-
1
-
-
84966192535
-
The histological structure of some human lung cancers and the possible implications for radiotherapy
-
Thomlinson, R. H. & Gray, L. H. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br. J. Cancer 9, 539-549 (1955).
-
(1955)
Br. J. Cancer
, vol.9
, pp. 539-549
-
-
Thomlinson, R.H.1
Gray, L.H.2
-
2
-
-
84960987950
-
Concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
-
Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S. & Scott, O. C. Concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br. J. Radiol. 26, 638-648 (1953). References 1 and 2 are classic papers describing both the general nature of the oxygen effect in reducing radiation sensitivity (reference 2) and the fact that the hypoxic cells almost certainly are present in human tumours (reference 1).
-
(1953)
Br. J. Radiol.
, vol.26
, pp. 638-648
-
-
Gray, L.H.1
Conger, A.D.2
Ebert, M.3
Hornsey, S.4
Scott, O.C.5
-
3
-
-
0021236301
-
Clinical trials of radiosensitizers: What should we expect?
-
Brown, J. M. Clinical trials of radiosensitizers: what should we expect? Int. J. Radiat. Oncol. Biol. Phys. 10, 495-499 (1984).
-
(1984)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.10
, pp. 495-499
-
-
Brown, J.M.1
-
4
-
-
0028632781
-
Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors
-
Overgaard, J. Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors. Oncol. Res. 6, 509-518 (1994).
-
(1994)
Oncol. Res.
, vol.6
, pp. 509-518
-
-
Overgaard, J.1
-
6
-
-
0029955072
-
Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
-
Nordsmark, M., Overgaard, M. & Overgaard, J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother. Oncol. 41, 31-40 (1996).
-
(1996)
Radiother. Oncol.
, vol.41
, pp. 31-40
-
-
Nordsmark, M.1
Overgaard, M.2
Overgaard, J.3
-
7
-
-
0032708195
-
Oxygenation of head and neck cancer: Changes during radiotherapy and impact on treatment outcome
-
Brizel, D. M., Dodge, R. K., Clough, R. W. & Dewhirst, M. W. Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother. Oncol. 53, 113-117 (1999).
-
(1999)
Radiother. Oncol.
, vol.53
, pp. 113-117
-
-
Brizel, D.M.1
Dodge, R.K.2
Clough, R.W.3
Dewhirst, M.W.4
-
8
-
-
0010992283
-
Conventional cancer therapy: Promise broken or promise delayed?
-
Tannock, I. F. Conventional cancer therapy: promise broken or promise delayed? Lancet 351 (Suppl. 2), 9-16 (1998).
-
(1998)
Lancet
, vol.351
, Issue.SUPPL. 2
, pp. 9-16
-
-
Tannock, I.F.1
-
9
-
-
0028603270
-
The influence of microenvironmental factors during cancer therapy
-
Durand, R. E. The influence of microenvironmental factors during cancer therapy. In vivo 8, 691-702 (1994).
-
(1994)
In Vivo
, vol.8
, pp. 691-702
-
-
Durand, R.E.1
-
10
-
-
0014292997
-
The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour
-
Tannock, I. F. The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour. Br. J. Cancer 22, 258-273 (1968).
-
(1968)
Br. J. Cancer
, vol.22
, pp. 258-273
-
-
Tannock, I.F.1
-
11
-
-
0019349297
-
Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells
-
Teicher, B. A., Lazo, J. S. & Sartorelli, A. C. Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells. Cancer Res. 41, 73-81 (1981).
-
(1981)
Cancer Res.
, vol.41
, pp. 73-81
-
-
Teicher, B.A.1
Lazo, J.S.2
Sartorelli, A.C.3
-
12
-
-
0029886833
-
Oxygen dependence of the cytotoxicity of the enediyne antitumour antibiotic esperamicin A1
-
Batchelder, R. M., Wilson, W. R., Hay, M. P. & Denny, W. A. Oxygen dependence of the cytotoxicity of the enediyne antitumour antibiotic esperamicin A1. Br. J. Cancer Suppl. 27, S52-S56 (1996).
-
(1996)
Br. J. Cancer Suppl.
, vol.27
-
-
Batchelder, R.M.1
Wilson, W.R.2
Hay, M.P.3
Denny, W.A.4
-
13
-
-
0037096732
-
Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene
-
Comerford, K. M. et al. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res. 62, 3387-3394 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 3387-3394
-
-
Comerford, K.M.1
-
14
-
-
0037365537
-
Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species
-
Wartenberg, M. et al. Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species. FASEB J. 17, 503-505 (2003).
-
(2003)
FASEB J.
, vol.17
, pp. 503-505
-
-
Wartenberg, M.1
-
15
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
-
Graeber, T. G. et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379, 88-91 (1996). Describes how hypoxia in tumours selects against wild-type p53 by causing apoptosis in these cells.
-
(1996)
Nature
, vol.379
, pp. 88-91
-
-
Graeber, T.G.1
-
16
-
-
0032565578
-
Mutagenesis induced by the tumor microenvironment
-
Yuan, J. & Glazer, P. M. Mutagenesis induced by the tumor microenvironment. Mutat. Res. 400, 439-446 (1998).
-
(1998)
Mutat. Res.
, vol.400
, pp. 439-446
-
-
Yuan, J.1
Glazer, P.M.2
-
17
-
-
0036359548
-
Hypoxia - A key regulatory factor in tumour growth
-
Harris, A. L. Hypoxia - a key regulatory factor in tumour growth. Nature Rev. Cancer 2, 38-47 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
18
-
-
0037478437
-
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
-
Pennacchietti, S. et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 3, 347-361 (2003).
-
(2003)
Cancer Cell
, vol.3
, pp. 347-361
-
-
Pennacchietti, S.1
-
19
-
-
0034037286
-
Microenvironment-induced cancer metastasis
-
Rofstad, E. K. Microenvironment-induced cancer metastasis. Int. J. Radiat. Biol. 76, 589-605 (2000).
-
(2000)
Int. J. Radiat. Biol.
, vol.76
, pp. 589-605
-
-
Rofstad, E.K.1
-
20
-
-
0037279517
-
The hypoxic tumour microenvironment and metastatic progression
-
Subarsky, P. & Hill, R. P. The hypoxic tumour microenvironment and metastatic progression. Clin. Exp. Metastasis 20, 237-250 (2003).
-
(2003)
Clin. Exp. Metastasis
, vol.20
, pp. 237-250
-
-
Subarsky, P.1
Hill, R.P.2
-
21
-
-
0029775242
-
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
-
Hockel, M. et al. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56, 4509-4515 (1996).
-
(1996)
Cancer Res.
, vol.56
, pp. 4509-4515
-
-
Hockel, M.1
-
22
-
-
0030022252
-
Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
-
Brizel, D. M. et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res. 56, 941-943 (1996).
-
(1996)
Cancer Res.
, vol.56
, pp. 941-943
-
-
Brizel, D.M.1
-
23
-
-
0022493495
-
SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells
-
Zeman, E. M., Brown, J. M., Lemmon, M. J., Hirst, V. K. & Lee, W. W. SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells. Int. J. Radiat. Oncol. Biol. Phys. 12, 1239-1242 (1986). The initial paper describing the hypoxic selectivity of tirapazamine for cell killing.
