus 로고
    • Dual function of UNC-51-like kinase (Ulk3) in the Sonic hedgehog signaling pathway
    • Maloverjan A, Piirsoo M, Kasak L, Peil L, Østerlund T, et al. 2010. Dual function of UNC-51-like kinase (Ulk3) in the Sonic hedgehog signaling pathway. J. Biol. Chem. 285:30079-90
    • (2010) J. Biol. Chem. , vol.285 , pp. 30079-30090
    • Maloverjan, A.1    Piirsoo, M.2    Kasak, L.3    Peil, L.4    Østerlund, T.5
  • 85
    • 33750543972 scopus 로고    scopus 로고
    • A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway
    • DOI 10.1158/0008-5472.CAN-06-0657
    • Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, et al. 2006. A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res. 66:10171-78 (Pubitemid 44672072)
    • (2006) Cancer Research , vol.66 , Issue.20 , pp. 10171-10178
    • Mao, J.1    Ligon, K.L.2    Rakhlin, E.Y.3    Thayer, S.P.4    Bronson, R.T.5    Rowitch, D.6    McMahon, A.P.7
  • 86
    • 0037144506 scopus 로고    scopus 로고
    • Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1
    • Mao J, Maye P, Kogerman P, Tejedor FJ, Toftgard R, et al. 2002. Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. J. Biol. Chem. 277:35156-61
    • (2002) J. Biol. Chem. , vol.277 , pp. 35156-35161
    • Mao, J.1    Maye, P.2    Kogerman, P.3    Tejedor, F.J.4    Toftgard, R.5
  • 87
    • 34249011892 scopus 로고    scopus 로고
    • Gas1 extends the range of Hedgehog action by facilitating its signaling
    • DOI 10.1101/gad.1546307
    • Martinelli DC, Fan CM. 2007. Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev. 21:1231-43 (Pubitemid 46789880)
    • (2007) Genes and Development , vol.21 , Issue.10 , pp. 1231-1243
    • Martinelli, D.C.1    Fan, C.-M.2
  • 88
    • 79751537538 scopus 로고    scopus 로고
    • Foxa1 and Foxa2 positively and negatively regulate Shh signaling to specify ventral midbrain progenitor identity
    • Mavromatakis YE, Lin W, Metzakopian E, Ferri AL M, Yan CH, et al. 2011. Foxa1 and Foxa2 positively and negatively regulate Shh signaling to specify ventral midbrain progenitor identity. Mech. Dev. 128:90-103
    • (2011) Mech. Dev. , vol.128 , pp. 90-103
    • Mavromatakis, Y.E.1    Lin, W.2    Metzakopian, E.3    Ferri, A.L.M.4    Yan, C.H.5
  • 89
    • 13944284208 scopus 로고    scopus 로고
    • Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation
    • DOI 10.1242/dev.01537
    • McDermott A, Gustafsson M, Elsam T, Hui C-c, Emerson CP, et al. 2005. Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation. Development 132:345-57 (Pubitemid 40268284)
    • (2005) Development , vol.132 , Issue.2 , pp. 345-357
    • McDermott, A.1    Gustafsson, M.2    Elsam, T.3    Hui, C.-C.4    Emerson Jr., C.P.5    Borycki, A.-G.6
  • 91
    • 77953693899 scopus 로고    scopus 로고
    • Targeting hedgehog-A cancer stem cell pathway
    • Merchant AA, Matsui W. 2010. Targeting Hedgehog-a cancer stem cell pathway. Clin. Cancer Res. 16:3130-40
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3130-3140
    • Merchant, A.A.1    Matsui, W.2
  • 93
    • 0033582908 scopus 로고    scopus 로고
    • Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of cubitus interruptus
    • Ḿethot N, Basler K. 1999. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell 96:819-31 (Pubitemid 29165085)
    • (1999) Cell , vol.96 , Issue.6 , pp. 819-831
    • Methot, N.1    Basler, K.2
  • 94
    • 0033789068 scopus 로고    scopus 로고
    • Suppressor of Fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
    • Ḿethot N, Basler K. 2000. Suppressor of Fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Development 127:4001-10
    • (2000) Development , vol.127 , pp. 4001-4010
    • Ḿethot, N.1    Basler, K.2
  • 95
    • 0035098013 scopus 로고    scopus 로고
    • An absolute requirement for Cubitus interruptus in Hedgehog signaling
