Hedgehog signaling regulates expansion of pancreatic epithelial cells

Developmental Biology

Volumn 280, Issue 1, 2005, Pages 111-121

  Kawahira, Hiroshi ^a   Scheel, David W ^a   Smith, Stuart B ^a   German, Michael S ^a   Hebrok, Matthias ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Hedgehog signaling; Islets; ngn3; Pancreas; Pax4 promoter

Indexed keywords

SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ECTOPIC PANCREAS; EMBRYO; EMBRYO DEVELOPMENT; EPITHELIUM CELL; GASTROINTESTINAL TRACT; MESENCHYME; MORPHOGENESIS; MOUSE; NEWBORN; NONHUMAN; ORGANOGENESIS; PANCREAS; PANCREAS FUNCTION; PANCREAS ISLET CELL; PANCREAS MALFORMATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TISSUE DIFFERENTIATION;

EID: 14844331446     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ydbio.2005.01.008     Document Type: Article

References (30)

1. U. Ahlgren, S.L. Pfaff, T.M. Jessell, T. Edlund, and H. Edlund Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells Nature 385 1997 257 260
2. A. Apelqvist, U. Ahlgren, and H. Edlund Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas Curr. Biol. 7 1997 801 804
3. P.T. Chuang, and A.P. McMahon Vertebrate Hedgehog signalling modulated by induction of a Hedgehog- binding protein Nature 397 1999 617 621
4. P.T. Chuang, T.N. Kawcak, and A.P. McMahon Feedback control of mammalian Hedgehog signaling by the Hedgehog-Binding Protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung Genes Dev. 17 2003 342 347
5. M.K. Cooper, J.A. Porter, K.E. Young, and P.A. Beachy Teratogen-mediated inhibition of target tissue response to Shh signaling Science 280 1998 1603 1607
6. G. Gabbiani, Y. Kapanci, P. Barazzone, and W.W. Franke Immunochemical identification of intermediate-sized filaments in human neoplastic cells. A diagnostic aid for the surgical pathologist Am. J. Pathol. 104 1981 206 216
7. G. Gradwohl, A. Dierich, M. LeMeur, and F. Guillemot neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas Proc. Natl. Acad. Sci. U. S. A. 97 2000 1607 1611
8. M. Hebrok Hedgehog signaling in pancreas development Mech. Dev. 20 2003 45 57
9. M. Hebrok, S.K. Kim, and D.A. Melton Notochord repression of endodermal Sonic hedgehog permits pancreas development Genes Dev. 12 1998 1705 1713
10. M. Hebrok, S.K. Kim, B. St Jacques, A.P. McMahon, and D.A. Melton Regulation of pancreas development by hedgehog signaling Development 127 2000 4905 4913
11. R.H. Hruban, N.V. Adsay, J. Albores-Saavedra, C. Compton, E.S. Garrett, S.N. Goodman, S.E. Kern, D.S. Klimstra, G. Kloppel, D.S. Longnecker, J. Luttges, and G.J. Offerhaus Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions Am. J. Surg. Pathol. 25 2001 579 586
12. J.P. Incardona, W. Gaffield, R.P. Kapur, and H. Roelink The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction Development 125 1998 3553 3562
13. P.W. Ingham, and A.P. McMahon Hedgehog signaling in animal development: paradigms and principles Genes Dev. 15 2001 3059 3087
14. H. Kawahira, N.H. Ma, E.S. Tzanakakis, A.P. McMahon, P.T. Chuang, and M. Hebrok Combined activities of hedgehog signaling inhibitors regulate pancreas development Development 130 2003 4871 4879
15. S.K. Kim, and M. Hebrok Intercellular signals regulating pancreas development and function Genes Dev. 15 2001 111 127
16. S.K. Kim, M. Hebrok, and D.A. Melton Notochord to endoderm signaling is required for pancreas development Development 124 1997 4243 4252
17. M.F. Offield, T.L. Jetton, P.A. Labosky, M. Ray, R.W. Stein, M.A. Magnuson, B.L. Hogan, and C.V. Wright PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum Development 122 1996 983 995
18. S. Pathi, S. Pagan-Westphal, D.P. Baker, E.A. Garber, P. Rayhorn, D. Bumcrot, C.J. Tabin, R. Blake Pepinsky, and K.P. Williams Comparative biological responses to human Sonic, Indian, and Desert hedgehog Mech. Dev. 106 2001 107 117
19. R. Pictet, and W.J. Rutter Development of the embryonic endocrine pancreas R.O. Greep E.B. Astwood D.F. Steiner N. Freinkel S.R. Geiger Handbook of Physiology vol. I 1972 American Physiological Society Washington, DC 25 76
20. M. Ramalho-Santos, D.A. Melton, and A.P. McMahon Hedgehog signals regulate multiple aspects of gastrointestinal development Development 127 2000 2763 2772
21. V.M. Schwitzgebel, D.W. Scheel, J.R. Conners, J. Kalamaras, J.E. Lee, D.J. Anderson, L. Sussel, J.D. Johnson, and M.S. German Expression of neurogenin3 reveals an islet cell precursor population in the pancreas Development 127 2000 3533 3542
22. L. Selander, and H. Edlund Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas Mech. Dev. 113 2002 189 192
23. J.M. Slack Developmental biology of the pancreas Development 121 1995 1569 1580
24. S.B. Smith, H. Watada, D.W. Scheel, C. Mrejen, and M.S. German Autoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoter J. Biol. Chem. 275 2000 36910 36919
25. L. Sussel, J. Kalamaras, D.J. Hartigan-O'Connor, J.J. Meneses, R.A. Pedersen, J.L. Rubenstein, and M.S. German Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells Development 125 1998 2213 2221
26. S.P. Thayer, M.P. di Magliano, P.W. Heiser, C.M. Nielsen, D.J. Roberts, G.Y. Lauwers, Y.P. Qi, S. Gysin, C. Fernandez-del Castillo, V. Yajnik, B. Antoniu, M. McMahon, A.L. Warshaw, and M. Hebrok Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis Nature 425 2003 851 856
27. M.K. Thomas, N. Rastalsky, J.H. Lee, and J.F. Habener Hedgehog signaling regulation of insulin production by pancreatic beta- cells Diabetes 49 2000 2039 2047
28. M.K. Thomas, J.H. Lee, N. Rastalsky, and J.F. Habener Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells Endocrinology 142 2001 1033 1040
29. X.M. Zhang, M. Ramalho-Santos, and A.P. McMahon Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node Cell 106 2001 781 792
30. A. Zoltan-Jones, L. Huang, S. Ghatak, and B.P. Toole Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells J. Biol. Chem. 278 2003 45801 45810