The sterol-sensing domain of patched protein seems to control smoothened activity through patched vesicular trafficking

Current Biology

Volumn 11, Issue 8, 2001, Pages 601-607

  Martín, Verónica ^a   Carrillo, Graciela ^a   Torroja, Carlos ^a   Guerrero, Isabel ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MUTANT; CHOLESTEROL; GENETIC CONSERVATION; HOMEOSTASIS; PROTEIN DOMAIN; SEQUENCE ANALYSIS; SIGNAL MOLECULE; SIGNAL TRANSDUCTION; STEROL; TUMOR SUPPRESSOR GENE; WILD RELATIVE;

ERINACEIDAE;

EID: 0035901616     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00178-6     Document Type: Article

References (27)

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2. Niemann-Pick C1 disease gene: Homology to mediators of cholesterol homeostasis
3. Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines
4. Morphogens, compartments, and pattern: Lessons from Drosophila?
5. A gain-of-function mutant of Patched dissects different responses to the Hedgehog gradient
6. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
7. The COE transcription factor collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing
8. Dual roles for Patched in sequestering and transducing Hedgehog
9. A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene Patched
10. Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
11. Patched overexpression alters wing disc size and pattern: Transcriptional and posttranscriptional effects on Hedgehog targets
12. Hedgehog activity, independent of Decapentaplegic, participates in wing disc patterning
13. Functional rafts in cell membranes
14. Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains
15. Transducing Hedgehog: The story so far
16. Hedgehog induces opposite changes in turnover and subcellular localization of Patched and Smoothened
17. Posttranscriptional regulation of Smoothened is part of a self-correcting mechanism in the Hedgehog signaling system
18. Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein
19. Hedgehog and Patched in neural development and disease
20. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
21. Teratogen-mediated inhibition of target tissue response to Shh signaling
22. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic Hedgehog signal transduction
23. Subcellular localization of the segment polarity protein Patched suggests an interaction with the Wingless reception complex in Drosophila embryos
24. Gradient formation of the TGF-β homolog Dpp
25. Cyclopamine inhibition of sonic hedgehog signal transduction is not mediated through effects on cholesterol transport
26. The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo
27. Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport