Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma

Laboratory Investigation

Volumn 90, Issue 12, 2010, Pages 1690-1703

  Pereira, Thiago De Almeida ^a,d   Witek, Rafal P ^a   Syn, Wing Kin ^a   Choi, Steve S ^a   Bradrick, Shelton ^b   Karaca, Gamze F ^a   Agboola, Kolade M ^a   Jung, Youngmi ^a   Omenetti, Alessia ^a   Moylan, Cynthia A ^a   Yang, Liu ^c   Fernandez Zapico, Martin E ^c   Jhaveri, Ravi ^b   Shah, Vijay H ^c   Pereira, Fausto E ^d   Diehl, Anna M ^a  

^a DUKE UNIVERSITY   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MAYO CLINIC   (United States)

^d FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

Author keywords

fibrosis; Hedgehog pathway; hepatitis B; hepatitis C; liver progenitors; morphogens

Indexed keywords

SONIC HEDGEHOG PROTEIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CELL CULTURE; CELL POPULATION; CELL STIMULATION; CELL TYPE; CHRONIC HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENDOTHELIUM CELL; FEMALE; FIBROGENESIS; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER CELL; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER INJURY; MALE; MYOFIBROBLAST; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TARGET CELL; VIRUS HEPATITIS;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELLS, CULTURED; DISEASE PROGRESSION; FEMALE; HEDGEHOG PROTEINS; HEPATITIS C, CHRONIC; HEPATITIS VIRUSES; HEPATOCYTES; HUMANS; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; SIGNAL TRANSDUCTION; VIRAL PROTEINS;

EID: 78649641423     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2010.147     Document Type: Article

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