-
(1986)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.2
, pp. 1239-1242
-
-
Zeman, E.M.1
Brown, J.M.2
Lemmon, M.J.3
Hirst, V.K.4
Lee, W.W.5
-
24
-
-
0025646401
-
Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors
-
Brown, J. M. & Lemmon, M. J. Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors. Cancer Res. 50, 7745-7749 (1990).
-
(1990)
Cancer Res.
, vol.50
, pp. 7745-7749
-
-
Brown, J.M.1
Lemmon, M.J.2
-
25
-
-
0027288316
-
SR 4233 (tirapazamine): A new anticancer drug exploiting hypoxia in solid tumours
-
Brown, J. M. SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours. Br. J. Cancer 67, 1163-1170 (1993).
-
(1993)
Br. J. Cancer
, vol.67
, pp. 1163-1170
-
-
Brown, J.M.1
-
26
-
-
0029959898
-
DNA cleavage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (SR4233): Evidence for involvement of hydroxyl radical
-
Daniels, J. S. & Gates, K. S. DNA cleavage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (SR4233): Evidence for involvement of hydroxyl radical. J. Am. Chem. Soc. 118, 3380-3385 (1996).
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 3380-3385
-
-
Daniels, J.S.1
Gates, K.S.2
-
27
-
-
0042348003
-
A mass spectrometry study of tirapazamine and its metabolites, insights into the mechanism of metabolic transformations and the characterization of reaction intermediates
-
Zagorevskii, D. et al. A mass spectrometry study of tirapazamine and its metabolites, insights into the mechanism of metabolic transformations and the characterization of reaction intermediates. J. Am. Soc. Mass Spectrom. 14, 881-892 (2003).
-
(2003)
J. Am. Soc. Mass Spectrom.
, vol.14
, pp. 881-892
-
-
Zagorevskii, D.1
-
28
-
-
0037460188
-
Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction
-
Anderson, R. F., Shinde, S. S., Hay, M. P., Gamage, S. A. & Denny, W. A. Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction. J. Am. Chem. Soc. 125, 748-756 (2003).
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 748-756
-
-
Anderson, R.F.1
Shinde, S.S.2
Hay, M.P.3
Gamage, S.A.4
Denny, W.A.5
-
29
-
-
0037105653
-
Tirapazamine: A hypoxia-activated topoisomerase II poison
-
Peters, K. B. & Brown, J. M. Tirapazamine: a hypoxia-activated topoisomerase II poison. Cancer Res. 62, 5248-5253 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 5248-5253
-
-
Peters, K.B.1
Brown, J.M.2
-
30
-
-
84965808588
-
Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin
-
Dorie, M. J. & Brown, J. M. Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin. Cancer Res. 53, 4633-4636 (1993). In vivo data showing that tirapazamine and cisplatin have a marked hypoxia and schedule-dependent synergism.
-
(1993)
Cancer Res.
, vol.53
, pp. 4633-4636
-
-
Dorie, M.J.1
Brown, J.M.2
-
31
-
-
0033063810
-
Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin
-
Kovacs, M. S. et al. Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin. Br. J Cancer 80, 1245-1251 (1999).
-
(1999)
Br. J. Cancer
, vol.80
, pp. 1245-1251
-
-
Kovacs, M.S.1
-
32
-
-
0034104328
-
Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group
-
von Pawel, J. et al. Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group. J. Clin. Oncol. 18, 1351-1359 (2000). Clinical data showing the efficacy of tirapazamine in combination with cisplatin in a randomized multicentre Phase III trial.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 1351-1359
-
-
Von Pawel, J.1
-
33
-
-
1642456411
-
Preliminary results of TROG 98.02-a randomized phase II study of 5-fluorouracil, cisplatin and radiation versus tirapazamine, cisplatin and radiation for advanced squamous cell carcinoma of the head and neck
-
Rischin, D. et al. Preliminary results of TROG 98.02-a randomized phase II study of 5-fluorouracil, cisplatin and radiation versus tirapazamine, cisplatin and radiation for advanced squamous cell carcinoma of the head and neck. Proc. Am. Soc. Clin. Oncol. 22, A1992 (2003).
-
(2003)
Proc. Am. Soc. Clin. Oncol.
, vol.22
-
-
Rischin, D.1
-
34
-
-
0027220811
-
Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: A new class of bioreductive agent
-
Patterson, L. H. Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent. Cancer Metastasis Rev. 12, 119-134 (1993).
-
(1993)
Cancer Metastasis Rev.
, vol.12
, pp. 119-134
-
-
Patterson, L.H.1
-
35
-
-
0036041236
-
Bioreductively activated antitumor N-oxides: The case of AQ4N, a unique approach to hypoxia-activated cancer chemotherapy
-
Patterson, L. H. Bioreductively activated antitumor N-oxides: the case of AQ4N, a unique approach to hypoxia-activated cancer chemotherapy. Drug Metab. Rev. 34, 581-592 (2002).
-
(2002)
Drug Metab. Rev.
, vol.34
, pp. 581-592
-
-
Patterson, L.H.1
-
36
-
-
0036015562
-
Tumour cytochrome P 450 and drug activation
-
Patterson, L. H. & Murray, G. I. Tumour cytochrome P450 and drug activation. Curr. Pharm. Des. 8, 1335-1347 (2002).
-
(2002)
Curr. Pharm. Des.
, vol.8
, pp. 1335-1347
-
-
Patterson, L.H.1
Murray, G.I.2
-
37
-
-
0034543132
-
AQ4N: A new approach to hypoxia-activated cancer chemotherapy
-
Patterson, L. H. & McKeown, S. R. AQ4N: a new approach to hypoxia-activated cancer chemotherapy. Br. J. Cancer 83, 1589-1593 (2000).
-
(2000)
Br. J. Cancer
, vol.83
, pp. 1589-1593
-
-
Patterson, L.H.1
McKeown, S.R.2
-
38
-
-
0034029002
-
Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent
-
Patterson, L. H. et al. Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent. Br. J. Cancer 82, 1984-1990 (2000). Demonstration of potentiation of radiation and chemotherapy by the bioreductive agent AQ4N.
-
(2000)
Br. J. Cancer
, vol.82
, pp. 1984-1990
-
-
Patterson, L.H.1
-
39
-
-
0028339820
-
Bioreductive drugs for cancer therapy: The search for tumor specificity
-
Adams, G. E. & Stratford, I. J. Bioreductive drugs for cancer therapy: the search for tumor specificity. Int. J. Radiat. Oncol. Biol. Phys. 29, 231-238 (1994).
-
(1994)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.29
, pp. 231-238
-
-
Adams, G.E.1
Stratford, I.J.2
-
40
-
-
0030028884
-
Hypoxia-specific cytotoxins in cancer therapy
-
Brown, J. M. & Siim, B. G. Hypoxia-specific cytotoxins in cancer therapy. Semin. Rad. Onc. 6, 22-36 (1996).
-
(1996)
Semin. Rad. Onc.
