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Volumn 19, Issue 8, 2013, Pages 854-895

The tumor microenvironment: Characterization, redox considerations, and novel approaches for reactive oxygen species-targeted gene therapy

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE PEROXIDASE; PEROXIREDOXIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

EID: 84882684320     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2011.4367     Document Type: Review
Times cited : (104)

References (354)
  • 1
    • 77953384917 scopus 로고    scopus 로고
    • Redox regulation in cancer: A double-edged sword with therapeutic potential
    • Acharya A, Das I, Chandhok D, and Saha T. Redox regulation in cancer: a double-edged sword with therapeutic potential. Oxid Med Cell Longev 3: 23-34, 2010.
    • (2010) Oxid Med Cell Longev , vol.3 , pp. 23-34
    • Acharya, A.1    Das, I.2    Chandhok, D.3    Saha, T.4
  • 2
    • 80054796744 scopus 로고    scopus 로고
    • Drug-induced senescence generates chemoresistant stemlike cells with low reactive oxygen species
    • Achuthan S, Santhoshkumar TR, Prabhakar J, Nair SA, and Pillai MR. Drug-induced senescence generates chemoresistant stemlike cells with low reactive oxygen species. J Biol Chem 286: 37813-37829, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 37813-37829
    • Achuthan, S.1    Santhoshkumar, T.R.2    Prabhakar, J.3    Nair, S.A.4    Pillai, M.R.5
  • 3
    • 79953712904 scopus 로고    scopus 로고
    • MicroRNA-128 downregulates Bax and induces apoptosis in human embryonic kidney cells
    • Adlakha YK and Saini N. MicroRNA-128 downregulates Bax and induces apoptosis in human embryonic kidney cells. Cell Mol Life Sci 68: 1415-1428, 2011.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 1415-1428
    • Adlakha, Y.K.1    Saini, N.2
  • 5
    • 63649133909 scopus 로고    scopus 로고
    • Angiogenic signalling pathways
    • Ahmed Z and Bicknell R. Angiogenic signalling pathways. Methods Mol Biol 467: 3-24, 2009.
    • (2009) Methods Mol Biol , vol.467 , pp. 3-24
    • Ahmed, Z.1    Bicknell, R.2
  • 8
    • 40049088602 scopus 로고    scopus 로고
    • The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages
    • Allavena P, Sica A, Solinas G, Porta C, and Mantovani A. The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages. Crit Rev Oncol Hematol 66: 1-9, 2008.
    • (2008) Crit Rev Oncol Hematol , vol.66 , pp. 1-9
    • Allavena, P.1    Sica, A.2    Solinas, G.3    Porta, C.4    Mantovani, A.5
  • 9
    • 20444493997 scopus 로고    scopus 로고
    • Secreted protein acidic and rich in cysteine produced by human melanoma cells modulates polymorphonuclear leukocyte recruitment and antitumor cytotoxic capacity
    • Alvarez MJ, Prada F, Salvatierra E, Bravo AI, Lutzky VP, Carbone C, Pitossi FJ, Chuluyan HE, and Podhajcer OL. Secreted protein acidic and rich in cysteine produced by human melanoma cells modulates polymorphonuclear leukocyte recruitment and antitumor cytotoxic capacity. Cancer Res 65: 5123-5132, 2005.
    • (2005) Cancer Res , vol.65 , pp. 5123-5132
    • Alvarez, M.J.1    Prada, F.2    Salvatierra, E.3    Bravo, A.I.4    Lutzky, V.P.5    Carbone, C.6    Pitossi, F.J.7    Chuluyan, H.E.8    Podhajcer, O.L.9
  • 13
    • 67349120863 scopus 로고    scopus 로고
    • Focus on mammalian thioredoxin reductases-important selenoproteins with versatile functions
    • Arner ES. Focus on mammalian thioredoxin reductases-important selenoproteins with versatile functions. Biochim Biophys Acta 1790: 495-526, 2009.
    • (2009) Biochim Biophys Acta , vol.1790 , pp. 495-526
    • Arner, E.S.1
  • 14
    • 33751178410 scopus 로고    scopus 로고
    • The thioredoxin system in cancer
    • Arner ES and Holmgren A. The thioredoxin system in cancer. Semin Cancer Biol 16: 420-426, 2006.
    • (2006) Semin Cancer Biol , vol.16 , pp. 420-426
    • Arner, E.S.1    Holmgren, A.2
  • 16
    • 60749108379 scopus 로고    scopus 로고
    • Regulation of autophagy by reactive oxygen species (ROS): Implications for cancer progression and treatment
    • Azad MB, Chen Y, and Gibson SB. Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment. Antioxid Redox Signal 11: 777-790, 2009.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 777-790
    • Azad, M.B.1    Chen, Y.2    Gibson, S.B.3
  • 17
    • 36348934576 scopus 로고    scopus 로고
    • Thioredoxin, produced by stromal cells retrieved from the lymph node microenvironment, rescues chronic lymphocytic leukemia cells from apoptosis in vitro
    • Backman E, Bergh AC, Lagerdahl I, Rydberg B, Sundstrom C, Tobin G, Rosenquist R, Linderholm M, and Rosen A. Thioredoxin, produced by stromal cells retrieved from the lymph node microenvironment, rescues chronic lymphocytic leukemia cells from apoptosis in vitro. Haematologica 92: 1495-1504, 2007.
    • (2007) Haematologica , vol.92 , pp. 1495-1504
    • Backman, E.1    Bergh, A.C.2    Lagerdahl, I.3    Rydberg, B.4    Sundstrom, C.5    Tobin, G.6    Rosenquist, R.7    Linderholm, M.8    Rosen, A.9
  • 18
    • 0026619273 scopus 로고
    • Deviant energetic metabolism of glycolytic cancer cells
    • Baggetto LG. Deviant energetic metabolism of glycolytic cancer cells. Biochimie 74: 959-974, 1992.
    • (1992) Biochimie , vol.74 , pp. 959-974
    • Baggetto, L.G.1
  • 19
    • 33846331272 scopus 로고    scopus 로고
    • Salivary analysis in oral cancer patients: DNA and protein oxidation, reactive nitrogen species, and antioxidant profile
    • Bahar G, Feinmesser R, Shpitzer T, Popovtzer A, and Nagler RM. Salivary analysis in oral cancer patients: DNA and protein oxidation, reactive nitrogen species, and antioxidant profile. Cancer 109: 54-59, 2007.
    • (2007) Cancer , vol.109 , pp. 54-59
    • Bahar, G.1    Feinmesser, R.2    Shpitzer, T.3    Popovtzer, A.4    Nagler, R.M.5
  • 21
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow
    • Balkwill F and Mantovani A. Inflammation and cancer: back to Virchow? Lancet 357: 539-545, 2001.
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 23
    • 57149089463 scopus 로고    scopus 로고
    • Glutathione peroxidase 2 inhibits cyclooxygenase-2-mediated migration and invasion of HT-29 adenocarcinoma cells but supports their growth as tumors in nude mice
    • Banning A, Kipp A, Schmitmeier S, Lowinger M, Florian S, Krehl S, Thalmann S, Thierbach R, Steinberg P, and Brigelius-Flohe R. Glutathione peroxidase 2 inhibits cyclooxygenase-2-mediated migration and invasion of HT-29 adenocarcinoma cells but supports their growth as tumors in nude mice. Cancer Res 68: 9746-9753, 2008.
    • (2008) Cancer Res , vol.68 , pp. 9746-9753
    • Banning, A.1    Kipp, A.2    Schmitmeier, S.3    Lowinger, M.4    Florian, S.5    Krehl, S.6    Thalmann, S.7    Thierbach, R.8    Steinberg, P.9    Brigelius-Flohe, R.10
  • 24
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    • Bedard K and Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87: 245-313, 2007.
    • (2007) Physiol Rev , vol.87 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 25
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G and Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3: 401-410, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 26
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • Bertout JA, Patel SA, and Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer 8: 967-975, 2008.
    • (2008) Nat Rev Cancer , vol.8 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 28
    • 72449177328 scopus 로고    scopus 로고
    • Matricellular proteins: An overview
    • Bornstein P. Matricellular proteins: an overview. J Cell Commun Signal 3: 163-165, 2009.
    • (2009) J Cell Commun Signal , vol.3 , pp. 163-165
    • Bornstein, P.1
  • 32
    • 77952541558 scopus 로고    scopus 로고
    • The sites and topology of mitochondrial superoxide production
    • Brand MD. The sites and topology of mitochondrial superoxide production. Exp Gerontol 45: 466-472, 2010.
    • (2010) Exp Gerontol , vol.45 , pp. 466-472
    • Brand, M.D.1
  • 33
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
    • Bristow RG and Hill RP. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 8: 180-192, 2008.
    • (2008) Nat Rev Cancer , vol.8 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 34
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown JM and Wilson WR. Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 4: 437-447, 2004.
    • (2004) Nat Rev Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 35
    • 77649189072 scopus 로고    scopus 로고
    • Characterization of molecular and functional alterations of tumor endothelial cells to design anti-angiogenic strategies
    • Bussolati B, Deregibus MC, and Camussi G. Characterization of molecular and functional alterations of tumor endothelial cells to design anti-angiogenic strategies. Curr Vasc Pharmacol 8: 220-232, 2010.
    • (2010) Curr Vasc Pharmacol , vol.8 , pp. 220-232
    • Bussolati, B.1    Deregibus, M.C.2    Camussi, G.3
  • 36
    • 80052655345 scopus 로고    scopus 로고
    • Tumor exploits alternative strategies to achieve vascularization
    • Bussolati B, Grange C, and Camussi G. Tumor exploits alternative strategies to achieve vascularization. FASEB J 25, 2874-2882, 2011.
    • (2011) FASEB J , vol.25 , pp. 2874-2882
    • Bussolati, B.1    Grange, C.2    Camussi, G.3
  • 37
    • 80053030114 scopus 로고    scopus 로고
    • The cancer stem cell niche-there goes the neighborhood
    • Cabarcas SM, Mathews LA, and Farrar WL. The cancer stem cell niche-there goes the neighborhood? Int J Cancer 129: 2315-2327, 2011.
    • (2011) Int J Cancer , vol.129 , pp. 2315-2327
    • Cabarcas, S.M.1    Mathews, L.A.2    Farrar, W.L.3
  • 38
    • 0017406503 scopus 로고
    • Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria
    • Cadenas E, Boveris A, Ragan CI, and Stoppani AO. Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria. Arch Biochem Biophys 180: 248-257, 1977.
    • (1977) Arch Biochem Biophys , vol.180 , pp. 248-257
    • Cadenas, E.1    Boveris, A.2    Ragan, C.I.3    Stoppani, A.O.4
  • 40
    • 46149087993 scopus 로고    scopus 로고
    • R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways
    • Cao Y, Cao R, and Hedlund EM. R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways. J Mol Med (Berl) 86: 785-789, 2008.
    • (2008) J Mol Med (Berl) , vol.86 , pp. 785-789
    • Cao, Y.1    Cao, R.2    Hedlund, E.M.3
  • 41
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P and Jain RK. Angiogenesis in cancer and other diseases. Nature 407: 249-257, 2000.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 42
    • 0033040739 scopus 로고    scopus 로고
    • Does vitamin C act as a pro-oxidant under physiological conditions
    • Carr A and Frei B. Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J 13: 1007-1024, 1999.
    • (1999) FASEB J , vol.13 , pp. 1007-1024
    • Carr, A.1    Frei, B.2
  • 43
    • 34250635065 scopus 로고    scopus 로고
    • Mitochondrial nitric oxide in the signaling of cell integrated responses
    • Carreras MC and Poderoso JJ. Mitochondrial nitric oxide in the signaling of cell integrated responses. Am J Physiol Cell Physiol 292: C1569-C1580, 2007.
    • (2007) Am J Physiol Cell Physiol , vol.292
    • Carreras, M.C.1    Poderoso, J.J.2
  • 44
    • 51949087589 scopus 로고    scopus 로고
    • The redox state of the lung cancer microenvironment depends on the levels of thioredoxin expressed by tumor cells and affects tumor progression and response to prooxidants
    • Ceccarelli J, Delfino L, Zappia E, Castellani P, Borghi M, Ferrini S, Tosetti F, and Rubartelli A. The redox state of the lung cancer microenvironment depends on the levels of thioredoxin expressed by tumor cells and affects tumor progression and response to prooxidants. Int J Cancer 123: 1770-1778, 2008.
    • (2008) Int J Cancer , vol.123 , pp. 1770-1778
    • Ceccarelli, J.1    Delfino, L.2    Zappia, E.3    Castellani, P.4    Borghi, M.5    Ferrini, S.6    Tosetti, F.7    Rubartelli, A.8
  • 45
    • 0034682786 scopus 로고    scopus 로고
    • Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: A mechanism of O2 sensing
    • Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, and Schumacker PT. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem 275: 25130-25138, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 25130-25138
    • Chandel, N.S.1    McClintock, D.S.2    Feliciano, C.E.3    Wood, T.M.4    Melendez, J.A.5    Rodriguez, A.M.6    Schumacker, P.T.7
  • 46
    • 65849126073 scopus 로고    scopus 로고
    • Comparative assessment of urinary oxidative indices in breast and colorectal cancer patients
    • Chandramathi S, Suresh K, Anita ZB, and Kuppusamy UR. Comparative assessment of urinary oxidative indices in breast and colorectal cancer patients. J Cancer Res Clin Oncol 135: 319-323, 2009.
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 319-323
    • Chandramathi, S.1    Suresh, K.2    Anita, Z.B.3    Kuppusamy, U.R.4
  • 47
    • 52649117561 scopus 로고    scopus 로고
    • Evaluation of oxidative stress in colorectal cancer patients
    • Chang D, Wang F, Zhao YS, and Pan HZ. Evaluation of oxidative stress in colorectal cancer patients. Biomed Environ Sci 21: 286-289, 2008.
    • (2008) Biomed Environ Sci , vol.21 , pp. 286-289
    • Chang, D.1    Wang, F.2    Zhao, Y.S.3    Pan, H.Z.4
  • 48
    • 77953800122 scopus 로고    scopus 로고
    • Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells
    • Chang Q, Pan J, Wang X, Zhang Z, Chen F, and Shi X. Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells. Cancer Res 70: 5127-5135, 2010.
    • (2010) Cancer Res , vol.70 , pp. 5127-5135
    • Chang, Q.1    Pan, J.2    Wang, X.3    Zhang, Z.4    Chen, F.5    Shi, X.6
  • 50
    • 79952162068 scopus 로고    scopus 로고
    • Positron emission tomography imaging of cancer biology: Current status and future prospects
    • Chen K and Chen X. Positron emission tomography imaging of cancer biology: current status and future prospects. Semin Oncol 38: 70-86, 2011.
    • (2011) Semin Oncol , vol.38 , pp. 70-86
    • Chen, K.1    Chen, X.2
  • 51
    • 30544431972 scopus 로고    scopus 로고
    • Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin i expression
    • Chen MF, Keng PC, Shau H, Wu CT, Hu YC, Liao SK, and Chen WC. Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression. Int J Radiat Oncol Biol Phys 64: 581-591, 2006.
    • (2006) Int J Radiat Oncol Biol Phys , vol.64 , pp. 581-591
    • Chen, M.F.1    Keng, P.C.2    Shau, H.3    Wu, C.T.4    Hu, Y.C.5    Liao, S.K.6    Chen, W.C.7
  • 54
    • 79951517175 scopus 로고    scopus 로고
    • An insult-inducible vector system activated by hypoxia and oxidative stress for neuronal gene therapy
    • Cheng MY, Lee IP, Jin M, Sun G, Zhao H, Steinberg GK, and Sapolsky RM. An insult-inducible vector system activated by hypoxia and oxidative stress for neuronal gene therapy. Transl Stroke Res 2: 92-100, 2011.
    • (2011) Transl Stroke Res , vol.2 , pp. 92-100
    • Cheng, M.Y.1    Lee, I.P.2    Jin, M.3    Sun, G.4    Zhao, H.5    Steinberg, G.K.6    Sapolsky, R.M.7
  • 55
    • 77953935500 scopus 로고    scopus 로고
    • Tumour hypoxia induces a metabolic shift causing acidosis: A common feature in cancer
    • Chiche J, Brahimi-Horn MC, and Pouyssegur J. Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer. J Cell Mol Med 14: 771-794, 2010.
    • (2010) J Cell Mol Med , vol.14 , pp. 771-794
    • Chiche, J.1    Brahimi-Horn, M.C.2    Pouyssegur, J.3
  • 56
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxiainducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    • Chiche J, Ilc K, Laferriere J, Trottier E, Dayan F, Mazure NM, Brahimi-Horn MC, and Pouyssegur J. Hypoxiainducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res 69: 358-368, 2009.
    • (2009) Cancer Res , vol.69 , pp. 358-368
    • Chiche, J.1    Ilc, K.2    Laferriere, J.3    Trottier, E.4    Dayan, F.5    Mazure, N.M.6    Brahimi-Horn, M.C.7    Pouyssegur, J.8
  • 58
    • 75449110199 scopus 로고    scopus 로고
    • Silencing the peroxiredoxin III gene inhibits cell proliferation in breast cancer
    • Chua PJ, Lee EH, Yu Y, Yip GW, Tan PH, and Bay BH. Silencing the peroxiredoxin III gene inhibits cell proliferation in breast cancer. Int J Oncol 36: 359-364, 2010.
    • (2010) Int J Oncol , vol.36 , pp. 359-364
    • Chua, P.J.1    Lee, E.H.2    Yu, Y.3    Yip, G.W.4    Tan, P.H.5    Bay, B.H.6
  • 60
    • 76049083966 scopus 로고    scopus 로고
    • Reactive oxygen species, cellular redox systems, and apoptosis
    • Circu ML and Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 48: 749-762, 2010.
    • (2010) Free Radic Biol Med , vol.48 , pp. 749-762
    • Circu, M.L.1    Aw, T.Y.2
  • 62
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: Premises, promises and challenges
    • Clevers H. The cancer stem cell: premises, promises and challenges. Nat Med 17: 313-319, 2011.
    • (2011) Nat Med , vol.17 , pp. 313-319
    • Clevers, H.1
  • 65
    • 40949114493 scopus 로고    scopus 로고
    • The radiation-inducible pE9 promoter driving inducible nitric oxide synthase radiosensitizes hypoxic tumour cells to radiation
    • Coulter JA, McCarthy HO,Worthington J, Robson T, Scott S, and Hirst DG. The radiation-inducible pE9 promoter driving inducible nitric oxide synthase radiosensitizes hypoxic tumour cells to radiation. Gene Ther 15: 495-503, 2008.
    • (2008) Gene Ther , vol.15 , pp. 495-503
    • Coulter, J.A.1    McCarthy, H.O.2    Worthington, J.3    Robson, T.4    Scott, S.5    Hirst, D.G.6
  • 66
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM and Werb Z. Inflammation and cancer. Nature 420: 860-867, 2002.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 67
    • 79952340427 scopus 로고    scopus 로고
    • Remodeling and homeostasis of the extracellular matrix: Implications for fibrotic diseases and cancer
    • Cox TR and Erler JT. Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer. Dis Model Mech 4: 165-178, 2011.
    • (2011) Dis Model Mech , vol.4 , pp. 165-178
    • Cox, T.R.1    Erler, J.T.2
  • 68
    • 32244440896 scopus 로고    scopus 로고
    • Oxidative stress profiling: Part II. Theory, technology, and practice
    • Cutler RG, Plummer J, Chowdhury K, and Heward C. Oxidative stress profiling: part II. Theory, technology, and practice. Ann N Y Acad Sci 1055: 136-158, 2005.
    • (2005) Ann N y Acad Sci , vol.1055 , pp. 136-158
    • Cutler, R.G.1    Plummer, J.2    Chowdhury, K.3    Heward, C.4
  • 69
    • 0027512020 scopus 로고
    • Reactive oxygen intermediates target CC(A/T)6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation
    • Datta R, Taneja N, Sukhatme VP, Qureshi SA, Weichselbaum R, and Kufe DW. Reactive oxygen intermediates target CC(A/T)6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation. Proc Natl Acad Sci U S A 90: 2419-2422, 1993.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 2419-2422
    • Datta, R.1    Taneja, N.2    Sukhatme, V.P.3    Qureshi, S.A.4    Weichselbaum, R.5    Kufe, D.W.6
  • 70
    • 40849133786 scopus 로고    scopus 로고
    • Silencing of peroxiredoxin 3 and peroxiredoxin 5 reveals the role of mitochondrial peroxiredoxins in the protection of human neuroblastoma SH-SY5Y cells toward MPP+
    • De Simoni S, Goemaere J, and Knoops B. Silencing of peroxiredoxin 3 and peroxiredoxin 5 reveals the role of mitochondrial peroxiredoxins in the protection of human neuroblastoma SH-SY5Y cells toward MPP+ . Neurosci Lett 433: 219-224, 2008.
    • (2008) Neurosci Lett , vol.433 , pp. 219-224
    • De Simoni, S.1    Goemaere, J.2    Knoops, B.3
  • 71
    • 30144443269 scopus 로고    scopus 로고
    • Paradoxical roles of the immune system during cancer development
    • de Visser KE, Eichten A, and Coussens LM. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6: 24-37, 2006.
    • (2006) Nat Rev Cancer , vol.6 , pp. 24-37
    • De Visser, K.E.1    Eichten, A.2    Coussens, L.M.3
  • 73
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G, and Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7: 11-20, 2008.
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • Deberardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 75
    • 77954563614 scopus 로고    scopus 로고
    • Interactions between lymphocytes and myeloid cells regulate pro-versus anti-tumor immunity
    • DeNardo DG, Andreu P, and Coussens LM. Interactions between lymphocytes and myeloid cells regulate pro-versus anti-tumor immunity. Cancer Metastasis Rev 29: 309-316, 2010.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 309-316
    • Denardo, D.G.1    Andreu, P.2    Coussens, L.M.3
  • 77
    • 50149097983 scopus 로고    scopus 로고
    • Hypoxia, HIF1 and glucose metabolism in the solid tumour
    • Denko NC. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer 8: 705-713, 2008.
    • (2008) Nat Rev Cancer , vol.8 , pp. 705-713
    • Denko, N.C.1
  • 78
    • 70549102512 scopus 로고    scopus 로고
    • Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress
    • Dewhirst MW. Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress. Radiat Res 172: 653-665, 2009.
    • (2009) Radiat Res , vol.172 , pp. 653-665
    • Dewhirst, M.W.1
  • 79
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • Dewhirst MW, Cao Y, and Moeller B. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer 8: 425-437, 2008.
    • (2008) Nat Rev Cancer , vol.8 , pp. 425-437
    • Dewhirst, M.W.1    Cao, Y.2    Moeller, B.3
  • 80
    • 73949101383 scopus 로고    scopus 로고
    • Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation
    • Diaz B, Shani G, Pass I, Anderson D, Quintavalle M, and Courtneidge SA. Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation. Sci Signal 2: ra53, 2009.
    • (2009) Sci Signal , vol.2
    • Diaz, B.1    Shani, G.2    Pass, I.3    Anderson, D.4    Quintavalle, M.5    Courtneidge, S.A.6
  • 82
    • 34248162970 scopus 로고    scopus 로고
    • Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity
    • Ding WQ and Lind SE. Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity. Mol Cancer Ther 6: 1467-1474, 2007.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1467-1474
    • Ding, W.Q.1    Lind, S.E.2
  • 83
    • 67649842379 scopus 로고    scopus 로고
    • Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation
    • Dixit D, Sharma V, Ghosh S, Koul N, Mishra PK, and Sen E. Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation. Free Radic Biol Med 47: 364-374, 2009.
    • (2009) Free Radic Biol Med , vol.47 , pp. 364-374
    • Dixit, D.1    Sharma, V.2    Ghosh, S.3    Koul, N.4    Mishra, P.K.5    Sen, E.6
  • 84
    • 45249092773 scopus 로고    scopus 로고
    • Oxidative stress caused by blocking of mitochondrial complex i H( + ) pumping as a link in aging/disease vicious cycle
    • Dlaskova A, Hlavata L, and Jezek P. Oxidative stress caused by blocking of mitochondrial complex I H( + ) pumping as a link in aging/disease vicious cycle. Int J Biochem Cell Biol 40: 1792-1805, 2008.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 1792-1805
    • Dlaskova, A.1    Hlavata, L.2    Jezek, P.3
  • 85
    • 33847048710 scopus 로고    scopus 로고
    • Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications
    • Dome B, Hendrix MJ, Paku S, Tovari J, and Timar J. Alternative vascularization mechanisms in cancer: pathology and therapeutic implications. Am J Pathol 170: 1-15, 2007.
    • (2007) Am J Pathol , vol.170 , pp. 1-15
    • Dome, B.1    Hendrix, M.J.2    Paku, S.3    Tovari, J.4    Timar, J.5
  • 86
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Droge W. Free radicals in the physiological control of cell function. Physiol Rev 82: 47-95, 2002.
    • (2002) Physiol Rev , vol.82 , pp. 47-95
    • Droge, W.1
  • 87
    • 78751614988 scopus 로고    scopus 로고
    • Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer
    • Du J, Liu J, Smith BJ, Tsao MS, and Cullen JJ. Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer. Cancer Gene Ther 18: 135-143, 2011.
    • (2011) Cancer Gene Ther , vol.18 , pp. 135-143
    • Du, J.1    Liu, J.2    Smith, B.J.3    Tsao, M.S.4    Cullen, J.J.5
  • 89
    • 79953774326 scopus 로고    scopus 로고
    • Non-viral nucleic acid delivery: Key challenges and future directions
    • Elsabahy M, Nazarali A, and Foldvari M. Non-viral nucleic acid delivery: key challenges and future directions. Curr Drug Deliv 8: 235-244, 2011.
    • (2011) Curr Drug Deliv , vol.8 , pp. 235-244
    • Elsabahy, M.1    Nazarali, A.2    Foldvari, M.3
  • 91
    • 34247205331 scopus 로고    scopus 로고
    • Effects of MnSOD-plasmid liposome gene therapy on antioxidant levels in irradiated murine oral cavity orthotopic tumors
    • Epperly MW, Wegner R, Kanai AJ, Kagan V, Greenberger EE, Nie S, and Greenberger JS. Effects of MnSOD-plasmid liposome gene therapy on antioxidant levels in irradiated murine oral cavity orthotopic tumors. Radiat Res 167: 289-297, 2007.
