ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

Science

Volumn 320, Issue 5876, 2008, Pages 661-664

  Ishikawa, Kaori ^a,b   Takenaga, Keizo ^c,d   Akimoto, Miho ^d   Koshikawa, Nobuko ^c   Yamaguchi, Aya ^a   Imanishi, Hirotake ^a   Nakada, Kazuto ^a   Honma, Yoshio ^d   Hayashi, Jun Ichi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c CHIBA CANCER CENTER   (Japan)

^d SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; DNA; NADH DEHYDROGENASE SUBUNIT 6, MOUSE; SCAVENGER;

CYTOLOGY; MITOCHONDRIAL DNA; MUTATION; RODENT; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL FUNCTION; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME DEFECT; FRAMESHIFT MUTATION; GENE MUTATION; HUMAN; HUMAN CELL; METASTASIS; MISSENSE MUTATION; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATORY MECHANISM; ANIMAL; GENETICS; HELA CELL; HYBRID CELL; METABOLISM; MUTATION; TUMOR CELL LINE;

MUS;

ACETYLCYSTEINE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DNA, MITOCHONDRIAL; DNA, NEOPLASM; ELECTRON TRANSPORT COMPLEX I; FREE RADICAL SCAVENGERS; HELA CELLS; HUMANS; HYBRID CELLS; MICE; MUTATION; NADH DEHYDROGENASE; NEOPLASM METASTASIS; REACTIVE OXYGEN SPECIES;

EID: 43249112094     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1156906     Document Type: Article

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28. This work was supported by Grants-in-Aid for Scientific Research (S) from the Japan Society for Promotion of Science (JSPS), by Grants-in-Aid for Creative Scientific Research from JSPS, and by Grants-in-Aid for Scientific Research on Priority Areas from The Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) to J.-I.H. This work was also supported by grants for a Research Fellowship from JSPS for Young Scientists to K.I. and by Grants-in-Aid for Third Term Comprehensive Control Research for Cancer from the Ministry of Health, Labour, and Welfare and for Scientific Research from MEXT to K.T. All animal experiments were performed in compliance with the institutional guidelines (Chiba Cancer Center and University of Tsukuba) for the care and use of laboratory animals.