, vol.6
, pp. 22-36
-
-
Brown, J.M.1
Siim, B.G.2
-
41
-
-
0034941481
-
Anticancer prodrugs for application in monotherapy: Targeting hypoxia, tumor-associated enzymes, and receptors
-
de Groot, F. M., Damen, E. W. & Scheeren, H. W. Anticancer prodrugs for application in monotherapy: targeting hypoxia, tumor-associated enzymes, and receptors. Curr. Med. Chem. 8, 1093-1122 (2001).
-
(2001)
Curr. Med. Chem.
, vol.8
, pp. 1093-1122
-
-
De Groot, F.M.1
Damen, E.W.2
Scheeren, H.W.3
-
42
-
-
0027219332
-
Bioreducible mustards: A paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs)
-
Denny, W. A. & Wilson, W. R. Bioreducible mustards: a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs). Cancer Metastasis Rev. 12, 135-151 (1993).
-
(1993)
Cancer Metastasis Rev.
, vol.12
, pp. 135-151
-
-
Denny, W.A.1
Wilson, W.R.2
-
43
-
-
0035352723
-
Recent advances in bioreductive drug targeting
-
Naylor, M. A. & Thomson, P. Recent advances in bioreductive drug targeting. Mini Rev. Med. Chem. 1, 17-29 (2001).
-
(2001)
Mini Rev. Med. Chem.
, vol.1
, pp. 17-29
-
-
Naylor, M.A.1
Thomson, P.2
-
44
-
-
0031742631
-
Bioreductive therapies: An overview of drugs and their mechanisms of action
-
Rauth, A. M., Melo, T. & Misra, V. Bioreductive therapies: an overview of drugs and their mechanisms of action. Int. J. Radiat. Oncol. Biol. Phys. 42, 755-762 (1998).
-
(1998)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.42
, pp. 755-762
-
-
Rauth, A.M.1
Melo, T.2
Misra, V.3
-
45
-
-
0026698228
-
Use of hypoxia-directed drugs in the therapy of solid tumors
-
Rockwell, S. Use of hypoxia-directed drugs in the therapy of solid tumors. Semin. Oncol. 19, 29-40 (1992).
-
(1992)
Semin. Oncol.
, vol.19
, pp. 29-40
-
-
Rockwell, S.1
-
46
-
-
0027328452
-
The experimental development of bioreductive drugs and their role in cancer therapy
-
Workman, P. & Stratford, I. J. The experimental development of bioreductive drugs and their role in cancer therapy. Cancer Metastasis Rev. 12, 73-82 (1993).
-
(1993)
Cancer Metastasis Rev.
, vol.12
, pp. 73-82
-
-
Workman, P.1
Stratford, I.J.2
-
47
-
-
0344629821
-
NLCQ-1 (NSC 709257): Exploiting hypoxia with a weak DNA-intercalating bioreductive drug
-
Papadopoulou, M. V. & Bloomer, W. D. NLCQ-1 (NSC 709257): exploiting hypoxia with a weak DNA-intercalating bioreductive drug. Clin. Cancer Res. 9, 5714-5720 (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 5714-5720
-
-
Papadopoulou, M.V.1
Bloomer, W.D.2
-
48
-
-
0034997032
-
Extravascular transport of the DNA intercalator and topoisomerase poison N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): Diffusion and metabolism in multicellular layers of tumor cells
-
Hicks, K. O., Pruijn, F. B., Baguley, B. C. & Wilson, W. R. Extravascular transport of the DNA intercalator and topoisomerase poison N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): diffusion and metabolism in multicellular layers of tumor cells. J. Pharmacol. Exp. Ther. 297, 1088-1098 (2001).
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.297
, pp. 1088-1098
-
-
Hicks, K.O.1
Pruijn, F.B.2
Baguley, B.C.3
Wilson, W.R.4
-
49
-
-
0038054178
-
Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting
-
Delahoussaye, Y. M., Hay, M. P., Pruijn, F. B., Denny, W. A. & Brown, J. M. Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting. Biochem. Pharmacol. 65, 1807-1815 (2003).
-
(2003)
Biochem. Pharmacol.
, vol.65
, pp. 1807-1815
-
-
Delahoussaye, Y.M.1
Hay, M.P.2
Pruijn, F.B.3
Denny, W.A.4
Brown, J.M.5
-
50
-
-
0347593966
-
DNA-targeted 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine
-
Hay, M. P. et al. DNA-targeted 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine. J. Med. Chem. 47, 475-488 (2004).
-
(2004)
J. Med. Chem.
, vol.47
, pp. 475-488
-
-
Hay, M.P.1
-
51
-
-
0029884764
-
Recent developments in the design of bioreductive drugs
-
Denny, W. A., Wilson, W. R. & Hay, M. P. Recent developments in the design of bioreductive drugs. Br. J. Cancer Suppl. 27, S32-S38 (1996).
-
(1996)
Br. J. Cancer Suppl.
, vol.27
-
-
Denny, W.A.1
Wilson, W.R.2
Hay, M.P.3
-
52
-
-
0027227590
-
Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin
-
Koch, C. J. Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin. Cancer Res. 53, 3992-3997 (1993).
-
(1993)
Cancer Res.
, vol.53
, pp. 3992-3997
-
-
Koch, C.J.1
-
53
-
-
3042537843
-
Oxygen dependence of the metabolic activation and cytotoxicity of tirapazamine: Implications for exptravascular transport and activity in tumors
-
in the press
-
Hicks, K. O., Siim, B. G., Pruijn, F. B. & Wilson, W. R. Oxygen dependence of the metabolic activation and cytotoxicity of tirapazamine: Implications for exptravascular transport and activity in tumors. Radiat. Res. (in the press).
-
Radiat. Res.
-
-
Hicks, K.O.1
Siim, B.G.2
Pruijn, F.B.3
Wilson, W.R.4
-
54
-
-
0023741181
-
Oxygen and exposure kinetics as factors influencing the cytotoxicity of porfiromycin, a mitomycin C analogue, in Chinese hamster ovary cells
-
Marshall, R. S. & Rauth, A. M. Oxygen and exposure kinetics as factors influencing the cytotoxicity of porfiromycin, a mitomycin C analogue, in Chinese hamster ovary cells. Cancer Res. 48, 5655-5659 (1988).
-
(1988)
Cancer Res.
, vol.48
, pp. 5655-5659
-
-
Marshall, R.S.1
Rauth, A.M.2
-
55
-
-
0027981814
-
Oxygen dependence of the cytotoxicity and metabolic activation of 4-alkylamino-5-nitroquinoline bioreductive drugs
-
Siim, B. G., Atwell, G. J. & Wilson, W. R. Oxygen dependence of the cytotoxicity and metabolic activation of 4-alkylamino-5-nitroquinoline bioreductive drugs. Br. J. Cancer 70, 596-603 (1994).