    • (2007) Radiat Res , vol.167 , pp. 289-297
    • Epperly, M.W.1    Wegner, R.2    Kanai, A.J.3    Kagan, V.4    Greenberger, E.E.5    Nie, S.6    Greenberger, J.S.7
  • 93
    • 4444339833 scopus 로고    scopus 로고
    • Oxidative DNA damage and disease: Induction, repair and significance
    • Evans MD, Dizdaroglu M, and Cooke MS. Oxidative DNA damage and disease: induction, repair and significance. Mutat Res 567: 1-61, 2004.
    • (2004) Mutat Res , vol.567 , pp. 1-61
    • Evans, M.D.1    Dizdaroglu, M.2    Cooke, M.S.3
  • 94
    • 64149087422 scopus 로고    scopus 로고
    • Therapeutic strategies by modulating oxygen stress in cancer and inflammation
    • Fang J, Seki T, and Maeda H. Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv Drug Deliv Rev 61: 290-302, 2009.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 290-302
    • Fang, J.1    Seki, T.2    Maeda, H.3
  • 96
    • 78650528780 scopus 로고    scopus 로고
    • The role of Stat5 transcription factors as tumor suppressors or oncogenes
    • Ferbeyre G and Moriggl R. The role of Stat5 transcription factors as tumor suppressors or oncogenes. Biochim Biophys Acta 1815: 104-114, 2011.
    • (2011) Biochim Biophys Acta , vol.1815 , pp. 104-114
    • Ferbeyre, G.1    Moriggl, R.2
  • 98
    • 0033840389 scopus 로고    scopus 로고
    • Vasculogenic mimicry and tumor angiogenesis
    • Folberg R, Hendrix MJ, and Maniotis AJ. Vasculogenic mimicry and tumor angiogenesis. Am J Pathol 156: 361-381, 2000.
    • (2000) Am J Pathol , vol.156 , pp. 361-381
    • Folberg, R.1    Hendrix, M.J.2    Maniotis, A.J.3
  • 99
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 285: 1182-1186, 1971.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 100
    • 60749137151 scopus 로고    scopus 로고
    • NADPH oxidasedependent signaling in endothelial cells: Role in physiology and pathophysiology
    • Frey RS, Ushio-Fukai M, and Malik AB. NADPH oxidasedependent signaling in endothelial cells: role in physiology and pathophysiology. Antioxid Redox Signal 11: 791-810, 2009.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 791-810
    • Frey, R.S.1    Ushio-Fukai, M.2    Malik, A.B.3
  • 102
    • 33847349283 scopus 로고    scopus 로고
    • Reactive oxygen species: A breath of life or death
    • Fruehauf JP and Meyskens FL, Jr. Reactive oxygen species: a breath of life or death? Clin Cancer Res 13: 789-794, 2007.
    • (2007) Clin Cancer Res , vol.13 , pp. 789-794
    • Fruehauf, J.P.1    Meyskens Jr., F.L.2
  • 103
    • 77950279550 scopus 로고    scopus 로고
    • Tumor microvasculature and microenvironment: Novel insights through intravital imaging in pre-clinical models
    • Fukumura D, Duda DG, Munn LL, and Jain RK. Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation 17: 206-225, 2010.
    • (2010) Microcirculation , vol.17 , pp. 206-225
    • Fukumura, D.1    Duda, D.G.2    Munn, L.L.3    Jain, R.K.4
  • 109
    • 79957532451 scopus 로고    scopus 로고
    • Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness
    • Giannoni E, Bianchini F, Calorini L, and Chiarugi P. Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness. Antioxid Redox Signal 14: 2361-2371, 2011.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 2361-2371
    • Giannoni, E.1    Bianchini, F.2    Calorini, L.3    Chiarugi, P.4
  • 110
    • 0033006040 scopus 로고    scopus 로고
    • Pharmacology of the eosinophil
    • Giembycz MA and Lindsay MA. Pharmacology of the eosinophil. Pharmacol Rev 51: 213-340, 1999.
    • (1999) Pharmacol Rev , vol.51 , pp. 213-340
    • Giembycz, M.A.1    Lindsay, M.A.2
  • 111
    • 33746802358 scopus 로고    scopus 로고
    • Redox signaling in cancer biology
    • Gius D and Spitz DR. Redox signaling in cancer biology. Antioxid Redox Signal 8: 1249-1252, 2006.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 1249-1252
    • Gius, D.1    Spitz, D.R.2
  • 112
    • 80054693822 scopus 로고    scopus 로고
    • Catalase overexpression in mammary cancer cells leads to a less aggressive phenotype and an altered response to chemotherapy
    • Glorieux C, Dejeans N, Sid B, Beck R, Calderon PB, and Verrax J. Catalase overexpression in mammary cancer cells leads to a less aggressive phenotype and an altered response to chemotherapy. Biochem Pharmacol 82: 1384-1390, 2011.
    • (2011) Biochem Pharmacol , vol.82 , pp. 1384-1390
    • Glorieux, C.1    Dejeans, N.2    Sid, B.3    Beck, R.4    Calderon, P.B.5    Verrax, J.6
  • 114
    • 77949643542 scopus 로고    scopus 로고
    • Nox-4-dependent nuclear H2O2 drives DNA oxidation resulting in 8-OHdG as urinary biomarker and hemangioendothelioma formation
    • Gordillo G, Fang H, Park H, and Roy S. Nox-4-dependent nuclear H2O2 drives DNA oxidation resulting in 8-OHdG as urinary biomarker and hemangioendothelioma formation. Antioxid Redox Signal 12: 933-943, 2010.
    • (2010) Antioxid Redox Signal , vol.12 , pp. 933-943
    • Gordillo, G.1    Fang, H.2    Park, H.3    Roy, S.4
  • 115
    • 78149431906 scopus 로고    scopus 로고
    • Point mutations in c-Myc uncouple neoplastic transformation from multiple other phenotypes in rat fibroblasts
    • Graves JA, Rothermund K, Wang T, Qian W, Van Houten B, and Prochownik EV. Point mutations in c-Myc uncouple neoplastic transformation from multiple other phenotypes in rat fibroblasts. PLoS One 5: e13717, 2010.
    • (2010) PLoS One , vol.5
    • Graves, J.A.1    Rothermund, K.2    Wang, T.3    Qian, W.4    Van Houten, B.5    Prochownik, E.V.6
  • 116
    • 79953328298 scopus 로고    scopus 로고
    • Tumor-associated neutrophils: New targets for cancer therapy
    • Gregory AD and Houghton AM. Tumor-associated neutrophils: new targets for cancer therapy. Cancer Res 71: 2411-2416, 2011.
    • (2011) Cancer Res , vol.71 , pp. 2411-2416
    • Gregory, A.D.1    Houghton, A.M.2
  • 118
    • 77955274524 scopus 로고    scopus 로고
    • Redox metabolism and malignancy
    • Grek CL and Tew KD. Redox metabolism and malignancy. Curr Opin Pharmacol 10: 362-368, 2010.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 362-368
    • Grek, C.L.1    Tew, K.D.2
  • 119
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D and Weinberg RA. Hallmarks of cancer: the next generation. Cell 144: 646-674, 2011.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 120
    • 3042660859 scopus 로고    scopus 로고
    • Physiological roles of xanthine oxidoreductase
    • Harrison R. Physiological roles of xanthine oxidoreductase. Drug Metab Rev 36: 363-375, 2004.
    • (2004) Drug Metab Rev , vol.36 , pp. 363-375
    • Harrison, R.1
  • 123
    • 63549121490 scopus 로고    scopus 로고
    • NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer
    • Hayes JD and McMahon M. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci 34: 176-188, 2009.
    • (2009) Trends Biochem Sci , vol.34 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 124
    • 79952901838 scopus 로고    scopus 로고
    • Retargeting adenoviral vectors to improve gene transfer into tumors
    • Hogg RT, Thorpe P, and Gerard RD. Retargeting adenoviral vectors to improve gene transfer into tumors. Cancer Gene Ther 18: 275-287, 2011.
    • (2011) Cancer Gene Ther , vol.18 , pp. 275-287
    • Hogg, R.T.1    Thorpe, P.2    Gerard, R.D.3
  • 125
    • 77949495963 scopus 로고    scopus 로고
    • Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34 + hematopoietic progenitor cells
    • Hole PS, Pearn L, Tonks AJ, James PE, Burnett AK, Darley RL, and Tonks A. Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34 + hematopoietic progenitor cells. Blood 115: 1238-1246, 2010.
    • (2010) Blood , vol.115 , pp. 1238-1246
    • Hole, P.S.1    Pearn, L.2    Tonks, A.J.3    James, P.E.4    Burnett, A.K.5    Darley, R.L.6    Tonks, A.7
  • 126
    • 70449095882 scopus 로고    scopus 로고
    • Thioredoxin reductase 1 ablation sensitizes colon cancer cells to methylseleninatemediated cytotoxicity
    • Honeggar M, Beck R, and Moos PJ. Thioredoxin reductase 1 ablation sensitizes colon cancer cells to methylseleninatemediated cytotoxicity. Toxicol Appl Pharmacol 241: 348-355, 2009.
    • (2009) Toxicol Appl Pharmacol , vol.241 , pp. 348-355
    • Honeggar, M.1    Beck, R.2    Moos, P.J.3
  • 127
    • 77953565568 scopus 로고    scopus 로고
    • The paradox of tumor-associated neutrophils: Fueling tumor growth with cytotoxic substances
    • Houghton AM. The paradox of tumor-associated neutrophils: fueling tumor growth with cytotoxic substances. Cell Cycle 9: 1732-1737, 2010.
    • (2010) Cell Cycle , vol.9 , pp. 1732-1737
    • Houghton, A.M.1
  • 128
    • 84865523103 scopus 로고    scopus 로고
    • Imaging the impact of Nox4 in cycling hypoxia-mediated U87 glioblastoma invasion and infiltration
    • Hsieh CH, Chang HT, Shen WC, Shyu WC, and Liu RS. Imaging the impact of Nox4 in cycling hypoxia-mediated U87 glioblastoma invasion and infiltration. Mol Imaging Biol 14: 489-499, 2012.
    • (2012) Mol Imaging Biol , vol.14 , pp. 489-499
    • Hsieh, C.H.1    Chang, H.T.2    Shen, W.C.3    Shyu, W.C.4    Liu, R.S.5
  • 129
    • 28244447656 scopus 로고    scopus 로고
    • Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: Role in cell proliferation and response to oxidative stress
    • Hu Y, Rosen DG, Zhou Y, Feng L, Yang G, Liu J, and Huang P. Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. J Biol Chem 280: 39485-39492, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 39485-39492
    • Hu, Y.1    Rosen, D.G.2    Zhou, Y.3    Feng, L.4    Yang, G.5    Liu, J.6    Huang, P.7
  • 131
    • 33845327099 scopus 로고    scopus 로고
    • Biomarkers for oxidative stress status of DNA, lipids, and proteins in vitro and in vivo cancer research
    • Hwang ES and Kim GH. Biomarkers for oxidative stress status of DNA, lipids, and proteins in vitro and in vivo cancer research. Toxicology 229: 1-10, 2007.
    • (2007) Toxicology , vol.229 , pp. 1-10
    • Hwang, E.S.1    Kim, G.H.2
  • 132
    • 70849099495 scopus 로고    scopus 로고
    • The extracellular matrix: Not just pretty fibrils
    • Hynes RO. The extracellular matrix: not just pretty fibrils. Science 326: 1216-1219, 2009.
    • (2009) Science , vol.326 , pp. 1216-1219
    • Hynes, R.O.1
  • 134
    • 0035300474 scopus 로고    scopus 로고
    • Gene therapy targeting for hepatocellular carcinoma: Selective and enhanced suicide gene expression regulated by a hypoxia-inducible enhancer linked to a human alphafetoprotein promoter
    • Ido A, Uto H, Moriuchi A, Nagata K, Onaga Y, Onaga M, Hori T, Hirono S, Hayashi K, Tamaoki T, and Tsubouchi H. Gene therapy targeting for hepatocellular carcinoma: selective and enhanced suicide gene expression regulated by a hypoxia-inducible enhancer linked to a human alphafetoprotein promoter. Cancer Res 61: 3016-3021, 2001.
    • (2001) Cancer Res , vol.61 , pp. 3016-3021
    • Ido, A.1    Uto, H.2    Moriuchi, A.3    Nagata, K.4    Onaga, Y.5    Onaga, M.6    Hori, T.7    Hirono, S.8    Hayashi, K.9    Tamaoki, T.10    Tsubouchi, H.11
  • 138
    • 0028270384 scopus 로고
    • Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer
    • Jaruga P, Zastawny TH, Skokowski J, Dizdaroglu M, and Olinski R. Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer. FEBS Lett 341: 59-64, 1994.
