The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Nature

Volumn 452, Issue 7184, 2008, Pages 230-233

  Christofk, Heather R ^a   Vander Heiden, Matthew G ^a,b   Harris, Marian H ^c   Ramanathan, Arvind ^d   Gerszten, Robert E ^a,d,e   Wei, Ru ^d   Fleming, Mark D ^c   Schreiber, Stuart L ^d,f   Cantley, Lewis C ^a,g  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f HARVARD UNIVERSITY   (United States)

^g BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOENZYME; LACTIC ACID; PYRUVATE KINASE; PYRUVATE KINASE M1; PYRUVATE KINASE M2; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

CANCER; ENZYME ACTIVITY; GENE EXPRESSION; GROWTH; METABOLISM; PHENOTYPE; TUMOR;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL METABOLISM; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME MECHANISM; GENE SWITCHING; GLYCOLYSIS; HUMAN; HUMAN CELL; METABOLISM; MOUSE; NONHUMAN; NUDE MOUSE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SPLICING; TUMOR CELL; TUMOR GROWTH; TUMOR XENOGRAFT;

MUS MUSCULUS;

EID: 40749163248     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature06734     Document Type: Article

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