    • Ḿethot N, Basler K. 2001. An absolute requirement for Cubitus interruptus in Hedgehog signaling. Development 128:733-42 (Pubitemid 32229250)
    • (2001) Development , vol.128 , Issue.5 , pp. 733-742
    • Methot, N.1    Basler, K.2
  • 97
    • 0031683165 scopus 로고    scopus 로고
    • Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
    • DOI 10.1038/1711
    • Motoyama J, Lui J, Mo R, Ding Q, Post M, Hui C-c. 1998a. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat. Genet. 20:54-57 (Pubitemid 28410344)
    • (1998) Nature Genetics , vol.20 , Issue.1 , pp. 54-57
    • Motoyama, J.1    Liu, J.2    Mo, R.3    Ding, Q.4    Post, M.5    Hui, C.-C.6
  • 98
    • 0037706929 scopus 로고    scopus 로고
    • Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification
    • DOI 10.1016/S0012-1606(03)00159-3
    • Motoyama J, Milenkovic L, Iwama M, Shikata Y, ScottM P, et al. 2003. Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. Dev. Biol. 259:150-61 (Pubitemid 36703150)
    • (2003) Developmental Biology , vol.259 , Issue.1 , pp. 150-161
    • Motoyama, J.1    Milenkovic, L.2    Iwama, M.3    Shikata, Y.4    Scott, M.P.5    Hui, C.-C.6
  • 99
    • 0031989439 scopus 로고    scopus 로고
    • Ptch2, a second mousePatched gene is co-expressed with Sonic hedgehog
    • Motoyama J, Takabatake T, Takeshima K, Hui C-c. 1998b. Ptch2, a second mousePatched gene is co-expressed with Sonic hedgehog. Nat. Genet. 18:104-6
    • (1998) Nat. Genet. , vol.18 , pp. 104-6
    • Motoyama, J.1    Takabatake, T.2    Takeshima, K.3    C-C, H.4
  • 100
    • 0033781026 scopus 로고    scopus 로고
    • Gli regulation by the opposing activities of Fused and Suppressor of Fused
    • Murone M, Luoh SM, Stone D, Li W, Gurney A, et al. 2000. Gli regulation by the opposing activities of Fused and Suppressor of Fused. Nat. Cell Biol. 2:310-12
    • (2000) Nat. Cell Biol. , vol.2 , pp. 310-312
    • Murone, M.1    Luoh, S.M.2    Stone, D.3    Li, W.4    Gurney, A.5
  • 101
    • 58149506283 scopus 로고    scopus 로고
    • GLI1 is regulated through Smoothenedindependent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
    • Nolan-Stevaux O, Lau J, TruittM L, ChuG C, Hebrok M, et al. 2009. GLI1 is regulated through Smoothenedindependent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev. 23:24-36
    • (2009) Genes Dev. , vol.23 , pp. 24-36
    • Nolan-Stevaux, O.1    Lau, J.2    Truittm, L.3    Chug, C.4    Hebrok, M.5
  • 102
    • 0025331133 scopus 로고
    • Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila
    • Orenic TV, Slusarski DC, Kroll KL, Holmgren RA. 1990. Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. Genes Dev. 4:1053-67
    • (1990) Genes Dev. , vol.4 , pp. 1053-1067
    • Orenic, T.V.1    Slusarski, D.C.2    Kroll, K.L.3    Holmgren, R.A.4
  • 103
    • 33646270662 scopus 로고    scopus 로고
    • Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
    • Pan Y, Bai CB, Joyner AL, Wang B. 2006. Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol. Cell. Biol. 26:3365-77
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 3365-3377
    • Pan, Y.1    Bai, C.B.2    Joyner, A.L.3    Wang, B.4
  • 104
    • 34249717798 scopus 로고    scopus 로고
    • A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome
    • DOI 10.1074/jbc.M608599200
    • Pan Y, Wang B. 2007. A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome. J. Biol. Chem. 282:10846-52 (Pubitemid 47100745)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.15 , pp. 10846-10852
    • Pan, Y.1    Wang, B.2
  • 105
    • 58549117286 scopus 로고    scopus 로고
    • Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development
    • Pan Y, Wang C, Wang B. 2009. Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev. Biol. 326:177-89
    • (2009) Dev. Biol. , vol.326 , pp. 177-189
    • Pan, Y.1    Wang, C.2    Wang, B.3
  • 107
    • 0027423758 scopus 로고
    • Crystal structure of a five-finger GLI-DNA complex: New perspectives on zinc fingers
