β-arrestin-mediated localization of smoothened to the primary cilium

Science

Volumn 320, Issue 5884, 2008, Pages 1777-1781

  Kovacs, Jeffrey J ^a   Whalen, Erin J ^a   Liu, Renshui ^a   Xiao, Kunhong ^a   Kim, Jihee ^a   Chen, Minyong ^a   Wang, Jiangbo ^a   Chen, Wei ^a   Lefkowitz, Robert J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN 1; BETA ARRESTIN 2; CYCLOPAMINE; KINESIN; PROTEIN KIF3A; SMALL INTERFERING RNA; SMOOTHENED PROTEIN;

MEMBRANE; PROTEIN; RNA; SIGNALING; TUMOR;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; ENDOCYTOSIS; EUKARYOTIC FLAGELLUM; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; ARRESTINS; CILIA; HEDGEHOG PROTEINS; KINESIN; MICE; MICROSCOPY, CONFOCAL; MOLECULAR MOTOR PROTEINS; NIH 3T3 CELLS; PROTEIN TRANSPORT; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFECTION;

ERINACEIDAE; MAMMALIA;

EID: 46449127054     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1157983     Document Type: Article

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27. We thank S. Dewire, J. Violin, S. Ahn, and E. Reiter for critical commentary; J. Reiter for scientific discussions; C. Hubbert and A. Guardiola for technical assistance; D. Addison, E. Hall, and D. Sawyer for administrative assistance; and P. Beachy for GFP-Smo plasmid. This work was supported in part by NIH grants HL16037 and HL70631. Additional funding was provided by NIH grant 5RO1 CA113656-02. J.J.K. is supported by NIH grant 5T32 AI007217-25. W.C. is a V Foundation Scholar. R.J.L. is an investigator with the Howard Hughes Medical Institute.