-
(1994)
Br. J. Cancer
, vol.70
, pp. 596-603
-
-
Siim, B.G.1
Atwell, G.J.2
Wilson, W.R.3
-
56
-
-
0028200679
-
Exploiting tumor hypoxia through bioreductive release of diffusible cytotoxins: The cobalt(III)-nitrogen mustard complex SN 24771
-
Wilson, W. R., Moselen, J. W., Cliffe, S., Denny, W. A. & Ware, D. C. Exploiting tumor hypoxia through bioreductive release of diffusible cytotoxins: the cobalt(III)-nitrogen mustard complex SN 24771. Int. J. Radiat. Oncol. Biol. Phys. 29, 323-327 (1994).
-
(1994)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.29
, pp. 323-327
-
-
Wilson, W.R.1
Moselen, J.W.2
Cliffe, S.3
Denny, W.A.4
Ware, D.C.5
-
57
-
-
0030926491
-
Cells at intermediate oxygen levels can be more important than the 'hypoxic fraction' in determining tumor response to fractionated radiotherapy
-
Wouters, B. G. & Brown, J. M. Cells at intermediate oxygen levels can be more important than the 'hypoxic fraction' in determining tumor response to fractionated radiotherapy. Radiat. Res. 147, 541-550 (1997).
-
(1997)
Radiat. Res.
, vol.147
, pp. 541-550
-
-
Wouters, B.G.1
Brown, J.M.2
-
58
-
-
0034652379
-
Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice
-
Lee, A. E. & Wilson, W. R. Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice. Toxicol. Appl. Pharmacol. 163, 50-59 (2000).
-
(2000)
Toxicol. Appl. Pharmacol.
, vol.163
, pp. 50-59
-
-
Lee, A.E.1
Wilson, W.R.2
-
59
-
-
0020632173
-
Identification of a hypoxic population of bone marrow cells
-
Allalunis, M. J., Chapman, J. D. & Turner, A. R. Identification of a hypoxic population of bone marrow cells. Int. J. Radiat. Oncol. Biol. Phys. 9, 227-232 (1983).
-
(1983)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.9
, pp. 227-232
-
-
Allalunis, M.J.1
Chapman, J.D.2
Turner, A.R.3
-
60
-
-
0027443181
-
The role of hypoxia in the maintenance of hematopoietic stem cells
-
Cipolleschi, M. G., Dello Sbarba, P. & Olivotto, M. The role of hypoxia in the maintenance of hematopoietic stem cells. Blood 82, 2031-2037 (1993).
-
(1993)
Blood
, vol.82
, pp. 2031-2037
-
-
Cipolleschi, M.G.1
Dello Sbarba, P.2
Olivotto, M.3
-
61
-
-
0031306972
-
Nitro reduction as an electronic switch for bioreductive drug activation
-
Siim, B. G., Denny, W. A. & Wilson, W. R. Nitro reduction as an electronic switch for bioreductive drug activation. Oncol. Res. 9, 357-369 (1997).
-
(1997)
Oncol. Res.
, vol.9
, pp. 357-369
-
-
Siim, B.G.1
Denny, W.A.2
Wilson, W.R.3
-
62
-
-
0037399470
-
Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: Distinct mechanisms of bioreductive activation
-
Helsby, N. A. et al. Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation. Chem. Res. Toxicol. 16, 469-478 (2003).
-
(2003)
Chem. Res. Toxicol.
, vol.16
, pp. 469-478
-
-
Helsby, N.A.1
-
63
-
-
0036494169
-
Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures
-
Wilson, W. R. et al. Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures. Cancer Res. 62, 1425-1432 (2002). Demonstrates the use of three-dimensional cell cultures to show bystander effects from GDEPT.
-
(2002)
Cancer Res.
, vol.62
, pp. 1425-1432
-
-
Wilson, W.R.1
-
64
-
-
0034212605
-
Synthesis and evaluation of nitroheterocyclic phosphoramidates as hypoxia-selective alkylating agents
-
Borch, R. F. et al. Synthesis and evaluation of nitroheterocyclic phosphoramidates as hypoxia-selective alkylating agents. J. Med. Chem. 43, 2258-2265 (2000).
-
(2000)
J. Med. Chem.
, vol.43
, pp. 2258-2265
-
-
Borch, R.F.1
-
65
-
-
0035846072
-
Hypoxia-selective antitumor agents. 16. Nitroarylmethyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine
-
Tercel, M. et al. Hypoxia-selective antitumor agents. 16. Nitroarylmethyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine. J. Med. Chem. 44, 3511-3522 (2001).
-
(2001)
J. Med. Chem.
, vol.44
, pp. 3511-3522
-
-
Tercel, M.1
-
66
-
-
0028200679
-
Exploiting tumor hypoxia through bioreductive release of diffusible cytotoxins: The cobalt(III)-nitrogen mustard complex SN 24771
-
Wilson, W. R., Moselen, J. W., Cliffe, S., Denny, W. A. & Ware, D. C. Exploiting tumor hypoxia through bioreductive release of diffusible cytotoxins: the cobalt(III)-nitrogen mustard complex SN 24771. Int. J. Radiat. Oncol. Biol. Phys. 29, 323-327 (1994).
-
(1994)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.29
, pp. 323-327
-
-
Wilson, W.R.1
Moselen, J.W.2
Cliffe, S.3
Denny, W.A.4
Ware, D.C.5
-
67
-
-
0036569920
-
Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: A key factor in controlling hypoxia-selective drug release
-
Everett, S. A. et al. Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: a key factor in controlling hypoxia-selective drug release. Biochem. Pharmacol. 63, 1629-1639 (2002).
-
(2002)
Biochem. Pharmacol.
, vol.63
, pp. 1629-1639
-
-
Everett, S.A.1
-
68
-
-
0031706557
-
Radiation-activated prodrugs as hypoxia-selective cytotoxins: Model studies with nitroarylmethyl quaternary salts
-
Wilson, W. R., Tercel, M., Anderson, R. F. & Denny, W. A. Radiation-activated prodrugs as hypoxia-selective cytotoxins: model studies with nitroarylmethyl quaternary salts. Anticancer Drug Des. 13, 663-685 (1998).
-
(1998)
Anticancer Drug Des.
, vol.13
, pp. 663-685
-
-
Wilson, W.R.1
Tercel, M.2
Anderson, R.F.3
Denny, W.A.4
-
69
-
-
0036895522
-
Pathways of reductive fragmentation of heterocyclic nitroarylmethyl quaternary ammonium prodrugs of mechlorethamine
-
Kriste, A. G., Tercel, M., Anderson, R. F., Ferry, D. M. & Wilson, W. R. Pathways of reductive fragmentation of heterocyclic nitroarylmethyl quaternary ammonium prodrugs of mechlorethamine. Radiat. Res. 158, 753-762 (2002).
-
(2002)
Radiat. Res.
, vol.158
, pp. 753-762
-
-
Kriste, A.G.1
Tercel, M.2
Anderson, R.F.3
Ferry, D.M.4
Wilson, W.R.5
-
70
-
-
4644296027
-
Optimization of the auxiliary ligand shell of cobalt(III)(8-hydroxyquinoline) complexes as model hypoxia-selective radiation-activated prodrugs
-
in the press
-
Ahn, G., Ware, D. C., Denny, W. A. & Wilson, W. R. Optimization of the auxiliary ligand shell of cobalt(III)(8-hydroxyquinoline) complexes as model hypoxia-selective radiation-activated prodrugs. Radiat. Res. (in the press).
