Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

eLife

Volumn 2013, Issue 2, 2013, Pages

  Nachtergaele, Sigrid ^a   Whalen, Daniel M ^b   Mydock, Laurel K ^c   Zhao, Zhonghua ^d   Malinauskas, Tomas ^b   Krishnan, Kathiresan ^c   Ingham, Philip W ^d,e   Covey, Douglas F ^c   Siebold, Christian ^b   Rohatgi, Rajat ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^e NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

FRIZZLED PROTEIN; G PROTEIN COUPLED RECEPTOR; LIGAND; PROTEIN BINDING; RECOMBINANT PROTEIN; SMOH PROTEIN, ZEBRAFISH; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; STEROL; ZEBRAFISH PROTEIN;

AFFINITY CHROMATOGRAPHY; ANIMAL; ANIMAL CELL; ANIMAL EMBRYO; ANTAGONISTS AND INHIBITORS; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COLUMN CHROMATOGRAPHY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CRYSTALLIZATION; ESCHERICHIA COLI; EXTRACELLULAR SPACE; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IN SITU HYBRIDIZATION; INTRACELLULAR SIGNALING; LIGHT SCATTERING; METABOLISM; MOLECULAR DOCKING; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; WNT SIGNALING PATHWAY; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION; ZEBRA FISH;

ANIMALS; ANTAGONISTS AND INHIBITORS; BINDING SITES; CHEMISTRY; CRYSTALLOGRAPHY, X-RAY; EMBRYO, NONMAMMALIAN; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETICS; GROWTH AND DEVELOPMENT; HEDGEHOG PROTEINS; LIGANDS; METABOLISM; MICE; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; STEROLS; STRUCTURE-ACTIVITY RELATIONSHIP; ZEBRAFISH; ZEBRAFISH PROTEINS;

ERINACEIDAE; VERTEBRATA;

EID: 84887326705     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.01340.001     Document Type: Article

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