β-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway

Science

Volumn 306, Issue 5705, 2004, Pages 2264-2267

  Wilbanks, Alyson M ^a   Fralish, Gregory B ^a   Kirby, Margaret L ^a   Barak, Larry S ^a   Li, Yin Xiong ^a   Caron, Marc G ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SCAFFOLDS; SIGNALING;

HEDGEHOG (HH) SIGNALING; INTRACELLULAR SIGNALS; MULTIFUNCTIONAL PROTEINS; ZEBRAFISH DEVELOPMENT;

PROTEINS;

BETA ARRESTIN; BETA ARRESTIN 2; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

BIOLOGY;

ANIMAL CELL; ARTICLE; CANCER; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WILD TYPE; ZEBRA FISH;

ANIMALS; ARRESTINS; CELL DIFFERENTIATION; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; MEMBRANE PROTEINS; MUSCLE CELLS; MUSCLE FIBERS; MUTATION; PHENOTYPE; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; ZEBRAFISH; ZEBRAFISH PROTEINS;

ANIMALIA; DANIO RERIO; ERINACEIDAE;

EID: 11144285406     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1104193     Document Type: Article

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30. We thank R. Lefkowitz for valuable guidance and critical discussions; M. Zdanowicz and P. Zhang for excellent technical assistance; A. Amsterdam, B. Hogan, and P. Beachy for critical review of the manuscript and N. Hopkins, R. Jahns, L. Hein, A. Schier, F. Stockdale, and R. Moon for providing key reagents. Supported by NIH grants GM069086-01 (to G.B.F.), HL36059 (to M.L.K.), HL61365 (to L.S.B.), and NS19576 (to M.G.C.).