-
Radiat. Res.
-
-
Ahn, G.1
Ware, D.C.2
Denny, W.A.3
Wilson, W.R.4
-
71
-
-
0034024791
-
A novel class of antitumor prodrug, 1-(2′-oxopropyl) -5-fluorouracil (OFU001), that releases 5-fluorouracil upon hypoxic irradiation
-
Shibamoto, Y., Zhou, L., Hatta, H., Mori, M. & Nishimoto, S. A novel class of antitumor prodrug, 1-(2′- oxopropyl)-5-fluorouracil (OFU001), that releases 5-fluorouracil upon hypoxic irradiation. Jpn J. Cancer Res. 91, 433-438 (2000).
-
(2000)
Jpn J. Cancer Res.
, vol.91
, pp. 433-438
-
-
Shibamoto, Y.1
Zhou, L.2
Hatta, H.3
Mori, M.4
Nishimoto, S.5
-
72
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
-
Zhong, H. et al. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res. 59, 5830-5835 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
-
73
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
-
Talks, K. L. et al. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 157, 411-421 (2000).
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 411-421
-
-
Talks, K.L.1
-
74
-
-
0031742542
-
Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes
-
Shibata, T., Akiyama, N., Noda, M., Sasai, K. & Hiraoka, M. Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes. Int. J. Radiat. Oncol. Biol. Phys. 42, 913-916 (1998).
-
(1998)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.42
, pp. 913-916
-
-
Shibata, T.1
Akiyama, N.2
Noda, M.3
Sasai, K.4
Hiraoka, M.5
-
75
-
-
0035123128
-
Gene directed enzyme/prodrug therapy of cancer: Historical appraisal and future prospectives
-
Greco, O. & Dachs, G. U. Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives. J. Cell Physiol. 187, 22-36 (2001).
-
(2001)
J. Cell Physiol.
, vol.187
, pp. 22-36
-
-
Greco, O.1
Dachs, G.U.2
-
76
-
-
0037386279
-
Hypoxia-mediated tumour targeting
-
Binley, K. et al. Hypoxia-mediated tumour targeting. Gene Ther. 10, 540-549 (2003).
-
(2003)
Gene Ther.
, vol.10
, pp. 540-549
-
-
Binley, K.1
-
77
-
-
0036145795
-
Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy
-
Shibata, T., Giaccia, A. J. & Brown, J. M. Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy. Neoplasia 4, 40-48 (2002).
-
(2002)
Neoplasia
, vol.4
, pp. 40-48
-
-
Shibata, T.1
Giaccia, A.J.2
Brown, J.M.3
-
78
-
-
0036328116
-
Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours
-
Patterson, A. V. et al. Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours. Gene Ther. 9, 946-954 (2002).
-
(2002)
Gene Ther.
, vol.9
, pp. 946-954
-
-
Patterson, A.V.1
-
79
-
-
0028800141
-
Enzyme/prodrug gene therapy: Comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line
-
Trinh, Q. T., Austin, E. A., Murray, D. M., Knick, V. C. & Huber, B. E. Enzyme/prodrug gene therapy: comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line. Cancer Res. 55, 4808-4812 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 4808-4812
-
-
Trinh, Q.T.1
Austin, E.A.2
Murray, D.M.3
Knick, V.C.4
Huber, B.E.5
-
80
-
-
0037279816
-
Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N
-
McCarthy, H. O. et al. Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N. Cancer Gene Ther. 10, 40-48 (2003).
-
(2003)
Cancer Gene Ther.
, vol.10
, pp. 40-48
-
-
McCarthy, H.O.1
-
81
-
-
0033998433
-
The macrophage: A novel system to deliver gene therapy to pathological hypoxia
-
Griffiths, L. et al. The macrophage: a novel system to deliver gene therapy to pathological hypoxia. Gene Ther. 7, 255-262 (2000).
-
(2000)
Gene Ther.
, vol.7
, pp. 255-262
-
-
Griffiths, L.1
-
82
-
-
0036007293
-
Expression of HIF-1α by human macrophages: Implications for the use of macrophages in hypoxia-regulated cancer gene therapy
-
Burke, B. et al. Expression of HIF-1α by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. J. Pathol. 196, 204-212 (2002).
-
(2002)
J. Pathol.
, vol.196
, pp. 204-212
-
-
Burke, B.1
-
83
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza, G. L. Targeting HIF-1 for cancer therapy. Nature Rev. Cancer 3, 721-732 (2003).
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
84
-
-
0242331755
-
HIF-1 as a target for drug development
-
Giaccia, A., Siim, B. G. & Johnson, R. S. HIF-1 as a target for drug development. Nature Rev. Drug Discov. 2, 803-811 (2003).
-
(2003)
Nature Rev. Drug Discov.
, vol.2
, pp. 803-811
-
-
Giaccia, A.1
Siim, B.G.2
Johnson, R.S.3
-
85
-
-
0036122242
-
Involvement of hypoxia-inducible factor 1 in human cancer
-
Semenza, G. L. Involvement of hypoxia-inducible factor 1 in human cancer. Intern. Med. 41, 79-83 (2002).
-
(2002)
Intern. Med.
, vol.41
, pp. 79-83
-
-
Semenza, G.L.1
-
86
-
-
0034529914
-
Suppression of tumor growth through disruption of hypoxia-inducible transcription
-
Kung, A. L., Wang, S., Klco, J. M., Kaelin, W. G. & Livingston, D. M. Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nature Med. 6, 1335-1340 (2000).
-
(2000)
Nature Med.
, vol.6
, pp. 1335-1340
-
-
Kung, A.L.1
Wang, S.2
Klco, J.M.3
Kaelin, W.G.4
Livingston, D.M.5
-
87
-
-
0036682284
-
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
-
Rapisarda, A. et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res. 62, 4316-4324 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 4316-4324
-
-
Rapisarda, A.1
-
88
-
-
0035003528
-
Gene transfer of antisense hypoxia inducible factor-1α enhances the therapeutic efficacy of cancer immunotherapy
-
Sun, X. et al. Gene transfer of antisense hypoxia inducible factor-1α enhances the therapeutic efficacy of cancer immunotherapy. Gene Ther. 8, 638-645 (2001).
-
(2001)
Gene Ther.
, vol.8
, pp. 638-645
-
-
Sun, X.1
-
89
-
-
0036569704
-
Geldanamycin induces degradation of hypoxia-inducible factor 1α protein via the proteosome pathway in prostate cancer cells
-
Mabjeesh, N. J. et al. Geldanamycin induces degradation of hypoxia-inducible factor 1α protein via the proteosome pathway in prostate cancer cells. Cancer Res. 62, 2478-2482 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 2478-2482
-
-
Mabjeesh, N.J.1
-
90
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
Mabjeesh, N. J. et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 3, 363-375 (2003).
-
(2003)
Cancer Cell
, vol.3
, pp. 363-375
-
-
Mabjeesh, N.J.1
-
91
-
-
0037414180
-
YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1
-
Yeo, E. J. et al. YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J. Natl Cancer Inst. 95, 516-525 (2003).
