Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

Molecular Cell

Volumn 30, Issue 4, 2008, Pages 393-402

  Kaelin Jr , William G ^a,b,c   Ratcliffe, Peter J ^d  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; 2 OXOGLUTARIC ACID ANTAGONIST; ASCORBIC ACID; ASPARAGINE; HEAT SHOCK PROTEIN 90 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IRON; IRON CHELATING AGENT; NITRIC OXIDE; OXYGENASE; PROLYL HYDROXYLASE DOMAIN INHIBITOR; PROTEIN INHIBITOR; REACTIVE OXYGEN METABOLITE; SORAFENIB; SUNITINIB;

ANEMIA; CELL MATURATION; CELL METABOLISM; CHEMICAL ANALYSIS; CITRIC ACID CYCLE; ENZYME STABILITY; GENE THERAPY; GENETIC TRANSCRIPTION; HEART INFARCTION; HUMAN; HYDROXYLATION; INFLAMMATION; KIDNEY CANCER; METAZOON; NEOPLASM; NONHUMAN; OXYGEN SENSING; PHYSIOLOGY; REVIEW; VASCULAR DISEASE;

ANIMALS; ASCORBIC ACID; ASPARAGINE; CITRIC ACID CYCLE; ENZYME STABILITY; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; IRON; ISOENZYMES; NITRIC OXIDE; OXYGEN; PROCOLLAGEN-PROLINE DIOXYGENASE; REACTIVE OXYGEN SPECIES; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

METAZOA;

EID: 43649093915     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2008.04.009     Document Type: Review

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