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Volumn 143, Issue 5, 2012, Pages

Hedgehog controls hepatic stellate cell fate by regulating metabolism

Author keywords

Gene Regulation; Liver Disease; Mouse Model; Signal Transduction

Indexed keywords

GLYCOLYTIC ENZYME; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTIC ACID; SONIC HEDGEHOG PROTEIN;

EID: 84868102616     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.07.115     Document Type: Article
Times cited : (210)

References (59)
  • 1
    • 32044435802 scopus 로고    scopus 로고
    • Adipogenic phenotype of hepatic stellate cells
    • H. Tsukamoto Adipogenic phenotype of hepatic stellate cells Alcohol Clin Exp Res 29 2005 132S 133S
    • (2005) Alcohol Clin Exp Res , vol.29
    • Tsukamoto, H.1
  • 2
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
    • S.L. Friedman Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver Physiol Rev 88 2008 125 172
    • (2008) Physiol Rev , vol.88 , pp. 125-172
    • Friedman, S.L.1
  • 3
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • J. Jiang, C.C. Hui Hedgehog signaling in development and cancer Dev Cell 15 2008 801 812
    • (2008) Dev Cell , vol.15 , pp. 801-812
    • Jiang, J.1    Hui, C.C.2
  • 4
    • 77953766440 scopus 로고    scopus 로고
    • Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: The role of negative feedback
    • a002014
    • V. Ribes, J. Briscoe Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedback Cold Spring Harb Perspect Biol 1 2009 a002014
    • (2009) Cold Spring Harb Perspect Biol , vol.1
    • Ribes, V.1    Briscoe, J.2
  • 6
    • 80054022786 scopus 로고    scopus 로고
    • Gli proteins in development and disease
    • C.C. Hui, S. Angers Gli proteins in development and disease Annu Rev Cell Dev Biol 27 2011 513 537
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 513-537
    • Hui, C.C.1    Angers, S.2
  • 7
    • 77952898697 scopus 로고    scopus 로고
    • Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals
    • B. Stecca, A. Ruiz i Altaba Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals J Mol Cell Biol 2 2010 84 95
    • (2010) J Mol Cell Biol , vol.2 , pp. 84-95
    • Stecca, B.1    Ruiz Altaba I, A.2
  • 8
    • 77953661272 scopus 로고    scopus 로고
    • The human glioma-associated oncogene homolog 1 (GLI1) family of transcription factors in gene regulation and diseases
    • H. Zhu, H.W. Lo The human glioma-associated oncogene homolog 1 (GLI1) family of transcription factors in gene regulation and diseases Curr Genomics 11 2010 238 245
    • (2010) Curr Genomics , vol.11 , pp. 238-245
    • Zhu, H.1    Lo, H.W.2
  • 9
    • 77955420936 scopus 로고    scopus 로고
    • Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer
    • M.T. Barakat, E.W. Humke, M.P. Scott Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer Trends Mol Med 16 2010 337 348
    • (2010) Trends Mol Med , vol.16 , pp. 337-348
    • Barakat, M.T.1    Humke, E.W.2    Scott, M.P.3
  • 10
    • 80055042635 scopus 로고    scopus 로고
    • Up-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication
    • S.S. Choi, S. Bradrick, G. Qiang Up-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication Hepatology 54 2011 1580 1590
    • (2011) Hepatology , vol.54 , pp. 1580-1590
    • Choi, S.S.1    Bradrick, S.2    Qiang, G.3
  • 11
    • 73349130440 scopus 로고    scopus 로고
    • Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown vs white adipose cell fate
    • J.A. Pospisilik, D. Schramek, H. Schnidar Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown vs white adipose cell fate Cell 140 2010 148 160
    • (2010) Cell , vol.140 , pp. 148-160
    • Pospisilik, J.A.1    Schramek, D.2    Schnidar, H.3
  • 12
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • P.A. Beachy, S.S. Karhadkar, D.M. Berman Tissue repair and stem cell renewal in carcinogenesis Nature 432 2004 324 331
    • (2004) Nature , vol.432 , pp. 324-331
    • Beachy, P.A.1    Karhadkar, S.S.2    Berman, D.M.3
  • 13
    • 72749094687 scopus 로고    scopus 로고
    • Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis
    • S.S. Choi, A. Omenetti, R.P. Witek Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis Am J Physiol Gastrointest Liver Physiol 297 2009 G1093 G1106
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.297
    • Choi, S.S.1    Omenetti, A.2    Witek, R.P.3
  • 14
    • 77951249823 scopus 로고    scopus 로고
    • Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation-related protein (ADRP)
    • T.F. Lee, K.M. Mak, O. Rackovsky Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation-related protein (ADRP) J Cell Physiol 223 2010 648 657
    • (2010) J Cell Physiol , vol.223 , pp. 648-657
    • Lee, T.F.1    Mak, K.M.2    Rackovsky, O.3
  • 15
    • 80051551271 scopus 로고    scopus 로고
    • Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis
    • J. Kluwe, N. Wongsiriroj, J.S. Troeger Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis Gut 60 2011 1260 1268
    • (2011) Gut , vol.60 , pp. 1260-1268
    • Kluwe, J.1    Wongsiriroj, N.2    Troeger, J.S.3
  • 16
    • 0035691559 scopus 로고    scopus 로고
    • Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation
    • F. Long, X.M. Zhang, S. Karp Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation Development 128 2001 5099 5108
    • (2001) Development , vol.128 , pp. 5099-5108
    • Long, F.1    Zhang, X.M.2    Karp, S.3
  • 17
    • 0035968125 scopus 로고    scopus 로고
    • Non-invasive visualization of sperm mitochondria behavior in transgenic mice with introduced green fluorescent protein (GFP)
    • H. Shitara, H. Kaneda, A. Sato Non-invasive visualization of sperm mitochondria behavior in transgenic mice with introduced green fluorescent protein (GFP) FEBS Lett 500 2001 7 11
    • (2001) FEBS Lett , vol.500 , pp. 7-11
    • Shitara, H.1    Kaneda, H.2    Sato, A.3
  • 18
    • 36549011761 scopus 로고    scopus 로고
    • Sonic Hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells
    • L. Yang, Y. Wang, H. Mao Sonic Hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells J Hepatol 48 2008 98 106
    • (2008) J Hepatol , vol.48 , pp. 98-106
    • Yang, L.1    Wang, Y.2    Mao, H.3
  • 19
    • 78449240951 scopus 로고    scopus 로고
    • Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway
    • S.S. Choi, W.K. Syn, G.F. Karaca Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway J Biol Chem 285 2010 36551 36560
    • (2010) J Biol Chem , vol.285 , pp. 36551-36560
    • Choi, S.S.1    Syn, W.K.2    Karaca, G.F.3
  • 20
    • 76649126249 scopus 로고    scopus 로고
    • Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
    • A. Le, C.R. Cooper, A.M. Gouw Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression Proc Natl Acad Sci U S A 107 2010 2037 2042
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 2037-2042
    • Le, A.1    Cooper, C.R.2    Gouw, A.M.3
  • 21
    • 80052080626 scopus 로고    scopus 로고
    • Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster
    • A.E. Toku, S.D. Tekir, F.B. Ozbayraktar Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster Comput Biol Chem 35 2011 282 292
    • (2011) Comput Biol Chem , vol.35 , pp. 282-292
    • Toku, A.E.1    Tekir, S.D.2    Ozbayraktar, F.B.3
  • 22
    • 70449580319 scopus 로고    scopus 로고
    • Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
    • K. Lee, H. Zhang, D.Z. Qian Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization Proc Natl Acad Sci U S A 106 2009 17910 17915
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 17910-17915
    • Lee, K.1    Zhang, H.2    Qian, D.Z.3
  • 23
    • 77951436593 scopus 로고    scopus 로고
    • Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice
    • B. Ochoa, W.K. Syn, I. Delgado Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice Hepatology 51 2010 1712 1723
    • (2010) Hepatology , vol.51 , pp. 1712-1723
    • Ochoa, B.1    Syn, W.K.2    Delgado, I.3
  • 24
    • 80052420490 scopus 로고    scopus 로고
    • Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer
    • G.M. Philips, I.S. Chan, M. Swiderska Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer PLoS One 6 2011 e2393
    • (2011) PLoS One , vol.6 , pp. 2393
    • Philips, G.M.1    Chan, I.S.2    Swiderska, M.3