    • (1994) FEBS Lett , vol.341 , pp. 59-64
    • Jaruga, P.1    Zastawny, T.H.2    Skokowski, J.3    Dizdaroglu, M.4    Olinski, R.5
  • 139
    • 69049090808 scopus 로고    scopus 로고
    • Mitochondrial reticulum network dynamics in relation to oxidative stress, redox regulation, and hypoxia
    • Jezek P and Plecita-Hlavata L. Mitochondrial reticulum network dynamics in relation to oxidative stress, redox regulation, and hypoxia. Int J Biochem Cell Biol 41: 1790-1804, 2009.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 1790-1804
    • Jezek, P.1    Plecita-Hlavata, L.2
  • 140
    • 79954579633 scopus 로고    scopus 로고
    • EMT: A new vision of hypoxia promoting cancer progression
    • Jiang J, Tang YL, and Liang XH. EMT: a new vision of hypoxia promoting cancer progression. Cancer Biol Ther 11: 714-723, 2011.
    • (2011) Cancer Biol Ther , vol.11 , pp. 714-723
    • Jiang, J.1    Tang, Y.L.2    Liang, X.H.3
  • 141
    • 77954351631 scopus 로고    scopus 로고
    • High levels of Nrf2 determine chemoresistance in type II endometrial cancer
    • Jiang T, Chen N, Zhao F, Wang XJ, Kong B, Zheng W, and Zhang DD. High levels of Nrf2 determine chemoresistance in type II endometrial cancer. Cancer Res 70: 5486-5496, 2010.
    • (2010) Cancer Res , vol.70 , pp. 5486-5496
    • Jiang, T.1    Chen, N.2    Zhao, F.3    Wang, X.J.4    Kong, B.5    Zheng, W.6    Zhang, D.D.7
  • 142
    • 77953208358 scopus 로고    scopus 로고
    • MiR-1226 targets expression of the mucin 1 oncoprotein and induces cell death
    • Jin C, Rajabi H, and Kufe D. miR-1226 targets expression of the mucin 1 oncoprotein and induces cell death. Int J Oncol 37: 61-69, 2010.
    • (2010) Int J Oncol , vol.37 , pp. 61-69
    • Jin, C.1    Rajabi, H.2    Kufe, D.3
  • 143
    • 79958845363 scopus 로고    scopus 로고
    • Tumor-infiltrating immune cells and prognosis: The potential link between conventional cancer therapy and immunity
    • Jochems C and Schlom J. Tumor-infiltrating immune cells and prognosis: the potential link between conventional cancer therapy and immunity. Exp Biol Med (Maywood) 236: 567-579, 2011.
    • (2011) Exp Biol Med (Maywood) , vol.236 , pp. 567-579
    • Jochems, C.1    Schlom, J.2
  • 144
    • 61849135453 scopus 로고    scopus 로고
    • Tumor suppressors and cell metabolism: A recipe for cancer growth
    • Jones RG and Thompson CB. Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev 23: 537-548, 2009.
    • (2009) Genes Dev , vol.23 , pp. 537-548
    • Jones, R.G.1    Thompson, C.B.2
  • 145
    • 79953705886 scopus 로고    scopus 로고
    • Choosing between glycolysis and oxidative phosphorylation: A tumor's dilemma
    • Jose C, Bellance N, and Rossignol R. Choosing between glycolysis and oxidative phosphorylation: a tumor's dilemma? Biochim Biophys Acta 1807: 552-561, 2011.
    • (2011) Biochim Biophys Acta , vol.1807 , pp. 552-561
    • Jose, C.1    Bellance, N.2    Rossignol, R.3
  • 146
    • 35848942608 scopus 로고    scopus 로고
    • Heme oxygenase-1 in tumors: Is it a false friend
    • Jozkowicz A, Was H, and Dulak J. Heme oxygenase-1 in tumors: is it a false friend? Antioxid Redox Signal 9: 2099-2117, 2007.
    • (2007) Antioxid Redox Signal , vol.9 , pp. 2099-2117
    • Jozkowicz, A.1    Was, H.2    Dulak, J.3
  • 147
    • 54549113030 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
    • Kaelin WG, Jr. The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat Rev Cancer 8: 865-873, 2008.
    • (2008) Nat Rev Cancer , vol.8 , pp. 865-873
    • Kaelin Jr., W.G.1
  • 148
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
    • Kaelin WG, Jr., and Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 30: 393-402, 2008.
    • (2008) Mol Cell , vol.30 , pp. 393-402
    • Kaelin Jr., W.G.1    Ratcliffe, P.J.2
  • 149
    • 59449107051 scopus 로고    scopus 로고
    • Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes
    • Kalinina EV, Chernov NN, and Saprin AN. Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes. Biochemistry (Mosc) 73: 1493-1510, 2008.
    • (2008) Biochemistry (Mosc) , vol.73 , pp. 1493-1510
    • Kalinina, E.V.1    Chernov, N.N.2    Saprin, A.N.3
  • 150
    • 67650657198 scopus 로고    scopus 로고
    • Roles of Nox1 and other Nox isoforms in cancer development
    • Kamata T. Roles of Nox1 and other Nox isoforms in cancer development. Cancer Sci 100: 1382-1388, 2009.
    • (2009) Cancer Sci , vol.100 , pp. 1382-1388
    • Kamata, T.1
  • 151
    • 79956191029 scopus 로고    scopus 로고
    • Chronic inflammation and cancer: The role of the mitochondria
    • 413
    • Kamp DW, Shacter E, and Weitzman SA. Chronic inflammation and cancer: the role of the mitochondria. Oncology (Williston Park) 25: 400-410, 413, 2011.
    • (2011) Oncology (Williston Park) , vol.25 , pp. 400-410
    • Kamp, D.W.1    Shacter, E.2    Weitzman, S.A.3
  • 153
    • 79959223223 scopus 로고    scopus 로고
    • Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomas
    • Karihtala P, Kauppila S, Soini Y, and Arja Jukkola V. Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomas. BMC Cancer 11: 262, 2011.
    • (2011) BMC Cancer , vol.11 , pp. 262
    • Karihtala, P.1    Kauppila, S.2    Soini, Y.3    Arja Jukkola, V.4
  • 154
    • 34247527730 scopus 로고    scopus 로고
    • Hypoxia-inducible factors, stem cells, and cancer
    • Keith B and Simon MC. Hypoxia-inducible factors, stem cells, and cancer. Cell 129: 465-472, 2007.
    • (2007) Cell , vol.129 , pp. 465-472
    • Keith, B.1    Simon, M.C.2
  • 155
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • Kensler TW, Wakabayashi N, and Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47: 89-116, 2007.
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 159
    • 78149254492 scopus 로고    scopus 로고
    • Myeloperoxidase expression as a potential determinant of parthenolide-induced apoptosis in leukemia bulk and leukemia stem cells
    • Kim YR, Eom JI, Kim SJ, Jeung HK, Cheong JW, Kim JS, and Min YH. Myeloperoxidase expression as a potential determinant of parthenolide-induced apoptosis in leukemia bulk and leukemia stem cells. J Pharmacol Exp Ther 335: 389-400, 2010.
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 389-400
    • Kim, Y.R.1    Eom, J.I.2    Kim, S.J.3    Jeung, H.K.4    Cheong, J.W.5    Kim, J.S.6    Min, Y.H.7
  • 160
    • 1342328149 scopus 로고    scopus 로고
    • Superoxide dismutases in malignant cells and human tumors
    • Kinnula VL and Crapo JD. Superoxide dismutases in malignant cells and human tumors. Free Radic Biol Med 36: 718-744, 2004.
    • (2004) Free Radic Biol Med , vol.36 , pp. 718-744
    • Kinnula, V.L.1    Crapo, J.D.2
  • 161
    • 40949126440 scopus 로고    scopus 로고
    • Mitochondrial complex III regulates hypoxic activation of HIF
    • Klimova T and Chandel NS. Mitochondrial complex III regulates hypoxic activation of HIF. Cell Death Differ 15: 660-666, 2008.
    • (2008) Cell Death Differ , vol.15 , pp. 660-666
    • Klimova, T.1    Chandel, N.S.2
  • 163
    • 3543008924 scopus 로고    scopus 로고
    • Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    • Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, and Yamamoto M. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 24: 7130-7139, 2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 7130-7139
    • Kobayashi, A.1    Kang, M.I.2    Okawa, H.3    Ohtsuji, M.4    Zenke, Y.5    Chiba, T.6    Igarashi, K.7    Yamamoto, M.8
  • 164
    • 3042794972 scopus 로고    scopus 로고
    • Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes
    • Kobayashi A, Ohta T, and Yamamoto M. Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes. Methods Enzymol 378: 273-286, 2004.
    • (2004) Methods Enzymol , vol.378 , pp. 273-286
    • Kobayashi, A.1    Ohta, T.2    Yamamoto, M.3
  • 166
  • 167
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • Koppenol WH, Bounds PL, and Dang CV. Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 11: 325-337, 2011.
    • (2011) Nat Rev Cancer , vol.11 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 169
    • 79954459921 scopus 로고    scopus 로고
    • Regulation of mitochondrial metabolism: Yet another facet in the biology of the oncoprotein Bcl-2
    • Krishna S, Low IC, and Pervaiz S. Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2. Biochem J 435: 545-551, 2011.
    • (2011) Biochem J , vol.435 , pp. 545-551
    • Krishna, S.1    Low, I.C.2    Pervaiz, S.3
  • 170
    • 44449147036 scopus 로고    scopus 로고
    • Tumor cell metabolism: Cancer's Achilles' heel
    • Kroemer G and Pouyssegur J. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 13: 472-482, 2008.
    • (2008) Cancer Cell , vol.13 , pp. 472-482
    • Kroemer, G.1    Pouyssegur, J.2
  • 171
    • 34249303104 scopus 로고    scopus 로고
    • Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) and genetic polymorphisms in breast cancer patients
    • Kuo HW, Chou SY, Hu TW, Wu FY, and Chen DJ. Urinary 8-hydroxy-2′- deoxyguanosine (8-OHdG) and genetic polymorphisms in breast cancer patients. Mutat Res 631: 62-68, 2007.
    • (2007) Mutat Res , vol.631 , pp. 62-68
    • Kuo, H.W.1    Chou, S.Y.2    Hu, T.W.3    Wu, F.Y.4    Chen, D.J.5
  • 172
    • 79960027346 scopus 로고    scopus 로고
    • Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production
    • Ladelfa MF, Toledo MF, Laiseca JE, and Monte M. Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production. Antioxid Redox Signal 15: 1749-1761, 2011.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1749-1761
    • Ladelfa, M.F.1    Toledo, M.F.2    Laiseca, J.E.3    Monte, M.4
  • 173
    • 1542406446 scopus 로고    scopus 로고
    • NOX enzymes and the biology of reactive oxygen
    • Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol 4: 181-189, 2004.
    • (2004) Nat Rev Immunol , vol.4 , pp. 181-189
    • Lambeth, J.D.1
  • 175
    • 0035071662 scopus 로고    scopus 로고
    • The effects of extracellular pH on immune function
    • Lardner A. The effects of extracellular pH on immune function. J Leukoc Biol 69: 522-530, 2001.
    • (2001) J Leukoc Biol , vol.69 , pp. 522-530
    • Lardner, A.1
  • 178
    • 78649679218 scopus 로고    scopus 로고
    • The Roles of microRNAs in the cancer invasion-metastasis cascade
    • Le XF, Merchant O, Bast RC, and Calin GA. The Roles of microRNAs in the cancer invasion-metastasis cascade. Cancer Microenviron 3: 137-147, 2010.
    • (2010) Cancer Microenviron , vol.3 , pp. 137-147
    • Le, X.F.1    Merchant, O.2    Bast, R.C.3    Calin, G.A.4
  • 181
    • 79957921039 scopus 로고    scopus 로고
    • Growing tumor vessels: More than one way to skin a cat -implications for angiogenesis targeted cancer therapies
    • Leite de Oliveira R, Hamm A, and Mazzone M. Growing tumor vessels: more than one way to skin a cat -implications for angiogenesis targeted cancer therapies. Mol Aspects Med 32: 71-87, 2011.
    • (2011) Mol Aspects Med , vol.32 , pp. 71-87
    • Leite De Oliveira, R.1    Hamm, A.2    Mazzone, M.3
  • 182
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine AJ and Puzio-Kuter AM. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 330: 1340-1344, 2010.
    • (2010) Science , vol.330 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 183
    • 34347206848 scopus 로고    scopus 로고
    • Adenovirus tumor targeting and hepatic untargeting by a coxsackie/adenovirus receptor ectodomain anti-carcinoembryonic antigen bispecific adapter
    • Li HJ, Everts M, Pereboeva L, Komarova S, Idan A, Curiel DT, and Herschman HR. Adenovirus tumor targeting and hepatic untargeting by a coxsackie/adenovirus receptor ectodomain anti-carcinoembryonic antigen bispecific adapter. Cancer Res 67: 5354-5361, 2007.
    • (2007) Cancer Res , vol.67 , pp. 5354-5361
    • Li, H.J.1    Everts, M.2    Pereboeva, L.3    Komarova, S.4    Idan, A.5    Curiel, D.T.6    Herschman, H.R.7
  • 185
    • 78349257041 scopus 로고    scopus 로고
    • Hypoxia and hypoxia inducible factors in cancer stem cell maintenance
    • Li Z and Rich JN. Hypoxia and hypoxia inducible factors in cancer stem cell maintenance. Curr Top Microbiol Immunol 345: 21-30, 2010.
    • (2010) Curr Top Microbiol Immunol , vol.345 , pp. 21-30
    • Li, Z.1    Rich, J.N.2
  • 186
    • 61649088812 scopus 로고    scopus 로고
    • The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress
    • Limon-Pacheco J and Gonsebatt ME. The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress. Mutat Res 674: 137-147, 2009.