    • Pavletich NP, Pabo CO. 1993. Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. Science 261:1701-7 (Pubitemid 23332917)
    • (1993) Science , vol.261 , Issue.5129 , pp. 1701-1707
    • Pavletich, N.P.1    Pabo, C.O.2
  • 109
    • 77955362243 scopus 로고    scopus 로고
    • Hedgehog controls neural stem cells through p53-independent regulation of Nanog
    • Po A, Ferretti E, Miele E, De Smaele E, Paganelli A, et al. 2010. Hedgehog controls neural stem cells through p53-independent regulation of Nanog. EMBO J. 29:2646-58
    • (2010) EMBO J. , vol.29 , pp. 2646-2658
    • Po, A.1    Ferretti, E.2    Miele, E.3    De Smaele, E.4    Paganelli, A.5
  • 110
    • 0026761497 scopus 로고
    • Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster
    • Preat T. 1992. Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster. Genetics 132:725-36
    • (1992) Genetics , vol.132 , pp. 725-736
    • Preat, T.1
  • 113
    • 77955057511 scopus 로고    scopus 로고
    • Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signaling
    • Raisin S, Ruel L, Ranieri N, Staccini-Lavenant L, Therond PP. 2010. Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signaling. Dev. Biol. 344:119-28
    • (2010) Dev. Biol. , vol.344 , pp. 119-128
    • Raisin, S.1    Ruel, L.2    Ranieri, N.3    Staccini-Lavenant, L.4    Therond, P.P.5
  • 114
    • 77953045687 scopus 로고    scopus 로고
    • Distinct Sonic hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube
    • Ribes V, Balaskas N, Sasai N, Cruz C, Dessaud E, et al. 2010. Distinct Sonic hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes Dev. 24:1186-200
    • (2010) Genes Dev. , vol.24 , pp. 1186-200
    • Ribes, V.1    Balaskas, N.2    Sasai, N.3    Cruz, C.4    Dessaud, E.5
  • 115
    • 31544461492 scopus 로고    scopus 로고
    • Protein kinase C-δ and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling
    • DOI 10.1158/0008-5472.CAN-05-2539
    • Riob́o NA, Haines GM, Emerson CP. 2006a. Protein kinase C-δ and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in Hedgehog signaling. Cancer Res. 66:839-45 (Pubitemid 43165949)
    • (2006) Cancer Research , vol.66 , Issue.2 , pp. 839-845
    • Riobo, N.A.1    Haines, G.M.2    Emerson Jr., C.P.3
  • 117
    • 0030838880 scopus 로고    scopus 로고
    • Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2
    • DOI 10.1016/S0092-8674(00)80331-1
    • Robbins DJ, Nybakken KE, Kobayashi R, Sisson JC, Bishop JM, et al. 1997. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein Costal2. Cell 90:225-34 (Pubitemid 27329708)
    • (1997) Cell , vol.90 , Issue.2 , pp. 225-234
    • Robbins, D.J.1    Nybakken, K.E.2    Kobayashi, R.3    Sisson, J.C.4    Bishop, J.M.5    Therond, P.P.6
  • 119
    • 26444577884 scopus 로고    scopus 로고
    • A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2
    • DOI 10.1093/hmg/ddi222
    • Roessler E, Ermilov AN, Grange DK, Wang A, Grachtchouk M, et al. 2005. A previously unidentified aminoterminal domain regulates transcriptional activity of wild-type and disease-associated humanGLI2. Hum. Mol. Genet. 14:2181-88 (Pubitemid 41418017)
    • (2005) Human Molecular Genetics , vol.14 , Issue.15 , pp. 2181-2188
    • Roessler, E.1    Ermilov, A.N.2    Grange, D.K.3    Wang, A.4    Grachtchouk, M.5    Dlugosz, A.A.6    Muenke, M.7
  • 120
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • DOI 10.1126/science.1139740
    • Rohatgi R, Milenkovic L, Scott MP. 2007. Patched1 regulates Hedgehog signaling at the primary cilium. Science 317:372-76 (Pubitemid 47106377)
    • (2007) Science , vol.317 , Issue.5836 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 121
    • 36148939854 scopus 로고    scopus 로고
    • Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling
    • DOI 10.1242/dev.011577