  • 25
    • 34247619364 scopus 로고    scopus 로고
    • Gene expression profiles during hepatic stellate cell activation in culture and in vivo
    • S. De Minicis, E. Seki, H. Uchinami Gene expression profiles during hepatic stellate cell activation in culture and in vivo Gastroenterology 132 2007 1937 1946
    • (2007) Gastroenterology , vol.132 , pp. 1937-1946
    • De Minicis, S.1    Seki, E.2    Uchinami, H.3
  • 26
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • M.G. Vander Heiden, L.C. Cantley, C.B. Thompson Understanding the Warburg effect: the metabolic requirements of cell proliferation Science 324 2009 1029 1033
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 27
    • 79952749503 scopus 로고    scopus 로고
    • Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
    • Q. Sun, X. Chen, J. Ma Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth Proc Natl Acad Sci U S A 108 2011 4129 4134
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4129-4134
    • Sun, Q.1    Chen, X.2    Ma, J.3
  • 28
    • 33749478922 scopus 로고    scopus 로고
    • Cancer's molecular sweet tooth and the Warburg effect
    • J.W. Kim, C.V. Dang Cancer's molecular sweet tooth and the Warburg effect Cancer Res 66 2006 8927 8930
    • (2006) Cancer Res , vol.66 , pp. 8927-8930
    • Kim, J.W.1    Dang, C.V.2
  • 29
    • 17844383964 scopus 로고    scopus 로고
    • Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
    • A. Ramanathan, C. Wang, S.L. Schreiber Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements Proc Natl Acad Sci U S A 102 2005 5992 5997
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 5992-5997
    • Ramanathan, A.1    Wang, C.2    Schreiber, S.L.3
  • 30
  • 31
    • 66749119621 scopus 로고    scopus 로고
    • Evidence for allosteric interactions of antagonist binding to the smoothened receptor
    • C.M. Rominger, W.L. Bee, R.A. Copeland Evidence for allosteric interactions of antagonist binding to the smoothened receptor J Pharmacol Exp Ther 329 2009 995 1005
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 995-1005
    • Rominger, C.M.1    Bee, W.L.2    Copeland, R.A.3
  • 32
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • G.L. Semenza, P.H. Roth, H.M. Fang Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1 J Biol Chem 269 1994 23757 23763
    • (1994) J Biol Chem , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3
  • 33
    • 33846209631 scopus 로고    scopus 로고
    • Hypoxia induces the activation of human hepatic stellate cells LX-2 through TGF-beta signaling pathway
    • Y.F. Shi, C.C. Fong, Q. Zhang Hypoxia induces the activation of human hepatic stellate cells LX-2 through TGF-beta signaling pathway FEBS Lett 581 2007 203 210
    • (2007) FEBS Lett , vol.581 , pp. 203-210
    • Shi, Y.F.1    Fong, C.C.2    Zhang, Q.3
  • 34
    • 0033592863 scopus 로고    scopus 로고
    • Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver
    • J.A. Bezerra, T.H. Bugge, H. Melin-Aldana Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver Proc Natl Acad Sci U S A 96 1999 15143 15148
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 15143-15148
    • Bezerra, J.A.1    Bugge, T.H.2    Melin-Aldana, H.3
  • 35
    • 13444269608 scopus 로고    scopus 로고
    • Tissue repair: An important determinant of final outcome of toxicant-induced injury
    • H.M. Mehendale Tissue repair: an important determinant of final outcome of toxicant-induced injury Toxicol Pathol 33 2005 41 51
    • (2005) Toxicol Pathol , vol.33 , pp. 41-51
    • Mehendale, H.M.1
  • 36
    • 40749163248 scopus 로고    scopus 로고
    • The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    • H.R. Christofk, M.G. Vander Heiden, M.H. Harris The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth Nature 452 2008 230 233
    • (2008) Nature , vol.452 , pp. 230-233
    • Christofk, H.R.1    Vander Heiden, M.G.2    Harris, M.H.3
  • 37
    • 77449131347 scopus 로고    scopus 로고
    • Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
    • T. Hitosugi, S. Kang, M.G. Vander Heiden Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth Sci Signal 2 2009 ra73