    • (2009) Mutat Res , vol.674 , pp. 137-147
    • Limon-Pacheco, J.1    Gonsebatt, M.E.2
  • 189
    • 30744454042 scopus 로고    scopus 로고
    • Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase
    • Liu J, Du J, Zhang Y, Sun W, Smith BJ, Oberley LW, and Cullen JJ. Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase. Hum Gene Ther 17: 105-116, 2006.
    • (2006) Hum Gene Ther , vol.17 , pp. 105-116
    • Liu, J.1    Du, J.2    Zhang, Y.3    Sun, W.4    Smith, B.J.5    Oberley, L.W.6    Cullen, J.J.7
  • 190
    • 1642288979 scopus 로고    scopus 로고
    • Redox regulation of pancreatic cancer cell growth: Role of glutathione peroxidase in the suppression of the malignant phenotype
    • Liu J, Hinkhouse MM, Sun W, Weydert CJ, Ritchie JM, Oberley LW, and Cullen JJ. Redox regulation of pancreatic cancer cell growth: role of glutathione peroxidase in the suppression of the malignant phenotype. Hum Gene Ther 15: 239-250, 2004.
    • (2004) Hum Gene Ther , vol.15 , pp. 239-250
    • Liu, J.1    Hinkhouse, M.M.2    Sun, W.3    Weydert, C.J.4    Ritchie, J.M.5    Oberley, L.W.6    Cullen, J.J.7
  • 193
    • 33846987527 scopus 로고    scopus 로고
    • Excessive superoxide anion generation plays a key role in carcinogenesis
    • Lopez-Lazaro M. Excessive superoxide anion generation plays a key role in carcinogenesis. Int J Cancer 120: 1378-1380, 2007.
    • (2007) Int J Cancer , vol.120 , pp. 1378-1380
    • Lopez-Lazaro, M.1
  • 194
    • 77953954538 scopus 로고    scopus 로고
    • Chemical and molecular mechanisms of antioxidants: Experimental approaches and model systems
    • Lu JM, Lin PH, Yao Q, and Chen C. Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. J Cell Mol Med 14: 840-860, 2010.
    • (2010) J Cell Mol Med , vol.14 , pp. 840-860
    • Lu, J.M.1    Lin, P.H.2    Yao, Q.3    Chen, C.4
  • 195
    • 78650373860 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factors: Master regulators of metastasis
    • Lu X and Kang Y. Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin Cancer Res 16: 5928-5935, 2010.
    • (2010) Clin Cancer Res , vol.16 , pp. 5928-5935
    • Lu, X.1    Kang, Y.2
  • 196
    • 73649105869 scopus 로고    scopus 로고
    • Viral-based gene delivery and regulated gene expression for targeted cancer therapy
    • Lu Y and Madu CO. Viral-based gene delivery and regulated gene expression for targeted cancer therapy. Expert Opin Drug Deliv 7: 19-35, 2010.
    • (2010) Expert Opin Drug Deliv , vol.7 , pp. 19-35
    • Lu, Y.1    Madu, C.O.2
  • 197
    • 70449524431 scopus 로고    scopus 로고
    • Peroxiredoxin i plays a protective role against cisplatin cytotoxicity through mitogen activated kinase signals
    • Ma D, Warabi E, Yanagawa T, Kimura S, Harada H, Yamagata K, and Ishii T. Peroxiredoxin I plays a protective role against cisplatin cytotoxicity through mitogen activated kinase signals. Oral Oncol 45: 1037-1043, 2009.
    • (2009) Oral Oncol , vol.45 , pp. 1037-1043
    • Ma, D.1    Warabi, E.2    Yanagawa, T.3    Kimura, S.4    Harada, H.5    Yamagata, K.6    Ishii, T.7
  • 199
    • 8844230280 scopus 로고    scopus 로고
    • Mutant KrasV12 increases COX-2, peroxides and DNA damage in lung cells
    • Maciag A, Sithanandam G, and Anderson LM. Mutant KrasV12 increases COX-2, peroxides and DNA damage in lung cells. Carcinogenesis 25: 2231-2237, 2004.
    • (2004) Carcinogenesis , vol.25 , pp. 2231-2237
    • Maciag, A.1    Sithanandam, G.2    Anderson, L.M.3
  • 200
    • 78649364332 scopus 로고    scopus 로고
    • Hypoxiainducible factors and the response to hypoxic stress
    • Majmundar AJ, Wong WJ, and Simon MC. Hypoxiainducible factors and the response to hypoxic stress. Mol Cell 40: 294-309, 2010.
    • (2010) Mol Cell , vol.40 , pp. 294-309
    • Majmundar, A.J.1    Wong, W.J.2    Simon, M.C.3
  • 201
    • 69049117556 scopus 로고    scopus 로고
    • Mast cells in tumor growth: Angiogenesis, tissue remodelling and immune-modulation
    • Maltby S, Khazaie K, and McNagny KM. Mast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation. Biochim Biophys Acta 1796: 19-26, 2009.
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 19-26
    • Maltby, S.1    Khazaie, K.2    McNagny, K.M.3
  • 202
    • 80051503653 scopus 로고    scopus 로고
    • What does matrix metalloproteinase-1 expression in patients with breast cancer really tell us
    • Mannello F. What does matrix metalloproteinase-1 expression in patients with breast cancer really tell us? BMC Med 9: 95, 2011.
    • (2011) BMC Med , vol.9 , pp. 95
    • Mannello, F.1
  • 203
    • 80052729096 scopus 로고    scopus 로고
    • Hypoxia and neural stem cells: From invertebrates to brain cancer stem cells
    • Mannello F, Medda V, and Tonti GA. Hypoxia and neural stem cells: from invertebrates to brain cancer stem cells. Int J Dev Biol 55: 569-581, 2011.
    • (2011) Int J Dev Biol , vol.55 , pp. 569-581
    • Mannello, F.1    Medda, V.2    Tonti, G.A.3
  • 204
    • 48149086744 scopus 로고    scopus 로고
    • Nipple aspirate fluids from women with breast cancer contain increased levels of group IIa secretory phospholipase A2
    • Mannello F, Qin W, Zhu W, Fabbri L, Tonti GA, and Sauter ER. Nipple aspirate fluids from women with breast cancer contain increased levels of group IIa secretory phospholipase A2. Breast Cancer Res Treat 111: 209-218, 2008.
    • (2008) Breast Cancer Res Treat , vol.111 , pp. 209-218
    • Mannello, F.1    Qin, W.2    Zhu, W.3    Fabbri, L.4    Tonti, G.A.5    Sauter, E.R.6
  • 205
    • 70149093209 scopus 로고    scopus 로고
    • Protein oxidation in breast microenvironment: Nipple aspirate fluid collected from breast cancer women contains increased protein carbonyl concentration
    • Mannello F, Tonti GA, and Medda V. Protein oxidation in breast microenvironment: nipple aspirate fluid collected from breast cancer women contains increased protein carbonyl concentration. Cell Oncol 31: 383-392, 2009.
    • (2009) Cell Oncol , vol.31 , pp. 383-392
    • Mannello, F.1    Tonti, G.A.2    Medda, V.3
  • 206
    • 77952970259 scopus 로고    scopus 로고
    • Detection of superoxide dismutase-1 in nipple aspirate fluids: A reactive oxygen species-regulating enzyme in the breast cancer microenvironment
    • Mannello F, Tonti GA, Pederzoli A, Simone P, Smaniotto A, and Medda V. Detection of superoxide dismutase-1 in nipple aspirate fluids: a reactive oxygen species-regulating enzyme in the breast cancer microenvironment. Clin Breast Cancer 10: 238-45, 2010.
    • (2010) Clin Breast Cancer , vol.10 , pp. 238-245
    • Mannello, F.1    Tonti, G.A.2    Pederzoli, A.3    Simone, P.4    Smaniotto, A.5    Medda, V.6
  • 208
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani A, Sozzani S, Locati M, Allavena P, and Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23: 549-555, 2002.
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 211
    • 79551634458 scopus 로고    scopus 로고
    • Autophagy in tumorigenesis and energy metabolism: Friend by day, foe by night
    • Mathew R and White E. Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night. Curr Opin Genet Dev 21: 113-119, 2011.
    • (2011) Curr Opin Genet Dev , vol.21 , pp. 113-119
    • Mathew, R.1    White, E.2
  • 213
    • 77951162650 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in stem cells and cancer
    • Mazumdar J, Dondeti V, and Simon MC. Hypoxia-inducible factors in stem cells and cancer. J Cell Mol Med 13: 4319-4328, 2009.
    • (2009) J Cell Mol Med , vol.13 , pp. 4319-4328
    • Mazumdar, J.1    Dondeti, V.2    Simon, M.C.3
  • 214
    • 23044500915 scopus 로고    scopus 로고
    • Pyruvate kinase type M2 and its role in tumor growth and spreading
    • Mazurek S, Boschek CB, Hugo F, and Eigenbrodt E. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol 15: 300-308, 2005.
    • (2005) Semin Cancer Biol , vol.15 , pp. 300-308
    • Mazurek, S.1    Boschek, C.B.2    Hugo, F.3    Eigenbrodt, E.4
  • 215
    • 73349133007 scopus 로고    scopus 로고
    • Thioredoxins and glutaredoxins: Unifying elements in redox biology
    • Meyer Y, Buchanan BB, Vignols F, and Reichheld JP. Thioredoxins and glutaredoxins: unifying elements in redox biology. Annu Rev Genet 43: 335-367, 2009.
    • (2009) Annu Rev Genet , vol.43 , pp. 335-367
    • Meyer, Y.1    Buchanan, B.B.2    Vignols, F.3    Reichheld, J.P.4
  • 216
    • 67650699286 scopus 로고    scopus 로고
    • Molecular regulation of tumor angiogenesis and perfusion via redox signaling
    • Miller TW, Isenberg JS, and Roberts DD. Molecular regulation of tumor angiogenesis and perfusion via redox signaling. Chem Rev 109: 3099-3124, 2009.
    • (2009) Chem Rev , vol.109 , pp. 3099-3124
    • Miller, T.W.1    Isenberg, J.S.2    Roberts, D.D.3
  • 217
    • 77952959173 scopus 로고    scopus 로고
    • Downregulation of catalase by reactive oxygen species via hypermethylation of CpG island II on the catalase promoter
    • Min JY, Lim SO, and Jung G. Downregulation of catalase by reactive oxygen species via hypermethylation of CpG island II on the catalase promoter. FEBS Lett 584: 2427-2432, 2010.
    • (2010) FEBS Lett , vol.584 , pp. 2427-2432
    • Min, J.Y.1    Lim, S.O.2    Jung, G.3
  • 219
    • 77956224494 scopus 로고    scopus 로고
    • Oxygen in stem cell biology: A critical component of the stem cell niche
    • Mohyeldin A, Garzon-Muvdi T, and Quinones-Hinojosa A. Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 7: 150-161, 2010.
    • (2010) Cell Stem Cell , vol.7 , pp. 150-161
    • Mohyeldin, A.1    Garzon-Muvdi, T.2    Quinones-Hinojosa, A.3
  • 223
  • 224
    • 35648941579 scopus 로고    scopus 로고
    • Targeting NOX, INOS and COX-2 in inflammatory cells: Chemoprevention using food phytochemicals
    • Murakami A and Ohigashi H. Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals. Int J Cancer 121: 2357-2363, 2007.
    • (2007) Int J Cancer , vol.121 , pp. 2357-2363
    • Murakami, A.1    Ohigashi, H.2
  • 225
    • 4444298235 scopus 로고    scopus 로고
    • Involvement of pattern recognition receptors in the induction of cytokines and reactive oxygen intermediates production by human monocytes/macrophages stimulated with tumour cells
    • Mytar B, Woloszyn M, Macura-Biegun A, Hajto B, Ruggiero I, Piekarska B, and Zembala M. Involvement of pattern recognition receptors in the induction of cytokines and reactive oxygen intermediates production by human monocytes/macrophages stimulated with tumour cells. Anticancer Res 24: 2287-2293, 2004.
    • (2004) Anticancer Res , vol.24 , pp. 2287-2293
    • Mytar, B.1    Woloszyn, M.2    Macura-Biegun, A.3    Hajto, B.4    Ruggiero, I.5    Piekarska, B.6    Zembala, M.7
  • 226
    • 42349094504 scopus 로고    scopus 로고
    • Tumor escape mechanism governed by myeloid-derived suppressor cells
    • Nagaraj S and Gabrilovich DI. Tumor escape mechanism governed by myeloid-derived suppressor cells. Cancer Res 68: 2561-2563, 2008.
    • (2008) Cancer Res , vol.68 , pp. 2561-2563
    • Nagaraj, S.1    Gabrilovich, D.I.2
  • 228
    • 34548080939 scopus 로고    scopus 로고
    • Are peroxiredoxins tumor suppressors
    • Neumann CA and Fang Q. Are peroxiredoxins tumor suppressors? Curr Opin Pharmacol 7: 375-380, 2007.
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 375-380
    • Neumann, C.A.1    Fang, Q.2
  • 229
    • 84858964113 scopus 로고    scopus 로고
    • Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis
    • Niture SK and Jaiswal AK. Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis. J Biol Chem 287: 9873-9886, 2012.