-
(2003)
J. Natl. Cancer Inst.
, vol.95
, pp. 516-525
-
-
Yeo, E.J.1
-
92
-
-
0005311884
-
Anaerobic bacteria as a gene delivery system to tumors
-
Lemmon, M. J. et al. Anaerobic bacteria as a gene delivery system to tumors. Proc. Am. Assoc. Cancer Res. 35, 374 (1994).
-
(1994)
Proc. Am. Assoc. Cancer Res.
, vol.35
, pp. 374
-
-
Lemmon, M.J.1
-
93
-
-
0029932035
-
Anaerobic bacteria as a delivery system for cancer gene therapy: Activation of 5-fluorocytosine by genetically engineered clostridia
-
Fox, M. E. et al. Anaerobic bacteria as a delivery system for cancer gene therapy: activation of 5-fluorocytosine by genetically engineered clostridia. Gene Ther. 3, 173-178 (1996).
-
(1996)
Gene Ther.
, vol.3
, pp. 173-178
-
-
Fox, M.E.1
-
94
-
-
0030865697
-
Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment
-
Lemmon, M. L. et al. Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment. Gene Ther. 4, 791-796 (1997).
-
(1997)
Gene Ther.
, vol.4
, pp. 791-796
-
-
Lemmon, M.L.1
-
95
-
-
33747149297
-
Localization of the vegetative form of Clostridium tetani in mouse tumors following intravenous spore administration
-
Malmgren, R. A. & Flanigan, C. C. Localization of the vegetative form of Clostridium tetani in mouse tumors following intravenous spore administration. Cancer Res. 15, 473-478 (1955).
-
(1955)
Cancer Res.
, vol.15
, pp. 473-478
-
-
Malmgren, R.A.1
Flanigan, C.C.2
-
96
-
-
0003041879
-
Onkolyseversuche mit apathogenen anaeroben sporenbildern am ehrlich tumor des maus
-
Möse, J. R. & Möse, G. Onkolyseversuche mit apathogenen anaeroben Sporenbildern am Ehrlich Tumor des Maus. Z. Krebsforsch 63, 63-74 (1959).
-
(1959)
Z. Krebsforsch.
, vol.63
, pp. 63-74
-
-
Möse, J.R.1
Möse, G.2
-
97
-
-
0000775441
-
Oncolysis by clostridia. I. Activity of Clostridium butyricum (M-55) and other nonpathogenic clostridia against the Ehrlich carcinoma
-
Möse, J. R. & Möse, G. Oncolysis by clostridia. I. Activity of Clostridium butyricum (M-55) and other nonpathogenic clostridia against the Ehrlich carcinoma. Cancer Res. 24, 212-216 (1964).
-
(1964)
Cancer Res.
, vol.24
, pp. 212-216
-
-
Möse, J.R.1
Möse, G.2
-
98
-
-
78651152166
-
Oncolysis by clostridia. III. Effects of clostridia and chemotherapeutic agents on rodent tumors
-
Thiele, E. H., Arison, R. N. & Boxer, G. E. Oncolysis by clostridia. III. Effects of clostridia and chemotherapeutic agents on rodent tumors. Cancer Res. 24 (1964).
-
(1964)
Cancer Res.
, vol.24
-
-
Thiele, E.H.1
Arison, R.N.2
Boxer, G.E.3
-
99
-
-
0001448008
-
Oncolysis by clostridia V. Transplanted tumors of the hamster
-
Engelbart, K. & Gericke, D. Oncolysis by clostridia V. Transplanted tumors of the hamster. Cancer Res. 24, 239-243 (1964).
-
(1964)
Cancer Res.
, vol.24
, pp. 239-243
-
-
Engelbart, K.1
Gericke, D.2
-
100
-
-
0002483330
-
Clostridial oncolysis in man
-
Carey, R. W., Holland, J. F., Whang, H. Y., Neter, E. & Bryant, B. Clostridial oncolysis in man. Europ. J. Cancer 3, 37-46 (1967).
-
(1967)
Europ. J. Cancer
, vol.3
, pp. 37-46
-
-
Carey, R.W.1
Holland, J.F.2
Whang, H.Y.3
Neter, E.4
Bryant, B.5
-
101
-
-
0018098489
-
The liquefaction (oncolysis) of malignant gliomas by a non pathogenic clostridium
-
Heppner, F. & Mose, J. R. The liquefaction (oncolysis) of malignant gliomas by a non pathogenic clostridium. Acta Neuro. 12, 123-125 (1978).
-
(1978)
Acta Neuro.
, vol.12
, pp. 123-125
-
-
Heppner, F.1
Mose, J.R.2
-
102
-
-
0008635091
-
Oncolysis of malignant gliomas of the brain
-
Heppner, F., Mose, J., Ascher, P. W. & Walter, G. Oncolysis of malignant gliomas of the brain. 13th Int. Cong. Chemother. 226, 38-45 (1983).
-
(1983)
13th Int. Cong. Chemother.
, vol.226
, pp. 38-45
-
-
Heppner, F.1
Mose, J.2
Ascher, P.W.3
Walter, G.4
-
103
-
-
0030854392
-
Tumor-targeted Salmonella as a novel anticancer vector
-
Pawelek, J. M., Low, K. B. & Bermudes, D. Tumor-targeted Salmonella as a novel anticancer vector. Cancer Res. 57, 4537-4544 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 4537-4544
-
-
Pawelek, J.M.1
Low, K.B.2
Bermudes, D.3
-
104
-
-
0036140068
-
Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma
-
Toso, J. F. et al. Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma. J. Clin. Oncol. 20, 142-152 (2002).
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 142-152
-
-
Toso, J.F.1
-
105
-
-
85047697737
-
Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis
-
Liu, S. C., Minton, N. P., Giaccia, A. J. & Brown, J. M. Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis. Gene Ther. 9, 291-296 (2002). First data demonstrating in vivo efficacy of CDEPT.
-
(2002)
Gene Ther.
, vol.9
, pp. 291-296
-
-
Liu, S.C.1
Minton, N.P.2
Giaccia, A.J.3
Brown, J.M.4
-
106
-
-
0029609610
-
Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954
-
Bridgewater, J. A. et al. Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954. Eur. J. Cancer 31A, 2362-2370 (1995).
-
(1995)
Eur. J. Cancer
, vol.31 A
, pp. 2362-2370
-
-
Bridgewater, J.A.1
-
108
-
-
0030971014
-
Antibody-directed enzyme prodrug therapy: Pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial
-
Martin, J. et al. Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial. Cancer Chemother. Pharmacol. 40, 189-201 (1997).
-
(1997)
Cancer Chemother. Pharmacol.
, vol.40
, pp. 189-201
-
-
Martin, J.1
-
109
-
-
0033083206
-
Stimulation of tumors to synthesize tumor necrosis factor-α in situ using 5,6-dimethylxanthenone-4-acetic acid: A novel approach to cancer therapy
-
Joseph, W. R. et al. Stimulation of tumors to synthesize tumor necrosis factor-α in situ using 5,6-dimethylxanthenone-4-acetic acid: a novel approach to cancer therapy. Cancer Res. 59, 633-638 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 633-638
-
-
Joseph, W.R.1
-
110
-
-
0037068317
-
The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor-1 knockout mice
-
Zhao, L., Ching, L. M., Kestell, P. & Baguley, B. C. The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor-1 knockout mice. Br. J. Cancer 87, 465-470 (2002).