    • (2009) Sci Signal , vol.2 , pp. 73
    • Hitosugi, T.1    Kang, S.2    Vander Heiden, M.G.3
  • 38
    • 78049480651 scopus 로고    scopus 로고
    • Stress signaling in the methionine-choline-deficient model of murine fatty liver disease
    • 1739 e1
    • R.K. Soon Jr., J.S. Yan, J.P. Grenert Stress signaling in the methionine-choline-deficient model of murine fatty liver disease Gastroenterology 139 2010 1730 1739 1739 e1
    • (2010) Gastroenterology , vol.139 , pp. 1730-1739
    • Soon, Jr.R.K.1    Yan, J.S.2    Grenert, J.P.3
  • 39
    • 77953305752 scopus 로고    scopus 로고
    • Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: Impact on mitochondrial S-adenosyl-L-methionine and glutathione
    • F. Caballero, A. Fernandez, N. Matias Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione J Biol Chem 285 2010 18528 18536
    • (2010) J Biol Chem , vol.285 , pp. 18528-18536
    • Caballero, F.1    Fernandez, A.2    Matias, N.3
  • 40
    • 33747048138 scopus 로고    scopus 로고
    • Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis
    • H. Uchinami, E. Seki, D.A. Brenner Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis Hepatology 44 2006 420 429
    • (2006) Hepatology , vol.44 , pp. 420-429
    • Uchinami, H.1    Seki, E.2    Brenner, D.A.3
  • 41
    • 49449097533 scopus 로고    scopus 로고
    • Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease
    • K. Takeda, Y. Kojima, K. Ikejima Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease Proc Natl Acad Sci U S A 105 2008 10895 10900
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10895-10900
    • Takeda, K.1    Kojima, Y.2    Ikejima, K.3
  • 42
    • 20644441579 scopus 로고    scopus 로고
    • Differential regulation of extracellular matrix synthesis during liver regeneration after partial hepatectomy in rats
    • K.L. Rudolph, C. Trautwein, S. Kubicka Differential regulation of extracellular matrix synthesis during liver regeneration after partial hepatectomy in rats Hepatology 30 1999 1159 1166
    • (1999) Hepatology , vol.30 , pp. 1159-1166
    • Rudolph, K.L.1    Trautwein, C.2    Kubicka, S.3
  • 43
    • 0035144232 scopus 로고    scopus 로고
    • Sinusoidal ultrastructure evaluated during the revascularization of regenerating rat liver
    • K.E. Wack, M.A. Ross, V. Zegarra Sinusoidal ultrastructure evaluated during the revascularization of regenerating rat liver Hepatology 33 2001 363 378
    • (2001) Hepatology , vol.33 , pp. 363-378
    • Wack, K.E.1    Ross, M.A.2    Zegarra, V.3
  • 44
    • 0028887389 scopus 로고
    • Hepatic collagen synthesis and degradation during liver regeneration after partial hepatectomy
    • H. Yamamoto, Y. Murawaki, H. Kawasaki Hepatic collagen synthesis and degradation during liver regeneration after partial hepatectomy Hepatology 21 1995 155 161
    • (1995) Hepatology , vol.21 , pp. 155-161
    • Yamamoto, H.1    Murawaki, Y.2    Kawasaki, H.3
  • 45
    • 32444433057 scopus 로고    scopus 로고
    • Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet
    • A.C. Igolnikov, R.M. Green Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet J Hepatol 44 2006 586 592
    • (2006) J Hepatol , vol.44 , pp. 586-592
    • Igolnikov, A.C.1    Green, R.M.2
  • 46
    • 67649446810 scopus 로고    scopus 로고
    • Integrative genomic analyses on GLI1: Positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals
    • Y. Katoh, M. Katoh Integrative genomic analyses on GLI1: positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals Int J Oncol 35 2009 187 192
    • (2009) Int J Oncol , vol.35 , pp. 187-192
    • Katoh, Y.1    Katoh, M.2
  • 47
    • 82655181516 scopus 로고    scopus 로고
    • Obesity short-circuits stemness gene network in human adipose multipotent stem cells
    • M. Roldan, M. Macias-Gonzalez, R. Garcia Obesity short-circuits stemness gene network in human adipose multipotent stem cells FASEB J 25 2011 4111 4126
    • (2011) FASEB J , vol.25 , pp. 4111-4126
    • Roldan, M.1    MacIas-Gonzalez, M.2    Garcia, R.3
  • 48
    • 77951722845 scopus 로고    scopus 로고