    • (2012) J Biol Chem , vol.287 , pp. 9873-9886
    • Niture, S.K.1    Jaiswal, A.K.2
  • 230
    • 18044364791 scopus 로고    scopus 로고
    • Mechanism of the tumor suppressive effect of MnSOD overexpression
    • Oberley LW. Mechanism of the tumor suppressive effect of MnSOD overexpression. Biomed Pharmacother 59: 143-148, 2005.
    • (2005) Biomed Pharmacother , vol.59 , pp. 143-148
    • Oberley, L.W.1
  • 231
    • 0018749490 scopus 로고
    • Role of superoxide dismutase in cancer: A review
    • Oberley LW and Buettner GR. Role of superoxide dismutase in cancer: a review. Cancer Res 39: 1141-1149, 1979.
    • (1979) Cancer Res , vol.39 , pp. 1141-1149
    • Oberley, L.W.1    Buettner, G.R.2
  • 233
    • 67349177832 scopus 로고    scopus 로고
    • Overexpression of catalase delays G0/G1-to S-phase transition during cell cycle progression in mouse aortic endothelial cells
    • Onumah OE, Jules GE, Zhao Y, Zhou L, Yang H, and Guo Z. Overexpression of catalase delays G0/G1-to S-phase transition during cell cycle progression in mouse aortic endothelial cells. Free Radic Biol Med 46: 1658-1667, 2009.
    • (2009) Free Radic Biol Med , vol.46 , pp. 1658-1667
    • Onumah, O.E.1    Jules, G.E.2    Zhao, Y.3    Zhou, L.4    Yang, H.5    Guo, Z.6
  • 234
    • 65249138393 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: Linking inflammation and cancer
    • Ostrand-Rosenberg S and Sinha P. Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol 182: 4499-4506, 2009.
    • (2009) J Immunol , vol.182 , pp. 4499-4506
    • Ostrand-Rosenberg, S.1    Sinha, P.2
  • 235
    • 34748858784 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis: Impact on cancer therapy
    • Ozben T. Oxidative stress and apoptosis: impact on cancer therapy. J Pharm Sci 96: 2181-2196, 2007.
    • (2007) J Pharm Sci , vol.96 , pp. 2181-2196
    • Ozben, T.1
  • 236
    • 77954562833 scopus 로고    scopus 로고
    • Metastasis: Cancer cell's escape from oxidative stress
    • Pani G, Galeotti T, and Chiarugi P. Metastasis: cancer cell's escape from oxidative stress. Cancer Metastasis Rev 29: 351-378, 2010.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 351-378
    • Pani, G.1    Galeotti, T.2    Chiarugi, P.3
  • 238
    • 34250318625 scopus 로고    scopus 로고
    • From selenium to selenoproteins: Synthesis, identity, and their role in human health
    • Papp LV, Lu J, Holmgren A, and Khanna KK. From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal 9: 775-806, 2007.
    • (2007) Antioxid Redox Signal , vol.9 , pp. 775-806
    • Papp, L.V.1    Lu, J.2    Holmgren, A.3    Khanna, K.K.4
  • 240
    • 78649659788 scopus 로고    scopus 로고
    • PH control mechanisms of tumor survival and growth
    • Parks SK, Chiche J, and Pouyssegur J. pH control mechanisms of tumor survival and growth. J Cell Physiol 226: 299-308, 2011.
    • (2011) J Cell Physiol , vol.226 , pp. 299-308
    • Parks, S.K.1    Chiche, J.2    Pouyssegur, J.3
  • 241
    • 0036892284 scopus 로고    scopus 로고
    • Probing the structural and molecular diversity of tumor vasculature
    • Pasqualini R, Arap W, and McDonald DM. Probing the structural and molecular diversity of tumor vasculature. Trends Mol Med 8: 563-571, 2002.
    • (2002) Trends Mol Med , vol.8 , pp. 563-571
    • Pasqualini, R.1    Arap, W.2    McDonald, D.M.3
  • 242
    • 20044387052 scopus 로고    scopus 로고
    • Combined efficacy of tamoxifen and coenzyme Q10 on the status of lipid peroxidation and antioxidants in DMBA induced breast cancer
    • Perumal SS, Shanthi P, and Sachdanandam P. Combined efficacy of tamoxifen and coenzyme Q10 on the status of lipid peroxidation and antioxidants in DMBA induced breast cancer. Mol Cell Biochem 273: 151-160, 2005.
    • (2005) Mol Cell Biochem , vol.273 , pp. 151-160
    • Perumal, S.S.1    Shanthi, P.2    Sachdanandam, P.3
  • 243
  • 244
    • 77952568396 scopus 로고    scopus 로고
    • Hallmarks of cancer: Interactions with the tumor stroma
    • Pietras K and Ostman A. Hallmarks of cancer: interactions with the tumor stroma. Exp Cell Res 316: 1324-1331, 2010.
    • (2010) Exp Cell Res , vol.316 , pp. 1324-1331
    • Pietras, K.1    Ostman, A.2
  • 245
    • 79551676410 scopus 로고    scopus 로고
    • Cancer stem cells switch on tumor neovascularization
    • Ping YF and Bian XW. Cancer stem cells switch on tumor neovascularization. Curr Mol Med 11: 69-75, 2011.
    • (2011) Curr Mol Med , vol.11 , pp. 69-75
    • Ping, Y.F.1    Bian, X.W.2
  • 246
    • 17644408406 scopus 로고    scopus 로고
    • Extracellular matrix (ECM) microstructural composition regulates local cell-ECM biomechanics and fundamental fibroblast behavior: A multidimensional perspective
    • Pizzo AM, Kokini K, Vaughn LC, Waisner BZ, and Voytik-Harbin SL. Extracellular matrix (ECM) microstructural composition regulates local cell-ECM biomechanics and fundamental fibroblast behavior: a multidimensional perspective. J Appl Physiol 98: 1909-1921, 2005.
    • (2005) J Appl Physiol , vol.98 , pp. 1909-1921
    • Pizzo, A.M.1    Kokini, K.2    Vaughn, L.C.3    Waisner, B.Z.4    Voytik-Harbin, S.L.5
  • 247
    • 78650173598 scopus 로고    scopus 로고
    • Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction
    • Poerschke RL and Moos PJ. Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction. Biochem Pharmacol 81: 211-221, 2011.
    • (2011) Biochem Pharmacol , vol.81 , pp. 211-221
    • Poerschke, R.L.1    Moos, P.J.2
  • 248
    • 0842282482 scopus 로고    scopus 로고
    • Imbalance of antioxidant enzymes in tumor cells and inhibition of proliferation and malignant features by scavenging hydrogen peroxide
    • Policastro L, Molinari B, Larcher F, Blanco P, Podhajcer OL, Costa CS, Rojas P, and Duran H. Imbalance of antioxidant enzymes in tumor cells and inhibition of proliferation and malignant features by scavenging hydrogen peroxide. Mol Carcinog 39: 103-113, 2004.
    • (2004) Mol Carcinog , vol.39 , pp. 103-113
    • Policastro, L.1    Molinari, B.2    Larcher, F.3    Blanco, P.4    Podhajcer, O.L.5    Costa, C.S.6    Rojas, P.7    Duran, H.8
  • 249
    • 68249107275 scopus 로고    scopus 로고
    • Suppression of cancer growth by nonviral gene therapy based on a novel reactive oxygen species-responsive promoter
    • Policastro LL, Ibanez IL, Duran HA, Soria G, Gottifredi V, and Podhajcer OL. Suppression of cancer growth by nonviral gene therapy based on a novel reactive oxygen species-responsive promoter. Mol Ther 17: 1355-1364, 2009.
    • (2009) Mol Ther , vol.17 , pp. 1355-1364
    • Policastro, L.L.1    Ibanez, I.L.2    Duran, H.A.3    Soria, G.4    Gottifredi, V.5    Podhajcer, O.L.6
  • 252
    • 33646865219 scopus 로고    scopus 로고
    • Nanoparticle tethered antioxidant response element as a biosensor for oxygen induced toxicity in retinal endothelial cells
    • Prow T, Grebe R, Merges C, Smith JN, McLeod DS, Leary JF, and Lutty GA. Nanoparticle tethered antioxidant response element as a biosensor for oxygen induced toxicity in retinal endothelial cells. Mol Vis 12: 616-625, 2006.
    • (2006) Mol Vis , vol.12 , pp. 616-625
    • Prow, T.1    Grebe, R.2    Merges, C.3    Smith, J.N.4    McLeod, D.S.5    Leary, J.F.6    Lutty, G.A.7
  • 253
    • 80053036165 scopus 로고    scopus 로고
    • The role of p53 in metabolic regulation
    • Puzio-Kuter AM. The role of p53 in metabolic regulation. Genes Cancer 2: 385-391, 2011.
    • (2011) Genes Cancer , vol.2 , pp. 385-391
    • Puzio-Kuter, A.M.1
  • 255
    • 77951627263 scopus 로고    scopus 로고
    • Radiosensitive gene therapy through imRNA expression for silencing manganese superoxide dismutase
    • Qu Y, Zhao S, Hong J, and Tang S. Radiosensitive gene therapy through imRNA expression for silencing manganese superoxide dismutase. J Cancer Res Clin Oncol 136: 953-959, 2010.
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 953-959
    • Qu, Y.1    Zhao, S.2    Hong, J.3    Tang, S.4
  • 256
    • 78649704325 scopus 로고    scopus 로고
    • Autophagy and metabolism
    • Rabinowitz JD and White E. Autophagy and metabolism. Science 330: 1344-1348, 2010.
    • (2010) Science , vol.330 , pp. 1344-1348
    • Rabinowitz, J.D.1    White, E.2
  • 258
    • 0036261824 scopus 로고    scopus 로고
    • Efficient mobilization and recruitment of marrow-derived endothelial and hematopoietic stem cells by adenoviral vectors expressing angiogenic factors
    • Rafii S, Heissig B, and Hattori K. Efficient mobilization and recruitment of marrow-derived endothelial and hematopoietic stem cells by adenoviral vectors expressing angiogenic factors. Gene Ther 9: 631-641, 2002.
    • (2002) Gene Ther , vol.9 , pp. 631-641
    • Rafii, S.1    Heissig, B.2    Hattori, K.3
  • 259
    • 67649525776 scopus 로고    scopus 로고
    • Angiogenesis in premalignant conditions
    • Raica M, Cimpean AM, and Ribatti D. Angiogenesis in premalignant conditions. Eur J Cancer 45: 1924-1934, 2009.
    • (2009) Eur J Cancer , vol.45 , pp. 1924-1934
    • Raica, M.1    Cimpean, A.M.2    Ribatti, D.3
  • 260
    • 80054959409 scopus 로고    scopus 로고
    • Revisiting the TCA cycle: Signaling to tumor formation
    • Raimundo N, Baysal BE, and Shadel GS. Revisiting the TCA cycle: signaling to tumor formation. Trends Mol Med 17: 641-649, 2012.
    • (2012) Trends Mol Med , vol.17 , pp. 641-649
    • Raimundo, N.1    Baysal, B.E.2    Shadel, G.S.3
  • 262
    • 77951432631 scopus 로고    scopus 로고
    • The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation -why mitochondria are targets for cancer therapy
    • Ralph SJ, Rodriguez-Enriquez S, Neuzil J, Saavedra E, and Moreno-Sanchez R. The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation -why mitochondria are targets for cancer therapy. Mol Aspects Med 31: 145-170, 2010.
    • (2010) Mol Aspects Med , vol.31 , pp. 145-170
    • Ralph, S.J.1    Rodriguez-Enriquez, S.2    Neuzil, J.3    Saavedra, E.4    Moreno-Sanchez, R.5
  • 263
    • 40949142209 scopus 로고    scopus 로고
    • The role of hypoxia-inducible factors in tumorigenesis
    • Rankin EB and Giaccia AJ. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ 15: 678-685, 2008.
    • (2008) Cell Death Differ , vol.15 , pp. 678-685
    • Rankin, E.B.1    Giaccia, A.J.2
  • 265
    • 28844443129 scopus 로고    scopus 로고
    • Endogenous thioredoxin is required for redox cycling of anthracyclines and p53-dependent apoptosis in cancer cells
    • Ravi D, Muniyappa H, and Das KC. Endogenous thioredoxin is required for redox cycling of anthracyclines and p53-dependent apoptosis in cancer cells. J Biol Chem 280: 40084-40096, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 40084-40096
    • Ravi, D.1    Muniyappa, H.2    Das, K.C.3
  • 266
    • 25144453937 scopus 로고    scopus 로고
    • NADPH oxidase and endothelial cell function
    • Ray R and Shah AM. NADPH oxidase and endothelial cell function. Clin Sci (Lond) 109: 217-226, 2005.
    • (2005) Clin Sci (Lond) , vol.109 , pp. 217-226
    • Ray, R.1    Shah, A.M.2
  • 267
    • 53249154670 scopus 로고    scopus 로고
    • Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling
    • Reddy NM, Kleeberger SR, Bream JH, Fallon PG, Kensler TW, Yamamoto M, and Reddy SP. Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling. Oncogene 27: 5821-5832, 2008.