-
(2002)
Br. J. Cancer
, vol.87
, pp. 465-470
-
-
Zhao, L.1
Ching, L.M.2
Kestell, P.3
Baguley, B.C.4
-
111
-
-
0037125028
-
Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid
-
Ching, L. M. et al. Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid. Br. J. Cancer 86, 1937-1942 (2002).
-
(2002)
Br. J. Cancer
, vol.86
, pp. 1937-1942
-
-
Ching, L.M.1
-
112
-
-
0037106501
-
Effects of 5,6-dimethylxanthenone-4-acetic acid on human tumor microcirculation assessed by dynamic contrast-enhanced magnetic resonance imaging
-
Galbraith, S. M. et al. Effects of 5,6-dimethylxanthenone-4-acetic acid on human tumor microcirculation assessed by dynamic contrast-enhanced magnetic resonance imaging. J. Clin. Oncol. 20, 3826-3840 (2002).
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 3826-3840
-
-
Galbraith, S.M.1
-
113
-
-
0035134791
-
Improvement of Clostridium tumour targeting vectors evaluated in rat rhabdomyosarcomas
-
Theys, J. et al. Improvement of Clostridium tumour targeting vectors evaluated in rat rhabdomyosarcomas. FEMS Immunol. Med. Microbiol. 30, 37-41 (2001).
-
(2001)
FEMS Immunol. Med. Microbiol.
, vol.30
, pp. 37-41
-
-
Theys, J.1
-
114
-
-
0035909908
-
Combination bacteriolytic therapy for the treatment of experimental tumors
-
Dang, L. H., Bettegowda, C., Huso, D. L., Kinzler, K. W. & Vogelstein, B. Combination bacteriolytic therapy for the treatment of experimental tumors. Proc. Natl Acad. Sci. USA 98, 15155-15160 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 15155-15160
-
-
Dang, L.H.1
Bettegowda, C.2
Huso, D.L.3
Kinzler, K.W.4
Vogelstein, B.5
-
115
-
-
0141507967
-
Multicellular resistance to tirapazamine is due to restricted extravascular transport in HT29 multicellular layer cultures: A pharmacokinetic/pharmacodynamic study
-
Hicks, K. O., Pruijn, F. B., Sturman, J. R., Denny, W. A. & Wilson, W. R. Multicellular resistance to tirapazamine is due to restricted extravascular transport in HT29 multicellular layer cultures: A pharmacokinetic/pharmacodynamic study. Cancer Res. 63, 5970-5977 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 5970-5977
-
-
Hicks, K.O.1
Pruijn, F.B.2
Sturman, J.R.3
Denny, W.A.4
Wilson, W.R.5
-
116
-
-
1942424798
-
2-Amino metabolites are key mediatiors of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT
-
Helsby, N. A., Ferry, D. M., Patterson, A. V., Pullen, S. M. & Wilson, W. R. 2-amino metabolites are key mediatiors of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT. Br. J. Cancer 90, 1084-1092 (2004).
-
(2004)
Br. J. Cancer
, vol.90
, pp. 1084-1092
-
-
Helsby, N.A.1
Ferry, D.M.2
Patterson, A.V.3
Pullen, S.M.4
Wilson, W.R.5
-
117
-
-
0038523737
-
Tumor hypoxia at the micro-regional level: Clinical relevance and predictive value of exdogenous and endogenous hypoxic cell markers
-
Bussink, J., Kaanders, J. H. A. M. & van der Kogel, A. J. Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exdogenous and endogenous hypoxic cell markers. Radiother. Oncol. 67, 3-15 (2003).
-
(2003)
Radiother. Oncol.
, vol.67
, pp. 3-15
-
-
Bussink, J.1
Kaanders, J.H.A.M.2
Van Der Kogel, A.J.3
-
118
-
-
0014525030
-
2,4-Dinitro-5-ethyleneiminobenzamide (CB 1954): A potent and selective inhibitor of the growth of the Walker carcinoma 256
-
Cobb, L. M. et al. 2,4-Dinitro-5-ethyleneiminobenzamide (CB 1954): A potent and selective inhibitor of the growth of the Walker carcinoma 256. Biochem. Pharmacol. 18, 1519-1527 (1969).
-
(1969)
Biochem. Pharmacol.
, vol.18
, pp. 1519-1527
-
-
Cobb, L.M.1
-
119
-
-
0024209370
-
A new cytotoxic, DNA interstrand crosslinking agent, 5-(Aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(Aziridin-1-YL)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells
-
Knox, R. J., Friedlos, F., Jarman, M. & Roberts, J. J. A new cytotoxic, DNA interstrand crosslinking agent, 5-(Aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(Aziridin-1-YL)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells. Biochem. Pharm. 37, 4661-4669 (1988).
-
(1988)
Biochem. Pharm.
, vol.37
, pp. 4661-4669
-
-
Knox, R.J.1
Friedlos, F.2
Jarman, M.3
Roberts, J.J.4
-
120
-
-
0024205344
-
The nitroreductase enzyme in Walker cells that activates 5-(Aziridin-1-YL)-2,4-dinitrobenzamide (CB 1954) to 5-(Aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1. 6. 99. 2)
-
Knox, R. J. et al. The nitroreductase enzyme in Walker cells that activates 5-(Aziridin-1-YL)-2,4-dinitrobenzamide (CB 1954) to 5-(Aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1. 6. 99. 2). Biochem. Pharmacol. 37, 4671-4677 (1988).
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 4671-4677
-
-
Knox, R.J.1
-
121
-
-
0026745562
-
The bioactivation of 5-(Aziridin-1-YL)-2,4-dinitrobenzamide (CB 1954)-I Purification and properties of a nitroreductase enzyme from Escherichia Coli: A potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT)
-
Anlezark, G. M. et al. The bioactivation of 5-(Aziridin-1-YL)-2,4-dinitrobenzamide (CB 1954)-I Purification and properties of a nitroreductase enzyme from Escherichia Coli: A potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT). Biochem. Pharmacol. 44, 2289-2295 (1992).
-
(1992)
Biochem. Pharmacol.
, vol.44
, pp. 2289-2295
-
-
Anlezark, G.M.1
-
122
-
-
0034814342
-
Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: A phase I and pharmacokinetic study of its prodrug, CB1954
-
Chung-Faye, G. et al. Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: a phase I and pharmacokinetic study of its prodrug, CB1954. Clin. Cancer Res. 7, 2662-2668 (2001).
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 2662-2668
-
-
Chung-Faye, G.1
-
123
-
-
0019834471
-
Radiosensitizing and cytotoxicity studies with CB 1954 (2,4-dinitro-5-aziridinylbenzamide)
-
Stratford, I. J., Williamson, C., Hoe, S. & Adams, G. E. Radiosensitizing and cytotoxicity studies with CB 1954 (2,4-dinitro-5-aziridinylbenzamide). Radiat. Res. 88, 502-509 (1981).