    • Signals from dying hepatocytes trigger growth of liver progenitors
    • Y. Jung, R.P. Witek, W.K. Syn Signals from dying hepatocytes trigger growth of liver progenitors Gut 59 2010 655 665
    • (2010) Gut , vol.59 , pp. 655-665
    • Jung, Y.1    Witek, R.P.2    Syn, W.K.3
  • 49
    • 27144554034 scopus 로고    scopus 로고
    • Role for hedgehog signaling in hepatic stellate cell activation and viability
    • J.K. Sicklick, Y.X. Li, S.S. Choi Role for hedgehog signaling in hepatic stellate cell activation and viability Lab Invest 85 2005 1368 1380
    • (2005) Lab Invest , vol.85 , pp. 1368-1380
    • Sicklick, J.K.1    Li, Y.X.2    Choi, S.S.3
  • 51
    • 36849021771 scopus 로고    scopus 로고
    • Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
    • D.F. Higgins, K. Kimura, W.M. Bernhardt Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition J Clin Invest 117 2007 3810 3820
    • (2007) J Clin Invest , vol.117 , pp. 3810-3820
    • Higgins, D.F.1    Kimura, K.2    Bernhardt, W.M.3
  • 52
    • 2542610720 scopus 로고    scopus 로고
    • Preprocessing of oligonucleotide array data
    • author reply 658
    • Z. Wu, R.A. Irizarry Preprocessing of oligonucleotide array data Nat Biotechnol 22 2004 656 658 author reply 658
    • (2004) Nat Biotechnol , vol.22 , pp. 656-658
    • Wu, Z.1    Irizarry, R.A.2
  • 53
    • 4344571581 scopus 로고    scopus 로고
    • Rank products: A simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments
    • R. Breitling, P. Armengaud, A. Amtmann Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments FEBS Lett 573 2004 83 92
    • (2004) FEBS Lett , vol.573 , pp. 83-92
    • Breitling, R.1    Armengaud, P.2    Amtmann, A.3
  • 54
    • 33751384465 scopus 로고    scopus 로고
    • GATHER: A systems approach to interpreting genomic signatures
    • J.T. Chang, J.R. Nevins GATHER: a systems approach to interpreting genomic signatures Bioinformatics 22 2006 2926 2933
    • (2006) Bioinformatics , vol.22 , pp. 2926-2933
    • Chang, J.T.1    Nevins, J.R.2
  • 55
    • 24744440133 scopus 로고    scopus 로고
    • Evidence that phosphorylation of the RNA polymerase II carboxyl-terminal repeats is similar in yeast and humans
    • D.P. Morris, G.A. Michelotti, D.A. Schwinn Evidence that phosphorylation of the RNA polymerase II carboxyl-terminal repeats is similar in yeast and humans J Biol Chem 280 2005 31368 31377
    • (2005) J Biol Chem , vol.280 , pp. 31368-31377
    • Morris, D.P.1    Michelotti, G.A.2    Schwinn, D.A.3
  • 56
    • 78449240951 scopus 로고    scopus 로고
    • Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway
    • S.S. Choi, W.K. Syn, G.F. Karaca Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway J Biol Chem 285 2010 36551 36560
    • (2010) J Biol Chem , vol.285 , pp. 36551-36560
    • Choi, S.S.1    Syn, W.K.2    Karaca, G.F.3
  • 57
    • 0026341256 scopus 로고
    • Characterization of fat-storing cell lines derived from normal and CCl4-cirrhotic livers Differences in the production of interleukin-6
    • P. Greenwel, M. Schwartz, M. Rosas Characterization of fat-storing cell lines derived from normal and CCl4-cirrhotic livers Differences in the production of interleukin-6 Lab Invest 65 1991 644 653
    • (1991) Lab Invest , vol.65 , pp. 644-653
    • Greenwel, P.1    Schwartz, M.2    Rosas, M.3
  • 58
    • 0035691559 scopus 로고    scopus 로고
    • Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation
    • F. Long, X.M. Zhang, S. Karp Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation Development 128 2001 5099 5108
    • (2001) Development , vol.128 , pp. 5099-5108
    • Long, F.1    Zhang, X.M.2    Karp, S.3
  • 59
    • 0035968125 scopus 로고    scopus 로고
    • Non-invasive visualization of sperm mitochondria behavior in transgenic mice with introduced green fluorescent protein (GFP)
    • H. Shitara, H. Kaneda, A. Sato Non-invasive visualization of sperm mitochondria behavior in transgenic mice with introduced green fluorescent protein (GFP) FEBS Lett 500 2001 7 11
    • (2001) FEBS Lett , vol.500 , pp. 7-11
    • Shitara, H.1    Kaneda, H.2    Sato, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.