    • Ruel L, Gallet A, Raisin S, Truchi A, Staccini-Lavenant L, et al. 2007. Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signaling. Development 134:3677-89 (Pubitemid 350104377)
    • (2007) Development , vol.134 , Issue.20 , pp. 3677-3689
    • Ruel, L.1    Gallet, A.2    Raisin, S.3    Truchi, A.4    Staccini-Lavenant, L.5    Cervantes, A.6    Therond, P.P.7
  • 123
    • 0026023193 scopus 로고
    • The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A
    • Ruppert JM, Vogelstein B, Kinzler KW. 1991. The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A. Mol. Cell. Biol. 11:1724-28 (Pubitemid 21895533)
    • (1991) Molecular and Cellular Biology , vol.11 , Issue.3 , pp. 1724-1728
    • Ruppert, J.M.1    Vogelstein, B.2    Kinzler, K.W.3
  • 124
    • 0030891148 scopus 로고    scopus 로고
    • A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro
    • Sasaki H, Hui C-c, Nakafuku M, Kondoh H. 1997. A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124:1313-22 (Pubitemid 27190104)
    • (1997) Development , vol.124 , Issue.7 , pp. 1313-1322
    • Sasaki, H.1    Hui, C.-C.2    Nakafuku, M.3    Kondoh, H.4
  • 125
    • 0032848136 scopus 로고    scopus 로고
    • Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling
    • Sasaki H, Nishizaki Y, Hui C-c, Nakafuku M, Kondoh H. 1999. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 126:3915-24 (Pubitemid 29440488)
    • (1999) Development , vol.126 , Issue.17 , pp. 3915-3924
    • Sasaki, H.1    Nishizaki, Y.2    Hui, C.-C.3    Nakafuku, M.4    Kondoh, H.5
  • 126
    • 60549104260 scopus 로고    scopus 로고
    • Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway
    • Schnidar H, Ebert M, Klingler S, Mangelberger D, Kasper M, et al. 2009. Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway. Cancer Res. 69:1284-92
    • (2009) Cancer Res , vol.69 , pp. 1284-1292
    • Schnidar, H.1    Ebert, M.2    Klingler, S.3    Mangelberger, D.4    Kasper, M.5
  • 127
    • 41149180853 scopus 로고    scopus 로고
    • An amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signaling diversity in chordates
    • Shimeld SM, Van den Heuvel M, Dawber R, Briscoe J. 2007. An amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signaling diversity in chordates. PLoS ONE 2(9):e864
    • (2007) PLoS ONE , vol.2 , Issue.9
    • Shimeld, S.M.1    Van Den Heuvel, M.2    Dawber, R.3    Briscoe, J.4
  • 129
    • 0030754171 scopus 로고    scopus 로고
    • Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway
    • DOI 10.1016/S0092-8674(00)80332-3
    • Sisson JC, Ho KS, Suyama K, Scott MP. 1997. Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway. Cell 90:235-45 (Pubitemid 27329709)
    • (1997) Cell , vol.90 , Issue.2 , pp. 235-245
    • Sisson, J.C.1    Ho, K.S.2    Suyama, K.3    Scott, M.P.4
  • 130
    • 30044442183 scopus 로고    scopus 로고
    • Processing of the Drosophila Hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component slimb
    • DOI 10.1016/j.cub.2005.12.012, PII S0960982205015666
    • Smelkinson MG, Kalderon D. 2006. Processing of the Drosophila Hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding of the SCF component Slimb. Curr. Biol. 16:110-16 (Pubitemid 43049894)
    • (2006) Current Biology , vol.16 , Issue.1 , pp. 110-116
    • Smelkinson, M.G.1    Kalderon, D.2
  • 131
    • 34848892735 scopus 로고    scopus 로고
    • Slimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation
    • DOI 10.1016/j.devcel.2007.09.006, PII S1534580707003474
    • Smelkinson MG, Zhou Q, Kalderon D. 2007. Regulation of Ci-SCFSlimb binding, Ci proteolysis, andHedgehog pathway activity by Ci phosphorylation. Dev. Cell 13:481-95 (Pubitemid 47500813)
    • (2007) Developmental Cell , vol.13 , Issue.4 , pp. 481-495
    • Smelkinson, M.G.1    Zhou, Q.2    Kalderon, D.3
  • 132
    • 77954955134 scopus 로고    scopus 로고
    • Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain
    • Sousa VH, Fishell G. 2010. Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain. Curr. Opin. Genet. Dev. 20:391-99
    • (2010) Curr. Opin. Genet. Dev. , vol.20 , pp. 391-399
    • Sousa, V.H.1    Fishell, G.2
  • 133
    • 14644401158 scopus 로고    scopus 로고
    • A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
    • DOI 10.1101/gad.325905
    • Stamataki D, Ulloa F, Tsoni SV, Mynett A, Briscoe J. 2005. A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube. Genes Dev. 19:626-41 (Pubitemid 40314994)
    • (2005) Genes and Development , vol.19 , Issue.5 , pp. 626-641
    • Stamataki, D.1    Ulloa, F.2    Tsoni, S.V.3    Mynett, A.4    Briscoe, J.5
  • 134
    • 62649094925 scopus 로고    scopus 로고
    • A GLI-p53 inhibitory loop controls neural stem cell and tumor cell numbers
    • Stecca B, Ruiz i Altaba A. 2009. A GLI-p53 inhibitory loop controls neural stem cell and tumor cell numbers. EMBO J. 28:663-76
    • (2009) EMBO J. , vol.28 , pp. 663-676
    • Stecca, B.1    Ruiz, I.2    Altaba, A.3
  • 135
    • 77952898697 scopus 로고    scopus 로고
    • Context-dependent regulation of the GLI code in cancer by Hedgehog and non-Hedgehog signals
    • Stecca B, Ruiz i Altaba A. 2010. Context-dependent regulation of the GLI code in cancer by Hedgehog and non-Hedgehog signals. J. Mol. Cell Biol. 2:84-95
    • (2010) J. Mol. Cell Biol. , vol.2 , pp. 84-95
    • Stecca, B.1    Ruiz, I.2    Altaba, A.3
  • 136
  • 137
    • 59849117823 scopus 로고    scopus 로고
    • Gli2 is a novel regulator of Sox2 expression in telencephalic neuroepithelial cells
    • Takanaga H, Tsuchida-StraetenN, Nishide K, Watanabe A, Aburatani H, et al. 2009. Gli2 is a novel regulator of Sox2 expression in telencephalic neuroepithelial cells. Stem Cells 27:165-74
    • (2009) Stem Cells , vol.27 , pp. 165-174
    • Takanaga, H.1    Tsuchida-Straetenn Nishide, K.2    Watanabe, A.3    Aburatani, H.4
  • 138
    • 14744268335 scopus 로고    scopus 로고
    • A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo
    • DOI 10.1242/dev.01606
    • Tay SY, Ingham PW, Roy S. 2005. A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo. Development 132:625-34 (Pubitemid 40352823)
    • (2005) Development , vol.132 , Issue.4 , pp. 625-634
    • Tay, S.Y.1    Ingham, P.W.2    Roy, S.3
  • 139
    • 77649337790 scopus 로고    scopus 로고
    • Hedgehog beyond medulloblastoma and basal cell carcinoma
    • Teglund S, Toftgard R. 2010. Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim. Biophys. Acta 1805:181-208
    • (2010) Biochim. Biophys. Acta , vol.1805 , pp. 181-208
    • Teglund, S.1    Toftgard, R.2
  • 141
    • 33646103902 scopus 로고    scopus 로고
    • The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice
    • Tenzen T, Allen BL K, Cole F, Kang JS, Krauss RS, et al. 2006. The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev. Cell 10:647-56
    • (2006) Dev. Cell , vol.10 , pp. 647-656
    • Tenzen, T.1    Allen, B.L.K.2    Cole, F.3    Kang, J.S.4    Krauss, R.S.5
  • 142
    • 0037083760 scopus 로고    scopus 로고
    • Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling
    • DOI 10.1101/gad.219202
    • te Welscher P, Fernandez-TeranM, Ros MA, ZellerR. 2002a. Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling. Genes Dev. 16:421-26 (Pubitemid 34165099)
    • (2002) Genes and Development , vol.16 , Issue.4 , pp. 421-426
    • Te Welscher, P.1    Fernandez-Teran, M.2    Ros, M.A.3    Zeller, R.4
  • 143
    • 0037174679 scopus 로고    scopus 로고
    • Progression of vertebrate limb development through SHH-mediated counteraction of GLI3
    • DOI 10.1126/science.1075620
    • te Welscher P, Zuniga A, Kuijper S, Drenth T, Goedemans HJ, et al,2002b,Progression of vertebrate limb development through SHH-mediated counteraction of GLI3. Science, 298,827-30. (Pubitemid 35231535)
    • (2002) Science , vol.298 , Issue.5594 , pp. 827-830