-
(1981)
Radiat. Res.
, vol.88
, pp. 502-509
-
-
Stratford, I.J.1
Williamson, C.2
Hoe, S.3
Adams, G.E.4
-
124
-
-
0026665360
-
Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells
-
Palmer, B. D., Wilson, W. R., Cliffe, S. & Denny, W. A. Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells. J. Med. Chem. 35, 3214-3222 (1992).
-
(1992)
J. Med. Chem.
, vol.35
, pp. 3214-3222
-
-
Palmer, B.D.1
Wilson, W.R.2
Cliffe, S.3
Denny, W.A.4
-
125
-
-
0032053823
-
The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
-
Brown, J. M. & Giaccia, A. J. The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy. Cancer Res. 58, 1408-1416 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 1408-1416
-
-
Brown, J.M.1
Giaccia, A.J.2
-
126
-
-
0035131933
-
Mitochondrial dysfunction after aerobic exposure to the hypoxic cytotoxin tirapazamine
-
Wouters, B. G. et al. Mitochondrial dysfunction after aerobic exposure to the hypoxic cytotoxin tirapazamine. Cancer Res. 61, 145-152 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 145-152
-
-
Wouters, B.G.1
-
127
-
-
0035300410
-
Expression of hypoxia-inducible factor-1α: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
-
Aebersold, D. M. et al. Expression of hypoxia-inducible factor-1α: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res. 61, 2911-2916 (2001). Shows that HIF-1 can be used as an endogenous marker of tumour hypoxia to predict response to radiotherapy.
-
(2001)
Cancer Res.
, vol.61
, pp. 2911-2916
-
-
Aebersold, D.M.1
-
128
-
-
0028182816
-
Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors
-
Rampling, R., Cruickshank, G., Lewis, A. D., Fitzsimmons, S. A. & Workman, P. Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors. Int. J. Radiat. Oncol. Biol. Phys. 29, 427-431 (1994).
-
(1994)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.29
, pp. 427-431
-
-
Rampling, R.1
Cruickshank, G.2
Lewis, A.D.3
Fitzsimmons, S.A.4
Workman, P.5
-
129
-
-
0032726709
-
Polarographic measurements of oxygen tension in human glioma and surrounding peritumoural brain tissue
-
Collingridge, D. R., Piepmeier, J. M., Rockwell, S. & Knisely, J. P. Polarographic measurements of oxygen tension in human glioma and surrounding peritumoural brain tissue. Radiother. Oncol. 53, 127-131 (1999).
-
(1999)
Radiother. Oncol.
, vol.53
, pp. 127-131
-
-
Collingridge, D.R.1
Piepmeier, J.M.2
Rockwell, S.3
Knisely, J.P.4
-
130
-
-
0028242772
-
Measurement of human tumour oxygenation status by a polarographic needle electrode
-
Nordsmark, M., Bentzen, S. M. & Overgaard, J. Measurement of human tumour oxygenation status by a polarographic needle electrode. Acta Oncol. 33, 383-389 (1994).
-
(1994)
Acta Oncol.
, vol.33
, pp. 383-389
-
-
Nordsmark, M.1
Bentzen, S.M.2
Overgaard, J.3
-
131
-
-
0344936018
-
Oxygenation of squamous cell carcinoma of the head and neck: Comparison of primary tumors, neck node metastases, and normal tissue
-
Becker, A. et al. Oxygenation of squamous cell carcinoma of the head and neck: comparison of primary tumors, neck node metastases, and normal tissue. Int. J. Radiat. Oncol. Biol. Phys. 42, 35-41 (1998).
-
(1998)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.42
, pp. 35-41
-
-
Becker, A.1
-
132
-
-
0037963317
-
Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients
-
Le, Q. T. et al. Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients. Int. J. Radiat. Oncol. Biol. Phys. 56, 375-383 (2003).
-
(2003)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.56
, pp. 375-383
-
-
Le, Q.T.1
-
133
-
-
0036021479
-
Hypoxia in breast cancer: Pathogenesis, characterization and biological/therapeutic implications
-
Vaupel, P., Briest, S. & Hockel, M. Hypoxia in breast cancer: pathogenesis, characterization and biological/therapeutic implications. Wien. Med. Wochenschr. 152, 334-342 (2002).
-
(2002)
Wien. Med. Wochenschr.
, vol.152
, pp. 334-342
-
-
Vaupel, P.1
Briest, S.2
Hockel, M.3
-
134
-
-
0034333026
-
Pancreatic tumors show high levels of hypoxia
-
Koong, A. C. et al. Pancreatic tumors show high levels of hypoxia. Int. J. Radiat. Oncol. Biol. Phys. 48, 919-922 (2000).
-
(2000)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.48
, pp. 919-922
-
-
Koong, A.C.1
-
135
-
-
0030825252
-
Oxygen tension in human tumours measured with polarographic needle electrodes and its relationship to vascular density, necrosis and hypoxia
-
Lyng, H., Sundfor, K. & Rofstad, E. K. Oxygen tension in human tumours measured with polarographic needle electrodes and its relationship to vascular density, necrosis and hypoxia. Radiother. Oncol. 44, 163-169 (1997).
-
(1997)
Radiother. Oncol.
, vol.44
, pp. 163-169
-
-
Lyng, H.1
Sundfor, K.2
Rofstad, E.K.3
-
136
-
-
0031716020
-
Oxygenation predicts radiation response and survival in patients with cervix cancer
-
Fyles, A. W. et al. Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother. Oncol. 48, 149-156 (1998).
-
(1998)
Radiother. Oncol.
, vol.48
, pp. 149-156
-
-
Fyles, A.W.1
-
137
-
-
0037847453
-
Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas
-
Nordsmark, M. et al. Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas. Radiother. Oncol. 67, 35-44 (2003).
-
(2003)
Radiother. Oncol.
, vol.67
, pp. 35-44
-
-
Nordsmark, M.1
-
138
-
-
0034798395
-
Hypoxia in human prostate carcinoma: An Eppendorf PO 2 study
-
Movsas, B. et al. Hypoxia in human prostate carcinoma: an Eppendorf PO2 study. Am. J. Clin. Oncol. 24, 458-461 (2001).
-
(2001)
Am. J. Clin. Oncol.
, vol.24
, pp. 458-461
-
-
Movsas, B.1
-
139
-
-
0030465080
-
Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas
-
Brizel, D. M. et al. Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas. Cancer Res. 56, 5347-5350 (1996).
-
(1996)
Cancer Res.
, vol.56
, pp. 5347-5350
-
-
Brizel, D.M.1
-
140
-
-
0030199968
-
The relationship between tumor oxygenation and cell proliferation in human soft tissue sarcomas
-
Nordsmark, M. et al. The relationship between tumor oxygenation and cell proliferation in human soft tissue sarcomas. Int. J. Radiat. Oncol. Biol. Phys. 35, 701-708 (1996).
-
(1996)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.35
, pp. 701-708
-
-
Nordsmark, M.1
|