Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 9, 2009, Pages 3196-3201

  Rohatgi, Rajat ^a,b   Milenkovic, Ljiljana ^a,b   Corcoran, Ryan B ^a,b   Scott, Matthew P ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Developmental signaling; Hedgehog inhibitor; Primary cilium; Transport

Indexed keywords

PROTEIN INHIBITOR; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; SONIC HEDGEHOG PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL FATE; CELL GROWTH; CONTROLLED STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; HEDGEHOG PROTEINS; MICE; MICE, KNOCKOUT; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

ERINACEIDAE;

EID: 62549159642     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0813373106     Document Type: Article

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