    • Te Welscher, P.1    Zuniga, A.2    Kuijper, S.3    Drenth, T.4    Goedemans, H.J.5    Meijlink, F.6    Zeller, R.7
  • 144
    • 28544434064 scopus 로고    scopus 로고
    • A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-κB
    • DOI 10.1038/nsmb1018
    • Tian L, Holmgren RA, Matouschek A. 2005. A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-κB. Nat. Struct. Mol. Biol. 12:1045-53 (Pubitemid 41746774)
    • (2005) Nature Structural and Molecular Biology , vol.12 , Issue.12 , pp. 1045-1053
    • Tian, L.1    Holmgren, R.A.2    Matouschek, A.3
  • 145
    • 77958508124 scopus 로고    scopus 로고
    • A mechanism for vertebrate Hedgehog signaling: Recruitment to cilia and dissociation of SuFu-Gli protein complexes
    • Tukachinsky H, Lopez LV, Salic A. 2010. A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. J. Cell Biol. 191:415-29
    • (2010) J. Cell Biol. , vol.191 , pp. 415-429
    • Tukachinsky, H.1    Lopez, L.V.2    Salic, A.3
  • 147
    • 31744436876 scopus 로고    scopus 로고
    • Divergence of hedgehog signal transduction mechanism between Drosophila and mammals
    • DOI 10.1016/j.devcel.2005.12.014, PII S1534580706000062
    • Varjosalo M, Li SP, Taipale J. 2006. Divergence of Hedgehog signal transduction mechanism between Drosophila and mammals. Dev. Cell 10:177-86 (Pubitemid 43174951)
    • (2006) Developmental Cell , vol.10 , Issue.2 , pp. 177-186
    • Varjosalo, M.1    Li, S.-P.2    Taipale, J.3
  • 148
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: Functions and mechanisms
    • Varjosalo M, Taipale J. 2008. Hedgehog: functions and mechanisms. Genes Dev. 22:2454-72
    • (2008) Genes Dev , vol.22 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 149
    • 77958517140 scopus 로고    scopus 로고
    • Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activity
    • Villani RM, Adolphe C, Palmer J, Waters MJ, Wainwright BJ. 2010. Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activity. Cancer Prev. Res. 3:1222-34
    • (2010) Cancer Prev. Res. , vol.3 , pp. 1222-1234
    • Villani, R.M.1    Adolphe, C.2    Palmer, J.3    Waters, M.J.4    Wainwright, B.J.5
  • 151
    • 53549125545 scopus 로고    scopus 로고
    • A genome-scale analysis of the cis-regulatory circuitry underlying Sonic hedgehog-mediated patterning of the mammalian limb
    • Vokes SA, Ji H, Wong WH, McMahon AP. 2008. A genome-scale analysis of the cis-regulatory circuitry underlying Sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev. 22:2651-63
    • (2008) Genes Dev , vol.22 , pp. 2651-2663
    • Vokes, S.A.1    Ji, H.2    Wong, W.H.3    McMahon, A.P.4
  • 152
    • 0025812172 scopus 로고
    • GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families
    • Vortkamp A, Gessler M, Grzeschik K-H. 1991. GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families. Nature 352:539-40 (Pubitemid 21912379)
    • (1991) Nature , vol.352 , Issue.6335 , pp. 539-540
    • Vortkamp, A.1    Gessler, M.2    Grzeschik, K.-H.3
  • 153
    • 0034681266 scopus 로고    scopus 로고
    • Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
    • Wang B, Fallon JP, Beachy PA. 2000a. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100:423-34
    • (2000) Cell , vol.100 , pp. 423-434
    • Wang, B.1    Fallon, J.P.2    Beachy, P.A.3
  • 155
    • 77953050811 scopus 로고    scopus 로고
    • Suppressor of fused and Spop regulate the stability processing and function of Gli2 and Gli3 full-length activators but not their repressors
    • Wang C, Pan Y, Wang B. 2010a. Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors. Development 137:2001-9
    • (2010) Development , vol.137 , pp. 2001-9
    • Wang, C.1    Pan, Y.2    Wang, B.3
  • 156
    • 34247569471 scopus 로고    scopus 로고
    • The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning
    • DOI 10.1016/j.ydbio.2007.02.029, PII S0012160607001479