    • (2008) Oncogene , vol.27 , pp. 5821-5832
    • Reddy, N.M.1    Kleeberger, S.R.2    Bream, J.H.3    Fallon, P.G.4    Kensler, T.W.5    Yamamoto, M.6    Reddy, S.P.7
  • 268
    • 0034633602 scopus 로고    scopus 로고
    • Hydrogen peroxide: A key messenger that modulates protein phosphorylation through cysteine oxidation
    • Rhee SG, Bae YS, Lee SR, and Kwon J. Hydrogen peroxide: a key messenger that modulates protein phosphorylation through cysteine oxidation. Sci STKE 2000: pe1, 2000.
    • (2000) Sci STKE , vol.2000
    • Rhee, S.G.1    Bae, Y.S.2    Lee, S.R.3    Kwon, J.4
  • 270
    • 59249106025 scopus 로고    scopus 로고
    • Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma
    • Saga Y, Ohwada M, Suzuki M, Konno R, Kigawa J, Ueno S, and Mano H. Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma. Oncol Rep 20: 1299-1303, 2008.
    • (2008) Oncol Rep , vol.20 , pp. 1299-1303
    • Saga, Y.1    Ohwada, M.2    Suzuki, M.3    Konno, R.4    Kigawa, J.5    Ueno, S.6    Mano, H.7
  • 271
    • 80052047659 scopus 로고    scopus 로고
    • Recent advances in antiangiogenic therapy of cancer
    • Samant RS and Shevde LA. Recent advances in antiangiogenic therapy of cancer. Oncotarget 2: 122-134, 2011.
    • (2011) Oncotarget , vol.2 , pp. 122-134
    • Samant, R.S.1    Shevde, L.A.2
  • 272
    • 79952179447 scopus 로고    scopus 로고
    • ROS signaling by NOX4 drives fibroblast-to-myofibroblast differentiation in the diseased prostatic stroma
    • Sampson N, Koziel R, Zenzmaier C, Bubendorf L, Plas E, Jansen-Durr P, and Berger P. ROS signaling by NOX4 drives fibroblast-to-myofibroblast differentiation in the diseased prostatic stroma. Mol Endocrinol 25: 503-515, 2011.
    • (2011) Mol Endocrinol , vol.25 , pp. 503-515
    • Sampson, N.1    Koziel, R.2    Zenzmaier, C.3    Bubendorf, L.4    Plas, E.5    Jansen-Durr, P.6    Berger, P.7
  • 274
    • 78650890352 scopus 로고    scopus 로고
    • Regulation of autophagy by ROS: Physiology and pathology
    • Scherz-Shouval R and Elazar Z. Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci 36: 30-38, 2011.
    • (2011) Trends Biochem Sci , vol.36 , pp. 30-38
    • Scherz-Shouval, R.1    Elazar, Z.2
  • 275
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 276
    • 68749108106 scopus 로고    scopus 로고
    • Adenovirus receptors and their implications in gene delivery
    • Sharma A, Li X, Bangari DS, and Mittal SK. Adenovirus receptors and their implications in gene delivery. Virus Res 143: 184-194, 2009.
    • (2009) Virus Res , vol.143 , pp. 184-194
    • Sharma, A.1    Li, X.2    Bangari, D.S.3    Mittal, S.K.4
  • 277
    • 77957032845 scopus 로고    scopus 로고
    • Redox control of protein-DNA interactions: From molecular mechanisms to significance in signal transduction, gene expression, and DNA replication
    • Shlomai J. Redox control of protein-DNA interactions: from molecular mechanisms to significance in signal transduction, gene expression, and DNA replication. Antioxid Redox Signal 13: 1429-1476, 2010.
    • (2010) Antioxid Redox Signal , vol.13 , pp. 1429-1476
    • Shlomai, J.1
  • 279
    • 77957735624 scopus 로고    scopus 로고
    • Role of tumour-associated macrophages in cancerrelated inflammation
    • Sica A. Role of tumour-associated macrophages in cancerrelated inflammation. Exp Oncol 32: 153-158, 2010.
    • (2010) Exp Oncol , vol.32 , pp. 153-158
    • Sica, A.1
  • 286
    • 79956199030 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress drives tumor progression and metastasis: Should we use antioxidants as a key component of cancer treatment and prevention
    • Sotgia F, Martinez-Outschoorn UE, and Lisanti MP. Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention? BMC Med 9: 62, 2011.
    • (2011) BMC Med , vol.9 , pp. 62
    • Sotgia, F.1    Martinez-Outschoorn, U.E.2    Lisanti, M.P.3
  • 287
    • 0037160091 scopus 로고    scopus 로고
    • Topology of superoxide production from different sites in the mitochondrial electron transport chain
    • St-Pierre J, Buckingham JA, Roebuck SJ, and Brand MD. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem 277: 44784-44790, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 44784-44790
    • St-Pierre, J.1    Buckingham, J.A.2    Roebuck, S.J.3    Brand, M.D.4
  • 288
    • 33646698671 scopus 로고    scopus 로고
    • Hydrogen peroxide: A signaling messenger
    • Stone JR and Yang S. Hydrogen peroxide: a signaling messenger. Antioxid Redox Signal 8: 243-270, 2006.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 243-270
    • Stone, J.R.1    Yang, S.2
  • 289
    • 78650308850 scopus 로고    scopus 로고
    • New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
    • Swietach P, Hulikova A, Vaughan-Jones RD, and Harris AL. New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation. Oncogene 29: 6509-6521, 2010.
    • (2010) Oncogene , vol.29 , pp. 6509-6521
    • Swietach, P.1    Hulikova, A.2    Vaughan-Jones, R.D.3    Harris, A.L.4
  • 290
    • 0026021362 scopus 로고
    • Production of large amounts of hydrogen peroxide by human tumor cells
    • Szatrowski TP and Nathan CF. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 51: 794-798, 1991.
    • (1991) Cancer Res , vol.51 , pp. 794-798
    • Szatrowski, T.P.1    Nathan, C.F.2
  • 292
    • 78751703950 scopus 로고    scopus 로고
    • Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
    • Taguchi K, Motohashi H, and Yamamoto M. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells 16: 123-140, 2011.
    • (2011) Genes Cells , vol.16 , pp. 123-140
    • Taguchi, K.1    Motohashi, H.2    Yamamoto, M.3
  • 294
    • 79952366675 scopus 로고    scopus 로고
    • High-mobility group box 1, oxidative stress, and disease
    • Tang D, Kang R, Zeh HJ, 3rd, and Lotze MT. High-mobility group box 1, oxidative stress, and disease. Antioxid Redox Signal 14: 1315-1335, 2011.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 1315-1335
    • Tang, D.1    Kang, R.2    Zeh III, H.J.3    Lotze, M.T.4
  • 295
    • 68049143319 scopus 로고    scopus 로고
    • Overexpression of extracellular superoxide dismutase attenuates heparanase expression and inhibits breast carcinoma cell growth and invasion
    • Teoh ML, Fitzgerald MP, Oberley LW, and Domann FE. Overexpression of extracellular superoxide dismutase attenuates heparanase expression and inhibits breast carcinoma cell growth and invasion. Cancer Res 69: 6355-6363, 2009.
    • (2009) Cancer Res , vol.69 , pp. 6355-6363
    • Teoh, M.L.1    Fitzgerald, M.P.2    Oberley, L.W.3    Domann, F.E.4
  • 297
    • 84859103842 scopus 로고    scopus 로고
    • Antioxidants for prostate cancer chemoprevention: Challenges and opportunities
    • Thapa D and Ghosh R. Antioxidants for prostate cancer chemoprevention: challenges and opportunities. Biochem Pharmacol 83: 1319-1330, 2012.
    • (2012) Biochem Pharmacol , vol.83 , pp. 1319-1330
    • Thapa, D.1    Ghosh, R.2
  • 298
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • Thomlinson RH and Gray LH. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 9: 539-549, 1955.
    • (1955) Br J Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 299
    • 33645739790 scopus 로고    scopus 로고
    • Tumor stroma and regulation of cancer development
    • Tlsty TD and Coussens LM. Tumor stroma and regulation of cancer development. Annu Rev Pathol 1: 119-150, 2006.
    • (2006) Annu Rev Pathol , vol.1 , pp. 119-150
    • Tlsty, T.D.1    Coussens, L.M.2
  • 300
    • 72649102227 scopus 로고    scopus 로고
    • Catalytic mechanisms and specificities of glutathione peroxidases: Variations of a basic scheme
    • Toppo S, Flohe L, Ursini F, Vanin S, and Maiorino M. Catalytic mechanisms and specificities of glutathione peroxidases: variations of a basic scheme. Biochim Biophys Acta 1790: 1486-1500, 2009.
    • (2009) Biochim Biophys Acta , vol.1790 , pp. 1486-1500
    • Toppo, S.1    Flohe, L.2    Ursini, F.3    Vanin, S.4    Maiorino, M.5
  • 302
    • 67650071137 scopus 로고    scopus 로고
    • Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach
    • Trachootham D, Alexandre J, and Huang P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8: 579-591, 2009.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 579-591
    • Trachootham, D.1    Alexandre, J.2    Huang, P.3
  • 304
    • 0842266604 scopus 로고    scopus 로고
    • Oxidative protein folding in eukaryotes: Mechanisms and consequences
    • Tu BP, and Weissman JS. Oxidative protein folding in eukaryotes: mechanisms and consequences. J Cell Biol 164: 341-346, 2004.
    • (2004) J Cell Biol , vol.164 , pp. 341-346
    • Tu, B.P.1    Weissman, J.S.2
  • 306
    • 0035889658 scopus 로고    scopus 로고
    • Mn-SOD antisense upregulates in vivo apoptosis of squamous cell carcinoma cells by anticancer drugs and gamma-rays regulating expression of the BCL-2 family proteins, COX-2 and p21
    • Ueta E, Yoneda K, Kimura T, Tatemoto Y, Doi S, Yamamoto T, and Osaki T. Mn-SOD antisense upregulates in vivo apoptosis of squamous cell carcinoma cells by anticancer drugs and gamma-rays regulating expression of the BCL-2 family proteins, COX-2 and p21. Int J Cancer 94: 545-550, 2001.
    • (2001) Int J Cancer , vol.94 , pp. 545-550
    • Ueta, E.1    Yoneda, K.2    Kimura, T.3    Tatemoto, Y.4    Doi, S.5    Yamamoto, T.6    Osaki, T.7
  • 308
    • 33745217132 scopus 로고    scopus 로고
    • Redox signaling in angiogenesis: Role of NADPH oxidase
    • Ushio-Fukai M. Redox signaling in angiogenesis: role of NADPH oxidase. Cardiovasc Res 71: 226-235, 2006.
    • (2006) Cardiovasc Res , vol.71 , pp. 226-235
    • Ushio-Fukai, M.1
  • 309
    • 44449125132 scopus 로고    scopus 로고
    • Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy
    • Ushio-Fukai M and Nakamura Y. Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Lett 266: 37-52, 2008.
    • (2008) Cancer Lett , vol.266 , pp. 37-52
    • Ushio-Fukai, M.1    Nakamura, Y.2
  • 310
    • 70349368518 scopus 로고    scopus 로고
    • Novel role of NADPH oxidase in angiogenesis and stem/progenitor cell function
    • Ushio-Fukai M and Urao N. Novel role of NADPH oxidase in angiogenesis and stem/progenitor cell function. Antioxid Redox Signal 11: 2517-2533, 2009.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2517-2533
    • Ushio-Fukai, M.1    Urao, N.2
  • 312
    • 54049134838 scopus 로고    scopus 로고
    • Hypoxia and aggressive tumor phenotype: Implications for therapy and prognosis
    • Vaupel P. Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis. Oncologist 13 Suppl 3: 21-26, 2008.
    • (2008) Oncologist , vol.13 , Issue.SUPPL. 3 , pp. 21-26
    • Vaupel, P.1
  • 313
    • 77955294582 scopus 로고    scopus 로고
    • MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence
    • Venkataraman S, Alimova I, Fan R, Harris P, Foreman N, and Vibhakar R. MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence. PLoS One 5: e10748, 2010.
    • (2010) PLoS One , vol.5
    • Venkataraman, S.1    Alimova, I.2    Fan, R.3    Harris, P.4    Foreman, N.5    Vibhakar, R.6
  • 314
    • 77950910067 scopus 로고    scopus 로고
    • Mechanisms associated with mitochondrial-generated reactive oxygen species in cancer
    • Verschoor ML, Wilson LA, and Singh G. Mechanisms associated with mitochondrial-generated reactive oxygen species in cancer. Can J Physiol Pharmacol 88: 204-219, 2010.
    • (2010) Can J Physiol Pharmacol , vol.88 , pp. 204-219
    • Verschoor, M.L.1    Wilson, L.A.2    Singh, G.3
  • 315
    • 67449103011 scopus 로고    scopus 로고
    • Downregulation of the c-MYC target gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia
    • Vivas-Mejia PE, Ozpolat B, Chen X, and Lopez-Berestein G. Downregulation of the c-MYC target gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. Int J Cancer 125: 264-275, 2009.
    • (2009) Int J Cancer , vol.125 , pp. 264-275
    • Vivas-Mejia, P.E.1    Ozpolat, B.2    Chen, X.3    Lopez-Berestein, G.4
  • 317
    • 73949104703 scopus 로고    scopus 로고
    • Overexpression of Prdx6 and resistance to peroxideinduced death in Hepa1-6 cells: Prdx suppression increases apoptosis
    • Walsh B, Pearl A, Suchy S, Tartaglio J, Visco K, and Phelan SA. Overexpression of Prdx6 and resistance to peroxideinduced death in Hepa1-6 cells: Prdx suppression increases apoptosis. Redox Rep 14: 275-284, 2009.
    • (2009) Redox Rep , vol.14 , pp. 275-284
    • Walsh, B.1    Pearl, A.2    Suchy, S.3    Tartaglio, J.4    Visco, K.5    Phelan, S.A.6
  • 318
    • 80054959463 scopus 로고    scopus 로고
    • Underexpressed microRNA-199b-5p targets hypoxia-inducible factor-1alpha in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients
    • Wang C, Song B, Song W, Liu J, Sun A, Wu D, Yu H, Lian J, Chen L, and Han J. Underexpressed microRNA-199b-5p targets hypoxia-inducible factor-1alpha in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients. J Gastroenterol Hepatol 26: 1630-1637, 2011.
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 1630-1637
    • Wang, C.1    Song, B.2    Song, W.3    Liu, J.4    Sun, A.5    Wu, D.6    Yu, H.7    Lian, J.8    Chen, L.9    Han, J.10
  • 319
    • 58149105356 scopus 로고    scopus 로고
    • Cancer cell killing via ROS: To increase or decrease, that is the question
    • Wang J and Yi J. Cancer cell killing via ROS: to increase or decrease, that is the question. Cancer Biol Ther 7: 1875-1884, 2008.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1875-1884
    • Wang, J.1    Yi, J.2
  • 320
    • 28644438156 scopus 로고    scopus 로고
    • The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells
    • Wang T, Tamae D, LeBon T, Shively JE, Yen Y, and Li JJ. The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells. Cancer Res 65: 10338-10346, 2005.
    • (2005) Cancer Res , vol.65 , pp. 10338-10346
    • Wang, T.1    Tamae, D.2    Lebon, T.3    Shively, J.E.4    Yen, Y.5    Li, J.J.6
  • 321
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 123: 309-314, 1956.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 323
    • 70849093542 scopus 로고    scopus 로고
    • Reactive oxygen species-dependent signaling regulates cancer
    • Weinberg F and Chandel NS. Reactive oxygen species-dependent signaling regulates cancer. Cell Mol Life Sci 66: 3663-3673, 2009.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 3663-3673
    • Weinberg, F.1    Chandel, N.S.2
  • 325
    • 7944238044 scopus 로고    scopus 로고
    • Somatic alterations in the human cancer genome
    • Weir B, Zhao X, and Meyerson M. Somatic alterations in the human cancer genome. Cancer Cell 6: 433-438, 2004.
    • (2004) Cancer Cell , vol.6 , pp. 433-438
    • Weir, B.1    Zhao, X.2    Meyerson, M.3
  • 326
    • 31444444162 scopus 로고    scopus 로고
    • Integration of oxygen signaling at the consensus HRE
    • Wenger RH, Stiehl DP, and Camenisch G. Integration of oxygen signaling at the consensus HRE. Sci STKE 2005: re12, 2005.
    • (2005) Sci STKE , vol.2005
    • Wenger, R.H.1    Stiehl, D.P.2    Camenisch, G.3
  • 327
    • 0037157824 scopus 로고    scopus 로고
    • Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases
    • Werner E and Werb Z. Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. J Cell Biol 158: 357-368, 2002.
    • (2002) J Cell Biol , vol.158 , pp. 357-368
    • Werner, E.1    Werb, Z.2
  • 329
    • 33644827383 scopus 로고    scopus 로고
    • Bone-marrow haematopoieticstem-cell niches
    • Wilson A and Trumpp A. Bone-marrow haematopoieticstem-cell niches. Nat Rev Immunol 6: 93-106, 2006.
    • (2006) Nat Rev Immunol , vol.6 , pp. 93-106
    • Wilson, A.1    Trumpp, A.2
  • 330
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • Wilson WR and Hay MP. Targeting hypoxia in cancer therapy. Nat Rev Cancer 11: 393-410, 2011.
    • (2011) Nat Rev Cancer , vol.11 , pp. 393-410
    • Wilson, W.R.1    Hay, M.P.2
  • 332
    • 70349789713 scopus 로고    scopus 로고
    • Ras and Nox: Linked signaling networks
    • Wu RF and Terada LS. Ras and Nox: linked signaling networks? Free Radic Biol Med 47: 1276-1281, 2009.
    • (2009) Free Radic Biol Med , vol.47 , pp. 1276-1281
    • Wu, R.F.1    Terada, L.S.2
  • 333
    • 77951233373 scopus 로고    scopus 로고
    • Cancer associated fibroblasts (CAFs) in tumor microenvironment
    • Xing F, Saidou J, and Watabe K. Cancer associated fibroblasts (CAFs) in tumor microenvironment. Front Biosci 15: 166-179, 2010.
    • (2010) Front Biosci , vol.15 , pp. 166-179
    • Xing, F.1    Saidou, J.2    Watabe, K.3
  • 334
    • 84855482503 scopus 로고    scopus 로고
    • Novel, chimeric, cancer-specific, and radiation-inducible gene promoters for suicide gene therapy of cancer
    • Xiong J, Sun WJ, Wang WF, Liao ZK, Zhou FX, Kong HY, Xu Y, Xie CH, and Zhou YF. Novel, chimeric, cancer-specific, and radiation-inducible gene promoters for suicide gene therapy of cancer. Cancer 118: 536-548, 2012.
    • (2012) Cancer , vol.118 , pp. 536-548
    • Xiong, J.1    Sun, W.J.2    Wang, W.F.3    Liao, Z.K.4    Zhou, F.X.5    Kong, H.Y.6    Xu, Y.7    Xie, C.H.8    Zhou, Y.F.9
  • 335
    • 75849124916 scopus 로고    scopus 로고
    • Origin and function of tumor stroma fibroblasts
    • Xouri G and Christian S. Origin and function of tumor stroma fibroblasts. Semin Cell Dev Biol 21: 40-46, 2010.
    • (2010) Semin Cell Dev Biol , vol.21 , pp. 40-46
    • Xouri, G.1    Christian, S.2
  • 336
    • 79954516693 scopus 로고    scopus 로고
    • Quantitative mitochondrial redox imaging of breast cancer metastatic potential
    • Xu HN, Nioka S, Glickson JD, Chance B, and Li LZ. Quantitative mitochondrial redox imaging of breast cancer metastatic potential. J Biomed Opt 15: 036010, 2010.
    • (2010) J Biomed Opt , vol.15 , pp. 036010
    • Xu, H.N.1    Nioka, S.2    Glickson, J.D.3    Chance, B.4    Li, L.Z.5
  • 337
    • 78650982065 scopus 로고    scopus 로고
    • MiR-17* suppresses tumorigenicity of prostate cancer by inhibiting mitochondrial antioxidant enzymes
    • Xu Y, Fang F, Zhang J, Josson S, St. Clair WH, and St. Clair DK. miR-17* suppresses tumorigenicity of prostate cancer by inhibiting mitochondrial antioxidant enzymes. PLoS One 5: e14356, 2010.
    • (2010) PLoS One , vol.5
    • Xu, Y.1    Fang, F.2    Zhang, J.3    Josson, S.4    St. Clair, W.H.5    St. Clair, D.K.6
  • 338
    • 79956359793 scopus 로고    scopus 로고
    • Micro-RNA-22 regulates hypoxia signaling in colon cancer cells
    • Yamakuchi M, Yagi S, Ito T, and Lowenstein CJ. Micro-RNA-22 regulates hypoxia signaling in colon cancer cells. PLoS One 6: e20291, 2011.
    • (2011) PLoS One , vol.6
    • Yamakuchi, M.1    Yagi, S.2    Ito, T.3    Lowenstein, C.J.4
  • 339
    • 70249120673 scopus 로고    scopus 로고
    • Determinants of urinary 8-hydroxy-2′-deoxyguanosine in Chinese children with acute leukemia
    • Yang Y, Tian Y, Yan C, Jin X, Tang J, and Shen X. Determinants of urinary 8-hydroxy-2′-deoxyguanosine in Chinese children with acute leukemia. Environ Toxicol 24: 446-452, 2009.
    • (2009) Environ Toxicol , vol.24 , pp. 446-452
    • Yang, Y.1    Tian, Y.2    Yan, C.3    Jin, X.4    Tang, J.5    Shen, X.6
  • 340
    • 79959723691 scopus 로고    scopus 로고
    • Mitochondrial and energy metabolismrelated properties as novel indicators of lung cancer stem cells
    • Ye XQ, Li Q, Wang GH, Sun FF, Huang GJ, Bian XW, Yu SC, and Qian GS. Mitochondrial and energy metabolismrelated properties as novel indicators of lung cancer stem cells. Int J Cancer 129: 820-831, 2011.
    • (2011) Int J Cancer , vol.129 , pp. 820-831
    • Ye, X.Q.1    Li, Q.2    Wang, G.H.3    Sun, F.F.4    Huang, G.J.5    Bian, X.W.6    Yu, S.C.7    Qian, G.S.8
  • 342
    • 48249146576 scopus 로고    scopus 로고
    • Chemosensitisation by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2
    • Yeung BH, Wong KY, Lin MC, Wong CK, Mashima T, Tsuruo T, and Wong AS. Chemosensitisation by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2. Br J Cancer 99: 283-293, 2008.
    • (2008) Br J Cancer , vol.99 , pp. 283-293
    • Yeung, B.H.1    Wong, K.Y.2    Lin, M.C.3    Wong, C.K.4    Mashima, T.5    Tsuruo, T.6    Wong, A.S.7
  • 343
    • 39749177838 scopus 로고    scopus 로고
    • Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication
    • Yoo MH, Xu XM, Carlson BA, Patterson AD, Gladyshev VN, and Hatfield DL. Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication. PLoS One 2: e1112, 2007.
    • (2007) PLoS One , vol.2
    • Yoo, M.H.1    Xu, X.M.2    Carlson, B.A.3    Patterson, A.D.4    Gladyshev, V.N.5    Hatfield, D.L.6
  • 344
    • 77950890848 scopus 로고    scopus 로고
    • Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy
    • Zabirnyk O, Liu W, Khalil S, Sharma A, and Phang JM. Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy. Carcinogenesis 31: 446-454, 2010.
    • (2010) Carcinogenesis , vol.31 , pp. 446-454
    • Zabirnyk, O.1    Liu, W.2    Khalil, S.3    Sharma, A.4    Phang, J.M.5
  • 345
    • 4444268690 scopus 로고    scopus 로고
    • Mechanisms that regulate production of reactive oxygen species by cytochrome P450
    • Zangar RC, Davydov DR, and Verma S. Mechanisms that regulate production of reactive oxygen species by cytochrome P450. Toxicol Appl Pharmacol 199: 316-331, 2004.
    • (2004) Toxicol Appl Pharmacol , vol.199 , pp. 316-331
    • Zangar, R.C.1    Davydov, D.R.2    Verma, S.3
  • 346
    • 37849032288 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of siRNA against peroxiredoxin i enhances the radiosensitivity of human intestinal cancer
    • Zhang B, Wang Y, Liu K, Yang X, Song M, and Bai Y. Adenovirus-mediated transfer of siRNA against peroxiredoxin I enhances the radiosensitivity of human intestinal cancer. Biochem Pharmacol 75: 660-667, 2008.
    • (2008) Biochem Pharmacol , vol.75 , pp. 660-667
    • Zhang, B.1    Wang, Y.2    Liu, K.3    Yang, X.4    Song, M.5    Bai, Y.6
  • 347
    • 71549168293 scopus 로고    scopus 로고
    • Peroxiredoxins, a novel target in cancer radiotherapy
    • Zhang B, Wang Y, and Su Y. Peroxiredoxins, a novel target in cancer radiotherapy. Cancer Lett 286: 154-160, 2009.
    • (2009) Cancer Lett , vol.286 , pp. 154-160
    • Zhang, B.1    Wang, Y.2    Su, Y.3
  • 348
    • 33845442925 scopus 로고    scopus 로고
    • Mechanistic studies of the Nrf2-Keap1 signaling pathway
    • Zhang DD. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev 38: 769-789, 2006.
    • (2006) Drug Metab Rev , vol.38 , pp. 769-789
    • Zhang, D.D.1
  • 352
    • 33646231994 scopus 로고    scopus 로고
    • Complete elimination of colorectal tumor xenograft by combined manganese superoxide dismutase with tumor necrosis factor-related apoptosis-inducing ligand gene virotherapy
    • Zhang Y, Gu J, Zhao L, He L, Qian W, Wang J, Wang Y, Qian Q, Qian C, Wu J, and Liu XY. Complete elimination of colorectal tumor xenograft by combined manganese superoxide dismutase with tumor necrosis factor-related apoptosis-inducing ligand gene virotherapy. Cancer Res 66: 4291-4298, 2006.
    • (2006) Cancer Res , vol.66 , pp. 4291-4298
    • Zhang, Y.1    Gu, J.2    Zhao, L.3    He, L.4    Qian, W.5    Wang, J.6    Wang, Y.7    Qian, Q.8    Qian, C.9    Wu, J.10    Liu, X.Y.11


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