    • Wang C, R̈ uther U, Wang B. 2007. The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev. Biol. 305:460-69 (Pubitemid 46686613)
    • (2007) Developmental Biology , vol.305 , Issue.2 , pp. 460-469
    • Wang, C.1    Ruther, U.2    Wang, B.3
  • 157
    • 0034669178 scopus 로고    scopus 로고
    • Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activity of Cubitus interruptus
    • Wang G, Amanai K, Jiang J, Wang B, Jiang J. 2000b. Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activity of
    • (2000) Genes Dev , vol.14 , pp. 2893-905
    • Wang, G.1    Amanai, K.2    Jiang, J.3    Wang, B.4    Jiang, J.5
  • 158
    • 0033859849 scopus 로고    scopus 로고
    • Nuclear import of Cubitus interruptus is regulated by Hedgehog via a mechanism distinct from Ci stabilization and Ci activation
    • Wang QT, Holmgren RA. 2000. Nuclear import of Cubitus interruptus is regulated by Hedgehog via mechanism distinct from Ci stabilization and Ci activation. Development 127:3131-39 (Pubitemid 30611905)
    • (2000) Development , vol.127 , Issue.14 , pp. 3131-3139
    • Wang, Q.T.1    Holmgren, R.A.2
  • 159
    • 78349305842 scopus 로고    scopus 로고
    • Direct and indirect requirements of Shh/Gli signaling in early pituitary development
    • Wang Y, Martin JF, Bai CB. 2010b. Direct and indirect requirements of Shh/Gli signaling in early pituitary development. Dev. Biol. 348:199-209
    • (2010) Dev. Biol. , vol.348 , pp. 199-209
    • Wang, Y.1    Martin, J.F.2    Bai, C.B.3
  • 160
    • 77950671813 scopus 로고    scopus 로고
    • Kinetics of Hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation
    • Wen X, Lai CK, Evangelista M, Hongo J-A, de Sauvage FJ, et al. 2010. Kinetics of Hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation. Mol. Cell. Biol. 30:1910-22
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 1910-1922
    • Wen, X.1    Lai, C.K.2    Evangelista, M.3    Hongo, J.-A.4    De Sauvage, F.J.5
  • 162
    • 0037111827 scopus 로고    scopus 로고
    • A direct requirement for hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
    • DOI 10.1101/gad.1025702
    • Wijgerde M, McMahon JA, Rule M, McMahon AP. 2002. A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 16:2849-64 (Pubitemid 35334735)
    • (2002) Genes and Development , vol.16 , Issue.22 , pp. 2849-2864
    • Wijgerde, M.1    McMahon, J.A.2    Rule, M.3    McMahon, A.P.4
  • 163
    • 77953316514 scopus 로고    scopus 로고
    • Mechanism and evolution of cytosolic Hedgehog signal transduction
    • Wilson CW, Chuang P-T. 2010. Mechanism and evolution of cytosolic Hedgehog signal transduction. Development 137:2079-94
    • (2010) Development , vol.137 , pp. 2079-2094
    • Wilson, C.W.1    Chuang, P.-T.2
  • 164
    • 65549170297 scopus 로고    scopus 로고
    • Fused has evolved divergent roles in vertebrate Hedgehog signaling and motile ciliogenesis
    • Wilson CW, Nguyen CT, Chen M-H, Yang J-H, Gacayan R, et al. 2009. Fused has evolved divergent roles in vertebrate Hedgehog signaling and motile ciliogenesis. Nature 459:98-102
    • (2009) Nature , vol.459 , pp. 98-102
    • Wilson, C.W.1    Nguyen, C.T.2    Chen, M.-H.3    Yang, J.-H.4    Gacayan, R.5
  • 165
    • 0038376480 scopus 로고    scopus 로고
    • Multiple muscle cell identities induced by distinct levels and timing of Hedgehog activity in the zebrafish embryo
    • DOI 10.1016/S0960-9822(03)00461-5
    • Wolff C, Roy S, Ingham PW. 2003. Multiple muscle cell identities induced by distinct levels and timing of Hedgehog activity in the zebrafish embryo. Curr. Biol. 13:1169-81 (Pubitemid 36872939)
    • (2003) Current Biology , vol.13 , Issue.14 , pp. 1169-1181
    • Wolff, C.1    Roy, S.2    Ingham, P.W.3
  • 166
    • 69949136621 scopus 로고    scopus 로고
    • Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis
    • Wong SY, Seol AD, So PL, Ermilov AN, Bichakjian CK, et al. 2009. Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis. Nat. Med. 15:1055-61
    • (2009) Nat. Med. , vol.15 , pp. 1055-1061
    • Wong, S.Y.1    Seol, A.D.2    So, P.L.3    Ermilov, A.N.4    Bichakjian, C.K.5
  • 167
    • 75749139262 scopus 로고    scopus 로고
    • Activation of the Hedgehog-signaling pathway in human cancer and the clinical implications
    • Yang L, Xie G, Fan Q, Xie J. 2010. Activation of the Hedgehog-signaling pathway in human cancer and the clinical implications. Oncogene 29:469-81
    • (2010) Oncogene , vol.29 , pp. 469-481
    • Yang, L.1    Xie, G.2    Fan, Q.3    Xie, J.4
  • 168
    • 48449101742 scopus 로고    scopus 로고
    • Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
    • Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, et al. 2008. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 14:135-45
    • (2008) Cancer Cell , vol.14 , pp. 135-145
    • Yang, Z.J.1    Ellis, T.2    Markant, S.L.3    Read, T.A.4    Kessler, J.D.5
  • 169
    • 52149119128 scopus 로고    scopus 로고
    • A paracrine requirement forHedgehog signaling in cancer
    • Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, et al. 2008. A paracrine requirement forHedgehog signaling in cancer. Nature 455:406-10
    • (2008) Nature , vol.455 , pp. 406-410
    • Yauch, R.L.1    Gould, S.E.2    Scales, S.J.3    Tang, T.4    Tian, H.5
  • 170
    • 77955428416 scopus 로고    scopus 로고
    • NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53
    • Zbinden M, Duquet A, Lorente-Trigos A, Ngwabyt S-N, Borges I, Ruiz i Altaba A. 2010. NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53. EMBO J. 29:2659-74
    • (2010) EMBO J. , vol.29 , pp. 2659-2674
    • Zbinden, M.1    Duquet, A.2    Lorente-Trigos, A.3    Ngwabyt, S.-N.4    Borges, I.5
  • 172
    • 75849129292 scopus 로고    scopus 로고
    • Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase
    • Zhang Q, Shi S, Chen Y, Yue T, Li S, et al. 2009. Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase. Proc. Natl. Acad. Sci. USA 106:21191-96
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 21191-21196
    • Zhang, Q.1    Shi, S.2    Chen, Y.3    Yue, T.4    Li, S.5
  • 173
    • 33646893705 scopus 로고    scopus 로고
    • A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor
    • DOI 10.1016/j.devcel.2006.05.004, PII S1534580706002127
    • Zhang Q, Zhang L, Wang B, Ou CY, Chien CT, et al. 2006. A Hedgehog-induced BTB protein modulates Hedgehog signaling by degrading Ci/Gli transcription factor. Dev. Cell 10:719-29 (Pubitemid 43779117)
    • (2006) Developmental Cell , vol.10 , Issue.6 , pp. 719-729
    • Zhang, Q.1    Zhang, L.2    Wang, B.3    Ou, C.-Y.4    Chien, C.-T.5    Jiang, J.6
  • 174
    • 13344261322 scopus 로고    scopus 로고
    • Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of cubitus interruptus
    • DOI 10.1016/j.devcel.2005.01.001, PII S1534580705000031
    • Zhang W, Zhao Y, Tong C, Wang G, Wang B, et al. 2005. Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic cleavage of Cubitus interruptus. Dev. Cell 8:267-78 (Pubitemid 40197742)
    • (2005) Developmental Cell , vol.8 , Issue.2 , pp. 267-278
    • Zhang, W.1    Zhao, Y.2    Tong, C.3    Wang, G.4    Wang, B.5    Jia, J.6    Jiang, J.7
  • 175
    • 41649094573 scopus 로고    scopus 로고
    • Uncoupling sonic hedgehog control of pattern and expansion of the developing limb bud
    • DOI 10.1016/j.devcel.2008.01.008, PII S1534580708000361
    • Zhu J, Nakamura E, Nguyen M-T, Bao X, Akiyama H, et al. 2008. Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud. Dev. Cell 14:624-32 (Pubitemid 351479933)
    • (2008) Developmental Cell , vol.14 , Issue.4 , pp. 624-632
    • Zhu, J.1    Nakamura, E.2    Nguyen, M.-T.3    Bao, X.4    Akiyama, H.5    Mackem, S.6


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